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E5LBD7

- E5LBD7_HUMAN

UniProt

E5LBD7 - E5LBD7_HUMAN

Protein
Submitted name:

Paired box 6

Gene

PAX6

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. AT DNA binding Source: Ensembl
    2. double-stranded DNA binding Source: Ensembl
    3. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
    4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl

    GO - Biological processi

    1. astrocyte differentiation Source: Ensembl
    2. axon guidance Source: Ensembl
    3. cell fate determination Source: Ensembl
    4. cerebral cortex regionalization Source: Ensembl
    5. commitment of neuronal cell to specific neuron type in forebrain Source: Ensembl
    6. dorsal/ventral axis specification Source: Ensembl
    7. embryonic camera-type eye morphogenesis Source: Ensembl
    8. eye photoreceptor cell development Source: Ensembl
    9. forebrain anterior/posterior pattern specification Source: Ensembl
    10. forebrain dorsal/ventral pattern formation Source: Ensembl
    11. forebrain-midbrain boundary formation Source: Ensembl
    12. hindbrain development Source: Ensembl
    13. keratinocyte differentiation Source: Ensembl
    14. lacrimal gland development Source: Ensembl
    15. lens development in camera-type eye Source: Ensembl
    16. negative regulation of epithelial cell proliferation Source: Ensembl
    17. negative regulation of neuron differentiation Source: Ensembl
    18. neuron migration Source: Ensembl
    19. oligodendrocyte cell fate specification Source: Ensembl
    20. pancreatic A cell development Source: Ensembl
    21. pituitary gland development Source: Ensembl
    22. positive regulation of cell fate specification Source: Ensembl
    23. positive regulation of epithelial cell differentiation Source: Ensembl
    24. positive regulation of neuroblast proliferation Source: Ensembl
    25. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    26. protein localization to organelle Source: Ensembl
    27. regulation of cell migration Source: Ensembl
    28. regulation of timing of cell differentiation Source: Ensembl
    29. regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment Source: Ensembl
    30. regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification Source: Ensembl
    31. regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification Source: Ensembl
    32. salivary gland morphogenesis Source: Ensembl
    33. signal transduction involved in regulation of gene expression Source: Ensembl
    34. smoothened signaling pathway Source: Ensembl
    35. type B pancreatic cell differentiation Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Paired box 6Imported
    Gene namesi
    Name:PAX6Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. nuclear chromatin Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiE5LBD7.
    BgeeiE5LBD7.

    Family & Domainsi

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR009057. Homeodomain-like.
    IPR001523. Paired_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00292. PAX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS51057. PAIRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    E5LBD7-1 [UniParc]FASTAAdd to Basket

    « Hide

    GCVSKILGRY YETGSIRPRA IGGSKPRVAT P                       31
    Length:31
    Mass (Da):3,291
    Last modified:February 8, 2011 - v1
    Checksum:i9D961BA2C53686BC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei31 – 311Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HQ397714 Genomic DNA. Translation: ADP65746.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HQ397714 Genomic DNA. Translation: ADP65746.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    NextBioi 35497682.

    Gene expression databases

    ArrayExpressi E5LBD7.
    Bgeei E5LBD7.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR009057. Homeodomain-like.
    IPR001523. Paired_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00292. PAX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS51057. PAIRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "PAX6 gene analysis in irido-fundal coloboma."
      Kumar K., Tanwar M., Naithani P., Insaan R., Garg S., Venkatesh P., Dada R.
      Mol. Vis. 17:1414-1419(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiE5LBD7_HUMAN
    AccessioniPrimary (citable) accession number: E5LBD7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 8, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.