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Protein

Elongation factor G, mitochondrial

Gene

GFM1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.UniRule annotation

Pathwayi: polypeptide chain elongation

This protein is involved in the pathway polypeptide chain elongation, which is part of Protein biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway polypeptide chain elongation and in Protein biosynthesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi53 – 608GTPUniRule annotation
Nucleotide bindingi120 – 1245GTPUniRule annotation
Nucleotide bindingi174 – 1774GTPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Elongation factorUniRule annotationImported

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00345.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor G, mitochondrialUniRule annotation
Short name:
EF-GmtUniRule annotation
Alternative name(s):
Elongation factor G 1, mitochondrialUniRule annotation
Elongation factor G1UniRule annotation
Gene namesi
Name:GFM1UniRule annotationImported
Synonyms:EFG1UniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Mitochondrion UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MitochondrionUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000419038.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 321278Tr-type G (guanine nucleotide-binding)InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiKOG0465. Eukaryota.
COG0480. LUCA.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00054_B. EF_G_EF_2_B.
InterProiIPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004540. Transl_elong_EFG/EF2.
IPR005517. Transl_elong_EFG/EF2_IV.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PfamiPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SMARTiSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00484. EF-G. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E5KND5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLGAAAVA ALGRGRAPAS LGWQRKQVNW KACRWSSSGV IPNEKIRNIG
60 70 80 90 100
ISAHIDSGKT TLTERVLYYT GRIAKMHEVK GKDGVGAVMD SMELERQRGI
110 120 130 140 150
TIQSAATYTM WKDVNINIID TPGHVDFTIE VERALRVLDG AVLVLCAVGG
160 170 180 190 200
VQCQTMTVNR QMKRYNVPFL TFINKLDRMG SNPARALQQM RSKLNHNAAF
210 220 230 240 250
MQIPMGLEGN FKGIVDLIEE RAIYFDGDFG QIVRYGEIPA ELRAAATDHR
260 270 280 290 300
QELIECVANS DEQLGEMFLE EKIPSISDLK LAIRRATLKR SFTPVFLGSA
310 320 330 340 350
LKNKGVQPLL DAVLEYLPNP SEVQNYAILN KEDDSKEKTK ILMNSSRDNS
360 370 380 390 400
HPFVGLAFKL EVGRFGQLTY VRSYQGELKK GDTIYNTRTR KKVRLQRLAR
410 420 430 440 450
MHADMMEDVE EVYAGDICAL FGIDCASGDT FTDKANSGLS MESIHVPDPV
460 470 480 490 500
ISIAMKPSNK NDLEKFSKGI GRFTREDPTF KVYFDTENKE TVISGMGELH
510 520 530 540 550
LEIYAQRLER EYGCPCITGK PKVAFRETIT APVPFDFTHK KQSGGAGQYG
560 570 580 590 600
KVIGVLEPLD PEDYTKLEFS DETFGSNIPK QFVPAVEKGF LDACEKGPLS
610 620 630 640 650
GHKLSGLRFV LQDGAHHMVD SNEISFIRAG EGALKQALAN ATLCILEPIM
660 670 680 690 700
AVEVVAPNEF QGQVIAGINR RHGVITGQDG VEDYFTLYAD VPLNDMFGYS
710 720 730 740 750
TELRSCTEGK GEYTMEYSRY QPCLPSTQED VINKYLEATG QLPVKKGKAK

