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E5KLB6

- E5KLB6_HUMAN

UniProt

E5KLB6 - E5KLB6_HUMAN

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Protein

DNA ligase

Gene
LIG3, hCG_27675
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-KW
  3. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:LIG3Imported
ORF Names:hCG_27675Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: HPA
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10776.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.30.1740.10. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
IPR001510. Znf_PARP.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF00645. zf-PARP. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
PS00347. PARP_ZN_FINGER_1. 1 hit.
PS50064. PARP_ZN_FINGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E5KLB6-1 [UniParc]FASTAAdd to Basket

« Hide

MSLAFKIFFP QTLRALSRKE LCLFRKHHWR DVRQFSQWSE TDLLHGHPLF    50
LRRKPVLSFQ GSHLRSRATY LVFLPGLHVG LCSGPCEMAE QRFCVDYAKR 100
GTAGCKKCKE KIVKGVCRIG KVVPNPFSES GGDMKEWYHI KCMFEKLERA 150
RATTKKIEDL TELEGWEELE DNEKEQITQH IADLSSKAAG TPKKKAVVQA 200
KLTTTGQVTS PVKGASFVTS TNPRKFSGFS AKPNNSGEAP SSPTPKRSLS 250
SSKCDPRHKD CLLREFRKLC AMVADNPSYN TKTQIIQDFL RKGSAGDGFH 300
GDVYLTVKLL LPGVIKTVYN LNDKQIVKLF SRIFNCNPDD MARDLEQGDV 350
SETIRVFFEQ SKSFPPAAKS LLTIQEVDEF LLRLSKLTKE DEQQQALQDI 400
ASRCTANDLK CIIRLIKHDL KMNSGAKHVL DALDPNAYEA FKASRNLQDV 450
VERVLHNAQE VEKEPGQRRA LSVQASLMTP VQPMLAEACK SVEYAMKKCP 500
NGMFSEIKYD GERVQVHKNG DHFSYFSRSL KPVLPHKVAH FKDYIPQAFP 550
GGHSMILDSE VLLIDNKTGK PLPFGTLGVH KKAAFQDANV CLFVFDCIYF 600
NDVSLMDRPL CERRKFLHDN MVEIPNRIMF SEMKRVTKAL DLADMITRVI 650
QEGLEGLVLK DVKGTYEPGK RHWLKVKKDY LNEGAMADTA DLVVLGAFYG 700
QGSKGGMMSI FLMGCYDPGS QKWCTVTKCA GGHDDATLAR LQNELDMVKI 750
SKDPSKIPSW LKVNKIYYPD FIVPDPKKAA VWEITGAEFS KSEAHTADGI 800
SIRFPRCTRI RDDKDWKSAT NLPQLKELYQ LSKEKADFTV VAGDEGSSTT 850
GGSSEENKGP SGSAVSRKAP SKPSASTKKA EGKLSNSNSK DGNMQTAKPS 900
AMKVGEKLAT KSSPVKVGEK RKAADETLCQ TKRRPASEQR GRTVPAGRR 949
Length:949
Mass (Da):106,018
Last modified:February 8, 2011 - v1
Checksum:i0C10E40E0686DB77
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HQ204826 Genomic DNA. Translation: ADP89975.1.
HQ204827 Genomic DNA. Translation: ADP89977.1.
HQ204828 Genomic DNA. Translation: ADP89979.1.
HQ204829 Genomic DNA. Translation: ADP89981.1.
HQ204830 Genomic DNA. Translation: ADP89983.1.
HQ204831 Genomic DNA. Translation: ADP89985.1.
HQ204832 Genomic DNA. Translation: ADP89987.1.
HQ204833 Genomic DNA. Translation: ADP89989.1.
HQ204834 Genomic DNA. Translation: ADP89991.1.
HQ204835 Genomic DNA. Translation: ADP89993.1.
HQ204836 Genomic DNA. Translation: ADP89995.1.
HQ204837 Genomic DNA. Translation: ADP89997.1.
HQ204838 Genomic DNA. Translation: ADP89999.1.
HQ204839 Genomic DNA. Translation: ADP90001.1.
HQ204840 Genomic DNA. Translation: ADP90003.1.
HQ204841 Genomic DNA. Translation: ADP90005.1.
HQ204842 Genomic DNA. Translation: ADP90007.1.
HQ204843 Genomic DNA. Translation: ADP90009.1.
HQ204844 Genomic DNA. Translation: ADP90011.1.
HQ204845 Genomic DNA. Translation: ADP90013.1.
HQ204846 Genomic DNA. Translation: ADP90015.1.
HQ204847 Genomic DNA. Translation: ADP90017.1.
HQ204848 Genomic DNA. Translation: ADP90019.1.
HQ204849 Genomic DNA. Translation: ADP90021.1.
HQ204850 Genomic DNA. Translation: ADP90023.1.
HQ204851 Genomic DNA. Translation: ADP90025.1.
HQ204852 Genomic DNA. Translation: ADP90027.1.
HQ204853 Genomic DNA. Translation: ADP90029.1.
HQ204854 Genomic DNA. Translation: ADP90031.1.
HQ204855 Genomic DNA. Translation: ADP90033.1.
HQ204856 Genomic DNA. Translation: ADP90035.1.
HQ204857 Genomic DNA. Translation: ADP90037.1.
HQ204858 Genomic DNA. Translation: ADP90039.1.
HQ204859 Genomic DNA. Translation: ADP90041.1.
HQ204860 Genomic DNA. Translation: ADP90043.1.
HQ204861 Genomic DNA. Translation: ADP90045.1.
HQ204862 Genomic DNA. Translation: ADP90047.1.
HQ204863 Genomic DNA. Translation: ADP90049.1.
HQ204864 Genomic DNA. Translation: ADP90051.1.
HQ204865 Genomic DNA. Translation: ADP90053.1.
CH471147 Genomic DNA. Translation: EAW80197.1.
RefSeqiNP_002302.2. NM_002311.4.
UniGeneiHs.100299.

