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Protein

Putative dipeptidase MGYG_00085

Gene

MGYG_00085

Organism
Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes a wide range of dipeptides.By similarity

Catalytic activityi

Hydrolysis of dipeptides.PROSITE-ProRule annotation

Cofactori

Zn2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi56 – 561Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi58 – 581Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi168 – 1681Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi168 – 1681Zinc 2; catalyticPROSITE-ProRule annotation
Binding sitei195 – 1951SubstratePROSITE-ProRule annotation
Metal bindingi239 – 2391Zinc 2; catalyticPROSITE-ProRule annotation
Metal bindingi260 – 2601Zinc 2; catalyticPROSITE-ProRule annotation
Binding sitei271 – 2711SubstratePROSITE-ProRule annotation
Binding sitei331 – 3311SubstratePROSITE-ProRule annotation

GO - Molecular functioni

  1. dipeptidase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. metallopeptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM19.A01.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative dipeptidase MGYG_00085 (EC:3.4.13.19)
Gene namesi
ORF Names:MGYG_00085
OrganismiArthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum)
Taxonomic identifieri535722 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeMicrosporum
ProteomesiUP000002669: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence AnalysisAdd
BLAST
Chaini32 – 425394Putative dipeptidase MGYG_00085PRO_0000411211Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi107 ↔ 197PROSITE-ProRule annotation
Glycosylationi403 – 4031N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliE5R2Q7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M19 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiE5R2Q7.
OrthoDBiEOG7XM371.

Family and domain databases

InterProiIPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
PROSITEiPS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E5R2Q7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPERRSRLS ETAGLFVSLL ALTSIVPVQA VATVPQTDYA KRAERVLRSA
60 70 80 90 100
PLIDGHNDLP YAIRKSTRDQ IYDGKLPFET SLKGHTDLPR MRKGRMGGQF
110 120 130 140 150
WSVFIACPSD PNAPIDLPTF ATRDTLEQID VARRLVDKYS KDLMFCDNPG
160 170 180 190 200
CAKRAFRQGK IGSFLGIEGG HQVGSSIAAL RQAFYAGARY MTITHNCDNA
210 220 230 240 250
WATAASTVRA GKPDLGMTDF GPALIKEMNR LGMLVDLSHV SHQSMRDILK
260 270 280 290 300
VTKAPVIFSH SSAYEVSKHL RNVPDDVLKT VAKNNGVVMV TFVRTFVNVD
310 320 330 340 350
DPDSVDVNTI VKHIFHIAKV AGWDHVGLGG DYDGTTELPK GLEDVSKYPY
360 370 380 390 400
LIEKVLEAGA TEEQARKLVG ENVLRVWTEV EQIAKKIQRS GALPVEEVWK
410 420
GRNGTALSER STFIEGPAPL AYGCD
Length:425
Mass (Da):46,723
Last modified:February 8, 2011 - v1
Checksum:i8CF4ECF0EF852F64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS989822 Genomic DNA. Translation: EFQ97041.1.
RefSeqiXP_003175993.1. XM_003175945.1.

Genome annotation databases

GeneIDi10031304.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS989822 Genomic DNA. Translation: EFQ97041.1.
RefSeqiXP_003175993.1. XM_003175945.1.

3D structure databases

ProteinModelPortaliE5R2Q7.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM19.A01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi10031304.

Phylogenomic databases

InParanoidiE5R2Q7.
OrthoDBiEOG7XM371.

Family and domain databases

InterProiIPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
PROSITEiPS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4604 / CBS 118893.

Entry informationi

Entry nameiDPEP1_ARTGP
AccessioniPrimary (citable) accession number: E5R2Q7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: February 8, 2011
Last modified: January 7, 2015
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.