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Protein
Submitted name:

Mitochondrial transcription factor A

Gene

TFAM

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi50 – 118HMG boxPROSITE-ProRule annotationAdd BLAST69
DNA bindingi155 – 219HMG boxPROSITE-ProRule annotationAdd BLAST65

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Mitochondrial transcription factor AImported
Submitted name:
Transcription factor A, mitochondrial, isoform CRA_cImported
Gene namesi
Name:TFAMImported
ORF Names:hCG_40210Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500995364420 – 246Sequence analysisAdd BLAST227

Expressioni

Gene expression databases

BgeeiENSG00000108064.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000420588.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 118HMG box DNA-bindingInterPro annotationAdd BLAST69
Domaini155 – 219HMG box DNA-bindingInterPro annotationAdd BLAST65

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0381. Eukaryota.
COG5648. LUCA.
KOiK11830.
OMAiSEKEVYM.
OrthoDBiEOG091G0SA8.

Family and domain databases

Gene3Di1.10.30.10. 2 hits.
InterProiView protein in InterPro
IPR009071. HMG_box_dom.
PfamiView protein in Pfam
PF00505. HMG_box. 1 hit.
PF09011. HMG_box_2. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 2 hits.
SUPFAMiSSF47095. SSF47095. 2 hits.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 2 hits.

Sequencei

Sequence statusi: Complete.

E5KSU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFLRSMWGV LSALGRSGAE LCTGCGSRLR SPFSFVYLPR WFSSVLASCP
60 70 80 90 100
KKPVSSYLRF SKEQLPIFKA QNPDAKTTEL IRRIAQRWRE LPDSKKKIYQ
110 120 130 140 150
DAYRAEWQVY KEEISRFKEQ LTPSQIMSLE KEIMDKHLKR KAMTKKKELT
160 170 180 190 200
LLGKPKRPRS AYNVYVAERF QEAKGDSPQE KLKTVKENWK NLSDSEKELY
210 220 230 240
IQHAKEDETR YHNEMKSWEE QMIEVGRKDL LRRTIKKQRK YGAEEC
Length:246
Mass (Da):29,097
Last modified:February 8, 2011 - v1
Checksum:i81F00CFA12DA4924
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ206066 Genomic DNA. Translation: ADP91974.1.
HQ206067 Genomic DNA. Translation: ADP91975.1.
HQ206068 Genomic DNA. Translation: ADP91976.1.
HQ206069 Genomic DNA. Translation: ADP91977.1.
HQ206070 Genomic DNA. Translation: ADP91978.1.
HQ206071 Genomic DNA. Translation: ADP91979.1.
HQ206072 Genomic DNA. Translation: ADP91980.1.
HQ206073 Genomic DNA. Translation: ADP91981.1.
HQ206074 Genomic DNA. Translation: ADP91982.1.
HQ206075 Genomic DNA. Translation: ADP91983.1.
HQ206076 Genomic DNA. Translation: ADP91984.1.
HQ206077 Genomic DNA. Translation: ADP91985.1.
HQ206078 Genomic DNA. Translation: ADP91986.1.
HQ206079 Genomic DNA. Translation: ADP91987.1.
HQ206080 Genomic DNA. Translation: ADP91988.1.
HQ206081 Genomic DNA. Translation: ADP91989.1.
HQ206082 Genomic DNA. Translation: ADP91990.1.
HQ206083 Genomic DNA. Translation: ADP91991.1.
HQ206084 Genomic DNA. Translation: ADP91992.1.
HQ206085 Genomic DNA. Translation: ADP91993.1.
HQ206086 Genomic DNA. Translation: ADP91994.1.
HQ206087 Genomic DNA. Translation: ADP91995.1.
HQ206088 Genomic DNA. Translation: ADP91996.1.
HQ206089 Genomic DNA. Translation: ADP91997.1.
HQ206090 Genomic DNA. Translation: ADP91998.1.
HQ206091 Genomic DNA. Translation: ADP91999.1.
HQ206092 Genomic DNA. Translation: ADP92000.1.
HQ206093 Genomic DNA. Translation: ADP92001.1.
HQ206094 Genomic DNA. Translation: ADP92002.1.
HQ206095 Genomic DNA. Translation: ADP92003.1.
HQ206096 Genomic DNA. Translation: ADP92004.1.
HQ206097 Genomic DNA. Translation: ADP92005.1.
HQ206098 Genomic DNA. Translation: ADP92006.1.
HQ206100 Genomic DNA. Translation: ADP92008.1.
HQ206101 Genomic DNA. Translation: ADP92009.1.
HQ206102 Genomic DNA. Translation: ADP92010.1.
HQ206103 Genomic DNA. Translation: ADP92011.1.
HQ206104 Genomic DNA. Translation: ADP92012.1.
HQ206105 Genomic DNA. Translation: ADP92013.1.
CH471083 Genomic DNA. Translation: EAW54173.1.
CH471083 Genomic DNA. Translation: EAW54175.1.
RefSeqiNP_003192.1. NM_003201.2.
UniGeneiHs.594250.

