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Protein
Submitted name:

Bifunctional epoxide hydrolase 2

Gene

EPHX2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Bifunctional epoxide hydrolase 2Imported
Gene namesi
Name:EPHX2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000120915.13
HGNCiHGNC:3402 EPHX2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000120915

PTM / Processingi

Proteomic databases

MaxQBiE5RFU2
PeptideAtlasiE5RFU2
PRIDEiE5RFU2

Expressioni

Gene expression databases

BgeeiENSG00000120915
ExpressionAtlasiE5RFU2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE5RFU2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini246 – 499AB hydrolase-1InterPro annotationAdd BLAST254

Phylogenomic databases

GeneTreeiENSGT00530000063213

Family and domain databases

Gene3Di1.10.150.240, 1 hit
3.40.50.1000, 2 hits
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR036412 HAD-like_sf
IPR006439 HAD-SF_hydro_IA
IPR011945 HAD-SF_ppase_IA/epoxid_hydro_N
IPR023214 HAD_sf
IPR023198 PGP-like_dom2
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PRINTSiPR00111 ABHYDROLASE
PR00413 HADHALOGNASE
SUPFAMiSSF53474 SSF53474, 1 hit
SSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR02247 HAD-1A3-hyp, 1 hit
TIGR01509 HAD-SF-IA-v3, 1 hit

Sequencei

Sequence statusi: Complete.

E5RFU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLRAAVFDL DGVLALPAVF GVLGRTEEAL ALPRGLLNDA FQKGGPEGAT
60 70 80 90 100
TRLMKGEITL SQWIPLMEEN CRKCSETAKV CLPKNFSIKE IFDKAISARK
110 120 130 140 150
INRPMLQAAL MLRKKGFTTA ILTNTWLDDR AERDGLAQLM CELKMHFDFL
160 170 180 190 200
IESCQVGMVK PEPQIYKFLL DTLKASPSEV VFLDDIGANL KPARDLGMVT
210 220 230 240 250
ILVQDTDTAL KELEKVTGIQ LLNTPAPLPT SCNPSDMSHG YVTVKIPALA
260 270 280 290 300
QAGYRVLAMD MKGYGESSAP PEIEEYCMEV LCKEMVTFLD KLGLSQAVFI
310 320 330 340 350
GHDWGGMLVW YMALFYPERV RAVASLNTPF IPANPNMSPL ESIKANPVFD
360 370 380 390 400
YQLYFQEPGV AEAELEQNLS RTFKSLFRAS DESVLSMHKV CEAGGLFVNS
410 420 430 440 450
PEEPSLSRMV TEEEIQFYVQ QFKKSGFRGP LNWYRNMERN WKWACKSLGR
460 470 480 490 500
KILIPALMVT AEKDFVLVPQ MSQHMEDWIP HLKRGHIEDC GHWTQMDKPT
510 520
EVNQILIKWL DSDARNPPVV SKM
Length:523
Mass (Da):58,855
Last modified:February 8, 2011 - v1
Checksum:iDD9880A21053CCB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311103 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000518379; ENSP00000427956; ENSG00000120915
UCSCiuc064lll.1 human

Similar proteinsi

Entry informationi

Entry nameiE5RFU2_HUMAN
AccessioniPrimary (citable) accession number: E5RFU2
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: May 23, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health