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Protein
Submitted name:

Dynamin-like 120 kDa protein, mitochondrial

Gene

OPA1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Dynamin-like 120 kDa protein, mitochondrialImported
Submitted name:
Mitochondrial dynamin-like 120 kDa proteinImported
Submitted name:
Optic atrophy 1 (Autosomal dominant), isoform CRA_fImported
Gene namesi
Name:OPA1Imported
ORF Names:hCG_17270Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:8140. OPA1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiE5KLK1.

Expressioni

Gene expression databases

ExpressionAtlasiE5KLK1. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000354681.

Structurei

3D structure databases

SMRiE5KLK1. Positions 263-602.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini286 – 562277Dynamin-type G (guanine nucleotide-binding)InterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili171 – 19828Sequence analysisAdd
BLAST
Coiled coili216 – 25439Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.SAAS annotation
Contains dynamin-type G (guanine nucleotide-binding) domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0447. Eukaryota.
COG0699. LUCA.
GeneTreeiENSGT00550000074851.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001401. Dynamin_GTPase.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR033047. Opa1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF67. PTHR11566:SF67. 1 hit.
PfamiPF00350. Dynamin_N. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51718. G_DYNAMIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E5KLK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRLRRAAVA CEVCQSLVKH SSGIKGSLPL QKLHLVSRSI YHSHHPTLKL
60 70 80 90 100
QRPQLRTSFQ QFSSLTNLPL RKLKFSPIKY GYQPRRNFWP ARLATRLLKL
110 120 130 140 150
RYLILGSAVG GGYTAKKTFD QWKDMIPDLS EYKWIVPDIV WEIDEYIDFG
160 170 180 190 200
SPEETAFRAT DRGSESDKHF RKGLLGELIL LQQQIQEHEE EARRAAGQYS
210 220 230 240 250
TSYAQQKRKV SDKEKIDQLQ EELLHTQLKY QRILERLEKE NKELRKLVLQ
260 270 280 290 300
KDDKGIHHRK LKKSLIDMYS EVLDVLSDYD ASYNTQDHLP RVVVVGDQSA
310 320 330 340 350
GKTSVLEMIA QARIFPRGSG EMMTRSPVKV TLSEGPHHVA LFKDSSREFD
360 370 380 390 400
LTKEEDLAAL RHEIELRMRK NVKEGCTVSP ETISLNVKGP GLQRMVLVDL
410 420 430 440 450
PGVINTVTSG MAPDTKETIF SISKAYMQNP NAIILCIQDG SVDAERSIVT
460 470 480 490 500
DLVSQMDPHG RRTIFVLTKV DLAEKNVASP SRIQQIIEGK LFPMKALGYF
510 520 530 540 550
AVVTGKGNSS ESIEAIREYE EEFFQNSKLL KTSMLKAHQV TTRNLSLAVS
560 570 580 590 600
DCFWKMVRES VEQQADSFKA TRFNLETEWK NNYPRLRELD RNELFEKAKN
610 620 630 640 650
EILDEVISLS QVTPKHWEEI LQQSLWERVS THVIENIYLP AAQTMNSGTF
660 670 680 690 700
