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E5KR06

- E5KR06_HUMAN

UniProt

E5KR06 - E5KR06_HUMAN

Protein
Submitted name:

Myotonin-protein kinase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinaseSAAS annotation, Transferase

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Myotonin-protein kinaseImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Structurei

    3D structure databases

    SMRiE5KR06. Positions 11-416, 461-527.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains AGC-kinase C-terminal domain.SAAS annotation

    Phylogenomic databases

    KOiK08788.

    Family and domain databases

    InterProiIPR000961. AGC-kinase_C.
    IPR011009. Kinase-like_dom.
    IPR014930. Myotonic_dystrophy_kinase_coil.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF08826. DMPK_coil. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    ProDomiPD011252. Myotonic_dystrophy_kinase_coil. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E5KR06-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAEVRLRRL QQLVLDPGFL GLEPLLDLLL GVHQELGASE LAQDKYVADF    50
    LQWAEPIVVR LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK 100
    IMNKWDMLKR GEVSCFREER DVLVNGDRRW ITQLHFAFQD ENYLYLVMEY 150
    YVGGDLLTLL SKFGERIPAE MARFYLAEIV MAIDSVHRLG YVHRDIKPDN 200
    ILLDRCGHIR LADFGSCLKL RADGTVRSLV AVGTPDYLSP EILQAVGGGP 250
    GTGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYGKI VHYKEHLSLP 300
    LVDEGVPEEA RDFIQRLLCP PETRLGRGGA GDFRTHPFFF GLDWDGLRDS 350
    VPPFTPDFEG ATDTCNFDLV EDGLTAMVSG GGETLSDIRE GAPLGVHLPF 400
    VGYSYSCMAL RDSEVPGPTP MELEAEQLLE PHVQAPSLEP SVSPQDETAE 450
    VAVPAAVPAA EAEAEVTLRE LQEALEEEVL TRQSLSREME AIRTDNQNFA 500
    SQLREAEARN RDLEAHVRQL QERMELLQAE GATAVTGVPS PRATDPPSHL 550
    DGPPAVAVGQ CPLVGPGPMH RRHLLLPARV PRPGLSEALS LLLFAVVLSR 600
    AAALGCIGLV AHAGQLTAVW RRPGAARAP 629
    Length:629
    Mass (Da):69,385
    Last modified:February 8, 2011 - v1
    Checksum:i46783ED4AE65B493
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HQ205626 Genomic DNA. Translation: ADP91336.1.
    HQ205627 Genomic DNA. Translation: ADP91340.1.
    HQ205628 Genomic DNA. Translation: ADP91344.1.
    HQ205629 Genomic DNA. Translation: ADP91348.1.
    HQ205630 Genomic DNA. Translation: ADP91352.1.
    HQ205631 Genomic DNA. Translation: ADP91356.1.
    HQ205632 Genomic DNA. Translation: ADP91360.1.
    HQ205633 Genomic DNA. Translation: ADP91364.1.
    HQ205634 Genomic DNA. Translation: ADP91368.1.
    HQ205635 Genomic DNA. Translation: ADP91372.1.
    HQ205636 Genomic DNA. Translation: ADP91376.1.
    HQ205637 Genomic DNA. Translation: ADP91380.1.
    HQ205638 Genomic DNA. Translation: ADP91384.1.
    HQ205639 Genomic DNA. Translation: ADP91388.1.
    HQ205640 Genomic DNA. Translation: ADP91392.1.
    HQ205641 Genomic DNA. Translation: ADP91396.1.
    HQ205642 Genomic DNA. Translation: ADP91400.1.
    HQ205643 Genomic DNA. Translation: ADP91404.1.
    HQ205644 Genomic DNA. Translation: ADP91408.1.
    HQ205645 Genomic DNA. Translation: ADP91412.1.
    HQ205646 Genomic DNA. Translation: ADP91416.1.
    HQ205647 Genomic DNA. Translation: ADP91420.1.
    HQ205648 Genomic DNA. Translation: ADP91424.1.
    HQ205649 Genomic DNA. Translation: ADP91428.1.
    HQ205650 Genomic DNA. Translation: ADP91432.1.
    HQ205651 Genomic DNA. Translation: ADP91436.1.
    HQ205652 Genomic DNA. Translation: ADP91440.1.
    HQ205653 Genomic DNA. Translation: ADP91444.1.
    HQ205654 Genomic DNA. Translation: ADP91448.1.
    HQ205655 Genomic DNA. Translation: ADP91452.1.
    HQ205656 Genomic DNA. Translation: ADP91456.1.
    HQ205657 Genomic DNA. Translation: ADP91460.1.
    HQ205658 Genomic DNA. Translation: ADP91464.1.
    HQ205659 Genomic DNA. Translation: ADP91468.1.
    HQ205660 Genomic DNA. Translation: ADP91472.1.
    HQ205661 Genomic DNA. Translation: ADP91476.1.
    HQ205662 Genomic DNA. Translation: ADP91480.1.
    HQ205663 Genomic DNA. Translation: ADP91484.1.
    HQ205664 Genomic DNA. Translation: ADP91488.1.
    HQ205665 Genomic DNA. Translation: ADP91492.1.
    RefSeqiNP_004400.4. NM_004409.4.
    UniGeneiHs.631596.

