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E5KR08 (E5KR08_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

Myotonin-protein kinase EMBL ADP91337.1
Gene names
Name:DMPK EMBL EAW57380.1
ORF Names:hCG_1996612 EMBL EAW57380.1
OrganismHomo sapiens (Human) EMBL ADP91337.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length639 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. SAAS SAAS000961

Sequence similarities

Contains 1 AGC-kinase C-terminal domain.

Contains AGC-kinase C-terminal domain. SAAS SAAS000961

Ontologies

Keywords
   LigandATP-binding SAAS SAAS000961 RuleBase RU000304
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase SAAS SAAS000961
Transferase
Gene Ontology (GO)
   Biological_processcellular calcium ion homeostasis

Inferred from electronic annotation. Source: Ensembl

nuclear envelope organization

Inferred from electronic annotation. Source: Ensembl

regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction

Inferred from electronic annotation. Source: Ensembl

regulation of heart contraction

Inferred from electronic annotation. Source: Ensembl

regulation of myotube differentiation

Inferred from electronic annotation. Source: Ensembl

regulation of skeletal muscle contraction by calcium ion signaling

Inferred from electronic annotation. Source: Ensembl

regulation of sodium ion transport

Inferred from electronic annotation. Source: Ensembl

regulation of synapse structural plasticity

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintegral component of mitochondrial outer membrane

Inferred from electronic annotation. Source: Ensembl

nuclear membrane

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from electronic annotation. Source: Ensembl

sarcoplasmic reticulum membrane

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein serine/threonine kinase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
E5KR08 [UniParc].

Last modified February 8, 2011. Version 1.
Checksum: 69A831604F7F8D38

FASTA63970,371
        10         20         30         40         50         60 
MGGHFWPPEP YTVFMWGSPW EADSPRVKLR GREKGRQTEG GAFPLVSSAL SGDPRFFSPT 

        70         80         90        100        110        120 
TPPAEPIVVR LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR 

       130        140        150        160        170        180 
GEVSCFREER DVLVNGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE 

       190        200        210        220        230        240 
MARFYLAEIV MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL RADGTVRSLV 

       250        260        270        280        290        300 
AVGTPDYLSP EILQAVGGGP GTGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYGKI 

       310        320        330        340        350        360 
VHYKEHLSLP LVDEGVPEEA RDFIQRLLCP PETRLGRGGA GDFRTHPFFF GLDWDGLRDS 

       370        380        390        400        410        420 
VPPFTPDFEG ATDTCNFDLV EDGLTAMVSG GGETLSDIRE GAPLGVHLPF VGYSYSCMAL 

       430        440        450        460        470        480 
RDSEVPGPTP MELEAEQLLE PHVQAPSLEP SVSPQDETAE VAVPAAVPAA EAEAEVTLRE 

       490        500        510        520        530        540 
LQEALEEEVL TRQSLSREME AIRTDNQNFA SQLREAEARN RDLEAHVRQL QERMELLQAE 

       550        560        570        580        590        600 
GATAVTGVPS PRATDPPSHL DGPPAVAVGQ CPLVGPGPMH RRHLLLPARV PRPGLSEALS 

       610        620        630 
LLLFAVVLSR AAALGCIGLV AHAGQLTAVW RRPGAARAP 

« Hide

References

[1]"The sequence of the human genome."
Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H. expand/collapse author list , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[3]"Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing."
Wang W., Shen P., Thiyagarajan S., Lin S., Palm C., Horvath R., Klopstock T., Cutler D., Pique L., Schrijver I., Davis R.W., Mindrinos M., Speed T.P., Scharfe C.
Nucleic Acids Res. 39:44-58(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HQ205626 Genomic DNA. Translation: ADP91337.1.
HQ205627 Genomic DNA. Translation: ADP91341.1.
HQ205628 Genomic DNA. Translation: ADP91345.1.
HQ205629 Genomic DNA. Translation: ADP91349.1.
HQ205630 Genomic DNA. Translation: ADP91353.1.
HQ205631 Genomic DNA. Translation: ADP91357.1.
HQ205632 Genomic DNA. Translation: ADP91361.1.
HQ205633 Genomic DNA. Translation: ADP91365.1.
HQ205634 Genomic DNA. Translation: ADP91369.1.
HQ205635 Genomic DNA. Translation: ADP91373.1.
HQ205636 Genomic DNA. Translation: ADP91377.1.
HQ205637 Genomic DNA. Translation: ADP91381.1.
HQ205638 Genomic DNA. Translation: ADP91385.1.
HQ205639 Genomic DNA. Translation: ADP91389.1.
HQ205640 Genomic DNA. Translation: ADP91393.1.
HQ205641 Genomic DNA. Translation: ADP91397.1.
HQ205642 Genomic DNA. Translation: ADP91401.1.
HQ205643 Genomic DNA. Translation: ADP91405.1.
HQ205644 Genomic DNA. Translation: ADP91409.1.
HQ205645 Genomic DNA. Translation: ADP91413.1.
HQ205646 Genomic DNA. Translation: ADP91417.1.
HQ205647 Genomic DNA. Translation: ADP91421.1.
HQ205648 Genomic DNA. Translation: ADP91425.1.
HQ205649 Genomic DNA. Translation: ADP91429.1.
HQ205650 Genomic DNA. Translation: ADP91433.1.
HQ205651 Genomic DNA. Translation: ADP91437.1.
HQ205652 Genomic DNA. Translation: ADP91441.1.
HQ205653 Genomic DNA. Translation: ADP91445.1.
HQ205654 Genomic DNA. Translation: ADP91449.1.
HQ205655 Genomic DNA. Translation: ADP91453.1.
HQ205656 Genomic DNA. Translation: ADP91457.1.
HQ205657 Genomic DNA. Translation: ADP91461.1.
HQ205658 Genomic DNA. Translation: ADP91465.1.
HQ205659 Genomic DNA. Translation: ADP91469.1.
HQ205660 Genomic DNA. Translation: ADP91473.1.
HQ205661 Genomic DNA. Translation: ADP91477.1.
HQ205662 Genomic DNA. Translation: ADP91481.1.
HQ205663 Genomic DNA. Translation: ADP91485.1.
HQ205664 Genomic DNA. Translation: ADP91489.1.
HQ205665 Genomic DNA. Translation: ADP91493.1.
CH471126 Genomic DNA. Translation: EAW57380.1.
RefSeqNP_001075032.1. NM_001081563.2.
UniGeneHs.631596.

3D structure databases

ProteinModelPortalE5KR08.
SMRE5KR08. Positions 64-426, 471-537.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEE5KR08.

Protocols and materials databases

DNASU1760.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1760.
KEGGhsa:1760.
UCSCuc002pdd.1. human.

Organism-specific databases

CTD1760.

Phylogenomic databases

KOK08788.
PhylomeDBE5KR08.

Gene expression databases

ArrayExpressE5KR08.

Family and domain databases

InterProIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR014930. Myotonic_dystrophy_kinase_coil.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF08826. DMPK_coil. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
ProDomPD011252. Myotonic_dystrophy_kinase_coil. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSDMPK. human.
GenomeRNAi1760.
NextBio7169.

Entry information

Entry nameE5KR08_HUMAN
AccessionPrimary (citable) accession number: E5KR08
Entry history
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: March 19, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.