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Protein
Submitted name:

Peptidyl-prolyl cis-trans isomerase D

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, RotamaseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Peptidyl-prolyl cis-trans isomerase DImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303754.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 183165PPIase cyclophilin-typeInterPro annotationAdd
BLAST
Domaini223 – 25634TPR_REGIONInterPro annotationAdd
BLAST
Domaini273 – 34068TPR_REGIONInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PPIase cyclophilin-type domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG0546. Eukaryota.
COG0652. LUCA.
KOiK05864.
OMAiKGIGHTT.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
PF13176. TPR_7. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E5KN55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHPSPQAKP SNPSNPRVFF DVDIGGERVG RIVLELFADI VPKTAENFRA
60 70 80 90 100
LCTGEKGIGH TTGKPLHFKG CPFHRIIKKF MIQGGDFSNQ NGTGGESIYG
110 120 130 140 150
EKFEDENFHY KHDREGLLSM ANAGRNTNGS QFFITTVPTP HLDGKHVVFG
160 170 180 190 200
QVIKGIGVAR ILENVEVKGE KPAKLCVIAE CGELKEGDDG GIFPKDGSGD
210 220 230 240 250
SHPDFPEDAD IDLKDVDKIL LITEDLKNIG NTFFKSQNWE MAIKKYAEVL
260 270 280 290 300
RYVDSSKAVI ETADRAKLQP IALSCVLNIG ACKLKMSNWQ GAIDSCLEAL
310 320 330 340 350
ELDPSNTKAL YRRAQGWQGL KEYDQALADL KKAQGIAPED KAIQAELLKV
360 370
KQKIKAQKDK EKAVYAKMFA
Length:370
Mass (Da):40,764
Last modified:February 8, 2011 - v1
Checksum:i39D4100748B35D48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ205146 Genomic DNA. Translation: ADP90614.1.
HQ205147 Genomic DNA. Translation: ADP90615.1.
HQ205148 Genomic DNA. Translation: ADP90616.1.
HQ205149 Genomic DNA. Translation: ADP90617.1.
HQ205151 Genomic DNA. Translation: ADP90619.1.
HQ205152 Genomic DNA. Translation: ADP90620.1.
HQ205153 Genomic DNA. Translation: ADP90621.1.
HQ205154 Genomic DNA. Translation: ADP90622.1.
HQ205155 Genomic DNA. Translation: ADP90623.1.
HQ205156 Genomic DNA. Translation: ADP90624.1.
HQ205157 Genomic DNA. Translation: ADP90625.1.
HQ205158 Genomic DNA. Translation: ADP90626.1.
HQ205159 Genomic DNA. Translation: ADP90627.1.
HQ205160 Genomic DNA. Translation: ADP90628.1.
HQ205161 Genomic DNA. Translation: ADP90629.1.
HQ205162 Genomic DNA. Translation: ADP90630.1.
HQ205163 Genomic DNA. Translation: ADP90631.1.
HQ205165 Genomic DNA. Translation: ADP90633.1.
HQ205166 Genomic DNA. Translation: ADP90634.1.
HQ205168 Genomic DNA. Translation: ADP90636.1.
HQ205169 Genomic DNA. Translation: ADP90637.1.
HQ205170 Genomic DNA. Translation: ADP90638.1.
HQ205171 Genomic DNA. Translation: ADP90639.1.
HQ205172 Genomic DNA. Translation: ADP90640.1.
HQ205173 Genomic DNA. Translation: ADP90641.1.
HQ205174 Genomic DNA. Translation: ADP90642.1.
HQ205175 Genomic DNA. Translation: ADP90643.1.
HQ205176 Genomic DNA. Translation: ADP90644.1.
HQ205177 Genomic DNA. Translation: ADP90645.1.
HQ205178 Genomic DNA. Translation: ADP90646.1.
HQ205179 Genomic DNA. Translation: ADP90647.1.
HQ205180 Genomic DNA. Translation: ADP90648.1.
HQ205181 Genomic DNA. Translation: ADP90649.1.
HQ205182 Genomic DNA. Translation: ADP90650.1.
HQ205183 Genomic DNA. Translation: ADP90651.1.
HQ205184 Genomic DNA. Translation: ADP90652.1.
HQ205185 Genomic DNA. Translation: ADP90653.1.
RefSeqiNP_005029.1. NM_005038.2.
UniGeneiHs.183958.