    Genome annotation databases

    GeneIDi1760.
    KEGGihsa:1760.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HQ205626 Genomic DNA. Translation: ADP91336.1 .
    HQ205627 Genomic DNA. Translation: ADP91340.1 .
    HQ205628 Genomic DNA. Translation: ADP91344.1 .
    HQ205629 Genomic DNA. Translation: ADP91348.1 .
    HQ205630 Genomic DNA. Translation: ADP91352.1 .
    HQ205631 Genomic DNA. Translation: ADP91356.1 .
    HQ205632 Genomic DNA. Translation: ADP91360.1 .
    HQ205633 Genomic DNA. Translation: ADP91364.1 .
    HQ205634 Genomic DNA. Translation: ADP91368.1 .
    HQ205635 Genomic DNA. Translation: ADP91372.1 .
    HQ205636 Genomic DNA. Translation: ADP91376.1 .
    HQ205637 Genomic DNA. Translation: ADP91380.1 .
    HQ205638 Genomic DNA. Translation: ADP91384.1 .
    HQ205639 Genomic DNA. Translation: ADP91388.1 .
    HQ205640 Genomic DNA. Translation: ADP91392.1 .
    HQ205641 Genomic DNA. Translation: ADP91396.1 .
    HQ205642 Genomic DNA. Translation: ADP91400.1 .
    HQ205643 Genomic DNA. Translation: ADP91404.1 .
    HQ205644 Genomic DNA. Translation: ADP91408.1 .
    HQ205645 Genomic DNA. Translation: ADP91412.1 .
    HQ205646 Genomic DNA. Translation: ADP91416.1 .
    HQ205647 Genomic DNA. Translation: ADP91420.1 .
    HQ205648 Genomic DNA. Translation: ADP91424.1 .
    HQ205649 Genomic DNA. Translation: ADP91428.1 .
    HQ205650 Genomic DNA. Translation: ADP91432.1 .
    HQ205651 Genomic DNA. Translation: ADP91436.1 .
    HQ205652 Genomic DNA. Translation: ADP91440.1 .
    HQ205653 Genomic DNA. Translation: ADP91444.1 .
    HQ205654 Genomic DNA. Translation: ADP91448.1 .
    HQ205655 Genomic DNA. Translation: ADP91452.1 .
    HQ205656 Genomic DNA. Translation: ADP91456.1 .
    HQ205657 Genomic DNA. Translation: ADP91460.1 .
    HQ205658 Genomic DNA. Translation: ADP91464.1 .
    HQ205659 Genomic DNA. Translation: ADP91468.1 .
    HQ205660 Genomic DNA. Translation: ADP91472.1 .
    HQ205661 Genomic DNA. Translation: ADP91476.1 .
    HQ205662 Genomic DNA. Translation: ADP91480.1 .
    HQ205663 Genomic DNA. Translation: ADP91484.1 .
    HQ205664 Genomic DNA. Translation: ADP91488.1 .
    HQ205665 Genomic DNA. Translation: ADP91492.1 .
    RefSeqi NP_004400.4. NM_004409.4.
    UniGenei Hs.631596.

    3D structure databases

    SMRi E5KR06. Positions 11-416, 461-527.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 1760.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1760.
    KEGGi hsa:1760.

    Organism-specific databases

    CTDi 1760.

    Phylogenomic databases

    KOi K08788.

    Miscellaneous databases

    GenomeRNAii 1760.
    NextBioi 7169.

    Family and domain databases

    InterProi IPR000961. AGC-kinase_C.
    IPR011009. Kinase-like_dom.
    IPR014930. Myotonic_dystrophy_kinase_coil.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF08826. DMPK_coil. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    ProDomi PD011252. Myotonic_dystrophy_kinase_coil. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing."
      Wang W., Shen P., Thiyagarajan S., Lin S., Palm C., Horvath R., Klopstock T., Cutler D., Pique L., Schrijver I., Davis R.W., Mindrinos M., Speed T.P., Scharfe C.
      Nucleic Acids Res. 39:44-58(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiE5KR06_HUMAN
    AccessioniPrimary (citable) accession number: E5KR06
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 8, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.