Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Tissue-type plasminogen activator

Gene

PLAT

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Tissue-type plasminogen activatorImported
Gene namesi
Name:PLATImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:9051. PLAT.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104368.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500319854123 – 178Sequence analysisAdd BLAST156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi91 ↔ 108PROSITE-ProRule annotation
Disulfide bondi110 ↔ 119PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

MaxQBiE5RGA1.
PaxDbiE5RGA1.
PeptideAtlasiE5RGA1.
PRIDEiE5RGA1.

Expressioni

Gene expression databases

BgeeiENSG00000104368.
ExpressionAtlasiE5RGA1. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000220809.

Structurei

3D structure databases

ProteinModelPortaliE5RGA1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 81Fibronectin type-IInterPro annotationAdd BLAST43
Domaini82 – 120EGF-likeInterPro annotationAdd BLAST39
Domaini126 – 178KringleInterPro annotationAdd BLAST53

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, KringlePROSITE-ProRule annotationSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119133.

Family and domain databases

InterProiView protein in InterPro
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000083. Fibronectin_type1.
IPR000001. Kringle.
IPR013806. Kringle-like.
PfamiView protein in Pfam
PF00008. EGF. 1 hit.
PF00039. fn1. 1 hit.
PF00051. Kringle. 1 hit.
SMARTiView protein in SMART
SM00058. FN1. 1 hit.
SM00130. KR. 1 hit.
SUPFAMiSSF57440. SSF57440. 1 hit.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS01253. FN1_1. 1 hit.
PS51091. FN1_2. 1 hit.
PS50070. KRINGLE_2. 1 hit.

Sequencei

Sequence statusi: Fragment.

E5RGA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAMKRGLCC VLLLCGAVFV SPSQEIHARF RRGARSYQVI CRDEKTQMIY
60 70 80 90 100
QQHQSWLRPV LRSNRVEYCW CNSGRAQCHS VPVKSCSEPR CFNGGTCQQA
110 120 130 140 150
LYFSDFVCQC PEGFAGKCCE IDTRATCYED QGISYRGTWS TAESGAECTN
160 170
WNSSALAQKP YSGRRPDAIR LGLGNHNY
Length:178
Mass (Da):20,079
Last modified:February 8, 2011 - v1
Checksum:iE95ED63B8D766AAB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei178Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC083973 Genomic DNA. No translation available.
AC103724 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000520523; ENSP00000428797; ENSG00000104368.
UCSCiuc064mjw.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC083973 Genomic DNA. No translation available.
AC103724 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE5RGA1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000220809.

Proteomic databases

MaxQBiE5RGA1.
PaxDbiE5RGA1.
PeptideAtlasiE5RGA1.
PRIDEiE5RGA1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000520523; ENSP00000428797; ENSG00000104368.
UCSCiuc064mjw.1. human.

Organism-specific databases

HGNCiHGNC:9051. PLAT.
OpenTargetsiENSG00000104368.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119133.

Miscellaneous databases

ChiTaRSiPLAT. human.

Gene expression databases

BgeeiENSG00000104368.
ExpressionAtlasiE5RGA1. baseline and differential.

Family and domain databases

InterProiView protein in InterPro
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000083. Fibronectin_type1.
IPR000001. Kringle.
IPR013806. Kringle-like.
PfamiView protein in Pfam
PF00008. EGF. 1 hit.
PF00039. fn1. 1 hit.
PF00051. Kringle. 1 hit.
SMARTiView protein in SMART
SM00058. FN1. 1 hit.
SM00130. KR. 1 hit.
SUPFAMiSSF57440. SSF57440. 1 hit.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS01253. FN1_1. 1 hit.
PS51091. FN1_2. 1 hit.
PS50070. KRINGLE_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiE5RGA1_HUMAN
AccessioniPrimary (citable) accession number: E5RGA1
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: February 15, 2017
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.