E5RG63 (E5RG63_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Presenilin-2 CTF subunit Ensembl ENSP00000427806

Gene names

Name:

PSEN2 Ensembl ENSP00000427806

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000427806

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000427806

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS006639
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Notch signaling pathway Inferred from electronic annotation. Source: Compara T cell activation involved in immune response Inferred from electronic annotation. Source: Compara T cell receptor signaling pathway Inferred from electronic annotation. Source: Compara anagen Inferred from electronic annotation. Source: Compara apoptotic process Inferred from electronic annotation. Source: Compara beta-amyloid metabolic process Inferred from electronic annotation. Source: Compara brain morphogenesis Inferred from electronic annotation. Source: Compara calcium ion transport Inferred from electronic annotation. Source: Compara cardiac muscle contraction Inferred from electronic annotation. Source: Compara cell fate specification Inferred from electronic annotation. Source: Compara cellular protein metabolic process Inferred from electronic annotation. Source: Compara dorsal/ventral neural tube patterning Inferred from electronic annotation. Source: Compara embryonic limb morphogenesis Inferred from electronic annotation. Source: Compara endoplasmic reticulum calcium ion homeostasis Inferred from electronic annotation. Source: Compara forebrain development Inferred from electronic annotation. Source: Compara hematopoietic progenitor cell differentiation Inferred from electronic annotation. Source: Compara intracellular signal transduction Inferred from electronic annotation. Source: InterPro locomotion Inferred from electronic annotation. Source: Compara lung alveolus development Inferred from electronic annotation. Source: Compara memory Inferred from electronic annotation. Source: Compara myeloid leukocyte differentiation Inferred from electronic annotation. Source: Compara negative regulation of protein phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of coagulation Inferred from electronic annotation. Source: Compara protein processing Inferred from electronic annotation. Source: Compara protein transport Inferred from electronic annotation. Source: Compara regulation of epidermal growth factor-activated receptor activity Inferred from electronic annotation. Source: Compara regulation of protein binding Inferred from electronic annotation. Source: Compara regulation of synaptic plasticity Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from electronic annotation. Source: Compara somitogenesis Inferred from electronic annotation. Source: Compara thymus development Inferred from electronic annotation. Source: Compara
Cellular_component	Z disc Inferred from electronic annotation. Source: Compara cytosol Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW neuronal cell body Inferred from electronic annotation. Source: Compara
Molecular_function	aspartic-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	E5RG63 [UniParc]. Last modified February 8, 2011. Version 1. Checksum: ACA44C3A83C8C38E	FASTA	304	34,094
	10 20 30 40 50 60 MISVIVVMTI FLVVLYKYRC YKFIHGWLIM SSLMLLFLFT YIYLGEVLKT YNVAMDYPTL 70 80 90 100 110 120 LLTVWNFGAV GMVCIHWKGP LVLQQAYLIM ISALMALVFI KYLPEWSAWV ILGAISVYDL 130 140 150 160 170 180 VAVLCPKGPL RMLVETAQER NEPIFPALIY SSAMVWTVGM AKLDPSSQGA LQLPYDPEME 190 200 210 220 230 240 EDSYDSFGEP SYPEVFEPPL TGYPGEELEE EEERGVKLGL GDFIFYSVLV GKAAATGSGD 250 260 270 280 290 300 WNTTLACFVA ILIGLCLTLL LLAVFKKALP ALPISITFGL IFYFSTDNLV RPFMDTLASH QLYI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D., Porter K.M., Prigmore E. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL359732 Genomic DNA. No translation available. AL391628 Genomic DNA. No translation available.
IPI	IPI00983222.
3D structure databases
ProteinModelPortal	E5RG63.
SMR	E5RG63. Positions 206-304.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000472139; ENSP00000427806; ENSG00000143801.
Organism-specific databases
HGNC	HGNC:9509. PSEN2.
GenAtlas	Search...
Gene expression databases
ArrayExpress	E5RG63.
Bgee	E5RG63.
Family and domain databases
InterPro	IPR001493. Pept_A22A_PS2. IPR006639. Peptidase_A22. IPR001108. Peptidase_A22A. [Graphical view]
PANTHER	PTHR10202. PTHR10202. 1 hit.
Pfam	PF01080. Presenilin. 2 hits. [Graphical view]
PRINTS	PR01072. PRESENILIN. PR01074. PRESENILIN2.
SMART	SM00730. PSN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PSEN2. human.
NextBio	35497961.

Entry information

Entry name

E5RG63_HUMAN

Accession

Primary (citable) accession number: E5RG63

Entry history

Integrated into UniProtKB/TrEMBL:	February 8, 2011
Last sequence update:	February 8, 2011
Last modified:	April 3, 2013
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.