N
Length:751
Mass (Da):83,471
Last modified:February 8, 2011 - v1
Checksum:i5937FFB24A089E2E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei751 – 7511Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ205226 Genomic DNA. Translation: ADP90694.1.
HQ205227 Genomic DNA. Translation: ADP90695.1.
HQ205229 Genomic DNA. Translation: ADP90697.1.
HQ205230 Genomic DNA. Translation: ADP90698.1.
HQ205231 Genomic DNA. Translation: ADP90699.1.
HQ205234 Genomic DNA. Translation: ADP90702.1.
HQ205237 Genomic DNA. Translation: ADP90705.1.
HQ205238 Genomic DNA. Translation: ADP90706.1.
HQ205240 Genomic DNA. Translation: ADP90708.1.
HQ205241 Genomic DNA. Translation: ADP90709.1.
HQ205243 Genomic DNA. Translation: ADP90711.1.
HQ205244 Genomic DNA. Translation: ADP90712.1.
HQ205245 Genomic DNA. Translation: ADP90713.1.
HQ205247 Genomic DNA. Translation: ADP90715.1.
HQ205248 Genomic DNA. Translation: ADP90716.1.
HQ205249 Genomic DNA. Translation: ADP90717.1.
HQ205251 Genomic DNA. Translation: ADP90719.1.
HQ205252 Genomic DNA. Translation: ADP90720.1.
HQ205255 Genomic DNA. Translation: ADP90723.1.
HQ205258 Genomic DNA. Translation: ADP90726.1.
HQ205261 Genomic DNA. Translation: ADP90729.1.
HQ205262 Genomic DNA. Translation: ADP90730.1.
HQ205263 Genomic DNA. Translation: ADP90731.1.
HQ205264 Genomic DNA. Translation: ADP90732.1.
HQ205265 Genomic DNA. Translation: ADP90733.1.
KU178816 mRNA. Translation: ALQ34274.1.
RefSeqiNP_079272.4. NM_024996.5.
UniGeneiHs.518355.

Genome annotation databases

GeneIDi85476.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ205226 Genomic DNA. Translation: ADP90694.1.
HQ205227 Genomic DNA. Translation: ADP90695.1.
HQ205229 Genomic DNA. Translation: ADP90697.1.
HQ205230 Genomic DNA. Translation: ADP90698.1.
HQ205231 Genomic DNA. Translation: ADP90699.1.
HQ205234 Genomic DNA. Translation: ADP90702.1.
HQ205237 Genomic DNA. Translation: ADP90705.1.
HQ205238 Genomic DNA. Translation: ADP90706.1.
HQ205240 Genomic DNA. Translation: ADP90708.1.
HQ205241 Genomic DNA. Translation: ADP90709.1.
HQ205243 Genomic DNA. Translation: ADP90711.1.
HQ205244 Genomic DNA. Translation: ADP90712.1.
HQ205245 Genomic DNA. Translation: ADP90713.1.
HQ205247 Genomic DNA. Translation: ADP90715.1.
HQ205248 Genomic DNA. Translation: ADP90716.1.
HQ205249 Genomic DNA. Translation: ADP90717.1.
HQ205251 Genomic DNA. Translation: ADP90719.1.
HQ205252 Genomic DNA. Translation: ADP90720.1.
HQ205255 Genomic DNA. Translation: ADP90723.1.
HQ205258 Genomic DNA. Translation: ADP90726.1.
HQ205261 Genomic DNA. Translation: ADP90729.1.
HQ205262 Genomic DNA. Translation: ADP90730.1.
HQ205263 Genomic DNA. Translation: ADP90731.1.
HQ205264 Genomic DNA. Translation: ADP90732.1.
HQ205265 Genomic DNA. Translation: ADP90733.1.
KU178816 mRNA. Translation: ALQ34274.1.
RefSeqiNP_079272.4. NM_024996.5.
UniGeneiHs.518355.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000419038.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi85476.

Organism-specific databases

CTDi85476.

Phylogenomic databases

eggNOGiKOG0465. Eukaryota.
COG0480. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00345.

Miscellaneous databases

ChiTaRSiGFM1. human.
GenomeRNAii85476.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00054_B. EF_G_EF_2_B.
InterProiIPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004540. Transl_elong_EFG/EF2.
IPR005517. Transl_elong_EFG/EF2_IV.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PfamiPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SMARTiSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00484. EF-G. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing."
    Wang W., Shen P., Thiyagarajan S., Lin S., Palm C., Horvath R., Klopstock T., Cutler D., Pique L., Schrijver I., Davis R.W., Mindrinos M., Speed T.P., Scharfe C.
    Nucleic Acids Res. 39:44-58(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiE5KND5_HUMAN
AccessioniPrimary (citable) accession number: E5KND5
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: June 8, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.