Genome annotation databases

GeneIDi7019.
KEGGihsa:7019.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ206066 Genomic DNA. Translation: ADP91974.1.
HQ206067 Genomic DNA. Translation: ADP91975.1.
HQ206068 Genomic DNA. Translation: ADP91976.1.
HQ206069 Genomic DNA. Translation: ADP91977.1.
HQ206070 Genomic DNA. Translation: ADP91978.1.
HQ206071 Genomic DNA. Translation: ADP91979.1.
HQ206072 Genomic DNA. Translation: ADP91980.1.
HQ206073 Genomic DNA. Translation: ADP91981.1.
HQ206074 Genomic DNA. Translation: ADP91982.1.
HQ206075 Genomic DNA. Translation: ADP91983.1.
HQ206076 Genomic DNA. Translation: ADP91984.1.
HQ206077 Genomic DNA. Translation: ADP91985.1.
HQ206078 Genomic DNA. Translation: ADP91986.1.
HQ206079 Genomic DNA. Translation: ADP91987.1.
HQ206080 Genomic DNA. Translation: ADP91988.1.
HQ206081 Genomic DNA. Translation: ADP91989.1.
HQ206082 Genomic DNA. Translation: ADP91990.1.
HQ206083 Genomic DNA. Translation: ADP91991.1.
HQ206084 Genomic DNA. Translation: ADP91992.1.
HQ206085 Genomic DNA. Translation: ADP91993.1.
HQ206086 Genomic DNA. Translation: ADP91994.1.
HQ206087 Genomic DNA. Translation: ADP91995.1.
HQ206088 Genomic DNA. Translation: ADP91996.1.
HQ206089 Genomic DNA. Translation: ADP91997.1.
HQ206090 Genomic DNA. Translation: ADP91998.1.
HQ206091 Genomic DNA. Translation: ADP91999.1.
HQ206092 Genomic DNA. Translation: ADP92000.1.
HQ206093 Genomic DNA. Translation: ADP92001.1.
HQ206094 Genomic DNA. Translation: ADP92002.1.
HQ206095 Genomic DNA. Translation: ADP92003.1.
HQ206096 Genomic DNA. Translation: ADP92004.1.
HQ206097 Genomic DNA. Translation: ADP92005.1.
HQ206098 Genomic DNA. Translation: ADP92006.1.
HQ206100 Genomic DNA. Translation: ADP92008.1.
HQ206101 Genomic DNA. Translation: ADP92009.1.
HQ206102 Genomic DNA. Translation: ADP92010.1.
HQ206103 Genomic DNA. Translation: ADP92011.1.
HQ206104 Genomic DNA. Translation: ADP92012.1.
HQ206105 Genomic DNA. Translation: ADP92013.1.
CH471083 Genomic DNA. Translation: EAW54173.1.
CH471083 Genomic DNA. Translation: EAW54175.1.
RefSeqiNP_003192.1. NM_003201.2.
UniGeneiHs.594250.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000420588.

Protocols and materials databases

DNASUi7019.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi7019.
KEGGihsa:7019.

Organism-specific databases

CTDi7019.

Phylogenomic databases

eggNOGiKOG0381. Eukaryota.
COG5648. LUCA.
KOiK11830.
OMAiSEKEVYM.
OrthoDBiEOG091G0SA8.

Miscellaneous databases

ChiTaRSiTFAM. human.
GenomeRNAii7019.

Gene expression databases

BgeeiENSG00000108064.

Family and domain databases

Gene3Di1.10.30.10. 2 hits.
InterProiView protein in InterPro
IPR009071. HMG_box_dom.
PfamiView protein in Pfam
PF00505. HMG_box. 1 hit.
PF09011. HMG_box_2. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 2 hits.
SUPFAMiSSF47095. SSF47095. 2 hits.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiE5KSU5_HUMAN
AccessioniPrimary (citable) accession number: E5KSU5
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: April 12, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.