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E5KLB6

- E5KLB6_HUMAN

UniProt

E5KLB6 - E5KLB6_HUMAN

Protein

DNA ligase

Gene

LIG3

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-EC
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. DNA ligation involved in DNA repair Source: InterPro
    2. DNA recombination Source: UniProtKB-KW
    3. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Gene namesi
    Name:LIG3Imported
    ORF Names:hCG_27675Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: HPA

    Structurei

    3D structure databases

    SMRiE5KLB6. Positions 88-204, 257-833.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK10776.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1740.10. 1 hit.
    InterProiIPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    IPR001510. Znf_PARP.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    PF00645. zf-PARP. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    PS00347. PARP_ZN_FINGER_1. 1 hit.
    PS50064. PARP_ZN_FINGER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E5KLB6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLAFKIFFP QTLRALSRKE LCLFRKHHWR DVRQFSQWSE TDLLHGHPLF    50
    LRRKPVLSFQ GSHLRSRATY LVFLPGLHVG LCSGPCEMAE QRFCVDYAKR 100
    GTAGCKKCKE KIVKGVCRIG KVVPNPFSES GGDMKEWYHI KCMFEKLERA 150
    RATTKKIEDL TELEGWEELE DNEKEQITQH IADLSSKAAG TPKKKAVVQA 200
    KLTTTGQVTS PVKGASFVTS TNPRKFSGFS AKPNNSGEAP SSPTPKRSLS 250
    SSKCDPRHKD CLLREFRKLC AMVADNPSYN TKTQIIQDFL RKGSAGDGFH 300
    GDVYLTVKLL LPGVIKTVYN LNDKQIVKLF SRIFNCNPDD MARDLEQGDV 350
    SETIRVFFEQ SKSFPPAAKS LLTIQEVDEF LLRLSKLTKE DEQQQALQDI 400
    ASRCTANDLK CIIRLIKHDL KMNSGAKHVL DALDPNAYEA FKASRNLQDV 450
    VERVLHNAQE VEKEPGQRRA LSVQASLMTP VQPMLAEACK SVEYAMKKCP 500
    NGMFSEIKYD GERVQVHKNG DHFSYFSRSL KPVLPHKVAH FKDYIPQAFP 550
    GGHSMILDSE VLLIDNKTGK PLPFGTLGVH KKAAFQDANV CLFVFDCIYF 600
    NDVSLMDRPL CERRKFLHDN MVEIPNRIMF SEMKRVTKAL DLADMITRVI 650
    QEGLEGLVLK DVKGTYEPGK RHWLKVKKDY LNEGAMADTA DLVVLGAFYG 700
    QGSKGGMMSI FLMGCYDPGS QKWCTVTKCA GGHDDATLAR LQNELDMVKI 750
    SKDPSKIPSW LKVNKIYYPD FIVPDPKKAA VWEITGAEFS KSEAHTADGI 800
    SIRFPRCTRI RDDKDWKSAT NLPQLKELYQ LSKEKADFTV VAGDEGSSTT 850
    GGSSEENKGP SGSAVSRKAP SKPSASTKKA EGKLSNSNSK DGNMQTAKPS 900
    AMKVGEKLAT KSSPVKVGEK RKAADETLCQ TKRRPASEQR GRTVPAGRR 949
    Length:949
    Mass (Da):106,018
    Last modified:February 8, 2011 - v1
    Checksum:i0C10E40E0686DB77
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HQ204826 Genomic DNA. Translation: ADP89975.1.
    HQ204827 Genomic DNA. Translation: ADP89977.1.
    HQ204828 Genomic DNA. Translation: ADP89979.1.
    HQ204829 Genomic DNA. Translation: ADP89981.1.
    HQ204830 Genomic DNA. Translation: ADP89983.1.
    HQ204831 Genomic DNA. Translation: ADP89985.1.
    HQ204832 Genomic DNA. Translation: ADP89987.1.
    HQ204833 Genomic DNA. Translation: ADP89989.1.
    HQ204834 Genomic DNA. Translation: ADP89991.1.
    HQ204835 Genomic DNA. Translation: ADP89993.1.
    HQ204836 Genomic DNA. Translation: ADP89995.1.
    HQ204837 Genomic DNA. Translation: ADP89997.1.
    HQ204838 Genomic DNA. Translation: ADP89999.1.
    HQ204839 Genomic DNA. Translation: ADP90001.1.
    HQ204840 Genomic DNA. Translation: ADP90003.1.
    HQ204841 Genomic DNA. Translation: ADP90005.1.
    HQ204842 Genomic DNA. Translation: ADP90007.1.
    HQ204843 Genomic DNA. Translation: ADP90009.1.
    HQ204844 Genomic DNA. Translation: ADP90011.1.
    HQ204845 Genomic DNA. Translation: ADP90013.1.
    HQ204846 Genomic DNA. Translation: ADP90015.1.
    HQ204847 Genomic DNA. Translation: ADP90017.1.
    HQ204848 Genomic DNA. Translation: ADP90019.1.
    HQ204849 Genomic DNA. Translation: ADP90021.1.
    HQ204850 Genomic DNA. Translation: ADP90023.1.
    HQ204851 Genomic DNA. Translation: ADP90025.1.
    HQ204852 Genomic DNA. Translation: ADP90027.1.
    HQ204853 Genomic DNA. Translation: ADP90029.1.
    HQ204854 Genomic DNA. Translation: ADP90031.1.
    HQ204855 Genomic DNA. Translation: ADP90033.1.
    HQ204856 Genomic DNA. Translation: ADP90035.1.
    HQ204857 Genomic DNA. Translation: ADP90037.1.
    HQ204858 Genomic DNA. Translation: ADP90039.1.
    HQ204859 Genomic DNA. Translation: ADP90041.1.
    HQ204860 Genomic DNA. Translation: ADP90043.1.
    HQ204861 Genomic DNA. Translation: ADP90045.1.
    HQ204862 Genomic DNA. Translation: ADP90047.1.
    HQ204863 Genomic DNA. Translation: ADP90049.1.
    HQ204864 Genomic DNA. Translation: ADP90051.1.
    HQ204865 Genomic DNA. Translation: ADP90053.1.
    CH471147 Genomic DNA. Translation: EAW80197.1.
    RefSeqiNP_002302.2. NM_002311.4.
    UniGeneiHs.100299.

