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Protein
Submitted name:

Mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit

Gene

NDUFS1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

UbiquinoneImported

Names & Taxonomyi

Protein namesi
Submitted name:
Mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunitImported
Submitted name:
NADH dehydrogenase (Ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase), isoform CRA_bImported
Gene namesi
Name:NDUFS1Imported
ORF Names:hCG_17250Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000392709.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 108792Fe-2S ferredoxin-typeInterPro annotationAdd
BLAST
Domaini245 – 301574Fe-4S Mo/W bis-MGD-typeInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the complex I 75 kDa subunit family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2282. Eukaryota.
COG1034. LUCA.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR012675. Beta-grasp_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR000283. NADH_UbQ_OxRdtase_75kDa_su_CS.
IPR010228. NADH_UbQ_OxRdtase_Gsu.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
IPR015405. NuoG_C.
[Graphical view]
PfamiPF00384. Molybdopterin. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
PF09326. NADH_dhqG_C. 1 hit.
[Graphical view]
SMARTiSM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SUPFAMiSSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR01973. NuoG. 1 hit.
PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00641. COMPLEX1_75K_1. 1 hit.
PS00642. COMPLEX1_75K_2. 1 hit.
PS00643. COMPLEX1_75K_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E5KRK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRIPVRKAL VGLSKSPKGC VRTTATAASN LIEVFVDGQS VMVEPGTTVL
60 70 80 90 100
QACEKVGMQI PRFCYHERLS VAGNCRMCLV EIEKAPKVVA ACAMPVMKGW
110 120 130 140 150
NILTNSEKSK KAREGVMEFL LANHPLDCPI CDQGGECDLQ DQSMMFGNDR
160 170 180 190 200
SRFLEGKRAV EDKNIGPLVK TIMTRCIQCT RCIRFASEIA GVDDLGTTGR
210 220 230 240 250
GNDMQVGTYI EKMFMSELSG NIIDICPVGA LTSKPYAFTA RPWETRKTES
260 270 280 290 300
IDVMDAVGSN IVVSTRTGEV MRILPRMHED INEEWISDKT RFAYDGLKRQ
310 320 330 340 350
RLTEPMVRNE KGLLTYTSWE DALSRVAGML QSFQGKDVAA IAGGLVDAEA
360 370 380 390 400
LVALKDLLNR VDSDTLCTEE VFPTAGAGTD LRSNYLLNTT IAGVEEADVV
410 420 430 440 450
LLVGTNPRFE APLFNARIRK SWLHNDLKVA LIGSPVDLTY TYDHLGDSPK
460 470 480 490 500
ILQDIASGSH PFSQVLKEAK KPMVVLGSSA LQRNDGAAIL AAVSSIAQKI
510 520 530 540 550
RMTSGVTGDW KVMNILHRIA SQVAALDLGY KPGVEAIRKN PPKVLFLLGA
560 570 580 590 600
DGGCITRQDL PKDCFIIYQG HHGDVGAPIA DVILPGAAYT EKSATYVNTE
610 620 630 640 650
GRAQQTKVAV TPPGLAREDW KIIRALSEIA GMTLPYDTLD QVRNRLEEVS
660 670 680 690 700
PNLVRYDDIE GANYFQQANE LSKLVNQQLL ADPLVPPQLT IKDFYMTDSI
710 720
SRASQTMAKC VKAVTEGAQA VEEPSIC
Length:727
Mass (Da):79,468
Last modified:February 8, 2011 - v1
Checksum:i9C35F4B8294771FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ205706 Genomic DNA. Translation: ADP91534.1.
HQ205707 Genomic DNA. Translation: ADP91535.1.
HQ205708 Genomic DNA. Translation: ADP91536.1.
HQ205709 Genomic DNA. Translation: ADP91537.1.
HQ205710 Genomic DNA. Translation: ADP91538.1.
HQ205711 Genomic DNA. Translation: ADP91539.1.
HQ205712 Genomic DNA. Translation: ADP91540.1.
HQ205713 Genomic DNA. Translation: ADP91541.1.
HQ205714 Genomic DNA. Translation: ADP91542.1.
HQ205715 Genomic DNA. Translation: ADP91543.1.
HQ205716 Genomic DNA. Translation: ADP91544.1.
HQ205717 Genomic DNA. Translation: ADP91545.1.
HQ205718 Genomic DNA. Translation: ADP91546.1.
HQ205719 Genomic DNA. Translation: ADP91547.1.
HQ205720 Genomic DNA. Translation: ADP91548.1.
HQ205721 Genomic DNA. Translation: ADP91549.1.
HQ205722 Genomic DNA. Translation: ADP91550.1.
HQ205723 Genomic DNA. Translation: ADP91551.1.
HQ205724 Genomic DNA. Translation: ADP91552.1.
HQ205725 Genomic DNA. Translation: ADP91553.1.
HQ205726 Genomic DNA. Translation: ADP91554.1.
HQ205727 Genomic DNA. Translation: ADP91555.1.
HQ205728 Genomic DNA. Translation: ADP91556.1.
HQ205729 Genomic DNA. Translation: ADP91557.1.
HQ205730 Genomic DNA. Translation: ADP91558.1.
HQ205731 Genomic DNA. Translation: ADP91559.1.
HQ205732 Genomic DNA. Translation: ADP91560.1.
HQ205733 Genomic DNA. Translation: ADP91561.1.
HQ205734 Genomic DNA. Translation: ADP91562.1.
HQ205735 Genomic DNA. Translation: ADP91563.1.
HQ205736 Genomic DNA. Translation: ADP91564.1.
HQ205737 Genomic DNA. Translation: ADP91565.1.
HQ205738 Genomic DNA. Translation: ADP91566.1.
HQ205739 Genomic DNA. Translation: ADP91567.1.
HQ205740 Genomic DNA. Translation: ADP91568.1.
HQ205741 Genomic DNA. Translation: ADP91569.1.
HQ205742 Genomic DNA. Translation: ADP91570.1.
HQ205743 Genomic DNA. Translation: ADP91571.1.
HQ205744 Genomic DNA. Translation: ADP91572.1.
HQ205745 Genomic DNA. Translation: ADP91573.1.
CH471063 Genomic DNA. Translation: EAW70380.1.
RefSeqiNP_004997.4. NM_005006.6.
UniGeneiHs.471207.
Hs.598436.

