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E5R540

- KEX1_LEPMJ

UniProt

E5R540 - KEX1_LEPMJ

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 17 (01 Oct 2014)
      Sequence version 1 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei182 – 1821PROSITE-ProRule annotation
    Active sitei382 – 3821PROSITE-ProRule annotation
    Active sitei444 – 4441PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    ORF Names:Lema_P047160
    OrganismiLeptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam)
    Taxonomic identifieri985895 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaeLeptosphaeriaceaeLeptosphaeriaLeptosphaeria maculans complex
    ProteomesiUP000002668: Whole genome

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535Sequence AnalysisAdd
    BLAST
    Chaini36 – 641606Pheromone-processing carboxypeptidase KEX1PRO_0000411923Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi441 – 4411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi493 – 4931N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini36 – 515480LumenalSequence AnalysisAdd
    BLAST
    Topological domaini537 – 641105CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei516 – 53621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi522 – 5276Poly-Val

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    OMAiKACHEEL.
    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    E5R540-1 [UniParc]FASTAAdd to Basket

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    MASTYSTPRW RTALLGGFLT TLPWLSSGMA GKTQADYFIK SLPGAPEPLL    50
    KMHAGHIEVD AEHNGNLFFW HYENRHIADR QRTVLWLNGG PGCSSMDGAL 100
    MEVGPYRVQA DGNLHYNNGS WDEFANLLFV DQPVGTGFSY VNTDSYLTEL 150
    DQMANHMVIF LEKWFGLFPE YEHDDLYIAG ESYAGQHIPY IARAIVKRNK 200
    EQGKTPWALK GLLIGNGWIS PVDQYLSYIP YAYQNGLMKA DSDMAKRVEN 250
    QQRICIKKLE DGGMDAVDTN DCEQIMVNIL EETKDRKADR MNQCVNMYDI 300
    RLRDDASCGM NWPPDLASVT PYLRRPDVIQ ALHINPDKKT GWQECNGAVS 350
    GHFRAKKSEP SVRFLPELIP EVPTLLFSGD KDFICNHIGT EEMIKNMQWS 400
    GGKGFEVTPG VWAPKQDWTF EGEAAGSWQE ARNLTYVVFY NSSHMVPFDY 450
    PRRTRDMLDR FMGVDIEQIG GVPSDSRIDG EKGPLTSVGD HPNSTRAEED 500
    KATDVKQAEW KAYYRSGQVA LVVVVIVAAL WGIFLWRSRR RHTKTAYQGD 550
    DGDEGRESLL TGMGLDNFRR KERRSDLEAA DFDERELDDL DGASKKPGNG 600
    YASLGSEKER QSHNDSTFSL GGDSDDEAGS SDGPKRKGGS S 641
    Length:641
    Mass (Da):72,004
    Last modified:February 8, 2011 - v1
    Checksum:iEBC87398725E1F59
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FP929083 Genomic DNA. Translation: CBX92010.1.
    RefSeqiXP_003835375.1. XM_003835327.1.

    Genome annotation databases

    EnsemblFungiiCBX92010; CBX92010; LEMA_P047160.1.
    GeneIDi13284615.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FP929083 Genomic DNA. Translation: CBX92010.1 .
    RefSeqi XP_003835375.1. XM_003835327.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CBX92010 ; CBX92010 ; LEMA_P047160.1 .
    GeneIDi 13284615.

    Phylogenomic databases

    OMAi KACHEEL.
    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8.

    Entry informationi

    Entry nameiKEX1_LEPMJ
    AccessioniPrimary (citable) accession number: E5R540
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 17 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3