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Protein

rRNA adenine N(6)-methyltransferase

Gene

TFB1M

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation1
Binding sitei38S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei63S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation1
Binding sitei85S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei111S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei141S-adenosyl-L-methioninePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotation, RNA-bindingPROSITE-ProRule annotation, Transferase
Biological processrRNA processingUniRule annotation
LigandS-adenosyl-L-methioninePROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
rRNA adenine N(6)-methyltransferaseUniRule annotation (EC:2.1.1.-UniRule annotation)
Gene namesi
Name:TFB1MImported
ORF Names:hCG_32337Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000029639.10.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSG00000029639.

Structurei

3D structure databases

SMRiE5KTM5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 234rADcInterPro annotationAdd BLAST192

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0821. Eukaryota.
COG0030. LUCA.
KOiK15266.
OMAiFQFRRKH.
OrthoDBiEOG091G0ALA.

Family and domain databases

Gene3Di1.10.8.100. 1 hit.
HAMAPiMF_00607. 16SrRNA_methyltr_A. 1 hit.
InterProiView protein in InterPro
IPR001737. KsgA/Erm.
IPR023165. rRNA_Ade_diMease-like.
IPR020596. rRNA_Ade_Mease_Trfase_CS.
IPR020598. rRNA_Ade_methylase_Trfase_N.
IPR011530. rRNA_adenine_dimethylase.
IPR029063. SAM-dependent_MTases.
PANTHERiPTHR11727. PTHR11727. 1 hit.
PfamiView protein in Pfam
PF00398. RrnaAD. 1 hit.
SMARTiView protein in SMART
SM00650. rADc. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00755. ksgA. 1 hit.
PROSITEiView protein in PROSITE
PS01131. RRNA_A_DIMETH. 1 hit.
PS51689. SAM_RNA_A_N6_MT. 1 hit.

Sequencei

Sequence statusi: Complete.

E5KTM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASGKLSTC RLPPLPTIRE IIKLLRLQAA KQLSQNFLLD LRLTDKIVRK
60 70 80 90 100
AGNLTNAYVY EVGPGPGGIT RSILNADVAE LLVVEKDTRF IPGLQMLSDA
110 120 130 140 150
APGKLRIVHG DVLTFKVEKA FSESLKRPWE DDPPNVHIIG NLPFSVSTPL
160 170 180 190 200
IIKWLENISC RDGPFVYGRT QMTLTFQKEV AERLAANTGS KQRSRLSVMA
210 220 230 240 250
QYLCNVRHIF TIPGQAFVPK PEVDVGVVHF TPLIQPKIEQ PFKLVEKVVQ
260 270 280 290 300
NVFQFRRKYC HRGLRMLFPE AQRLESTGRL LELADIDPTL RPRQLSISHF
310 320 330 340
KSLCDVYRKM CDEDPQLFAY NFREELKRRK SKNEEKEEDD AENYRL
Length:346
Mass (Da):39,543
Last modified:February 8, 2011 - v1
Checksum:i4C34F4FD72B01286
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ206306 Genomic DNA. Translation: ADP92254.1.
HQ206307 Genomic DNA. Translation: ADP92255.1.
HQ206308 Genomic DNA. Translation: ADP92256.1.
HQ206309 Genomic DNA. Translation: ADP92257.1.
HQ206310 Genomic DNA. Translation: ADP92258.1.
HQ206311 Genomic DNA. Translation: ADP92259.1.
HQ206312 Genomic DNA. Translation: ADP92260.1.
HQ206313 Genomic DNA. Translation: ADP92261.1.
HQ206314 Genomic DNA. Translation: ADP92262.1.
HQ206315 Genomic DNA. Translation: ADP92263.1.
HQ206316 Genomic DNA. Translation: ADP92264.1.
HQ206317 Genomic DNA. Translation: ADP92265.1.
HQ206318 Genomic DNA. Translation: ADP92266.1.
HQ206319 Genomic DNA. Translation: ADP92267.1.
HQ206320 Genomic DNA. Translation: ADP92268.1.
HQ206321 Genomic DNA. Translation: ADP92269.1.
HQ206322 Genomic DNA. Translation: ADP92270.1.
HQ206323 Genomic DNA. Translation: ADP92271.1.
HQ206324 Genomic DNA. Translation: ADP92272.1.
HQ206325 Genomic DNA. Translation: ADP92273.1.
HQ206326 Genomic DNA. Translation: ADP92274.1.
HQ206327 Genomic DNA. Translation: ADP92275.1.
HQ206328 Genomic DNA. Translation: ADP92276.1.
HQ206329 Genomic DNA. Translation: ADP92277.1.
HQ206330 Genomic DNA. Translation: ADP92278.1.
HQ206331 Genomic DNA. Translation: ADP92279.1.
HQ206332 Genomic DNA. Translation: ADP92280.1.
HQ206333 Genomic DNA. Translation: ADP92281.1.
HQ206334 Genomic DNA. Translation: ADP92282.1.
HQ206335 Genomic DNA. Translation: ADP92283.1.
HQ206336 Genomic DNA. Translation: ADP92284.1.
HQ206337 Genomic DNA. Translation: ADP92285.1.
HQ206338 Genomic DNA. Translation: ADP92286.1.
HQ206339 Genomic DNA. Translation: ADP92287.1.
HQ206340 Genomic DNA. Translation: ADP92288.1.
HQ206341 Genomic DNA. Translation: ADP92289.1.
HQ206342 Genomic DNA. Translation: ADP92290.1.
HQ206343 Genomic DNA. Translation: ADP92291.1.
HQ206344 Genomic DNA. Translation: ADP92292.1.
HQ206345 Genomic DNA. Translation: ADP92293.1.
CH471051 Genomic DNA. Translation: EAW47690.1.
RefSeqiNP_057104.2. NM_016020.3.
UniGeneiHs.279908.
Hs.655297.

Genome annotation databases

GeneIDi51106.
KEGGihsa:51106.

Similar proteinsi

Entry informationi

Entry nameiE5KTM5_HUMAN
AccessioniPrimary (citable) accession number: E5KTM5
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: November 22, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.