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Protein
Submitted name:

Mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit

Gene

NDUFS1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandUbiquinoneImported

Names & Taxonomyi

Protein namesi
Submitted name:
Mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunitImported
Submitted name:
NADH dehydrogenase (Ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase), isoform CRA_bImported
Gene namesi
Name:NDUFS1Imported
ORF Names:hCG_17250Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000023228.13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiE5KRK5

Expressioni

Gene expression databases

BgeeiENSG00000023228
ExpressionAtlasiE5KRK5 baseline and differential

Structurei

3D structure databases

SMRiE5KRK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 1082Fe-2S ferredoxin-typeInterPro annotationAdd BLAST79
Domaini108 – 1474Fe-4S His(Cys)3-ligated-typeInterPro annotationAdd BLAST40
Domaini245 – 3014Fe-4S Mo/W bis-MGD-typeInterPro annotationAdd BLAST57

Sequence similaritiesi

Belongs to the complex I 75 kDa subunit family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2282 Eukaryota
COG1034 LUCA
KOiK03934

Family and domain databases

CDDicd00207 fer2, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006656 Mopterin_OxRdtase
IPR006963 Mopterin_OxRdtase_4Fe-4S_dom
IPR000283 NADH_UbQ_OxRdtase_75kDa_su_CS
IPR010228 NADH_UbQ_OxRdtase_Gsu
IPR019574 NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd
IPR015405 NuoG_C
PfamiView protein in Pfam
PF00384 Molybdopterin, 1 hit
PF10588 NADH-G_4Fe-4S_3, 1 hit
PF09326 NADH_dhqG_C, 1 hit
SMARTiView protein in SMART
SM00929 NADH-G_4Fe-4S_3, 1 hit
SUPFAMiSSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR01973 NuoG, 1 hit
PROSITEiView protein in PROSITE
PS51085 2FE2S_FER_2, 1 hit
PS51839 4FE4S_HC3, 1 hit
PS51669 4FE4S_MOW_BIS_MGD, 1 hit
PS00641 COMPLEX1_75K_1, 1 hit
PS00642 COMPLEX1_75K_2, 1 hit
PS00643 COMPLEX1_75K_3, 1 hit

Sequencei

Sequence statusi: Complete.

E5KRK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRIPVRKAL VGLSKSPKGC VRTTATAASN LIEVFVDGQS VMVEPGTTVL
60 70 80 90 100
QACEKVGMQI PRFCYHERLS VAGNCRMCLV EIEKAPKVVA ACAMPVMKGW
110 120 130 140 150
NILTNSEKSK KAREGVMEFL LANHPLDCPI CDQGGECDLQ DQSMMFGNDR
160 170 180 190 200
SRFLEGKRAV EDKNIGPLVK TIMTRCIQCT RCIRFASEIA GVDDLGTTGR
210 220 230 240 250
GNDMQVGTYI EKMFMSELSG NIIDICPVGA LTSKPYAFTA RPWETRKTES
260 270 280 290 300
IDVMDAVGSN IVVSTRTGEV MRILPRMHED INEEWISDKT RFAYDGLKRQ
310 320 330 340 350
RLTEPMVRNE KGLLTYTSWE DALSRVAGML QSFQGKDVAA IAGGLVDAEA
360 370 380 390 400
LVALKDLLNR VDSDTLCTEE VFPTAGAGTD LRSNYLLNTT IAGVEEADVV
410 420 430 440 450
LLVGTNPRFE APLFNARIRK SWLHNDLKVA LIGSPVDLTY TYDHLGDSPK
460 470 480 490 500
ILQDIASGSH PFSQVLKEAK KPMVVLGSSA LQRNDGAAIL AAVSSIAQKI
510 520 530 540 550
RMTSGVTGDW KVMNILHRIA SQVAALDLGY KPGVEAIRKN PPKVLFLLGA
560 570 580 590 600
DGGCITRQDL PKDCFIIYQG HHGDVGAPIA DVILPGAAYT EKSATYVNTE
610 620 630 640 650
GRAQQTKVAV TPPGLAREDW KIIRALSEIA GMTLPYDTLD QVRNRLEEVS
660 670 680 690 700
PNLVRYDDIE GANYFQQANE LSKLVNQQLL ADPLVPPQLT IKDFYMTDSI
710 720
SRASQTMAKC VKAVTEGAQA VEEPSIC
Length:727
Mass (Da):79,468
Last modified:February 8, 2011 - v1
Checksum:i9C35F4B8294771FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ205706 Genomic DNA Translation: ADP91534.1
HQ205707 Genomic DNA Translation: ADP91535.1
HQ205708 Genomic DNA Translation: ADP91536.1
HQ205709 Genomic DNA Translation: ADP91537.1
HQ205710 Genomic DNA Translation: ADP91538.1
HQ205711 Genomic DNA Translation: ADP91539.1
HQ205712 Genomic DNA Translation: ADP91540.1
HQ205713 Genomic DNA Translation: ADP91541.1
HQ205714 Genomic DNA Translation: ADP91542.1
HQ205715 Genomic DNA Translation: ADP91543.1
HQ205716 Genomic DNA Translation: ADP91544.1
HQ205717 Genomic DNA Translation: ADP91545.1
HQ205718 Genomic DNA Translation: ADP91546.1
HQ205719 Genomic DNA Translation: ADP91547.1
HQ205720 Genomic DNA Translation: ADP91548.1
HQ205721 Genomic DNA Translation: ADP91549.1
HQ205722 Genomic DNA Translation: ADP91550.1
HQ205723 Genomic DNA Translation: ADP91551.1
HQ205724 Genomic DNA Translation: ADP91552.1
HQ205725 Genomic DNA Translation: ADP91553.1
HQ205726 Genomic DNA Translation: ADP91554.1
HQ205727 Genomic DNA Translation: ADP91555.1
HQ205728 Genomic DNA Translation: ADP91556.1
HQ205729 Genomic DNA Translation: ADP91557.1
HQ205730 Genomic DNA Translation: ADP91558.1
HQ205731 Genomic DNA Translation: ADP91559.1
HQ205732 Genomic DNA Translation: ADP91560.1
HQ205733 Genomic DNA Translation: ADP91561.1
HQ205734 Genomic DNA Translation: ADP91562.1
HQ205735 Genomic DNA Translation: ADP91563.1
HQ205736 Genomic DNA Translation: ADP91564.1
HQ205737 Genomic DNA Translation: ADP91565.1
HQ205738 Genomic DNA Translation: ADP91566.1
HQ205739 Genomic DNA Translation: ADP91567.1
HQ205740 Genomic DNA Translation: ADP91568.1
HQ205741 Genomic DNA Translation: ADP91569.1
HQ205742 Genomic DNA Translation: ADP91570.1
HQ205743 Genomic DNA Translation: ADP91571.1
HQ205744 Genomic DNA Translation: ADP91572.1
HQ205745 Genomic DNA Translation: ADP91573.1
CH471063 Genomic DNA Translation: EAW70380.1
RefSeqiNP_004997.4, NM_005006.6
UniGeneiHs.471207
Hs.598436

Genome annotation databases

GeneIDi4719
KEGGihsa:4719

Similar proteinsi

Entry informationi

Entry nameiE5KRK5_HUMAN
AccessioniPrimary (citable) accession number: E5KRK5
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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