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E5KLB6

- E5KLB6_HUMAN

UniProt

E5KLB6 - E5KLB6_HUMAN

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Protein

DNA ligase

Gene

LIG3

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:LIG3Imported
ORF Names:hCG_27675Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: HPA
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiE5KLB6. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE5KLB6.
SMRiE5KLB6. Positions 88-204, 257-833.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10776.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.30.1740.10. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
IPR001510. Znf_PARP.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF00645. zf-PARP. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
PS00347. PARP_ZN_FINGER_1. 1 hit.
PS50064. PARP_ZN_FINGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E5KLB6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLAFKIFFP QTLRALSRKE LCLFRKHHWR DVRQFSQWSE TDLLHGHPLF
60 70 80 90 100
LRRKPVLSFQ GSHLRSRATY LVFLPGLHVG LCSGPCEMAE QRFCVDYAKR
110 120 130 140 150
GTAGCKKCKE KIVKGVCRIG KVVPNPFSES GGDMKEWYHI KCMFEKLERA
160 170 180 190 200
RATTKKIEDL TELEGWEELE DNEKEQITQH IADLSSKAAG TPKKKAVVQA
210 220 230 240 250
KLTTTGQVTS PVKGASFVTS TNPRKFSGFS AKPNNSGEAP SSPTPKRSLS
260 270 280 290 300
SSKCDPRHKD CLLREFRKLC AMVADNPSYN TKTQIIQDFL RKGSAGDGFH
310 320 330 340 350
GDVYLTVKLL LPGVIKTVYN LNDKQIVKLF SRIFNCNPDD MARDLEQGDV
360 370 380 390 400
SETIRVFFEQ SKSFPPAAKS LLTIQEVDEF LLRLSKLTKE DEQQQALQDI
410 420 430 440 450
ASRCTANDLK CIIRLIKHDL KMNSGAKHVL DALDPNAYEA FKASRNLQDV
460 470 480 490 500
VERVLHNAQE VEKEPGQRRA LSVQASLMTP VQPMLAEACK SVEYAMKKCP
510 520 530 540 550
NGMFSEIKYD GERVQVHKNG DHFSYFSRSL KPVLPHKVAH FKDYIPQAFP
560 570 580 590 600
GGHSMILDSE VLLIDNKTGK PLPFGTLGVH KKAAFQDANV CLFVFDCIYF
610 620 630 640 650
NDVSLMDRPL CERRKFLHDN MVEIPNRIMF SEMKRVTKAL DLADMITRVI
660 670 680 690 700
QEGLEGLVLK DVKGTYEPGK RHWLKVKKDY LNEGAMADTA DLVVLGAFYG
710 720 730 740 750
QGSKGGMMSI FLMGCYDPGS QKWCTVTKCA GGHDDATLAR LQNELDMVKI
760 770 780 790 800
SKDPSKIPSW LKVNKIYYPD FIVPDPKKAA VWEITGAEFS KSEAHTADGI
810 820 830 840 850
SIRFPRCTRI RDDKDWKSAT NLPQLKELYQ LSKEKADFTV VAGDEGSSTT
860 870 880 890 900
GGSSEENKGP SGSAVSRKAP SKPSASTKKA EGKLSNSNSK DGNMQTAKPS
910 920 930 940
AMKVGEKLAT KSSPVKVGEK RKAADETLCQ TKRRPASEQR GRTVPAGRR
Length:949
Mass (Da):106,018
Last modified:February 8, 2011 - v1
Checksum:i0C10E40E0686DB77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ204826 Genomic DNA. Translation: ADP89975.1.
HQ204827 Genomic DNA. Translation: ADP89977.1.
HQ204828 Genomic DNA. Translation: ADP89979.1.
HQ204829 Genomic DNA. Translation: ADP89981.1.
HQ204830 Genomic DNA. Translation: ADP89983.1.
HQ204831 Genomic DNA. Translation: ADP89985.1.
HQ204832 Genomic DNA. Translation: ADP89987.1.
HQ204833 Genomic DNA. Translation: ADP89989.1.
HQ204834 Genomic DNA. Translation: ADP89991.1.
HQ204835 Genomic DNA. Translation: ADP89993.1.
HQ204836 Genomic DNA. Translation: ADP89995.1.
HQ204837 Genomic DNA. Translation: ADP89997.1.
HQ204838 Genomic DNA. Translation: ADP89999.1.
HQ204839 Genomic DNA. Translation: ADP90001.1.
HQ204840 Genomic DNA. Translation: ADP90003.1.
HQ204841 Genomic DNA. Translation: ADP90005.1.
HQ204842 Genomic DNA. Translation: ADP90007.1.
HQ204843 Genomic DNA. Translation: ADP90009.1.
HQ204844 Genomic DNA. Translation: ADP90011.1.
HQ204845 Genomic DNA. Translation: ADP90013.1.
HQ204846 Genomic DNA. Translation: ADP90015.1.
HQ204847 Genomic DNA. Translation: ADP90017.1.
HQ204848 Genomic DNA. Translation: ADP90019.1.
HQ204849 Genomic DNA. Translation: ADP90021.1.
HQ204850 Genomic DNA. Translation: ADP90023.1.
HQ204851 Genomic DNA. Translation: ADP90025.1.
HQ204852 Genomic DNA. Translation: ADP90027.1.
HQ204853 Genomic DNA. Translation: ADP90029.1.
HQ204854 Genomic DNA. Translation: ADP90031.1.
HQ204855 Genomic DNA. Translation: ADP90033.1.
HQ204856 Genomic DNA. Translation: ADP90035.1.
HQ204857 Genomic DNA. Translation: ADP90037.1.
HQ204858 Genomic DNA. Translation: ADP90039.1.
HQ204859 Genomic DNA. Translation: ADP90041.1.
HQ204860 Genomic DNA. Translation: ADP90043.1.
HQ204861 Genomic DNA. Translation: ADP90045.1.
HQ204862 Genomic DNA. Translation: ADP90047.1.
HQ204863 Genomic DNA. Translation: ADP90049.1.
HQ204864 Genomic DNA. Translation: ADP90051.1.
HQ204865 Genomic DNA. Translation: ADP90053.1.
CH471147 Genomic DNA. Translation: EAW80197.1.
RefSeqiNP_002302.2. NM_002311.4.
UniGeneiHs.100299.