Genome annotation databases

GeneIDi3980.
KEGGihsa:3980.
UCSCiuc002hij.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HQ204826 Genomic DNA. Translation: ADP89975.1 .
HQ204827 Genomic DNA. Translation: ADP89977.1 .
HQ204828 Genomic DNA. Translation: ADP89979.1 .
HQ204829 Genomic DNA. Translation: ADP89981.1 .
HQ204830 Genomic DNA. Translation: ADP89983.1 .
HQ204831 Genomic DNA. Translation: ADP89985.1 .
HQ204832 Genomic DNA. Translation: ADP89987.1 .
HQ204833 Genomic DNA. Translation: ADP89989.1 .
HQ204834 Genomic DNA. Translation: ADP89991.1 .
HQ204835 Genomic DNA. Translation: ADP89993.1 .
HQ204836 Genomic DNA. Translation: ADP89995.1 .
HQ204837 Genomic DNA. Translation: ADP89997.1 .
HQ204838 Genomic DNA. Translation: ADP89999.1 .
HQ204839 Genomic DNA. Translation: ADP90001.1 .
HQ204840 Genomic DNA. Translation: ADP90003.1 .
HQ204841 Genomic DNA. Translation: ADP90005.1 .
HQ204842 Genomic DNA. Translation: ADP90007.1 .
HQ204843 Genomic DNA. Translation: ADP90009.1 .
HQ204844 Genomic DNA. Translation: ADP90011.1 .
HQ204845 Genomic DNA. Translation: ADP90013.1 .
HQ204846 Genomic DNA. Translation: ADP90015.1 .
HQ204847 Genomic DNA. Translation: ADP90017.1 .
HQ204848 Genomic DNA. Translation: ADP90019.1 .
HQ204849 Genomic DNA. Translation: ADP90021.1 .
HQ204850 Genomic DNA. Translation: ADP90023.1 .
HQ204851 Genomic DNA. Translation: ADP90025.1 .
HQ204852 Genomic DNA. Translation: ADP90027.1 .
HQ204853 Genomic DNA. Translation: ADP90029.1 .
HQ204854 Genomic DNA. Translation: ADP90031.1 .
HQ204855 Genomic DNA. Translation: ADP90033.1 .
HQ204856 Genomic DNA. Translation: ADP90035.1 .
HQ204857 Genomic DNA. Translation: ADP90037.1 .
HQ204858 Genomic DNA. Translation: ADP90039.1 .
HQ204859 Genomic DNA. Translation: ADP90041.1 .
HQ204860 Genomic DNA. Translation: ADP90043.1 .
HQ204861 Genomic DNA. Translation: ADP90045.1 .
HQ204862 Genomic DNA. Translation: ADP90047.1 .
HQ204863 Genomic DNA. Translation: ADP90049.1 .
HQ204864 Genomic DNA. Translation: ADP90051.1 .
HQ204865 Genomic DNA. Translation: ADP90053.1 .
CH471147 Genomic DNA. Translation: EAW80197.1 .
RefSeqi NP_002302.2. NM_002311.4.
UniGenei Hs.100299.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

DNASUi 3980.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3980.
KEGGi hsa:3980.
UCSCi uc002hij.3. human.

Organism-specific databases

CTDi 3980.

Phylogenomic databases

KOi K10776.

Miscellaneous databases

ChiTaRSi LIG3. human.
GenomeRNAii 3980.
NextBioi 15598.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.30.1740.10. 1 hit.
InterProi IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
IPR001510. Znf_PARP.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF00645. zf-PARP. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
PS00347. PARP_ZN_FINGER_1. 1 hit.
PS50064. PARP_ZN_FINGER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE.
  3. "Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing."
    Wang W., Shen P., Thiyagarajan S., Lin S., Palm C., Horvath R., Klopstock T., Cutler D., Pique L., Schrijver I., Davis R.W., Mindrinos M., Speed T.P., Scharfe C.
    Nucleic Acids Res. 39:44-58(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiE5KLB6_HUMAN
AccessioniPrimary (citable) accession number: E5KLB6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: July 9, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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