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Protein
Submitted name:

Tissue-type plasminogen activator

Gene

PLAT

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Tissue-type plasminogen activatorImported
Gene namesi
Name:PLATImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000104368.17
HGNCiHGNC:9051 PLAT

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104368

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500319854123 – 178Sequence analysisAdd BLAST156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi91 ↔ 108PROSITE-ProRule annotation
Disulfide bondi110 ↔ 119PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

MaxQBiE5RGA1
PeptideAtlasiE5RGA1
PRIDEiE5RGA1

Expressioni

Gene expression databases

BgeeiENSG00000104368
ExpressionAtlasiE5RGA1 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE5RGA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 81Fibronectin type-IInterPro annotationAdd BLAST43
Domaini82 – 120EGF-likeInterPro annotationAdd BLAST39
Domaini126 – 178KringleInterPro annotationAdd BLAST53

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, KringlePROSITE-ProRule annotationSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119133

Family and domain databases

Gene3Di2.40.20.10, 1 hit
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000083 Fibronectin_type1
IPR000001 Kringle
IPR013806 Kringle-like
IPR038178 Kringle_sf
IPR034811 tPA
PANTHERiPTHR44617 PTHR44617, 1 hit
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF00039 fn1, 1 hit
PF00051 Kringle, 1 hit
SMARTiView protein in SMART
SM00058 FN1, 1 hit
SM00130 KR, 1 hit
SUPFAMiSSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS01253 FN1_1, 1 hit
PS51091 FN1_2, 1 hit
PS50070 KRINGLE_2, 1 hit

Sequencei

Sequence statusi: Fragment.

E5RGA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAMKRGLCC VLLLCGAVFV SPSQEIHARF RRGARSYQVI CRDEKTQMIY
60 70 80 90 100
QQHQSWLRPV LRSNRVEYCW CNSGRAQCHS VPVKSCSEPR CFNGGTCQQA
110 120 130 140 150
LYFSDFVCQC PEGFAGKCCE IDTRATCYED QGISYRGTWS TAESGAECTN
160 170
WNSSALAQKP YSGRRPDAIR LGLGNHNY
Length:178
Mass (Da):20,079
Last modified:February 8, 2011 - v1
Checksum:iE95ED63B8D766AAB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei178Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC083973 Genomic DNA No translation available.
AC103724 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000520523; ENSP00000428797; ENSG00000104368
UCSCiuc064mjw.1 human

Similar proteinsi

Entry informationi

Entry nameiE5RGA1_HUMAN
AccessioniPrimary (citable) accession number: E5RGA1
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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