Genome annotation databases

GeneIDi4719.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ205706 Genomic DNA. Translation: ADP91534.1.
HQ205707 Genomic DNA. Translation: ADP91535.1.
HQ205708 Genomic DNA. Translation: ADP91536.1.
HQ205709 Genomic DNA. Translation: ADP91537.1.
HQ205710 Genomic DNA. Translation: ADP91538.1.
HQ205711 Genomic DNA. Translation: ADP91539.1.
HQ205712 Genomic DNA. Translation: ADP91540.1.
HQ205713 Genomic DNA. Translation: ADP91541.1.
HQ205714 Genomic DNA. Translation: ADP91542.1.
HQ205715 Genomic DNA. Translation: ADP91543.1.
HQ205716 Genomic DNA. Translation: ADP91544.1.
HQ205717 Genomic DNA. Translation: ADP91545.1.
HQ205718 Genomic DNA. Translation: ADP91546.1.
HQ205719 Genomic DNA. Translation: ADP91547.1.
HQ205720 Genomic DNA. Translation: ADP91548.1.
HQ205721 Genomic DNA. Translation: ADP91549.1.
HQ205722 Genomic DNA. Translation: ADP91550.1.
HQ205723 Genomic DNA. Translation: ADP91551.1.
HQ205724 Genomic DNA. Translation: ADP91552.1.
HQ205725 Genomic DNA. Translation: ADP91553.1.
HQ205726 Genomic DNA. Translation: ADP91554.1.
HQ205727 Genomic DNA. Translation: ADP91555.1.
HQ205728 Genomic DNA. Translation: ADP91556.1.
HQ205729 Genomic DNA. Translation: ADP91557.1.
HQ205730 Genomic DNA. Translation: ADP91558.1.
HQ205731 Genomic DNA. Translation: ADP91559.1.
HQ205732 Genomic DNA. Translation: ADP91560.1.
HQ205733 Genomic DNA. Translation: ADP91561.1.
HQ205734 Genomic DNA. Translation: ADP91562.1.
HQ205735 Genomic DNA. Translation: ADP91563.1.
HQ205736 Genomic DNA. Translation: ADP91564.1.
HQ205737 Genomic DNA. Translation: ADP91565.1.
HQ205738 Genomic DNA. Translation: ADP91566.1.
HQ205739 Genomic DNA. Translation: ADP91567.1.
HQ205740 Genomic DNA. Translation: ADP91568.1.
HQ205741 Genomic DNA. Translation: ADP91569.1.
HQ205742 Genomic DNA. Translation: ADP91570.1.
HQ205743 Genomic DNA. Translation: ADP91571.1.
HQ205744 Genomic DNA. Translation: ADP91572.1.
HQ205745 Genomic DNA. Translation: ADP91573.1.
CH471063 Genomic DNA. Translation: EAW70380.1.
RefSeqiNP_004997.4. NM_005006.6.
UniGeneiHs.471207.
Hs.598436.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000392709.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4719.

Organism-specific databases

CTDi4719.

Phylogenomic databases

eggNOGiKOG2282. Eukaryota.
COG1034. LUCA.

Miscellaneous databases

ChiTaRSiNDUFS1. human.
GenomeRNAii4719.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR012675. Beta-grasp_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR000283. NADH_UbQ_OxRdtase_75kDa_su_CS.
IPR010228. NADH_UbQ_OxRdtase_Gsu.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
IPR015405. NuoG_C.
[Graphical view]
PfamiPF00384. Molybdopterin. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
PF09326. NADH_dhqG_C. 1 hit.
[Graphical view]
SMARTiSM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SUPFAMiSSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR01973. NuoG. 1 hit.
PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00641. COMPLEX1_75K_1. 1 hit.
PS00642. COMPLEX1_75K_2. 1 hit.
PS00643. COMPLEX1_75K_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE.
  3. "Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing."
    Wang W., Shen P., Thiyagarajan S., Lin S., Palm C., Horvath R., Klopstock T., Cutler D., Pique L., Schrijver I., Davis R.W., Mindrinos M., Speed T.P., Scharfe C.
    Nucleic Acids Res. 39:44-58(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiE5KRK5_HUMAN
AccessioniPrimary (citable) accession number: E5KRK5
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: June 8, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.