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E5KLB5

- E5KLB5_HUMAN

UniProt

E5KLB5 - E5KLB5_HUMAN

Protein

DNA ligase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-EC
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. base-excision repair, DNA ligation Source: Ensembl
    2. DNA recombination Source: UniProtKB-KW
    3. DNA replication Source: UniProtKB-KW
    4. double-strand break repair via nonhomologous end joining Source: Ensembl
    5. mitochondrial DNA repair Source: Ensembl
    6. negative regulation of DNA recombination Source: Ensembl

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: HPA
    2. synaptonemal complex Source: Ensembl

    Structurei

    3D structure databases

    SMRiE5KLB5. Positions 88-204, 257-833, 928-1008.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK10776.
    OMAiLFSEMKH.
    PhylomeDBiE5KLB5.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1740.10. 1 hit.
    3.40.50.10190. 1 hit.
    InterProiIPR001357. BRCT_dom.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    IPR001510. Znf_PARP.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    PF00645. zf-PARP. 1 hit.
    [Graphical view]
    SMARTiSM00292. BRCT. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF52113. SSF52113. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS50172. BRCT. 1 hit.
    PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    PS00347. PARP_ZN_FINGER_1. 1 hit.
    PS50064. PARP_ZN_FINGER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E5KLB5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLAFKIFFP QTLRALSRKE LCLFRKHHWR DVRQFSQWSE TDLLHGHPLF     50
    LRRKPVLSFQ GSHLRSRATY LVFLPGLHVG LCSGPCEMAE QRFCVDYAKR 100
    GTAGCKKCKE KIVKGVCRIG KVVPNPFSES GGDMKEWYHI KCMFEKLERA 150
    RATTKKIEDL TELEGWEELE DNEKEQITQH IADLSSKAAG TPKKKAVVQA 200
    KLTTTGQVTS PVKGASFVTS TNPRKFSGFS AKPNNSGEAP SSPTPKRSLS 250
    SSKCDPRHKD CLLREFRKLC AMVADNPSYN TKTQIIQDFL RKGSAGDGFH 300
    GDVYLTVKLL LPGVIKTVYN LNDKQIVKLF SRIFNCNPDD MARDLEQGDV 350
    SETIRVFFEQ SKSFPPAAKS LLTIQEVDEF LLRLSKLTKE DEQQQALQDI 400
    ASRCTANDLK CIIRLIKHDL KMNSGAKHVL DALDPNAYEA FKASRNLQDV 450
    VERVLHNAQE VEKEPGQRRA LSVQASLMTP VQPMLAEACK SVEYAMKKCP 500
    NGMFSEIKYD GERVQVHKNG DHFSYFSRSL KPVLPHKVAH FKDYIPQAFP 550
    GGHSMILDSE VLLIDNKTGK PLPFGTLGVH KKAAFQDANV CLFVFDCIYF 600
    NDVSLMDRPL CERRKFLHDN MVEIPNRIMF SEMKRVTKAL DLADMITRVI 650
    QEGLEGLVLK DVKGTYEPGK RHWLKVKKDY LNEGAMADTA DLVVLGAFYG 700
    QGSKGGMMSI FLMGCYDPGS QKWCTVTKCA GGHDDATLAR LQNELDMVKI 750
    SKDPSKIPSW LKVNKIYYPD FIVPDPKKAA VWEITGAEFS KSEAHTADGI 800
    SIRFPRCTRI RDDKDWKSAT NLPQLKELYQ LSKEKADFTV VAGDEGSSTT 850
    GGSSEENKGP SGSAVSRKAP SKPSASTKKA EGKLSNSNSK DGNMQTAKPS 900
    AMKVGEKLAT KSSPVKVGEK RKAADETLCQ TKVLLDIFTG VRLYLPPSTP 950
    DFSRLRRYFV AFDGDLVQEF DMTSATHVLG SRDKNPAAQQ VSPEWIWACI 1000
    RKRRLVAPC 1009
    Length:1,009
    Mass (Da):112,907
    Last modified:February 8, 2011 - v1
    Checksum:i0E4057E33C3F19A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HQ204826 Genomic DNA. Translation: ADP89974.1.
    HQ204827 Genomic DNA. Translation: ADP89976.1.
    HQ204828 Genomic DNA. Translation: ADP89978.1.
    HQ204829 Genomic DNA. Translation: ADP89980.1.
    HQ204830 Genomic DNA. Translation: ADP89982.1.
    HQ204831 Genomic DNA. Translation: ADP89984.1.
    HQ204832 Genomic DNA. Translation: ADP89986.1.
    HQ204833 Genomic DNA. Translation: ADP89988.1.
    HQ204834 Genomic DNA. Translation: ADP89990.1.
    HQ204835 Genomic DNA. Translation: ADP89992.1.
    HQ204836 Genomic DNA. Translation: ADP89994.1.
    HQ204837 Genomic DNA. Translation: ADP89996.1.
    HQ204838 Genomic DNA. Translation: ADP89998.1.
    HQ204839 Genomic DNA. Translation: ADP90000.1.
    HQ204840 Genomic DNA. Translation: ADP90002.1.
    HQ204841 Genomic DNA. Translation: ADP90004.1.
    HQ204842 Genomic DNA. Translation: ADP90006.1.
    HQ204843 Genomic DNA. Translation: ADP90008.1.
    HQ204844 Genomic DNA. Translation: ADP90010.1.
    HQ204845 Genomic DNA. Translation: ADP90012.1.
    HQ204846 Genomic DNA. Translation: ADP90014.1.
    HQ204847 Genomic DNA. Translation: ADP90016.1.
    HQ204848 Genomic DNA. Translation: ADP90018.1.
    HQ204849 Genomic DNA. Translation: ADP90020.1.
    HQ204850 Genomic DNA. Translation: ADP90022.1.
    HQ204851 Genomic DNA. Translation: ADP90024.1.
    HQ204852 Genomic DNA. Translation: ADP90026.1.
    HQ204853 Genomic DNA. Translation: ADP90028.1.
    HQ204854 Genomic DNA. Translation: ADP90030.1.
    HQ204855 Genomic DNA. Translation: ADP90032.1.
    HQ204856 Genomic DNA. Translation: ADP90034.1.
    HQ204857 Genomic DNA. Translation: ADP90036.1.
    HQ204858 Genomic DNA. Translation: ADP90038.1.
    HQ204859 Genomic DNA. Translation: ADP90040.1.
    HQ204860 Genomic DNA. Translation: ADP90042.1.
    HQ204861 Genomic DNA. Translation: ADP90044.1.
    HQ204862 Genomic DNA. Translation: ADP90046.1.
    HQ204863 Genomic DNA. Translation: ADP90048.1.
    HQ204864 Genomic DNA. Translation: ADP90050.1.
    HQ204865 Genomic DNA. Translation: ADP90052.1.
    RefSeqiNP_039269.2. NM_013975.3.
    XP_005258028.1. XM_005257971.2.
    UniGeneiHs.100299.

