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E5KR06

- E5KR06_HUMAN

UniProt

E5KR06 - E5KR06_HUMAN

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Protein
Submitted name:

Myotonin-protein kinase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Myotonin-protein kinaseImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Expressioni

Gene expression databases

ExpressionAtlasiE5KR06. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE5KR06.
SMRiE5KR06. Positions 11-416, 461-527.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains AGC-kinase C-terminal domain.SAAS annotation

Phylogenomic databases

KOiK08788.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR014930. Myotonic_dystrophy_kinase_coil.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF08826. DMPK_coil. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
ProDomiPD011252. Myotonic_dystrophy_kinase_coil. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E5KR06-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAEVRLRRL QQLVLDPGFL GLEPLLDLLL GVHQELGASE LAQDKYVADF
60 70 80 90 100
LQWAEPIVVR LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK
110 120 130 140 150
IMNKWDMLKR GEVSCFREER DVLVNGDRRW ITQLHFAFQD ENYLYLVMEY
160 170 180 190 200
YVGGDLLTLL SKFGERIPAE MARFYLAEIV MAIDSVHRLG YVHRDIKPDN
210 220 230 240 250
ILLDRCGHIR LADFGSCLKL RADGTVRSLV AVGTPDYLSP EILQAVGGGP
260 270 280 290 300
GTGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYGKI VHYKEHLSLP
310 320 330 340 350
LVDEGVPEEA RDFIQRLLCP PETRLGRGGA GDFRTHPFFF GLDWDGLRDS
360 370 380 390 400
VPPFTPDFEG ATDTCNFDLV EDGLTAMVSG GGETLSDIRE GAPLGVHLPF
410 420 430 440 450
VGYSYSCMAL RDSEVPGPTP MELEAEQLLE PHVQAPSLEP SVSPQDETAE
460 470 480 490 500
VAVPAAVPAA EAEAEVTLRE LQEALEEEVL TRQSLSREME AIRTDNQNFA
510 520 530 540 550
SQLREAEARN RDLEAHVRQL QERMELLQAE GATAVTGVPS PRATDPPSHL
560 570 580 590 600
DGPPAVAVGQ CPLVGPGPMH RRHLLLPARV PRPGLSEALS LLLFAVVLSR
610 620
AAALGCIGLV AHAGQLTAVW RRPGAARAP
Length:629
Mass (Da):69,385
Last modified:February 8, 2011 - v1
Checksum:i46783ED4AE65B493
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HQ205626 Genomic DNA. Translation: ADP91336.1.
HQ205627 Genomic DNA. Translation: ADP91340.1.
HQ205628 Genomic DNA. Translation: ADP91344.1.
HQ205629 Genomic DNA. Translation: ADP91348.1.
HQ205630 Genomic DNA. Translation: ADP91352.1.
HQ205631 Genomic DNA. Translation: ADP91356.1.
HQ205632 Genomic DNA. Translation: ADP91360.1.
HQ205633 Genomic DNA. Translation: ADP91364.1.
HQ205634 Genomic DNA. Translation: ADP91368.1.
HQ205635 Genomic DNA. Translation: ADP91372.1.
HQ205636 Genomic DNA. Translation: ADP91376.1.
HQ205637 Genomic DNA. Translation: ADP91380.1.
HQ205638 Genomic DNA. Translation: ADP91384.1.
HQ205639 Genomic DNA. Translation: ADP91388.1.
HQ205640 Genomic DNA. Translation: ADP91392.1.
HQ205641 Genomic DNA. Translation: ADP91396.1.
HQ205642 Genomic DNA. Translation: ADP91400.1.
HQ205643 Genomic DNA. Translation: ADP91404.1.
HQ205644 Genomic DNA. Translation: ADP91408.1.
HQ205645 Genomic DNA. Translation: ADP91412.1.
HQ205646 Genomic DNA. Translation: ADP91416.1.
HQ205647 Genomic DNA. Translation: ADP91420.1.
HQ205648 Genomic DNA. Translation: ADP91424.1.
HQ205649 Genomic DNA. Translation: ADP91428.1.
HQ205650 Genomic DNA. Translation: ADP91432.1.
HQ205651 Genomic DNA. Translation: ADP91436.1.
HQ205652 Genomic DNA. Translation: ADP91440.1.
HQ205653 Genomic DNA. Translation: ADP91444.1.
HQ205654 Genomic DNA. Translation: ADP91448.1.
HQ205655 Genomic DNA. Translation: ADP91452.1.
HQ205656 Genomic DNA. Translation: ADP91456.1.
HQ205657 Genomic DNA. Translation: ADP91460.1.
HQ205658 Genomic DNA. Translation: ADP91464.1.
HQ205659 Genomic DNA. Translation: ADP91468.1.
HQ205660 Genomic DNA. Translation: ADP91472.1.
HQ205661 Genomic DNA. Translation: ADP91476.1.
HQ205662 Genomic DNA. Translation: ADP91480.1.
HQ205663 Genomic DNA. Translation: ADP91484.1.
HQ205664 Genomic DNA. Translation: ADP91488.1.
HQ205665 Genomic DNA. Translation: ADP91492.1.
RefSeqiNP_004400.4. NM_004409.4.
UniGeneiHs.631596.

