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Protein
Submitted name:

Dynamin-like 120 kDa protein, mitochondrial

Gene

OPA1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Dynamin-like 120 kDa protein, mitochondrialImported
Submitted name:
Mitochondrial dynamin-like 120 kDa proteinImported
Submitted name:
Optic atrophy 1 (Autosomal dominant), isoform CRA_gImported
Gene namesi
Name:OPA1Imported
ORF Names:hCG_17270Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:8140. OPA1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198836.

PTM / Processingi

Proteomic databases

EPDiE5KLJ5.
MaxQBiE5KLJ5.
PeptideAtlasiE5KLJ5.
PRIDEiE5KLJ5.

Expressioni

Gene expression databases

BgeeiENSG00000198836.
ExpressionAtlasiE5KLJ5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000354681.

Structurei

3D structure databases

ProteinModelPortaliE5KLJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini340 – 616Dynamin-type G (guanine nucleotide-binding)InterPro annotationAdd BLAST277

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili225 – 252Sequence analysisAdd BLAST28
Coiled coili270 – 308Sequence analysisAdd BLAST39

Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0447. Eukaryota.
COG0699. LUCA.
GeneTreeiENSGT00550000074851.
OMAiMTVKGPG.
OrthoDBiEOG091G01NV.
PhylomeDBiE5KLJ5.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001401. Dynamin_GTPase.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR033047. Opa1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF67. PTHR11566:SF67. 1 hit.
PfamiPF00350. Dynamin_N. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51718. G_DYNAMIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E5KLJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRLRRAAVA CEVCQSLVKH SSGIKGSLPL QKLHLVSRSI YHSHHPTLKL
60 70 80 90 100
QRPQLRTSFQ QFSSLTNLPL RKLKFSPIKY GYQPRRNFWP ARLATRLLKL
110 120 130 140 150
RYLILGSAVG GGYTAKKTFD QWKDMIPDLS EYKWIVPDIV WEIDEYIDFE
160 170 180 190 200
KIRKALPSSE DLVKLAPDFD KIVESLSLLK DFFTSGHKLV SEVIGASDLL
210 220 230 240 250
LLLGSPEETA FRATDRGSES DKHFRKGLLG ELILLQQQIQ EHEEEARRAA
260 270 280 290 300
GQYSTSYAQQ KRKVSDKEKI DQLQEELLHT QLKYQRILER LEKENKELRK
310 320 330 340 350
LVLQKDDKGI HHRKLKKSLI DMYSEVLDVL SDYDASYNTQ DHLPRVVVVG
360 370 380 390 400
DQSAGKTSVL EMIAQARIFP RGSGEMMTRS PVKVTLSEGP HHVALFKDSS
410 420 430 440 450
REFDLTKEED LAALRHEIEL RMRKNVKEGC TVSPETISLN VKGPGLQRMV
460 470 480 490 500
LVDLPGVINT VTSGMAPDTK ETIFSISKAY MQNPNAIILC IQDGSVDAER
510 520 530 540 550
SIVTDLVSQM DPHGRRTIFV LTKVDLAEKN VASPSRIQQI IEGKLFPMKA
560 570 580 590 600
LGYFAVVTGK GNSSESIEAI REYEEEFFQN SKLLKTSMLK AHQVTTRNLS
610 620 630 640 650
LAVSDCFWKM VRESVEQQAD SFKATRFNLE TEWKNNYPRL RELDRNELFE
660 670 680 690 700
KAKNEILDEV ISLSQVTPKH WEEILQQSLW ERVSTHVIEN IYLPAAQTMN
710 720 730 740 750
SGTFNTTVDI KLKQWTDKQL PNKAVEVAWE TLQEEFSRFM TEPKGKEHDD
760 770 780 790 800
IFDKLKEAVK EESIKRHKWN DFAEDSLRVI QHNALEDRSI SDKQQWDAAI
810 820 830 840 850
YFMEEALQAR LKDTENAIEN MVGPDWKKRW LYWKNRTQEQ CVHNETKNEL
860 870 880 890 900
EKMLKCNEEH PAYLASDEIT TVRKNLESRG VEVDPSLIKD TWHQVYRRHF
910 920 930 940 950
LKTALNHCNL CRRGFYYYQR HFVDSELECN DVVLFWRIQR MLAITANTLR
960 970 980 990 1000
QQLTNTEVRR LEKNVKEVLE DFAEDGEKKI KLLTGKRVQL AEDLKKVREI
1010
QEKLDAFIEA LHQEK
Length:1,015
Mass (Da):117,744
Last modified:February 8, 2011 - v1
Checksum:iEB0634781A361289
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC048351 Genomic DNA. No translation available.
AC106710 Genomic DNA. No translation available.
HQ204906 Genomic DNA. Translation: ADP90054.1.
HQ204907 Genomic DNA. Translation: ADP90062.1.
HQ204908 Genomic DNA. Translation: ADP90070.1.
HQ204910 Genomic DNA. Translation: ADP90086.1.
HQ204911 Genomic DNA. Translation: ADP90094.1.
HQ204912 Genomic DNA. Translation: ADP90102.1.
HQ204913 Genomic DNA. Translation: ADP90110.1.
HQ204914 Genomic DNA. Translation: ADP90118.1.
HQ204917 Genomic DNA. Translation: ADP90142.1.
HQ204918 Genomic DNA. Translation: ADP90150.1.
HQ204920 Genomic DNA. Translation: ADP90166.1.
HQ204921 Genomic DNA. Translation: ADP90174.1.
HQ204922 Genomic DNA. Translation: ADP90182.1.
HQ204923 Genomic DNA. Translation: ADP90190.1.
HQ204924 Genomic DNA. Translation: ADP90198.1.
HQ204925 Genomic DNA. Translation: ADP90206.1.
HQ204926 Genomic DNA. Translation: ADP90214.1.
HQ204927 Genomic DNA. Translation: ADP90222.1.
HQ204929 Genomic DNA. Translation: ADP90238.1.
HQ204930 Genomic DNA. Translation: ADP90246.1.
HQ204932 Genomic DNA. Translation: ADP90262.1.
HQ204933 Genomic DNA. Translation: ADP90270.1.
HQ204934 Genomic DNA. Translation: ADP90278.1.
HQ204935 Genomic DNA. Translation: ADP90286.1.
HQ204936 Genomic DNA. Translation: ADP90294.1.
HQ204938 Genomic DNA. Translation: ADP90310.1.
HQ204939 Genomic DNA. Translation: ADP90318.1.
HQ204940 Genomic DNA. Translation: ADP90326.1.
HQ204941 Genomic DNA. Translation: ADP90334.1.
HQ204942 Genomic DNA. Translation: ADP90342.1.
HQ204943 Genomic DNA. Translation: ADP90350.1.
HQ204944 Genomic DNA. Translation: ADP90358.1.
HQ204945 Genomic DNA. Translation: ADP90366.1.
CH471052 Genomic DNA. Translation: EAW78070.1.
RefSeqiNP_570850.2. NM_130837.2.
UniGeneiHs.594504.