NTTVDIKLKQ WTDKQLPNKA VEVAWETLQE EFSRFMTEPK GKEHDDIFDK
710 720 730 740 750
LKEAVKEESI KRHKWNDFAE DSLRVIQHNA LEDRSISDKQ QWDAAIYFME
760 770 780 790 800
EALQARLKDT ENAIENMVGP DWKKRWLYWK NRTQEQCVHN ETKNELEKML
810 820 830 840 850
KCNEEHPAYL ASDEITTVRK NLESRGVEVD PSLIKDTWHQ VYRRHFLKTA
860 870 880 890 900
LNHCNLCRRG FYYYQRHFVD SELECNDVVL FWRIQRMLAI TANTLRQQLT
910 920 930 940 950
NTEVRRLEKN VKEVLEDFAE DGEKKIKLLT GKRVQLAEDL KKVREIQEKL
960
DAFIEALHQE K
Length:961
Mass (Da):111,822
Last modified:February 8, 2011 - v1
Checksum:i480D9745E391A211
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC048351 Genomic DNA. No translation available.
AC106710 Genomic DNA. No translation available.
HQ204906 Genomic DNA. Translation: ADP90060.1.
HQ204907 Genomic DNA. Translation: ADP90068.1.
HQ204908 Genomic DNA. Translation: ADP90076.1.
HQ204909 Genomic DNA. Translation: ADP90084.1.
HQ204910 Genomic DNA. Translation: ADP90092.1.
HQ204911 Genomic DNA. Translation: ADP90100.1.
HQ204912 Genomic DNA. Translation: ADP90108.1.
HQ204913 Genomic DNA. Translation: ADP90116.1.
HQ204914 Genomic DNA. Translation: ADP90124.1.
HQ204915 Genomic DNA. Translation: ADP90132.1.
HQ204916 Genomic DNA. Translation: ADP90140.1.
HQ204917 Genomic DNA. Translation: ADP90148.1.
HQ204918 Genomic DNA. Translation: ADP90156.1.
HQ204919 Genomic DNA. Translation: ADP90164.1.
HQ204920 Genomic DNA. Translation: ADP90172.1.
HQ204921 Genomic DNA. Translation: ADP90180.1.
HQ204922 Genomic DNA. Translation: ADP90188.1.
HQ204923 Genomic DNA. Translation: ADP90196.1.
HQ204924 Genomic DNA. Translation: ADP90204.1.
HQ204925 Genomic DNA. Translation: ADP90212.1.
HQ204926 Genomic DNA. Translation: ADP90220.1.
HQ204927 Genomic DNA. Translation: ADP90228.1.
HQ204928 Genomic DNA. Translation: ADP90236.1.
HQ204929 Genomic DNA. Translation: ADP90244.1.
HQ204930 Genomic DNA. Translation: ADP90252.1.
HQ204931 Genomic DNA. Translation: ADP90260.1.
HQ204932 Genomic DNA. Translation: ADP90268.1.
HQ204933 Genomic DNA. Translation: ADP90276.1.
HQ204934 Genomic DNA. Translation: ADP90284.1.
HQ204935 Genomic DNA. Translation: ADP90292.1.
HQ204936 Genomic DNA. Translation: ADP90300.1.
HQ204937 Genomic DNA. Translation: ADP90308.1.
HQ204938 Genomic DNA. Translation: ADP90316.1.
HQ204939 Genomic DNA. Translation: ADP90324.1.
HQ204940 Genomic DNA. Translation: ADP90332.1.
HQ204941 Genomic DNA. Translation: ADP90340.1.
HQ204942 Genomic DNA. Translation: ADP90348.1.
HQ204943 Genomic DNA. Translation: ADP90356.1.
HQ204944 Genomic DNA. Translation: ADP90364.1.
HQ204945 Genomic DNA. Translation: ADP90372.1.
CH471052 Genomic DNA. Translation: EAW78069.1.
RefSeqiNP_570846.1. NM_130833.2.
UniGeneiHs.594504.

