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E5KLB6 (E5KLB6_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA ligase RuleBase RU000617
EC=6.5.1.1 RuleBase RU000617
Gene names
Name:LIG3 EMBL EAW80197.1
ORF Names:hCG_27675 EMBL EAW80197.1
OrganismHomo sapiens (Human) EMBL ADP89975.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length949 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). RuleBase RU000617

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. RuleBase RU004196

Sequences

Sequence LengthMass (Da)Tools
E5KLB6 [UniParc].

Last modified February 8, 2011. Version 1.
Checksum: 0C10E40E0686DB77

FASTA949106,018
        10         20         30         40         50         60 
MSLAFKIFFP QTLRALSRKE LCLFRKHHWR DVRQFSQWSE TDLLHGHPLF LRRKPVLSFQ 

        70         80         90        100        110        120 
GSHLRSRATY LVFLPGLHVG LCSGPCEMAE QRFCVDYAKR GTAGCKKCKE KIVKGVCRIG 

       130        140        150        160        170        180 
KVVPNPFSES GGDMKEWYHI KCMFEKLERA RATTKKIEDL TELEGWEELE DNEKEQITQH 

       190        200        210        220        230        240 
IADLSSKAAG TPKKKAVVQA KLTTTGQVTS PVKGASFVTS TNPRKFSGFS AKPNNSGEAP 

       250        260        270        280        290        300 
SSPTPKRSLS SSKCDPRHKD CLLREFRKLC AMVADNPSYN TKTQIIQDFL RKGSAGDGFH 

       310        320        330        340        350        360 
GDVYLTVKLL LPGVIKTVYN LNDKQIVKLF SRIFNCNPDD MARDLEQGDV SETIRVFFEQ 

       370        380        390        400        410        420 
SKSFPPAAKS LLTIQEVDEF LLRLSKLTKE DEQQQALQDI ASRCTANDLK CIIRLIKHDL 

       430        440        450        460        470        480 
KMNSGAKHVL DALDPNAYEA FKASRNLQDV VERVLHNAQE VEKEPGQRRA LSVQASLMTP 

       490        500        510        520        530        540 
VQPMLAEACK SVEYAMKKCP NGMFSEIKYD GERVQVHKNG DHFSYFSRSL KPVLPHKVAH 

       550        560        570        580        590        600 
FKDYIPQAFP GGHSMILDSE VLLIDNKTGK PLPFGTLGVH KKAAFQDANV CLFVFDCIYF 

       610        620        630        640        650        660 
NDVSLMDRPL CERRKFLHDN MVEIPNRIMF SEMKRVTKAL DLADMITRVI QEGLEGLVLK 

       670        680        690        700        710        720 
DVKGTYEPGK RHWLKVKKDY LNEGAMADTA DLVVLGAFYG QGSKGGMMSI FLMGCYDPGS 

       730        740        750        760        770        780 
QKWCTVTKCA GGHDDATLAR LQNELDMVKI SKDPSKIPSW LKVNKIYYPD FIVPDPKKAA 

       790        800        810        820        830        840 
VWEITGAEFS KSEAHTADGI SIRFPRCTRI RDDKDWKSAT NLPQLKELYQ LSKEKADFTV 

       850        860        870        880        890        900 
VAGDEGSSTT GGSSEENKGP SGSAVSRKAP SKPSASTKKA EGKLSNSNSK DGNMQTAKPS 

