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Protein

NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

Gene

NDUFV1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain.UniRule annotation

Catalytic activityi

NADH + acceptor = NAD+ + reduced acceptor.UniRule annotation
NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • FMNUniRule annotation
  • [4Fe-4S] clusterUniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transport, Respiratory chainUniRule annotation, Transport
Ligand4Fe-4SUniRule annotation, Flavoprotein, FMNUniRule annotation, Iron, Iron-sulfur, Metal-binding, NADUniRule annotation, UbiquinoneImported

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialUniRule annotation (EC:1.6.5.3UniRule annotation, EC:1.6.99.3UniRule annotation)
Gene namesi
Name:NDUFV1Imported
ORF Names:hCG_21057Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000167792.11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Expressioni

Gene expression databases

BgeeiENSG00000167792.

Structurei

3D structure databases

SMRiE5KNH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini364 – 409NADH_4Fe-4SInterPro annotationAdd BLAST46

Sequence similaritiesi

Belongs to the complex I 51 kDa subunit family.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiKOG2658. Eukaryota.
COG1894. LUCA.
KOiK03942.
OMAiSGMKWSF.
OrthoDBiEOG091G05AF.

Family and domain databases

InterProiView protein in InterPro
IPR001949. NADH-UbQ_OxRdtase_51kDa_CS.
IPR011537. NADH-UbQ_OxRdtase_suF.
IPR011538. Nuo51_FMN-bd.
IPR037225. Nuo51_FMN-bd_sf.
IPR019575. Nuop51_4Fe4S-bd.
IPR037207. Nuop51_4Fe4S-bd_sf.
IPR019554. Soluble_ligand-bd.
PfamiView protein in Pfam
PF01512. Complex1_51K. 1 hit.
PF10589. NADH_4Fe-4S. 1 hit.
PF10531. SLBB. 1 hit.
SMARTiView protein in SMART
SM00928. NADH_4Fe-4S. 1 hit.
SUPFAMiSSF140490. SSF140490. 1 hit.
SSF142019. SSF142019. 1 hit.
TIGRFAMsiTIGR01959. nuoF_fam. 1 hit.
PROSITEiView protein in PROSITE
PS00644. COMPLEX1_51K_1. 1 hit.
PS00645. COMPLEX1_51K_2. 1 hit.

Sequencei

Sequence statusi: Complete.

E5KNH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLATRRLLGW SLPARVSVRF SGDTTAPKKT SFGSLKDEDR IFTNLYGRHD
60 70 80 90 100
WRLKGSLSRG DWYKTKEILL KGPDWILGEI KTSGLRGRGG AGFPTGLKWS
110 120 130 140 150
FMNKPSDGRP KYLVVNADEG EPGTCKDREI LRHDPHKLLE GCLVGGRAMG
160 170 180 190 200
ARAAYIYIRG EFYNEASNLQ VAIREAYEAG LIGKNACGSG YDFDVFVVRG
210 220 230 240 250
AGAYICGEET ALIESIEGKQ GKPRLKPPFP ADVGVFGCPT TVANVETVAV
260 270 280 290 300
SPTICRRGGT WFAGFGRERN SGTKLFNISG HVNHPCTVEE EMSVPLKELI
310 320 330 340 350
EKHAGGVTGG WDNLLAVIPG GSSTPLIPKS VCETVLMDFD ALVQAQTGLG
360 370 380 390 400
TAAVIVMDRS TDIVKAIARL IEFYKHESCG QCTPCREGVD WMNKVMARFV
410 420 430 440 450
RGDARPAEID SLWEISKQIE GHTICALGDG AAWPVQGLIR HFRPELEERM
460
QRFAQQHQAR QAAS
Length:464
Mass (Da):50,817
Last modified:February 8, 2011 - v1
Checksum:i8C261EA3B0267256
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ205266 Genomic DNA. Translation: ADP90734.1.
HQ205267 Genomic DNA. Translation: ADP90735.1.
HQ205268 Genomic DNA. Translation: ADP90736.1.
HQ205269 Genomic DNA. Translation: ADP90737.1.
HQ205270 Genomic DNA. Translation: ADP90738.1.
HQ205271 Genomic DNA. Translation: ADP90739.1.
HQ205272 Genomic DNA. Translation: ADP90740.1.
HQ205273 Genomic DNA. Translation: ADP90741.1.
HQ205274 Genomic DNA. Translation: ADP90742.1.
HQ205275 Genomic DNA. Translation: ADP90743.1.
HQ205276 Genomic DNA. Translation: ADP90744.1.
HQ205277 Genomic DNA. Translation: ADP90745.1.
HQ205278 Genomic DNA. Translation: ADP90746.1.
HQ205279 Genomic DNA. Translation: ADP90747.1.
HQ205280 Genomic DNA. Translation: ADP90748.1.
HQ205281 Genomic DNA. Translation: ADP90749.1.
HQ205282 Genomic DNA. Translation: ADP90750.1.
HQ205283 Genomic DNA. Translation: ADP90751.1.
HQ205284 Genomic DNA. Translation: ADP90752.1.
HQ205285 Genomic DNA. Translation: ADP90753.1.
HQ205286 Genomic DNA. Translation: ADP90754.1.
HQ205287 Genomic DNA. Translation: ADP90755.1.
HQ205288 Genomic DNA. Translation: ADP90756.1.
HQ205289 Genomic DNA. Translation: ADP90757.1.
HQ205290 Genomic DNA. Translation: ADP90758.1.
HQ205291 Genomic DNA. Translation: ADP90759.1.
HQ205292 Genomic DNA. Translation: ADP90760.1.
HQ205293 Genomic DNA. Translation: ADP90761.1.
HQ205294 Genomic DNA. Translation: ADP90762.1.
HQ205295 Genomic DNA. Translation: ADP90763.1.
HQ205296 Genomic DNA. Translation: ADP90764.1.
HQ205297 Genomic DNA. Translation: ADP90765.1.
HQ205298 Genomic DNA. Translation: ADP90766.1.
HQ205299 Genomic DNA. Translation: ADP90767.1.
HQ205300 Genomic DNA. Translation: ADP90768.1.
HQ205301 Genomic DNA. Translation: ADP90769.1.
HQ205302 Genomic DNA. Translation: ADP90770.1.
HQ205303 Genomic DNA. Translation: ADP90771.1.
HQ205304 Genomic DNA. Translation: ADP90772.1.
HQ205305 Genomic DNA. Translation: ADP90773.1.
CH471076 Genomic DNA. Translation: EAW74656.1.
RefSeqiNP_009034.2. NM_007103.3.
UniGeneiHs.7744.

Genome annotation databases

GeneIDi4723.
KEGGihsa:4723.

Similar proteinsi

Entry informationi

Entry nameiE5KNH5_HUMAN
AccessioniPrimary (citable) accession number: E5KNH5
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: November 22, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.