E5KR08 (E5KR08_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Dystrophia myotonica-protein kinase, isoform CRA_a EMBL EAW57380.1

Submitted name:
Myotonin-protein kinase EMBL ADP91337.1

Gene names

Name:	DMPK EMBL EAW57380.1
ORF Names:	hCG_1996612 EMBL EAW57380.1

Organism

Homo sapiens (Human) EMBL ADP91337.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	639 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Contains 1 AGC-kinase C-terminal domain. SAAS SAAS000961

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304 SAAS SAAS000961 Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase SAAS SAAS000961 Transferase
Gene Ontology (GO)
Biological_process	cellular calcium ion homeostasis Inferred from electronic annotation. Source: Compara nuclear envelope organization Inferred from electronic annotation. Source: Compara regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction Inferred from electronic annotation. Source: Compara regulation of heart contraction Inferred from electronic annotation. Source: Compara regulation of myotube differentiation Inferred from electronic annotation. Source: Compara regulation of skeletal muscle contraction by calcium ion signaling Inferred from electronic annotation. Source: Compara regulation of sodium ion transport Inferred from electronic annotation. Source: Compara regulation of synapse structural plasticity Inferred from electronic annotation. Source: Compara
Cellular_component	integral to mitochondrial outer membrane Inferred from electronic annotation. Source: Compara nuclear membrane Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara sarcoplasmic reticulum membrane Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	E5KR08 [UniParc]. Last modified February 8, 2011. Version 1. Checksum: 69A831604F7F8D38	FASTA	639	70,371
	10 20 30 40 50 60 MGGHFWPPEP YTVFMWGSPW EADSPRVKLR GREKGRQTEG GAFPLVSSAL SGDPRFFSPT 70 80 90 100 110 120 TPPAEPIVVR LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR 130 140 150 160 170 180 GEVSCFREER DVLVNGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE 190 200 210 220 230 240 MARFYLAEIV MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL RADGTVRSLV 250 260 270 280 290 300 AVGTPDYLSP EILQAVGGGP GTGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYGKI 310 320 330 340 350 360 VHYKEHLSLP LVDEGVPEEA RDFIQRLLCP PETRLGRGGA GDFRTHPFFF GLDWDGLRDS 370 380 390 400 410 420 VPPFTPDFEG ATDTCNFDLV EDGLTAMVSG GGETLSDIRE GAPLGVHLPF VGYSYSCMAL 430 440 450 460 470 480 RDSEVPGPTP MELEAEQLLE PHVQAPSLEP SVSPQDETAE VAVPAAVPAA EAEAEVTLRE 490 500 510 520 530 540 LQEALEEEVL TRQSLSREME AIRTDNQNFA SQLREAEARN RDLEAHVRQL QERMELLQAE 550 560 570 580 590 600 GATAVTGVPS PRATDPPSHL DGPPAVAVGQ CPLVGPGPMH RRHLLLPARV PRPGLSEALS 610 620 630 LLLFAVVLSR AAALGCIGLV AHAGQLTAVW RRPGAARAP

References

[1]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing." Wang W., Shen P., Thiyagarajan S., Lin S., Palm C., Horvath R., Klopstock T., Cutler D., Pique L., Schrijver I., Davis R.W., Mindrinos M., Speed T.P., Scharfe C. Nucleic Acids Res. 39:44-58(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	HQ205626 Genomic DNA. Translation: ADP91337.1. HQ205627 Genomic DNA. Translation: ADP91341.1. HQ205628 Genomic DNA. Translation: ADP91345.1. HQ205629 Genomic DNA. Translation: ADP91349.1. HQ205630 Genomic DNA. Translation: ADP91353.1. HQ205631 Genomic DNA. Translation: ADP91357.1. HQ205632 Genomic DNA. Translation: ADP91361.1. HQ205633 Genomic DNA. Translation: ADP91365.1. HQ205634 Genomic DNA. Translation: ADP91369.1. HQ205635 Genomic DNA. Translation: ADP91373.1. HQ205636 Genomic DNA. Translation: ADP91377.1. HQ205637 Genomic DNA. Translation: ADP91381.1. HQ205638 Genomic DNA. Translation: ADP91385.1. HQ205639 Genomic DNA. Translation: ADP91389.1. HQ205640 Genomic DNA. Translation: ADP91393.1. HQ205641 Genomic DNA. Translation: ADP91397.1. HQ205642 Genomic DNA. Translation: ADP91401.1. HQ205643 Genomic DNA. Translation: ADP91405.1. HQ205644 Genomic DNA. Translation: ADP91409.1. HQ205645 Genomic DNA. Translation: ADP91413.1. HQ205646 Genomic DNA. Translation: ADP91417.1. HQ205647 Genomic DNA. Translation: ADP91421.1. HQ205648 Genomic DNA. Translation: ADP91425.1. HQ205649 Genomic DNA. Translation: ADP91429.1. HQ205650 Genomic DNA. Translation: ADP91433.1. HQ205651 Genomic DNA. Translation: ADP91437.1. HQ205652 Genomic DNA. Translation: ADP91441.1. HQ205653 Genomic DNA. Translation: ADP91445.1. HQ205654 Genomic DNA. Translation: ADP91449.1. HQ205655 Genomic DNA. Translation: ADP91453.1. HQ205656 Genomic DNA. Translation: ADP91457.1. HQ205657 Genomic DNA. Translation: ADP91461.1. HQ205658 Genomic DNA. Translation: ADP91465.1. HQ205659 Genomic DNA. Translation: ADP91469.1. HQ205660 Genomic DNA. Translation: ADP91473.1. HQ205661 Genomic DNA. Translation: ADP91477.1. HQ205662 Genomic DNA. Translation: ADP91481.1. HQ205663 Genomic DNA. Translation: ADP91485.1. HQ205664 Genomic DNA. Translation: ADP91489.1. HQ205665 Genomic DNA. Translation: ADP91493.1. CH471126 Genomic DNA. Translation: EAW57380.1.
IPI	IPI00305254.
RefSeq	NP_001075032.1. NM_001081563.1.
UniGene	Hs.631596.
3D structure databases
ProteinModelPortal	E5KR08.
SMR	E5KR08. Positions 64-426, 471-537.
ModBase	Search...
Proteomic databases
PRIDE	E5KR08.
Protocols and materials databases
DNASU	1760.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1760.
KEGG	hsa:1760.
Organism-specific databases
CTD	1760.
Phylogenomic databases
KO	K08788.
PhylomeDB	E5KR08.
Gene expression databases
ArrayExpress	E5KR08.
Bgee	E5KR08.
Family and domain databases
InterPro	IPR000961. AGC-kinase_C. IPR011009. Kinase-like_dom. IPR014930. Myotonic_dystrophy_kinase_coil. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF08826. DMPK_coil. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD011252. Myotonic_dystrophy_kinase_coil. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS51285. AGC_KINASE_CTER. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	DMPK. human.
GenomeRNAi	1760.
NextBio	7169.

Entry information

Entry name

E5KR08_HUMAN

Accession

Primary (citable) accession number: E5KR08

Entry history

Integrated into UniProtKB/TrEMBL:	February 8, 2011
Last sequence update:	February 8, 2011
Last modified:	March 6, 2013
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.