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Protein
Submitted name:

Mitochondrial dynamin-like 120 kDa protein

Gene

OPA1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Mitochondrial dynamin-like 120 kDa proteinImported
Submitted name:
Optic atrophy 1 (Autosomal dominant), isoform CRA_eImported
Gene namesi
Name:OPA1Imported
ORF Names:hCG_17270Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiE5KLK0
PeptideAtlasiE5KLK0
PRIDEiE5KLK0

PTM databases

iPTMnetiE5KLK0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini267 – 543Dynamin-type GInterPro annotationAdd BLAST277

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili197 – 235Sequence analysisAdd BLAST39
Coiled coili878 – 898Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

CDDicd08771 DLP_1, 1 hit
InterProiView protein in InterPro
IPR001401 Dynamin_GTPase
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR033047 Opa1
IPR027417 P-loop_NTPase
PANTHERiPTHR11566 PTHR11566, 1 hit
PTHR11566:SF67 PTHR11566:SF67, 1 hit
PfamiView protein in Pfam
PF00350 Dynamin_N, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51718 G_DYNAMIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

E5KLK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRLRRAAVA CEVCQSLVKH SSGIKGSLPL QKLHLVSRSI YHSHHPTLKL
60 70 80 90 100
QRPQLRTSFQ QFSSLTNLPL RKLKFSPIKY GYQPRRNFWP ARLATRLLKL
110 120 130 140 150
RYLILGSAVG GGYTAKKTFD QWKDMIPDLS EYKWIVPDIV WEIDEYIDFG
160 170 180 190 200
HKLVSEVIGA SDLLLLLGSP EETAFRATDR GSESDKHFRK VSDKEKIDQL
210 220 230 240 250
QEELLHTQLK YQRILERLEK ENKELRKLVL QKDDKGIHHR KLKKSLIDMY
260 270 280 290 300
SEVLDVLSDY DASYNTQDHL PRVVVVGDQS AGKTSVLEMI AQARIFPRGS
310 320 330 340 350
GEMMTRSPVK VTLSEGPHHV ALFKDSSREF DLTKEEDLAA LRHEIELRMR
360 370 380 390 400
KNVKEGCTVS PETISLNVKG PGLQRMVLVD LPGVINTVTS GMAPDTKETI
410 420 430 440 450
FSISKAYMQN PNAIILCIQD GSVDAERSIV TDLVSQMDPH GRRTIFVLTK
460 470 480 490 500
VDLAEKNVAS PSRIQQIIEG KLFPMKALGY FAVVTGKGNS SESIEAIREY
510 520 530 540 550
EEEFFQNSKL LKTSMLKAHQ VTTRNLSLAV SDCFWKMVRE SVEQQADSFK
560 570 580 590 600
ATRFNLETEW KNNYPRLREL DRNELFEKAK NEILDEVISL SQVTPKHWEE
610 620 630 640 650
ILQQSLWERV STHVIENIYL PAAQTMNSGT FNTTVDIKLK QWTDKQLPNK
660 670 680 690 700
AVEVAWETLQ EEFSRFMTEP KGKEHDDIFD KLKEAVKEES IKRHKWNDFA
710 720 730 740 750
EDSLRVIQHN ALEDRSISDK QQWDAAIYFM EEALQARLKD TENAIENMVG
760 770 780 790 800
PDWKKRWLYW KNRTQEQCVH NETKNELEKM LKCNEEHPAY LASDEITTVR
810 820 830 840 850
KNLESRGVEV DPSLIKDTWH QVYRRHFLKT ALNHCNLCRR GFYYYQRHFV
860 870 880 890 900
DSELECNDVV LFWRIQRMLA ITANTLRQQL TNTEVRRLEK NVKEVLEDFA
910 920 930 940
EDGEKKIKLL TGKRVQLAED LKKVREIQEK LDAFIEALHQ EK
Length:942
Mass (Da):109,427
Last modified:February 8, 2011 - v1
Checksum:i820B6AB3E4DC12A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ204906 Genomic DNA Translation: ADP90059.1
HQ204907 Genomic DNA Translation: ADP90067.1
HQ204908 Genomic DNA Translation: ADP90075.1
HQ204909 Genomic DNA Translation: ADP90083.1
HQ204910 Genomic DNA Translation: ADP90091.1
HQ204911 Genomic DNA Translation: ADP90099.1
HQ204912 Genomic DNA Translation: ADP90107.1
HQ204913 Genomic DNA Translation: ADP90115.1
HQ204914 Genomic DNA Translation: ADP90123.1
HQ204915 Genomic DNA Translation: ADP90131.1
HQ204916 Genomic DNA Translation: ADP90139.1
HQ204917 Genomic DNA Translation: ADP90147.1
HQ204918 Genomic DNA Translation: ADP90155.1
HQ204919 Genomic DNA Translation: ADP90163.1
HQ204920 Genomic DNA Translation: ADP90171.1
HQ204921 Genomic DNA Translation: ADP90179.1
HQ204922 Genomic DNA Translation: ADP90187.1
HQ204923 Genomic DNA Translation: ADP90195.1
HQ204924 Genomic DNA Translation: ADP90203.1
HQ204925 Genomic DNA Translation: ADP90211.1
HQ204926 Genomic DNA Translation: ADP90219.1
HQ204927 Genomic DNA Translation: ADP90227.1
HQ204928 Genomic DNA Translation: ADP90235.1
HQ204929 Genomic DNA Translation: ADP90243.1
HQ204930 Genomic DNA Translation: ADP90251.1
HQ204931 Genomic DNA Translation: ADP90259.1
HQ204932 Genomic DNA Translation: ADP90267.1
HQ204933 Genomic DNA Translation: ADP90275.1
HQ204934 Genomic DNA Translation: ADP90283.1
HQ204935 Genomic DNA Translation: ADP90291.1
HQ204936 Genomic DNA Translation: ADP90299.1
HQ204937 Genomic DNA Translation: ADP90307.1
HQ204938 Genomic DNA Translation: ADP90315.1
HQ204939 Genomic DNA Translation: ADP90323.1
HQ204940 Genomic DNA Translation: ADP90331.1
HQ204941 Genomic DNA Translation: ADP90339.1
HQ204942 Genomic DNA Translation: ADP90347.1
HQ204943 Genomic DNA Translation: ADP90355.1
HQ204944 Genomic DNA Translation: ADP90363.1
HQ204945 Genomic DNA Translation: ADP90371.1
CH471052 Genomic DNA Translation: EAW78068.1
RefSeqiNP_570845.1, NM_130832.2
UniGeneiHs.594504

Genome annotation databases

GeneIDi4976

Similar proteinsi

Entry informationi

Entry nameiE5KLK0_HUMAN
AccessioniPrimary (citable) accession number: E5KLK0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: May 23, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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