Genome annotation databases

GeneIDi1760.
KEGGihsa:1760.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HQ205626 Genomic DNA. Translation: ADP91336.1 .
HQ205627 Genomic DNA. Translation: ADP91340.1 .
HQ205628 Genomic DNA. Translation: ADP91344.1 .
HQ205629 Genomic DNA. Translation: ADP91348.1 .
HQ205630 Genomic DNA. Translation: ADP91352.1 .
HQ205631 Genomic DNA. Translation: ADP91356.1 .
HQ205632 Genomic DNA. Translation: ADP91360.1 .
HQ205633 Genomic DNA. Translation: ADP91364.1 .
HQ205634 Genomic DNA. Translation: ADP91368.1 .
HQ205635 Genomic DNA. Translation: ADP91372.1 .
HQ205636 Genomic DNA. Translation: ADP91376.1 .
HQ205637 Genomic DNA. Translation: ADP91380.1 .
HQ205638 Genomic DNA. Translation: ADP91384.1 .
HQ205639 Genomic DNA. Translation: ADP91388.1 .
HQ205640 Genomic DNA. Translation: ADP91392.1 .
HQ205641 Genomic DNA. Translation: ADP91396.1 .
HQ205642 Genomic DNA. Translation: ADP91400.1 .
HQ205643 Genomic DNA. Translation: ADP91404.1 .
HQ205644 Genomic DNA. Translation: ADP91408.1 .
HQ205645 Genomic DNA. Translation: ADP91412.1 .
HQ205646 Genomic DNA. Translation: ADP91416.1 .
HQ205647 Genomic DNA. Translation: ADP91420.1 .
HQ205648 Genomic DNA. Translation: ADP91424.1 .
HQ205649 Genomic DNA. Translation: ADP91428.1 .
HQ205650 Genomic DNA. Translation: ADP91432.1 .
HQ205651 Genomic DNA. Translation: ADP91436.1 .
HQ205652 Genomic DNA. Translation: ADP91440.1 .
HQ205653 Genomic DNA. Translation: ADP91444.1 .
HQ205654 Genomic DNA. Translation: ADP91448.1 .
HQ205655 Genomic DNA. Translation: ADP91452.1 .
HQ205656 Genomic DNA. Translation: ADP91456.1 .
HQ205657 Genomic DNA. Translation: ADP91460.1 .
HQ205658 Genomic DNA. Translation: ADP91464.1 .
HQ205659 Genomic DNA. Translation: ADP91468.1 .
HQ205660 Genomic DNA. Translation: ADP91472.1 .
HQ205661 Genomic DNA. Translation: ADP91476.1 .
HQ205662 Genomic DNA. Translation: ADP91480.1 .
HQ205663 Genomic DNA. Translation: ADP91484.1 .
HQ205664 Genomic DNA. Translation: ADP91488.1 .
HQ205665 Genomic DNA. Translation: ADP91492.1 .
RefSeqi NP_004400.4. NM_004409.4.
UniGenei Hs.631596.

3D structure databases

ProteinModelPortali E5KR06.
SMRi E5KR06. Positions 11-416, 461-527.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

DNASUi 1760.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1760.
KEGGi hsa:1760.

Organism-specific databases

CTDi 1760.

Phylogenomic databases

KOi K08788.

Miscellaneous databases

GenomeRNAii 1760.
NextBioi 7169.

Gene expression databases

ExpressionAtlasi E5KR06. baseline and differential.

Family and domain databases

InterProi IPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR014930. Myotonic_dystrophy_kinase_coil.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF08826. DMPK_coil. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
ProDomi PD011252. Myotonic_dystrophy_kinase_coil. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing."
    Wang W., Shen P., Thiyagarajan S., Lin S., Palm C., Horvath R., Klopstock T., Cutler D., Pique L., Schrijver I., Davis R.W., Mindrinos M., Speed T.P., Scharfe C.
    Nucleic Acids Res. 39:44-58(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiE5KR06_HUMAN
AccessioniPrimary (citable) accession number: E5KR06
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: October 29, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.