E5R2Q7 (DPEP1_ARTGP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative dipeptidase MGYG_00085
EC=3.4.13.19

Gene names

ORF Names:

MGYG_00085

Organism

Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum) [Complete proteome]

Taxonomic identifier

535722 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Onygenales › Arthrodermataceae › Arthroderma › Arthroderma gypseum

Protein attributes

Sequence length	425 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolyzes a wide range of dipeptides By similarity.
Catalytic activity	Hydrolysis of dipeptides.
Cofactor	Zinc By similarity.
Sequence similarities	Belongs to the peptidase M19 family.

Ontologies

Keywords
Domain	Signal
Ligand	Metal-binding Zinc
Molecular function	Dipeptidase Hydrolase Metalloprotease Protease
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	dipeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW dipeptidyl-peptidase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metalloexopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 31	31	Potential
	Chain	32 – 425	394	Putative dipeptidase MGYG_00085		PRO_0000411211
Sites
	Metal binding	56	1	Zinc 1; catalytic By similarity
	Metal binding	58	1	Zinc 1; catalytic By similarity
	Metal binding	168	1	Zinc 1; catalytic By similarity
	Metal binding	168	1	Zinc 2; catalytic By similarity
	Metal binding	239	1	Zinc 2; catalytic By similarity
	Metal binding	260	1	Zinc 2; catalytic By similarity
	Binding site	195	1	Substrate By similarity
	Binding site	271	1	Substrate By similarity
	Binding site	331	1	Substrate By similarity
Amino acid modifications
	Glycosylation	403	1	N-linked (GlcNAc...) Potential
	Disulfide bond	107 ↔ 197		By similarity

Sequences

	Sequence		Length	Mass (Da)
	E5R2Q7 [UniParc]. Last modified February 8, 2011. Version 1. Checksum: 8CF4ECF0EF852F64	FASTA	425	46,723
	10 20 30 40 50 60 MAPERRSRLS ETAGLFVSLL ALTSIVPVQA VATVPQTDYA KRAERVLRSA PLIDGHNDLP 70 80 90 100 110 120 YAIRKSTRDQ IYDGKLPFET SLKGHTDLPR MRKGRMGGQF WSVFIACPSD PNAPIDLPTF 130 140 150 160 170 180 ATRDTLEQID VARRLVDKYS KDLMFCDNPG CAKRAFRQGK IGSFLGIEGG HQVGSSIAAL 190 200 210 220 230 240 RQAFYAGARY MTITHNCDNA WATAASTVRA GKPDLGMTDF GPALIKEMNR LGMLVDLSHV 250 260 270 280 290 300 SHQSMRDILK VTKAPVIFSH SSAYEVSKHL RNVPDDVLKT VAKNNGVVMV TFVRTFVNVD 310 320 330 340 350 360 DPDSVDVNTI VKHIFHIAKV AGWDHVGLGG DYDGTTELPK GLEDVSKYPY LIEKVLEAGA 370 380 390 400 410 420 TEEQARKLVG ENVLRVWTEV EQIAKKIQRS GALPVEEVWK GRNGTALSER STFIEGPAPL AYGCD

References

[1]

"Comparative genome analysis of Trichophyton rubrum and related dermatophytes reveals candidate genes involved in infection." Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W., Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E., Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I., Rossi A., Saif S. , Samalova M., Saunders C.W., Shea T., Summerbell R.C., Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C. MBio 3:E259-E259(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC MYA-4604 / CBS 118893.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS989822 Genomic DNA. Translation: EFQ97041.1.
RefSeq	XP_003175993.1. XM_003175945.1.
3D structure databases
ProteinModelPortal	E5R2Q7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	10031304.
Family and domain databases
InterPro	IPR008257. Peptidase_M19. [Graphical view]
PANTHER	PTHR10443. PTHR10443. 1 hit.
Pfam	PF01244. Peptidase_M19. 1 hit. [Graphical view]
PROSITE	PS00869. RENAL_DIPEPTIDASE_1. False negative. PS51365. RENAL_DIPEPTIDASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DPEP1_ARTGP

Accession

Primary (citable) accession number: E5R2Q7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	February 8, 2011
Last modified:	March 6, 2013
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program