Genome annotation databases

GeneIDi3980.
KEGGihsa:3980.
UCSCiuc002hij.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ204826 Genomic DNA. Translation: ADP89975.1 .
HQ204827 Genomic DNA. Translation: ADP89977.1 .
HQ204828 Genomic DNA. Translation: ADP89979.1 .
HQ204829 Genomic DNA. Translation: ADP89981.1 .
HQ204830 Genomic DNA. Translation: ADP89983.1 .
HQ204831 Genomic DNA. Translation: ADP89985.1 .
HQ204832 Genomic DNA. Translation: ADP89987.1 .
HQ204833 Genomic DNA. Translation: ADP89989.1 .
HQ204834 Genomic DNA. Translation: ADP89991.1 .
HQ204835 Genomic DNA. Translation: ADP89993.1 .
HQ204836 Genomic DNA. Translation: ADP89995.1 .
HQ204837 Genomic DNA. Translation: ADP89997.1 .
HQ204838 Genomic DNA. Translation: ADP89999.1 .
HQ204839 Genomic DNA. Translation: ADP90001.1 .
HQ204840 Genomic DNA. Translation: ADP90003.1 .
HQ204841 Genomic DNA. Translation: ADP90005.1 .
HQ204842 Genomic DNA. Translation: ADP90007.1 .
HQ204843 Genomic DNA. Translation: ADP90009.1 .
HQ204844 Genomic DNA. Translation: ADP90011.1 .
HQ204845 Genomic DNA. Translation: ADP90013.1 .
HQ204846 Genomic DNA. Translation: ADP90015.1 .
HQ204847 Genomic DNA. Translation: ADP90017.1 .
HQ204848 Genomic DNA. Translation: ADP90019.1 .
HQ204849 Genomic DNA. Translation: ADP90021.1 .
HQ204850 Genomic DNA. Translation: ADP90023.1 .
HQ204851 Genomic DNA. Translation: ADP90025.1 .
HQ204852 Genomic DNA. Translation: ADP90027.1 .
HQ204853 Genomic DNA. Translation: ADP90029.1 .
HQ204854 Genomic DNA. Translation: ADP90031.1 .
HQ204855 Genomic DNA. Translation: ADP90033.1 .
HQ204856 Genomic DNA. Translation: ADP90035.1 .
HQ204857 Genomic DNA. Translation: ADP90037.1 .
HQ204858 Genomic DNA. Translation: ADP90039.1 .
HQ204859 Genomic DNA. Translation: ADP90041.1 .
HQ204860 Genomic DNA. Translation: ADP90043.1 .
HQ204861 Genomic DNA. Translation: ADP90045.1 .
HQ204862 Genomic DNA. Translation: ADP90047.1 .
HQ204863 Genomic DNA. Translation: ADP90049.1 .
HQ204864 Genomic DNA. Translation: ADP90051.1 .
HQ204865 Genomic DNA. Translation: ADP90053.1 .
CH471147 Genomic DNA. Translation: EAW80197.1 .
RefSeqi NP_002302.2. NM_002311.4.
UniGenei Hs.100299.

3D structure databases

ProteinModelPortali E5KLB6.
SMRi E5KLB6. Positions 88-204, 257-833.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

DNASUi 3980.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3980.
KEGGi hsa:3980.
UCSCi uc002hij.3. human.

Organism-specific databases

CTDi 3980.

Phylogenomic databases

KOi K10776.

Miscellaneous databases

ChiTaRSi LIG3. human.
GenomeRNAii 3980.
NextBioi 15598.

Gene expression databases

ExpressionAtlasi E5KLB6. baseline and differential.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.30.1740.10. 1 hit.
InterProi IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
IPR001510. Znf_PARP.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF00645. zf-PARP. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
PS00347. PARP_ZN_FINGER_1. 1 hit.
PS50064. PARP_ZN_FINGER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE.
  3. "Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing."
    Wang W., Shen P., Thiyagarajan S., Lin S., Palm C., Horvath R., Klopstock T., Cutler D., Pique L., Schrijver I., Davis R.W., Mindrinos M., Speed T.P., Scharfe C.
    Nucleic Acids Res. 39:44-58(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiE5KLB6_HUMAN
AccessioniPrimary (citable) accession number: E5KLB6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: October 29, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.