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E5R278

- MAP21_ARTGP

UniProt

E5R278 - MAP21_ARTGP

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Protein

Methionine aminopeptidase 2-1

Gene

MGYG_01664

Organism
Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei219 – 2191SubstrateUniRule annotation
Metal bindingi240 – 2401Divalent metal cation 1UniRule annotation
Metal bindingi251 – 2511Divalent metal cation 1UniRule annotation
Metal bindingi251 – 2511Divalent metal cation 2; catalyticUniRule annotation
Metal bindingi320 – 3201Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotation
Binding sitei328 – 3281SubstrateUniRule annotation
Metal bindingi353 – 3531Divalent metal cation 2; catalyticUniRule annotation
Metal bindingi448 – 4481Divalent metal cation 1UniRule annotation
Metal bindingi448 – 4481Divalent metal cation 2; catalyticUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-HAMAP
  2. metalloaminopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein initiator methionine removal Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase 2-1UniRule annotation (EC:3.4.11.18UniRule annotation)
Short name:
MAP 2-1UniRule annotation
Short name:
MetAP 2-1UniRule annotation
Alternative name(s):
Peptidase MUniRule annotation
Gene namesi
ORF Names:MGYG_01664
OrganismiArthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum)
Taxonomic identifieri535722 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeMicrosporum
ProteomesiUP000002669: Unassembled WGS sequence

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467Methionine aminopeptidase 2-1PRO_0000407618Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliE5R278.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi83 – 886Poly-Lys

Sequence similaritiesi

Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.UniRule annotation

Phylogenomic databases

InParanoidiE5R278.
OrthoDBiEOG7BGHW3.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPiMF_03175. MetAP_2_euk.
InterProiIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF55920. SSF55920. 2 hits.
TIGRFAMsiTIGR00501. met_pdase_II. 1 hit.
PROSITEiPS01202. MAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E5R278 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSKSPDGHR QGPNAESPSS SVAATTNPPK PAAASGLVQG MLDGDDEDED
60 70 80 90 100
GDDDGDNQRI GADLKSGVLP NNDGKKRKRK SNKKKKKKTS KGQQTTPPRV
110 120 130 140 150
SLPSIFHDQR YPEGEIVEYA ARNDNLQRTT AEELRHQAAI HNMDDEFLTD
160 170 180 190 200
YRQAAEVHRQ VRQYVQSIAK PGILMSELAE EIETGVRALT GHQGIETGDA
210 220 230 240 250
LKAGLAFPTG LCLNNVAAHW TPNPGAKEVI LKHDDVLKID FGVHVNGRIV
260 270 280 290 300
DSAFTVASNP VYDNLLTAVK AATNTGLKEA GIDARIDHIS GEIQEVMESY
310 320 330 340 350
EVEINGKAIP VKALRSLTGH NILRYKIHGE KQVPFVKSKT TQRMEEGDVF
360 370 380 390 400
AIETFGSTGK GYTRDEVGVY GYGLNEHAST AGLHHASAKS LLKTIRENFG
410 420 430 440 450
TLVFSRRYLE HMGVKNYHLG MRSLISNDIV ECYAPLVDVP GSYVAQFEHT
460
VLLRPNCKEI ISRGDDY
Length:467
Mass (Da):51,146
Last modified:February 8, 2011 - v1
Checksum:iFF54B66A7F399579
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS989822 Genomic DNA. Translation: EFQ98642.1.
RefSeqiXP_003177594.1. XM_003177546.1.

Genome annotation databases

GeneIDi10032929.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS989822 Genomic DNA. Translation: EFQ98642.1 .
RefSeqi XP_003177594.1. XM_003177546.1.

3D structure databases

ProteinModelPortali E5R278.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 10032929.

Phylogenomic databases

InParanoidi E5R278.
OrthoDBi EOG7BGHW3.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPi MF_03175. MetAP_2_euk.
InterProi IPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00557. Peptidase_M24. 1 hit.
[Graphical view ]
PRINTSi PR00599. MAPEPTIDASE.
SUPFAMi SSF55920. SSF55920. 2 hits.
TIGRFAMsi TIGR00501. met_pdase_II. 1 hit.
PROSITEi PS01202. MAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4604 / CBS 118893.

Entry informationi

Entry nameiMAP21_ARTGP
AccessioniPrimary (citable) accession number: E5R278
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: February 8, 2011
Last modified: October 29, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3