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Protein
Submitted name:

Mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit

Gene

NDUFS1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandUbiquinoneImported

Names & Taxonomyi

Protein namesi
Submitted name:
Mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunitImported
Submitted name:
NADH dehydrogenase (Ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase), isoform CRA_bImported
Gene namesi
Name:NDUFS1Imported
ORF Names:hCG_17250Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000023228.13.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSG00000023228.
ExpressionAtlasiE5KRK5. baseline and differential.

Structurei

3D structure databases

SMRiE5KRK5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 1082Fe-2S ferredoxin-typeInterPro annotationAdd BLAST79
Domaini245 – 3014Fe-4S Mo/W bis-MGD-typeInterPro annotationAdd BLAST57

Sequence similaritiesi

Belongs to the complex I 75 kDa subunit family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2282. Eukaryota.
COG1034. LUCA.
KOiK03934.

Family and domain databases

CDDicd00207. fer2. 1 hit.
Gene3Di3.10.20.30. 1 hit.
InterProiView protein in InterPro
IPR001041. 2Fe-2S_ferredoxin-type.
IPR012675. Beta-grasp_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR000283. NADH_UbQ_OxRdtase_75kDa_su_CS.
IPR010228. NADH_UbQ_OxRdtase_Gsu.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
IPR015405. NuoG_C.
PfamiView protein in Pfam
PF00384. Molybdopterin. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
PF09326. NADH_dhqG_C. 1 hit.
SMARTiView protein in SMART
SM00929. NADH-G_4Fe-4S_3. 1 hit.
SUPFAMiSSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR01973. NuoG. 1 hit.
PROSITEiView protein in PROSITE
PS51085. 2FE2S_FER_2. 1 hit.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00641. COMPLEX1_75K_1. 1 hit.
PS00642. COMPLEX1_75K_2. 1 hit.
PS00643. COMPLEX1_75K_3. 1 hit.

Sequencei

Sequence statusi: Complete.

E5KRK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRIPVRKAL VGLSKSPKGC VRTTATAASN LIEVFVDGQS VMVEPGTTVL
60 70 80 90 100
QACEKVGMQI PRFCYHERLS VAGNCRMCLV EIEKAPKVVA ACAMPVMKGW
110 120 130 140 150
NILTNSEKSK KAREGVMEFL LANHPLDCPI CDQGGECDLQ DQSMMFGNDR
160 170 180 190 200
SRFLEGKRAV EDKNIGPLVK TIMTRCIQCT RCIRFASEIA GVDDLGTTGR
210 220 230 240 250
GNDMQVGTYI EKMFMSELSG NIIDICPVGA LTSKPYAFTA RPWETRKTES
260 270 280 290 300
IDVMDAVGSN IVVSTRTGEV MRILPRMHED INEEWISDKT RFAYDGLKRQ
310 320 330 340 350
RLTEPMVRNE KGLLTYTSWE DALSRVAGML QSFQGKDVAA IAGGLVDAEA
360 370 380 390 400
LVALKDLLNR VDSDTLCTEE VFPTAGAGTD LRSNYLLNTT IAGVEEADVV
410 420 430 440 450
LLVGTNPRFE APLFNARIRK SWLHNDLKVA LIGSPVDLTY TYDHLGDSPK
460 470 480 490 500
ILQDIASGSH PFSQVLKEAK KPMVVLGSSA LQRNDGAAIL AAVSSIAQKI
510 520 530 540 550
RMTSGVTGDW KVMNILHRIA SQVAALDLGY KPGVEAIRKN PPKVLFLLGA
560 570 580 590 600
DGGCITRQDL PKDCFIIYQG HHGDVGAPIA DVILPGAAYT EKSATYVNTE
610 620 630 640 650
GRAQQTKVAV TPPGLAREDW KIIRALSEIA GMTLPYDTLD QVRNRLEEVS
660 670 680 690 700
PNLVRYDDIE GANYFQQANE LSKLVNQQLL ADPLVPPQLT IKDFYMTDSI
710 720
SRASQTMAKC VKAVTEGAQA VEEPSIC
Length:727
Mass (Da):79,468
Last modified:February 8, 2011 - v1
Checksum:i9C35F4B8294771FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ205706 Genomic DNA. Translation: ADP91534.1.
HQ205707 Genomic DNA. Translation: ADP91535.1.
HQ205708 Genomic DNA. Translation: ADP91536.1.
HQ205709 Genomic DNA. Translation: ADP91537.1.
HQ205710 Genomic DNA. Translation: ADP91538.1.
HQ205711 Genomic DNA. Translation: ADP91539.1.
HQ205712 Genomic DNA. Translation: ADP91540.1.
HQ205713 Genomic DNA. Translation: ADP91541.1.
HQ205714 Genomic DNA. Translation: ADP91542.1.
HQ205715 Genomic DNA. Translation: ADP91543.1.
HQ205716 Genomic DNA. Translation: ADP91544.1.
HQ205717 Genomic DNA. Translation: ADP91545.1.
HQ205718 Genomic DNA. Translation: ADP91546.1.
HQ205719 Genomic DNA. Translation: ADP91547.1.
HQ205720 Genomic DNA. Translation: ADP91548.1.
HQ205721 Genomic DNA. Translation: ADP91549.1.
HQ205722 Genomic DNA. Translation: ADP91550.1.
HQ205723 Genomic DNA. Translation: ADP91551.1.
HQ205724 Genomic DNA. Translation: ADP91552.1.
HQ205725 Genomic DNA. Translation: ADP91553.1.
HQ205726 Genomic DNA. Translation: ADP91554.1.
HQ205727 Genomic DNA. Translation: ADP91555.1.
HQ205728 Genomic DNA. Translation: ADP91556.1.
HQ205729 Genomic DNA. Translation: ADP91557.1.
HQ205730 Genomic DNA. Translation: ADP91558.1.
HQ205731 Genomic DNA. Translation: ADP91559.1.
HQ205732 Genomic DNA. Translation: ADP91560.1.
HQ205733 Genomic DNA. Translation: ADP91561.1.
HQ205734 Genomic DNA. Translation: ADP91562.1.
HQ205735 Genomic DNA. Translation: ADP91563.1.
HQ205736 Genomic DNA. Translation: ADP91564.1.
HQ205737 Genomic DNA. Translation: ADP91565.1.
HQ205738 Genomic DNA. Translation: ADP91566.1.
HQ205739 Genomic DNA. Translation: ADP91567.1.
HQ205740 Genomic DNA. Translation: ADP91568.1.
HQ205741 Genomic DNA. Translation: ADP91569.1.
HQ205742 Genomic DNA. Translation: ADP91570.1.
HQ205743 Genomic DNA. Translation: ADP91571.1.
HQ205744 Genomic DNA. Translation: ADP91572.1.
HQ205745 Genomic DNA. Translation: ADP91573.1.
CH471063 Genomic DNA. Translation: EAW70380.1.
RefSeqiNP_004997.4. NM_005006.6.
UniGeneiHs.471207.
Hs.598436.

Genome annotation databases

GeneIDi4719.
KEGGihsa:4719.

Similar proteinsi

Entry informationi

Entry nameiE5KRK5_HUMAN
AccessioniPrimary (citable) accession number: E5KRK5
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 27, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.