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Protein
Submitted name:

Paired box 6

Gene

PAX6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. AT DNA binding Source: Ensembl
  2. chromatin binding Source: Ensembl
  3. double-stranded DNA binding Source: Ensembl
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  6. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
  7. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl

GO - Biological processi

  1. astrocyte differentiation Source: Ensembl
  2. axon guidance Source: Ensembl
  3. cell fate determination Source: Ensembl
  4. cellular response to drug Source: Ensembl
  5. cellular response to fibroblast growth factor stimulus Source: Ensembl
  6. cellular response to glucose stimulus Source: Ensembl
  7. cellular response to insulin stimulus Source: Ensembl
  8. cellular response to prostaglandin E stimulus Source: Ensembl
  9. cerebellum development Source: Ensembl
  10. cerebral cortex regionalization Source: Ensembl
  11. commitment of neuronal cell to specific neuron type in forebrain Source: Ensembl
  12. dorsal/ventral axis specification Source: Ensembl
  13. embryonic camera-type eye morphogenesis Source: Ensembl
  14. establishment of mitotic spindle orientation Source: Ensembl
  15. eye photoreceptor cell development Source: Ensembl
  16. forebrain anterior/posterior pattern specification Source: Ensembl
  17. forebrain dorsal/ventral pattern formation Source: Ensembl
  18. forebrain-midbrain boundary formation Source: Ensembl
  19. insulin metabolic process Source: Ensembl
  20. interkinetic nuclear migration Source: Ensembl
  21. keratinocyte differentiation Source: Ensembl
  22. lacrimal gland development Source: Ensembl
  23. lens development in camera-type eye Source: Ensembl
  24. negative regulation of epithelial cell proliferation Source: Ensembl
  25. negative regulation of neural precursor cell proliferation Source: Ensembl
  26. negative regulation of neuron differentiation Source: Ensembl
  27. negative regulation of protein phosphorylation Source: Ensembl
  28. neural crest cell migration Source: Ensembl
  29. neuron migration Source: Ensembl
  30. olfactory bulb development Source: Ensembl
  31. oligodendrocyte cell fate specification Source: Ensembl
  32. pancreatic A cell development Source: Ensembl
  33. pituitary gland development Source: Ensembl
  34. positive regulation of cell fate specification Source: Ensembl
  35. positive regulation of epithelial cell differentiation Source: Ensembl
  36. positive regulation of glucagon secretion Source: Ensembl
  37. positive regulation of neuroblast proliferation Source: Ensembl
  38. positive regulation of neuron migration Source: Ensembl
  39. protein localization to organelle Source: Ensembl
  40. regulation of asymmetric cell division Source: Ensembl
  41. regulation of neuron projection development Source: Ensembl
  42. regulation of timing of cell differentiation Source: Ensembl
  43. regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment Source: Ensembl
  44. regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification Source: Ensembl
  45. regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification Source: Ensembl
  46. response to ethanol Source: Ensembl
  47. retina development in camera-type eye Source: Ensembl
  48. rhombomere morphogenesis Source: Ensembl
  49. salivary gland morphogenesis Source: Ensembl
  50. signal transduction involved in regulation of gene expression Source: Ensembl
  51. smoothened signaling pathway Source: Ensembl
  52. type B pancreatic cell differentiation Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Paired box 6Imported
Gene namesi
Name:PAX6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. nuclear chromatin Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiE5LBD7.
ExpressionAtlasiE5LBD7. baseline and differential.

Family & Domainsi

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00292. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51057. PAIRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

E5LBD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
GCVSKILGRY YETGSIRPRA IGGSKPRVAT P
Length:31
Mass (Da):3,291
Last modified:February 8, 2011 - v1
Checksum:i9D961BA2C53686BC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei31 – 311Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ397714 Genomic DNA. Translation: ADP65746.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ397714 Genomic DNA. Translation: ADP65746.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

ChiTaRSiPAX6. human.
NextBioi35497682.

Gene expression databases

BgeeiE5LBD7.
ExpressionAtlasiE5LBD7. baseline and differential.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00292. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51057. PAIRED_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "PAX6 gene analysis in irido-fundal coloboma."
    Kumar K., Tanwar M., Naithani P., Insaan R., Garg S., Venkatesh P., Dada R.
    Mol. Vis. 17:1414-1419(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiE5LBD7_HUMAN
AccessioniPrimary (citable) accession number: E5LBD7
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: March 4, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.