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Protein
Submitted name:

Dynamin-like 120 kDa protein, mitochondrial

Gene

OPA1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Dynamin-like 120 kDa protein, mitochondrialImported
Submitted name:
Mitochondrial dynamin-like 120 kDa proteinImported
Submitted name:
Optic atrophy 1 (Autosomal dominant), isoform CRA_hImported
Gene namesi
Name:OPA1Imported
ORF Names:hCG_17270Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000198836.8
HGNCiHGNC:8140 OPA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198836

Expressioni

Gene expression databases

BgeeiENSG00000198836

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini304 – 580Dynamin-type GInterPro annotationAdd BLAST277

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili189 – 216Sequence analysisAdd BLAST28
Coiled coili234 – 272Sequence analysisAdd BLAST39
Coiled coili915 – 935Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0447 Eukaryota
COG0699 LUCA
GeneTreeiENSGT00550000074851

Family and domain databases

CDDicd08771 DLP_1, 1 hit
InterProiView protein in InterPro
IPR001401 Dynamin_GTPase
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR033047 Opa1
IPR027417 P-loop_NTPase
PANTHERiPTHR11566 PTHR11566, 1 hit
PTHR11566:SF67 PTHR11566:SF67, 1 hit
PfamiView protein in Pfam
PF00350 Dynamin_N, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51718 G_DYNAMIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

E5KLJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRLRRAAVA CEVCQSLVKH SSGIKGSLPL QKLHLVSRSI YHSHHPTLKL
60 70 80 90 100
QRPQLRTSFQ QFSSLTNLPL RKLKFSPIKY GYQPRRNFWP ARLATRLLKL
110 120 130 140 150
RYLILGSAVG GGYTAKKTFD QWKDMIPDLS EYKWIVPDIV WEIDEYIDFG
160 170 180 190 200
HKLVSEVIGA SDLLLLLGSP EETAFRATDR GSESDKHFRK GLLGELILLQ
210 220 230 240 250
QQIQEHEEEA RRAAGQYSTS YAQQKRKVSD KEKIDQLQEE LLHTQLKYQR
260 270 280 290 300
ILERLEKENK ELRKLVLQKD DKGIHHRKLK KSLIDMYSEV LDVLSDYDAS
310 320 330 340 350
YNTQDHLPRV VVVGDQSAGK TSVLEMIAQA RIFPRGSGEM MTRSPVKVTL
360 370 380 390 400
SEGPHHVALF KDSSREFDLT KEEDLAALRH EIELRMRKNV KEGCTVSPET
410 420 430 440 450
ISLNVKGPGL QRMVLVDLPG VINTVTSGMA PDTKETIFSI SKAYMQNPNA
460 470 480 490 500
IILCIQDGSV DAERSIVTDL VSQMDPHGRR TIFVLTKVDL AEKNVASPSR
510 520 530 540 550
IQQIIEGKLF PMKALGYFAV VTGKGNSSES IEAIREYEEE FFQNSKLLKT
560 570 580 590 600
SMLKAHQVTT RNLSLAVSDC FWKMVRESVE QQADSFKATR FNLETEWKNN
610 620 630 640 650
YPRLRELDRN ELFEKAKNEI LDEVISLSQV TPKHWEEILQ QSLWERVSTH
660 670 680 690 700
VIENIYLPAA QTMNSGTFNT TVDIKLKQWT DKQLPNKAVE VAWETLQEEF
710 720 730 740 750
SRFMTEPKGK EHDDIFDKLK EAVKEESIKR HKWNDFAEDS LRVIQHNALE
760 770 780 790 800
DRSISDKQQW DAAIYFMEEA LQARLKDTEN AIENMVGPDW KKRWLYWKNR
810 820 830 840 850
TQEQCVHNET KNELEKMLKC NEEHPAYLAS DEITTVRKNL ESRGVEVDPS
860 870 880 890 900
LIKDTWHQVY RRHFLKTALN HCNLCRRGFY YYQRHFVDSE LECNDVVLFW
910 920 930 940 950
RIQRMLAITA NTLRQQLTNT EVRRLEKNVK EVLEDFAEDG EKKIKLLTGK
960 970
RVQLAEDLKK VREIQEKLDA FIEALHQEK
Length:979
Mass (Da):113,681
Last modified:February 8, 2011 - v1
Checksum:i45BB53BF00D02989
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC048351 Genomic DNA No translation available.
AC106710 Genomic DNA No translation available.
HQ204906 Genomic DNA Translation: ADP90058.1
HQ204907 Genomic DNA Translation: ADP90066.1
HQ204908 Genomic DNA Translation: ADP90074.1
HQ204909 Genomic DNA Translation: ADP90082.1
HQ204910 Genomic DNA Translation: ADP90090.1
HQ204911 Genomic DNA Translation: ADP90098.1
HQ204912 Genomic DNA Translation: ADP90106.1
HQ204913 Genomic DNA Translation: ADP90114.1
HQ204914 Genomic DNA Translation: ADP90122.1
HQ204915 Genomic DNA Translation: ADP90130.1
HQ204916 Genomic DNA Translation: ADP90138.1
HQ204917 Genomic DNA Translation: ADP90146.1
HQ204918 Genomic DNA Translation: ADP90154.1
HQ204919 Genomic DNA Translation: ADP90162.1
HQ204920 Genomic DNA Translation: ADP90170.1
HQ204921 Genomic DNA Translation: ADP90178.1
HQ204922 Genomic DNA Translation: ADP90186.1
HQ204923 Genomic DNA Translation: ADP90194.1
HQ204924 Genomic DNA Translation: ADP90202.1
HQ204925 Genomic DNA Translation: ADP90210.1
HQ204926 Genomic DNA Translation: ADP90218.1
HQ204927 Genomic DNA Translation: ADP90226.1
HQ204928 Genomic DNA Translation: ADP90234.1
HQ204929 Genomic DNA Translation: ADP90242.1
HQ204930 Genomic DNA Translation: ADP90250.1
HQ204931 Genomic DNA Translation: ADP90258.1
HQ204932 Genomic DNA Translation: ADP90266.1
HQ204933 Genomic DNA Translation: ADP90274.1
HQ204934 Genomic DNA Translation: ADP90282.1
HQ204935 Genomic DNA Translation: ADP90290.1
HQ204936 Genomic DNA Translation: ADP90298.1
HQ204937 Genomic DNA Translation: ADP90306.1
HQ204938 Genomic DNA Translation: ADP90314.1
HQ204939 Genomic DNA Translation: ADP90322.1
HQ204940 Genomic DNA Translation: ADP90330.1
HQ204941 Genomic DNA Translation: ADP90338.1
HQ204942 Genomic DNA Translation: ADP90346.1
HQ204943 Genomic DNA Translation: ADP90354.1
HQ204944 Genomic DNA Translation: ADP90362.1
HQ204945 Genomic DNA Translation: ADP90370.1
CH471052 Genomic DNA Translation: EAW78072.1
RefSeqiNP_570848.1, NM_130835.2
UniGeneiHs.594504

Genome annotation databases

EnsembliENST00000361715; ENSP00000355311; ENSG00000198836
GeneIDi4976
UCSCiuc003fth.4 human

Similar proteinsi

Entry informationi

Entry nameiE5KLJ9_HUMAN
AccessioniPrimary (citable) accession number: E5KLJ9
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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