Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Mitochondrial dynamin-like 120 kDa protein

Gene

OPA1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Mitochondrial dynamin-like 120 kDa proteinImported
Submitted name:
Optic atrophy 1 (Autosomal dominant), isoform CRA_dImported
Gene namesi
Name:OPA1Imported
ORF Names:hCG_17270Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiE5KLJ7. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000354681.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini322 – 598277Dynamin-type G (guanine nucleotide-binding)InterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili207 – 23428Sequence analysisAdd
BLAST
Coiled coili252 – 29039Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.SAAS annotation
Contains dynamin-type G (guanine nucleotide-binding) domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0447. Eukaryota.
COG0699. LUCA.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001401. Dynamin_GTPase.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR033047. Opa1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF67. PTHR11566:SF67. 1 hit.
PfamiPF00350. Dynamin_N. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51718. G_DYNAMIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E5KLJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRLRRAAVA CEVCQSLVKH SSGIKGSLPL QKLHLVSRSI YHSHHPTLKL
60 70 80 90 100
QRPQLRTSFQ QFSSLTNLPL RKLKFSPIKY GYQPRRNFWP ARLATRLLKL
110 120 130 140 150
RYLILGSAVG GGYTAKKTFD QWKDMIPDLS EYKWIVPDIV WEIDEYIDFE
160 170 180 190 200
KIRKALPSSE DLVKLAPDFD KIVESLSLLK DFFTSGSPEE TAFRATDRGS
210 220 230 240 250
ESDKHFRKGL LGELILLQQQ IQEHEEEARR AAGQYSTSYA QQKRKVSDKE
260 270 280 290 300
KIDQLQEELL HTQLKYQRIL ERLEKENKEL RKLVLQKDDK GIHHRKLKKS
310 320 330 340 350
LIDMYSEVLD VLSDYDASYN TQDHLPRVVV VGDQSAGKTS VLEMIAQARI
360 370 380 390 400
FPRGSGEMMT RSPVKVTLSE GPHHVALFKD SSREFDLTKE EDLAALRHEI
410 420 430 440 450
ELRMRKNVKE GCTVSPETIS LNVKGPGLQR MVLVDLPGVI NTVTSGMAPD
460 470 480 490 500
TKETIFSISK AYMQNPNAII LCIQDGSVDA ERSIVTDLVS QMDPHGRRTI
510 520 530 540 550
FVLTKVDLAE KNVASPSRIQ QIIEGKLFPM KALGYFAVVT GKGNSSESIE
560 570 580 590 600
AIREYEEEFF QNSKLLKTSM LKAHQVTTRN LSLAVSDCFW KMVRESVEQQ
610 620 630 640 650
ADSFKATRFN LETEWKNNYP RLRELDRNEL FEKAKNEILD EVISLSQVTP
660 670 680 690 700
KHWEEILQQS LWERVSTHVI ENIYLPAAQT MNSGTFNTTV DIKLKQWTDK
710 720 730 740 750
QLPNKAVEVA WETLQEEFSR FMTEPKGKEH DDIFDKLKEA VKEESIKRHK
760 770 780 790 800
WNDFAEDSLR VIQHNALEDR SISDKQQWDA AIYFMEEALQ ARLKDTENAI
810 820 830 840 850
ENMVGPDWKK RWLYWKNRTQ EQCVHNETKN ELEKMLKCNE EHPAYLASDE
860 870 880 890 900
ITTVRKNLES RGVEVDPSLI KDTWHQVYRR HFLKTALNHC NLCRRGFYYY
910 920 930 940 950
QRHFVDSELE CNDVVLFWRI QRMLAITANT LRQQLTNTEV RRLEKNVKEV
960 970 980 990
LEDFAEDGEK KIKLLTGKRV QLAEDLKKVR EIQEKLDAFI EALHQEK
Length:997
Mass (Da):115,884
Last modified:February 8, 2011 - v1
Checksum:i5D1F6B9BF800F35E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ204906 Genomic DNA. Translation: ADP90056.1.
HQ204907 Genomic DNA. Translation: ADP90064.1.
HQ204908 Genomic DNA. Translation: ADP90072.1.
HQ204910 Genomic DNA. Translation: ADP90088.1.
HQ204911 Genomic DNA. Translation: ADP90096.1.
HQ204912 Genomic DNA. Translation: ADP90104.1.
HQ204913 Genomic DNA. Translation: ADP90112.1.
HQ204914 Genomic DNA. Translation: ADP90120.1.
HQ204917 Genomic DNA. Translation: ADP90144.1.
HQ204918 Genomic DNA. Translation: ADP90152.1.
HQ204920 Genomic DNA. Translation: ADP90168.1.
HQ204921 Genomic DNA. Translation: ADP90176.1.
HQ204922 Genomic DNA. Translation: ADP90184.1.
HQ204923 Genomic DNA. Translation: ADP90192.1.
HQ204924 Genomic DNA. Translation: ADP90200.1.
HQ204925 Genomic DNA. Translation: ADP90208.1.
HQ204926 Genomic DNA. Translation: ADP90216.1.
HQ204927 Genomic DNA. Translation: ADP90224.1.
HQ204929 Genomic DNA. Translation: ADP90240.1.
HQ204930 Genomic DNA. Translation: ADP90248.1.
HQ204932 Genomic DNA. Translation: ADP90264.1.
HQ204933 Genomic DNA. Translation: ADP90272.1.
HQ204934 Genomic DNA. Translation: ADP90280.1.
HQ204935 Genomic DNA. Translation: ADP90288.1.
HQ204936 Genomic DNA. Translation: ADP90296.1.
HQ204938 Genomic DNA. Translation: ADP90312.1.
HQ204939 Genomic DNA. Translation: ADP90320.1.
HQ204940 Genomic DNA. Translation: ADP90328.1.
HQ204941 Genomic DNA. Translation: ADP90336.1.
HQ204942 Genomic DNA. Translation: ADP90344.1.
HQ204943 Genomic DNA. Translation: ADP90352.1.
HQ204944 Genomic DNA. Translation: ADP90360.1.
HQ204945 Genomic DNA. Translation: ADP90368.1.
CH471052 Genomic DNA. Translation: EAW78067.1.
RefSeqiNP_570849.2. NM_130836.2.
UniGeneiHs.594504.

