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Protein
Submitted name:

Mitochondrial transcription factor A

Gene

TFAM

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi50 – 118HMG boxPROSITE-ProRule annotationAdd BLAST69
DNA bindingi155 – 219HMG boxPROSITE-ProRule annotationAdd BLAST65

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Mitochondrial transcription factor AImported
Submitted name:
Transcription factor A, mitochondrial, isoform CRA_cImported
Gene namesi
Name:TFAMImported
ORF Names:hCG_40210Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000108064.10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_501430326420 – 246Sequence analysisAdd BLAST227

Proteomic databases

PRIDEiE5KSU5

Expressioni

Gene expression databases

BgeeiENSG00000108064
ExpressionAtlasiE5KSU5 baseline and differential

Structurei

3D structure databases

SMRiE5KSU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 118HMG boxInterPro annotationAdd BLAST69
Domaini155 – 219HMG boxInterPro annotationAdd BLAST65

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili201 – 221Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0381 Eukaryota
COG5648 LUCA
KOiK11830
OMAiQRTKYDA
OrthoDBiEOG091G0SA8

Family and domain databases

Gene3Di1.10.30.10, 2 hits
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF09011 HMG_box_2, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 2 hits
SUPFAMiSSF47095 SSF47095, 2 hits
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 2 hits

Sequencei

Sequence statusi: Complete.

E5KSU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFLRSMWGV LSALGRSGAE LCTGCGSRLR SPFSFVYLPR WFSSVLASCP
60 70 80 90 100
KKPVSSYLRF SKEQLPIFKA QNPDAKTTEL IRRIAQRWRE LPDSKKKIYQ
110 120 130 140 150
DAYRAEWQVY KEEISRFKEQ LTPSQIMSLE KEIMDKHLKR KAMTKKKELT
160 170 180 190 200
LLGKPKRPRS AYNVYVAERF QEAKGDSPQE KLKTVKENWK NLSDSEKELY
210 220 230 240
IQHAKEDETR YHNEMKSWEE QMIEVGRKDL LRRTIKKQRK YGAEEC
Length:246
Mass (Da):29,097
Last modified:February 8, 2011 - v1
Checksum:i81F00CFA12DA4924
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ206066 Genomic DNA Translation: ADP91974.1
HQ206067 Genomic DNA Translation: ADP91975.1
HQ206068 Genomic DNA Translation: ADP91976.1
HQ206069 Genomic DNA Translation: ADP91977.1
HQ206070 Genomic DNA Translation: ADP91978.1
HQ206071 Genomic DNA Translation: ADP91979.1
HQ206072 Genomic DNA Translation: ADP91980.1
HQ206073 Genomic DNA Translation: ADP91981.1
HQ206074 Genomic DNA Translation: ADP91982.1
HQ206075 Genomic DNA Translation: ADP91983.1
HQ206076 Genomic DNA Translation: ADP91984.1
HQ206077 Genomic DNA Translation: ADP91985.1
HQ206078 Genomic DNA Translation: ADP91986.1
HQ206079 Genomic DNA Translation: ADP91987.1
HQ206080 Genomic DNA Translation: ADP91988.1
HQ206081 Genomic DNA Translation: ADP91989.1
HQ206082 Genomic DNA Translation: ADP91990.1
HQ206083 Genomic DNA Translation: ADP91991.1
HQ206084 Genomic DNA Translation: ADP91992.1
HQ206085 Genomic DNA Translation: ADP91993.1
HQ206086 Genomic DNA Translation: ADP91994.1
HQ206087 Genomic DNA Translation: ADP91995.1
HQ206088 Genomic DNA Translation: ADP91996.1
HQ206089 Genomic DNA Translation: ADP91997.1
HQ206090 Genomic DNA Translation: ADP91998.1
HQ206091 Genomic DNA Translation: ADP91999.1
HQ206092 Genomic DNA Translation: ADP92000.1
HQ206093 Genomic DNA Translation: ADP92001.1
HQ206094 Genomic DNA Translation: ADP92002.1
HQ206095 Genomic DNA Translation: ADP92003.1
HQ206096 Genomic DNA Translation: ADP92004.1
HQ206097 Genomic DNA Translation: ADP92005.1
HQ206098 Genomic DNA Translation: ADP92006.1
HQ206100 Genomic DNA Translation: ADP92008.1
HQ206101 Genomic DNA Translation: ADP92009.1
HQ206102 Genomic DNA Translation: ADP92010.1
HQ206103 Genomic DNA Translation: ADP92011.1
HQ206104 Genomic DNA Translation: ADP92012.1
HQ206105 Genomic DNA Translation: ADP92013.1
CH471083 Genomic DNA Translation: EAW54173.1
CH471083 Genomic DNA Translation: EAW54175.1
RefSeqiNP_003192.1, NM_003201.2
UniGeneiHs.594250

Genome annotation databases

GeneIDi7019
KEGGihsa:7019

Similar proteinsi

Entry informationi

Entry nameiE5KSU5_HUMAN
AccessioniPrimary (citable) accession number: E5KSU5
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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