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Protein
Submitted name:

Peptidyl-prolyl cis-trans isomerase D

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, RotamasePROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Peptidyl-prolyl cis-trans isomerase DImported
Submitted name:
Testicular tissue protein Li 147Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000171497.4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiE5KN55

Expressioni

Gene expression databases

BgeeiENSG00000171497
ExpressionAtlasiE5KN55 baseline and differential

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIM27P143733EBI-10176944,EBI-719493

Protein-protein interaction databases

IntActiE5KN55, 1 interactor

Structurei

3D structure databases

SMRiE5KN55
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 183PPIase cyclophilin-typeInterPro annotationAdd BLAST165
Domaini223 – 256TPR_REGIONInterPro annotationAdd BLAST34
Repeati223 – 256TPRPROSITE-ProRule annotationAdd BLAST34
Domaini273 – 340TPR_REGIONInterPro annotationAdd BLAST68
Repeati273 – 306TPRPROSITE-ProRule annotationAdd BLAST34
Repeati307 – 340TPRPROSITE-ProRule annotationAdd BLAST34

Keywords - Domaini

TPR repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0546 Eukaryota
COG0652 LUCA
KOiK05864
OMAiAMCAIKL
OrthoDBiEOG091G0BGL

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PF13176 TPR_7, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
SSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

E5KN55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHPSPQAKP SNPSNPRVFF DVDIGGERVG RIVLELFADI VPKTAENFRA
60 70 80 90 100
LCTGEKGIGH TTGKPLHFKG CPFHRIIKKF MIQGGDFSNQ NGTGGESIYG
110 120 130 140 150
EKFEDENFHY KHDREGLLSM ANAGRNTNGS QFFITTVPTP HLDGKHVVFG
160 170 180 190 200
QVIKGIGVAR ILENVEVKGE KPAKLCVIAE CGELKEGDDG GIFPKDGSGD
210 220 230 240 250
SHPDFPEDAD IDLKDVDKIL LITEDLKNIG NTFFKSQNWE MAIKKYAEVL
260 270 280 290 300
RYVDSSKAVI ETADRAKLQP IALSCVLNIG ACKLKMSNWQ GAIDSCLEAL
310 320 330 340 350
ELDPSNTKAL YRRAQGWQGL KEYDQALADL KKAQGIAPED KAIQAELLKV
360 370
KQKIKAQKDK EKAVYAKMFA
Length:370
Mass (Da):40,764
Last modified:February 8, 2011 - v1
Checksum:i39D4100748B35D48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ205146 Genomic DNA Translation: ADP90614.1
HQ205147 Genomic DNA Translation: ADP90615.1
HQ205148 Genomic DNA Translation: ADP90616.1
HQ205149 Genomic DNA Translation: ADP90617.1
HQ205151 Genomic DNA Translation: ADP90619.1
HQ205152 Genomic DNA Translation: ADP90620.1
HQ205153 Genomic DNA Translation: ADP90621.1
HQ205154 Genomic DNA Translation: ADP90622.1
HQ205155 Genomic DNA Translation: ADP90623.1
HQ205156 Genomic DNA Translation: ADP90624.1
HQ205157 Genomic DNA Translation: ADP90625.1
HQ205158 Genomic DNA Translation: ADP90626.1
HQ205159 Genomic DNA Translation: ADP90627.1
HQ205160 Genomic DNA Translation: ADP90628.1
HQ205161 Genomic DNA Translation: ADP90629.1
HQ205162 Genomic DNA Translation: ADP90630.1
HQ205163 Genomic DNA Translation: ADP90631.1
HQ205165 Genomic DNA Translation: ADP90633.1
HQ205166 Genomic DNA Translation: ADP90634.1
HQ205168 Genomic DNA Translation: ADP90636.1
HQ205169 Genomic DNA Translation: ADP90637.1
HQ205170 Genomic DNA Translation: ADP90638.1
HQ205171 Genomic DNA Translation: ADP90639.1
HQ205172 Genomic DNA Translation: ADP90640.1
HQ205173 Genomic DNA Translation: ADP90641.1
HQ205174 Genomic DNA Translation: ADP90642.1
HQ205175 Genomic DNA Translation: ADP90643.1
HQ205176 Genomic DNA Translation: ADP90644.1
HQ205177 Genomic DNA Translation: ADP90645.1
HQ205178 Genomic DNA Translation: ADP90646.1
HQ205179 Genomic DNA Translation: ADP90647.1
HQ205180 Genomic DNA Translation: ADP90648.1
HQ205181 Genomic DNA Translation: ADP90649.1
HQ205182 Genomic DNA Translation: ADP90650.1
HQ205183 Genomic DNA Translation: ADP90651.1
HQ205184 Genomic DNA Translation: ADP90652.1
HQ205185 Genomic DNA Translation: ADP90653.1
HM005460 mRNA Translation: AEE61058.1
RefSeqiNP_005029.1, NM_005038.2
UniGeneiHs.183958

Genome annotation databases

GeneIDi5481
KEGGihsa:5481

Similar proteinsi

Entry informationi

Entry nameiE5KN55_HUMAN
AccessioniPrimary (citable) accession number: E5KN55
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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