       910        920        930        940 
AMKVGEKLAT KSSPVKVGEK RKAADETLCQ TKRRPASEQR GRTVPAGRR

« Hide

References

[1]"The sequence of the human genome."
Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H. expand/collapse author list , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[3]"Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing."
Wang W., Shen P., Thiyagarajan S., Lin S., Palm C., Horvath R., Klopstock T., Cutler D., Pique L., Schrijver I., Davis R.W., Mindrinos M., Speed T.P., Scharfe C.
Nucleic Acids Res. 39:44-58(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		HQ204826 Genomic DNA. Translation: ADP89975.1.
HQ204827 Genomic DNA. Translation: ADP89977.1.
HQ204828 Genomic DNA. Translation: ADP89979.1.
HQ204829 Genomic DNA. Translation: ADP89981.1.
HQ204830 Genomic DNA. Translation: ADP89983.1.
HQ204831 Genomic DNA. Translation: ADP89985.1.
HQ204832 Genomic DNA. Translation: ADP89987.1.
HQ204833 Genomic DNA. Translation: ADP89989.1.
HQ204834 Genomic DNA. Translation: ADP89991.1.
HQ204835 Genomic DNA. Translation: ADP89993.1.
HQ204836 Genomic DNA. Translation: ADP89995.1.
HQ204837 Genomic DNA. Translation: ADP89997.1.
HQ204838 Genomic DNA. Translation: ADP89999.1.
HQ204839 Genomic DNA. Translation: ADP90001.1.
HQ204840 Genomic DNA. Translation: ADP90003.1.
HQ204841 Genomic DNA. Translation: ADP90005.1.
HQ204842 Genomic DNA. Translation: ADP90007.1.
HQ204843 Genomic DNA. Translation: ADP90009.1.
HQ204844 Genomic DNA. Translation: ADP90011.1.
HQ204845 Genomic DNA. Translation: ADP90013.1.
HQ204846 Genomic DNA. Translation: ADP90015.1.
HQ204847 Genomic DNA. Translation: ADP90017.1.
HQ204848 Genomic DNA. Translation: ADP90019.1.
HQ204849 Genomic DNA. Translation: ADP90021.1.
HQ204850 Genomic DNA. Translation: ADP90023.1.
HQ204851 Genomic DNA. Translation: ADP90025.1.
HQ204852 Genomic DNA. Translation: ADP90027.1.
HQ204853 Genomic DNA. Translation: ADP90029.1.
HQ204854 Genomic DNA. Translation: ADP90031.1.
HQ204855 Genomic DNA. Translation: ADP90033.1.
HQ204856 Genomic DNA. Translation: ADP90035.1.
HQ204857 Genomic DNA. Translation: ADP90037.1.
HQ204858 Genomic DNA. Translation: ADP90039.1.
HQ204859 Genomic DNA. Translation: ADP90041.1.
HQ204860 Genomic DNA. Translation: ADP90043.1.
HQ204861 Genomic DNA. Translation: ADP90045.1.
HQ204862 Genomic DNA. Translation: ADP90047.1.
HQ204863 Genomic DNA. Translation: ADP90049.1.
HQ204864 Genomic DNA. Translation: ADP90051.1.
HQ204865 Genomic DNA. Translation: ADP90053.1.
CH471147 Genomic DNA. Translation: EAW80197.1.
IPIIPI00000156.
RefSeqNP_002302.2. NM_002311.4.
UniGeneHs.100299.

3D structure databases

ProteinModelPortalE5KLB6.
SMRE5KLB6. Positions 88-204, 257-833.
ModBaseSearch...

Proteomic databases

PRIDEE5KLB6.

Protocols and materials databases

DNASU3980.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3980.
KEGGhsa:3980.
UCSCuc002hij.3. human.

Organism-specific databases

CTD3980.

Phylogenomic databases

KOK10776.

Gene expression databases

ArrayExpressE5KLB6.
BgeeE5KLB6.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.30.1740.10. 1 hit.
InterProIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
IPR001510. Znf_PARP.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF00645. zf-PARP. 1 hit.
[Graphical view]
SUPFAMSSF50249. Nucleic_acid_OB. 1 hit.
SSF117018. SSF117018. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
PS00347. PARP_ZN_FINGER_1. 1 hit.
PS50064. PARP_ZN_FINGER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLIG3. human.
GenomeRNAi3980.
NextBio15598.

Entry information

Entry nameE5KLB6_HUMAN
AccessionPrimary (citable) accession number: E5KLB6
Entry history
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: April 3, 2013
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info