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Submitted name:

Paired box 6



Homo sapiens (Human)
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. AT DNA binding Source: Ensembl
    2. double-stranded DNA binding Source: Ensembl
    3. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
    4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl

    GO - Biological processi

    1. astrocyte differentiation Source: Ensembl
    2. axon guidance Source: Ensembl
    3. cell fate determination Source: Ensembl
    4. cerebral cortex regionalization Source: Ensembl
    5. commitment of neuronal cell to specific neuron type in forebrain Source: Ensembl
    6. dorsal/ventral axis specification Source: Ensembl
    7. embryonic camera-type eye morphogenesis Source: Ensembl
    8. eye photoreceptor cell development Source: Ensembl
    9. forebrain anterior/posterior pattern specification Source: Ensembl
    10. forebrain dorsal/ventral pattern formation Source: Ensembl
    11. forebrain-midbrain boundary formation Source: Ensembl
    12. hindbrain development Source: Ensembl
    13. keratinocyte differentiation Source: Ensembl
    14. lacrimal gland development Source: Ensembl
    15. lens development in camera-type eye Source: Ensembl
    16. negative regulation of epithelial cell proliferation Source: Ensembl
    17. negative regulation of neuron differentiation Source: Ensembl
    18. neuron migration Source: Ensembl
    19. oligodendrocyte cell fate specification Source: Ensembl
    20. pancreatic A cell development Source: Ensembl
    21. pituitary gland development Source: Ensembl
    22. positive regulation of cell fate specification Source: Ensembl
    23. positive regulation of epithelial cell differentiation Source: Ensembl
    24. positive regulation of neuroblast proliferation Source: Ensembl
    25. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    26. protein localization to organelle Source: Ensembl
    27. regulation of cell migration Source: Ensembl
    28. regulation of timing of cell differentiation Source: Ensembl
    29. regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment Source: Ensembl
    30. regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification Source: Ensembl
    31. regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification Source: Ensembl
    32. salivary gland morphogenesis Source: Ensembl
    33. signal transduction involved in regulation of gene expression Source: Ensembl
    34. smoothened signaling pathway Source: Ensembl
    35. type B pancreatic cell differentiation Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Paired box 6Imported
    Gene namesi
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. nuclear chromatin Source: Ensembl


    Gene expression databases


    Family & Domainsi

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR009057. Homeodomain-like.
    IPR001523. Paired_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00292. PAX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS51057. PAIRED_2. 1 hit.
    [Graphical view]


    Sequence statusi: Fragment.

    E5LBD7-1 [UniParc]FASTAAdd to Basket

    « Hide

    GCVSKILGRY YETGSIRPRA IGGSKPRVAT P                       31
    Mass (Da):3,291
    Last modified:February 8, 2011 - v1

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei31 – 311Imported

    Sequence databases

    Select the link destinations:
    Links Updated
    HQ397714 Genomic DNA. Translation: ADP65746.1.


    Sequence databases

    Select the link destinations:
    Links Updated
    HQ397714 Genomic DNA. Translation: ADP65746.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    NextBioi 35497682.

    Gene expression databases

    ArrayExpressi E5LBD7.
    Bgeei E5LBD7.

    Family and domain databases

    Gene3Di 1 hit.
    InterProi IPR009057. Homeodomain-like.
    IPR001523. Paired_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00292. PAX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS51057. PAIRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...


    1. "PAX6 gene analysis in irido-fundal coloboma."
      Kumar K., Tanwar M., Naithani P., Insaan R., Garg S., Venkatesh P., Dada R.
      Mol. Vis. 17:1414-1419(2011) [PubMed] [Europe PMC] [Abstract]

    Entry informationi

    Entry nameiE5LBD7_HUMAN
    AccessioniPrimary (citable) accession number: E5LBD7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 8, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.