Genome annotation databases

GeneIDi5481.
KEGGihsa:5481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ205146 Genomic DNA. Translation: ADP90614.1.
HQ205147 Genomic DNA. Translation: ADP90615.1.
HQ205148 Genomic DNA. Translation: ADP90616.1.
HQ205149 Genomic DNA. Translation: ADP90617.1.
HQ205151 Genomic DNA. Translation: ADP90619.1.
HQ205152 Genomic DNA. Translation: ADP90620.1.
HQ205153 Genomic DNA. Translation: ADP90621.1.
HQ205154 Genomic DNA. Translation: ADP90622.1.
HQ205155 Genomic DNA. Translation: ADP90623.1.
HQ205156 Genomic DNA. Translation: ADP90624.1.
HQ205157 Genomic DNA. Translation: ADP90625.1.
HQ205158 Genomic DNA. Translation: ADP90626.1.
HQ205159 Genomic DNA. Translation: ADP90627.1.
HQ205160 Genomic DNA. Translation: ADP90628.1.
HQ205161 Genomic DNA. Translation: ADP90629.1.
HQ205162 Genomic DNA. Translation: ADP90630.1.
HQ205163 Genomic DNA. Translation: ADP90631.1.
HQ205165 Genomic DNA. Translation: ADP90633.1.
HQ205166 Genomic DNA. Translation: ADP90634.1.
HQ205168 Genomic DNA. Translation: ADP90636.1.
HQ205169 Genomic DNA. Translation: ADP90637.1.
HQ205170 Genomic DNA. Translation: ADP90638.1.
HQ205171 Genomic DNA. Translation: ADP90639.1.
HQ205172 Genomic DNA. Translation: ADP90640.1.
HQ205173 Genomic DNA. Translation: ADP90641.1.
HQ205174 Genomic DNA. Translation: ADP90642.1.
HQ205175 Genomic DNA. Translation: ADP90643.1.
HQ205176 Genomic DNA. Translation: ADP90644.1.
HQ205177 Genomic DNA. Translation: ADP90645.1.
HQ205178 Genomic DNA. Translation: ADP90646.1.
HQ205179 Genomic DNA. Translation: ADP90647.1.
HQ205180 Genomic DNA. Translation: ADP90648.1.
HQ205181 Genomic DNA. Translation: ADP90649.1.
HQ205182 Genomic DNA. Translation: ADP90650.1.
HQ205183 Genomic DNA. Translation: ADP90651.1.
HQ205184 Genomic DNA. Translation: ADP90652.1.
HQ205185 Genomic DNA. Translation: ADP90653.1.
RefSeqiNP_005029.1. NM_005038.2.
UniGeneiHs.183958.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000303754.

Protocols and materials databases

DNASUi5481.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5481.
KEGGihsa:5481.

Organism-specific databases

CTDi5481.

Phylogenomic databases

eggNOGiKOG0546. Eukaryota.
COG0652. LUCA.
KOiK05864.
OMAiKGIGHTT.

Miscellaneous databases

GenomeRNAii5481.
NextBioi21218.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
PF13176. TPR_7. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing."
    Wang W., Shen P., Thiyagarajan S., Lin S., Palm C., Horvath R., Klopstock T., Cutler D., Pique L., Schrijver I., Davis R.W., Mindrinos M., Speed T.P., Scharfe C.
    Nucleic Acids Res. 39:44-58(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiE5KN55_HUMAN
AccessioniPrimary (citable) accession number: E5KN55
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: May 11, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.