Genome annotation databases

EnsembliENST00000361150; ENSP00000354781; ENSG00000198836.
GeneIDi4976.
UCSCiuc003ftk.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC048351 Genomic DNA. No translation available.
AC106710 Genomic DNA. No translation available.
HQ204906 Genomic DNA. Translation: ADP90060.1.
HQ204907 Genomic DNA. Translation: ADP90068.1.
HQ204908 Genomic DNA. Translation: ADP90076.1.
HQ204909 Genomic DNA. Translation: ADP90084.1.
HQ204910 Genomic DNA. Translation: ADP90092.1.
HQ204911 Genomic DNA. Translation: ADP90100.1.
HQ204912 Genomic DNA. Translation: ADP90108.1.
HQ204913 Genomic DNA. Translation: ADP90116.1.
HQ204914 Genomic DNA. Translation: ADP90124.1.
HQ204915 Genomic DNA. Translation: ADP90132.1.
HQ204916 Genomic DNA. Translation: ADP90140.1.
HQ204917 Genomic DNA. Translation: ADP90148.1.
HQ204918 Genomic DNA. Translation: ADP90156.1.
HQ204919 Genomic DNA. Translation: ADP90164.1.
HQ204920 Genomic DNA. Translation: ADP90172.1.
HQ204921 Genomic DNA. Translation: ADP90180.1.
HQ204922 Genomic DNA. Translation: ADP90188.1.
HQ204923 Genomic DNA. Translation: ADP90196.1.
HQ204924 Genomic DNA. Translation: ADP90204.1.
HQ204925 Genomic DNA. Translation: ADP90212.1.
HQ204926 Genomic DNA. Translation: ADP90220.1.
HQ204927 Genomic DNA. Translation: ADP90228.1.
HQ204928 Genomic DNA. Translation: ADP90236.1.
HQ204929 Genomic DNA. Translation: ADP90244.1.
HQ204930 Genomic DNA. Translation: ADP90252.1.
HQ204931 Genomic DNA. Translation: ADP90260.1.
HQ204932 Genomic DNA. Translation: ADP90268.1.
HQ204933 Genomic DNA. Translation: ADP90276.1.
HQ204934 Genomic DNA. Translation: ADP90284.1.
HQ204935 Genomic DNA. Translation: ADP90292.1.
HQ204936 Genomic DNA. Translation: ADP90300.1.
HQ204937 Genomic DNA. Translation: ADP90308.1.
HQ204938 Genomic DNA. Translation: ADP90316.1.
HQ204939 Genomic DNA. Translation: ADP90324.1.
HQ204940 Genomic DNA. Translation: ADP90332.1.
HQ204941 Genomic DNA. Translation: ADP90340.1.
HQ204942 Genomic DNA. Translation: ADP90348.1.
HQ204943 Genomic DNA. Translation: ADP90356.1.
HQ204944 Genomic DNA. Translation: ADP90364.1.
HQ204945 Genomic DNA. Translation: ADP90372.1.
CH471052 Genomic DNA. Translation: EAW78069.1.
RefSeqiNP_570846.1. NM_130833.2.
UniGeneiHs.594504.

3D structure databases

SMRiE5KLK1. Positions 263-602.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000354681.

Proteomic databases

EPDiE5KLK1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361150; ENSP00000354781; ENSG00000198836.
GeneIDi4976.
UCSCiuc003ftk.4. human.

Organism-specific databases

CTDi4976.
HGNCiHGNC:8140. OPA1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0447. Eukaryota.
COG0699. LUCA.
GeneTreeiENSGT00550000074851.

Miscellaneous databases

ChiTaRSiOPA1. human.
GenomeRNAii4976.
NextBioi19154.

Gene expression databases

ExpressionAtlasiE5KLK1. baseline and differential.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001401. Dynamin_GTPase.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR033047. Opa1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF67. PTHR11566:SF67. 1 hit.
PfamiPF00350. Dynamin_N. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51718. G_DYNAMIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing."
    Wang W., Shen P., Thiyagarajan S., Lin S., Palm C., Horvath R., Klopstock T., Cutler D., Pique L., Schrijver I., Davis R.W., Mindrinos M., Speed T.P., Scharfe C.
    Nucleic Acids Res. 39:44-58(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  7. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "N-terminome analysis of the human mitochondrial proteome."
    Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.
    Proteomics 15:2519-2524(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiE5KLK1_HUMAN
AccessioniPrimary (citable) accession number: E5KLK1
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: May 11, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.