    Genome annotation databases

    GeneIDi3980.
    KEGGihsa:3980.
    UCSCiuc002hij.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HQ204826 Genomic DNA. Translation: ADP89975.1 .
    HQ204827 Genomic DNA. Translation: ADP89977.1 .
    HQ204828 Genomic DNA. Translation: ADP89979.1 .
    HQ204829 Genomic DNA. Translation: ADP89981.1 .
    HQ204830 Genomic DNA. Translation: ADP89983.1 .
    HQ204831 Genomic DNA. Translation: ADP89985.1 .
    HQ204832 Genomic DNA. Translation: ADP89987.1 .
    HQ204833 Genomic DNA. Translation: ADP89989.1 .
    HQ204834 Genomic DNA. Translation: ADP89991.1 .
    HQ204835 Genomic DNA. Translation: ADP89993.1 .
    HQ204836 Genomic DNA. Translation: ADP89995.1 .
    HQ204837 Genomic DNA. Translation: ADP89997.1 .
    HQ204838 Genomic DNA. Translation: ADP89999.1 .
    HQ204839 Genomic DNA. Translation: ADP90001.1 .
    HQ204840 Genomic DNA. Translation: ADP90003.1 .
    HQ204841 Genomic DNA. Translation: ADP90005.1 .
    HQ204842 Genomic DNA. Translation: ADP90007.1 .
    HQ204843 Genomic DNA. Translation: ADP90009.1 .
    HQ204844 Genomic DNA. Translation: ADP90011.1 .
    HQ204845 Genomic DNA. Translation: ADP90013.1 .
    HQ204846 Genomic DNA. Translation: ADP90015.1 .
    HQ204847 Genomic DNA. Translation: ADP90017.1 .
    HQ204848 Genomic DNA. Translation: ADP90019.1 .
    HQ204849 Genomic DNA. Translation: ADP90021.1 .
    HQ204850 Genomic DNA. Translation: ADP90023.1 .
    HQ204851 Genomic DNA. Translation: ADP90025.1 .
    HQ204852 Genomic DNA. Translation: ADP90027.1 .
    HQ204853 Genomic DNA. Translation: ADP90029.1 .
    HQ204854 Genomic DNA. Translation: ADP90031.1 .
    HQ204855 Genomic DNA. Translation: ADP90033.1 .
    HQ204856 Genomic DNA. Translation: ADP90035.1 .
    HQ204857 Genomic DNA. Translation: ADP90037.1 .
    HQ204858 Genomic DNA. Translation: ADP90039.1 .
    HQ204859 Genomic DNA. Translation: ADP90041.1 .
    HQ204860 Genomic DNA. Translation: ADP90043.1 .
    HQ204861 Genomic DNA. Translation: ADP90045.1 .
    HQ204862 Genomic DNA. Translation: ADP90047.1 .
    HQ204863 Genomic DNA. Translation: ADP90049.1 .
    HQ204864 Genomic DNA. Translation: ADP90051.1 .
    HQ204865 Genomic DNA. Translation: ADP90053.1 .
    CH471147 Genomic DNA. Translation: EAW80197.1 .
    RefSeqi NP_002302.2. NM_002311.4.
    UniGenei Hs.100299.

    3D structure databases

    SMRi E5KLB6. Positions 88-204, 257-833.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 3980.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3980.
    KEGGi hsa:3980.
    UCSCi uc002hij.3. human.

    Organism-specific databases

    CTDi 3980.

    Phylogenomic databases

    KOi K10776.

    Miscellaneous databases

    ChiTaRSi LIG3. human.
    GenomeRNAii 3980.
    NextBioi 15598.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1740.10. 1 hit.
    InterProi IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    IPR001510. Znf_PARP.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    PF00645. zf-PARP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    PS00347. PARP_ZN_FINGER_1. 1 hit.
    PS50064. PARP_ZN_FINGER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of the human genome."
      Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
      , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
      Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. Cited for: NUCLEOTIDE SEQUENCE.
    3. "Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing."
      Wang W., Shen P., Thiyagarajan S., Lin S., Palm C., Horvath R., Klopstock T., Cutler D., Pique L., Schrijver I., Davis R.W., Mindrinos M., Speed T.P., Scharfe C.
      Nucleic Acids Res. 39:44-58(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiE5KLB6_HUMAN
    AccessioniPrimary (citable) accession number: E5KLB6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 8, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.