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Protein
Submitted name:

Glucocorticoid receptor

Gene

NR3C1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi418 – 493Nuclear receptorPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotationImported
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Glucocorticoid receptorImported
Submitted name:
Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor), isoform CRA_bImported
Gene namesi
Name:NR3C1Imported
ORF Names:hCG_37601Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000113580.14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiE5KQF5

Expressioni

Gene expression databases

BgeeiENSG00000113580
ExpressionAtlasiE5KQF5 baseline and differential

Structurei

3D structure databases

SMRiE5KQF5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini418 – 493Nuclear receptorInterPro annotationAdd BLAST76
Domaini524 – 742NR LBDInterPro annotationAdd BLAST219

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili112 – 132Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR001409 Glcrtcd_rcpt
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF02155 GCR, 1 hit
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00528 GLCORTICOIDR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

E5KQF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSKESLTPG REENPSSVLA QERGDVMDFY KTLRGGATVK VSASSPSLAV
60 70 80 90 100
ASQSDSKQRR LLVDFPKGSV SNAQQPDLSK AVSLSMGLYM GETETKVMGN
110 120 130 140 150
DLGFPQQGQI SLSSGETDLK LLEESIANLN RSTSVPENPK SSASTAVSAA
160 170 180 190 200
PTEKEFPKTH SDVSSEQQHL KGQTGTNGGN VKLYTTDQST FDILQDLEFS
210 220 230 240 250
SGSPGKETNE SPWRSDLLID ENCLLSPLAG EDDSFLLEGN SNEDCKPLIL
260 270 280 290 300
PDTKPKIKDN GDLVLSSPSN VTLPQVKTEK EDFIELCTPG VIKQEKLGTV
310 320 330 340 350
YCQASFPGAN IIGNKMSAIS VHGVSTSGGQ MYHYDMNTAS LSQQQDQKPI
360 370 380 390 400
FNVIPPIPVG SENWNRCQGS GDDNLTSLGT LNFPGRTVFS NGYSSPSMRP
410 420 430 440 450
DVSSPPSSSS TATTGPPPKL CLVCSDEASG CHYGVLTCGS CKVFFKRAVE
460 470 480 490 500
GQHNYLCAGR NDCIIDKIRR KNCPACRYRK CLQAGMNLEA RKTKKKIKGI
510 520 530 540 550
QQATTGVSQE TSENPGNKTI VPATLPQLTP TLVSLLEVIE PEVLYAGYDS
560 570 580 590 600
SVPDSTWRIM TTLNMLGGRQ VIAAVKWAKA IPGFRNLHLD DQMTLLQYSW
610 620 630 640 650
MFLMAFALGW RSYRQSSANL LCFAPDLIIN EQRMTLPCMY DQCKHMLYVS
660 670 680 690 700
SELHRLQVSY EEYLCMKTLL LLSSVPKDGL KSQELFDEIR MTYIKELGKA
710 720 730 740
IVKREGNSSQ NWQRFYQLTK LLDSMHENVM WLKPESTSHT LI
Length:742
Mass (Da):81,509
Last modified:February 8, 2011 - v1
Checksum:iE2D1F6EA0EE14704
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ205546 Genomic DNA Translation: ADP91134.1
HQ205547 Genomic DNA Translation: ADP91137.1
HQ205548 Genomic DNA Translation: ADP91140.1
HQ205549 Genomic DNA Translation: ADP91143.1
HQ205550 Genomic DNA Translation: ADP91146.1
HQ205551 Genomic DNA Translation: ADP91149.1
HQ205552 Genomic DNA Translation: ADP91152.1
HQ205553 Genomic DNA Translation: ADP91155.1
HQ205554 Genomic DNA Translation: ADP91158.1
HQ205555 Genomic DNA Translation: ADP91161.1
HQ205556 Genomic DNA Translation: ADP91164.1
HQ205557 Genomic DNA Translation: ADP91167.1
HQ205558 Genomic DNA Translation: ADP91170.1
HQ205559 Genomic DNA Translation: ADP91173.1
HQ205560 Genomic DNA Translation: ADP91176.1
HQ205561 Genomic DNA Translation: ADP91179.1
HQ205562 Genomic DNA Translation: ADP91182.1
HQ205563 Genomic DNA Translation: ADP91185.1
HQ205564 Genomic DNA Translation: ADP91188.1
HQ205565 Genomic DNA Translation: ADP91191.1
HQ205566 Genomic DNA Translation: ADP91194.1
HQ205567 Genomic DNA Translation: ADP91197.1
HQ205568 Genomic DNA Translation: ADP91200.1
HQ205569 Genomic DNA Translation: ADP91203.1
HQ205570 Genomic DNA Translation: ADP91206.1
HQ205571 Genomic DNA Translation: ADP91209.1
HQ205572 Genomic DNA Translation: ADP91212.1
HQ205573 Genomic DNA Translation: ADP91215.1
HQ205574 Genomic DNA Translation: ADP91218.1
HQ205575 Genomic DNA Translation: ADP91221.1
HQ205576 Genomic DNA Translation: ADP91224.1
HQ205577 Genomic DNA Translation: ADP91227.1
HQ205578 Genomic DNA Translation: ADP91230.1
HQ205579 Genomic DNA Translation: ADP91233.1
HQ205580 Genomic DNA Translation: ADP91236.1
HQ205581 Genomic DNA Translation: ADP91239.1
HQ205582 Genomic DNA Translation: ADP91242.1
HQ205583 Genomic DNA Translation: ADP91245.1
HQ205584 Genomic DNA Translation: ADP91248.1
HQ205585 Genomic DNA Translation: ADP91251.1
CH471062 Genomic DNA Translation: EAW61871.1
RefSeqiNP_001018661.1, NM_001020825.1
UniGeneiHs.122926

Genome annotation databases

GeneIDi2908

Similar proteinsi

Entry informationi

Entry nameiE5KQF5_HUMAN
AccessioniPrimary (citable) accession number: E5KQF5
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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