Genome annotation databases

EnsembliENST00000361510; ENSP00000355324; ENSG00000198836.
GeneIDi4976.
UCSCiuc003ftg.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC048351 Genomic DNA. No translation available.
AC106710 Genomic DNA. No translation available.
HQ204906 Genomic DNA. Translation: ADP90054.1.
HQ204907 Genomic DNA. Translation: ADP90062.1.
HQ204908 Genomic DNA. Translation: ADP90070.1.
HQ204910 Genomic DNA. Translation: ADP90086.1.
HQ204911 Genomic DNA. Translation: ADP90094.1.
HQ204912 Genomic DNA. Translation: ADP90102.1.
HQ204913 Genomic DNA. Translation: ADP90110.1.
HQ204914 Genomic DNA. Translation: ADP90118.1.
HQ204917 Genomic DNA. Translation: ADP90142.1.
HQ204918 Genomic DNA. Translation: ADP90150.1.
HQ204920 Genomic DNA. Translation: ADP90166.1.
HQ204921 Genomic DNA. Translation: ADP90174.1.
HQ204922 Genomic DNA. Translation: ADP90182.1.
HQ204923 Genomic DNA. Translation: ADP90190.1.
HQ204924 Genomic DNA. Translation: ADP90198.1.
HQ204925 Genomic DNA. Translation: ADP90206.1.
HQ204926 Genomic DNA. Translation: ADP90214.1.
HQ204927 Genomic DNA. Translation: ADP90222.1.
HQ204929 Genomic DNA. Translation: ADP90238.1.
HQ204930 Genomic DNA. Translation: ADP90246.1.
HQ204932 Genomic DNA. Translation: ADP90262.1.
HQ204933 Genomic DNA. Translation: ADP90270.1.
HQ204934 Genomic DNA. Translation: ADP90278.1.
HQ204935 Genomic DNA. Translation: ADP90286.1.
HQ204936 Genomic DNA. Translation: ADP90294.1.
HQ204938 Genomic DNA. Translation: ADP90310.1.
HQ204939 Genomic DNA. Translation: ADP90318.1.
HQ204940 Genomic DNA. Translation: ADP90326.1.
HQ204941 Genomic DNA. Translation: ADP90334.1.
HQ204942 Genomic DNA. Translation: ADP90342.1.
HQ204943 Genomic DNA. Translation: ADP90350.1.
HQ204944 Genomic DNA. Translation: ADP90358.1.
HQ204945 Genomic DNA. Translation: ADP90366.1.
CH471052 Genomic DNA. Translation: EAW78070.1.
RefSeqiNP_570850.2. NM_130837.2.
UniGeneiHs.594504.

3D structure databases

ProteinModelPortaliE5KLJ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000354681.

Proteomic databases

EPDiE5KLJ5.
MaxQBiE5KLJ5.
PeptideAtlasiE5KLJ5.
PRIDEiE5KLJ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361510; ENSP00000355324; ENSG00000198836.
GeneIDi4976.
UCSCiuc003ftg.4. human.

Organism-specific databases

CTDi4976.
HGNCiHGNC:8140. OPA1.
OpenTargetsiENSG00000198836.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0447. Eukaryota.
COG0699. LUCA.
GeneTreeiENSGT00550000074851.
OMAiMTVKGPG.
OrthoDBiEOG091G01NV.
PhylomeDBiE5KLJ5.

Miscellaneous databases

ChiTaRSiOPA1. human.
GenomeRNAii4976.

Gene expression databases

BgeeiENSG00000198836.
ExpressionAtlasiE5KLJ5. baseline and differential.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001401. Dynamin_GTPase.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR033047. Opa1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF67. PTHR11566:SF67. 1 hit.
PfamiPF00350. Dynamin_N. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51718. G_DYNAMIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE5KLJ5_HUMAN
AccessioniPrimary (citable) accession number: E5KLJ5
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: November 30, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.