Genome annotation databases

GeneIDi4976.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ204906 Genomic DNA. Translation: ADP90056.1.
HQ204907 Genomic DNA. Translation: ADP90064.1.
HQ204908 Genomic DNA. Translation: ADP90072.1.
HQ204910 Genomic DNA. Translation: ADP90088.1.
HQ204911 Genomic DNA. Translation: ADP90096.1.
HQ204912 Genomic DNA. Translation: ADP90104.1.
HQ204913 Genomic DNA. Translation: ADP90112.1.
HQ204914 Genomic DNA. Translation: ADP90120.1.
HQ204917 Genomic DNA. Translation: ADP90144.1.
HQ204918 Genomic DNA. Translation: ADP90152.1.
HQ204920 Genomic DNA. Translation: ADP90168.1.
HQ204921 Genomic DNA. Translation: ADP90176.1.
HQ204922 Genomic DNA. Translation: ADP90184.1.
HQ204923 Genomic DNA. Translation: ADP90192.1.
HQ204924 Genomic DNA. Translation: ADP90200.1.
HQ204925 Genomic DNA. Translation: ADP90208.1.
HQ204926 Genomic DNA. Translation: ADP90216.1.
HQ204927 Genomic DNA. Translation: ADP90224.1.
HQ204929 Genomic DNA. Translation: ADP90240.1.
HQ204930 Genomic DNA. Translation: ADP90248.1.
HQ204932 Genomic DNA. Translation: ADP90264.1.
HQ204933 Genomic DNA. Translation: ADP90272.1.
HQ204934 Genomic DNA. Translation: ADP90280.1.
HQ204935 Genomic DNA. Translation: ADP90288.1.
HQ204936 Genomic DNA. Translation: ADP90296.1.
HQ204938 Genomic DNA. Translation: ADP90312.1.
HQ204939 Genomic DNA. Translation: ADP90320.1.
HQ204940 Genomic DNA. Translation: ADP90328.1.
HQ204941 Genomic DNA. Translation: ADP90336.1.
HQ204942 Genomic DNA. Translation: ADP90344.1.
HQ204943 Genomic DNA. Translation: ADP90352.1.
HQ204944 Genomic DNA. Translation: ADP90360.1.
HQ204945 Genomic DNA. Translation: ADP90368.1.
CH471052 Genomic DNA. Translation: EAW78067.1.
RefSeqiNP_570849.2. NM_130836.2.
UniGeneiHs.594504.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000354681.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4976.

Organism-specific databases

CTDi4976.

Phylogenomic databases

eggNOGiKOG0447. Eukaryota.
COG0699. LUCA.

Miscellaneous databases

ChiTaRSiOPA1. human.
GenomeRNAii4976.
NextBioi19154.

Gene expression databases

ExpressionAtlasiE5KLJ7. baseline and differential.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001401. Dynamin_GTPase.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR033047. Opa1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF67. PTHR11566:SF67. 1 hit.
PfamiPF00350. Dynamin_N. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51718. G_DYNAMIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE.
  3. "Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing."
    Wang W., Shen P., Thiyagarajan S., Lin S., Palm C., Horvath R., Klopstock T., Cutler D., Pique L., Schrijver I., Davis R.W., Mindrinos M., Speed T.P., Scharfe C.
    Nucleic Acids Res. 39:44-58(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiE5KLJ7_HUMAN
AccessioniPrimary (citable) accession number: E5KLJ7
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: May 11, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.