    Genome annotation databases

    GeneIDi3980.
    KEGGihsa:3980.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HQ204826 Genomic DNA. Translation: ADP89974.1 .
    HQ204827 Genomic DNA. Translation: ADP89976.1 .
    HQ204828 Genomic DNA. Translation: ADP89978.1 .
    HQ204829 Genomic DNA. Translation: ADP89980.1 .
    HQ204830 Genomic DNA. Translation: ADP89982.1 .
    HQ204831 Genomic DNA. Translation: ADP89984.1 .
    HQ204832 Genomic DNA. Translation: ADP89986.1 .
    HQ204833 Genomic DNA. Translation: ADP89988.1 .
    HQ204834 Genomic DNA. Translation: ADP89990.1 .
    HQ204835 Genomic DNA. Translation: ADP89992.1 .
    HQ204836 Genomic DNA. Translation: ADP89994.1 .
    HQ204837 Genomic DNA. Translation: ADP89996.1 .
    HQ204838 Genomic DNA. Translation: ADP89998.1 .
    HQ204839 Genomic DNA. Translation: ADP90000.1 .
    HQ204840 Genomic DNA. Translation: ADP90002.1 .
    HQ204841 Genomic DNA. Translation: ADP90004.1 .
    HQ204842 Genomic DNA. Translation: ADP90006.1 .
    HQ204843 Genomic DNA. Translation: ADP90008.1 .
    HQ204844 Genomic DNA. Translation: ADP90010.1 .
    HQ204845 Genomic DNA. Translation: ADP90012.1 .
    HQ204846 Genomic DNA. Translation: ADP90014.1 .
    HQ204847 Genomic DNA. Translation: ADP90016.1 .
    HQ204848 Genomic DNA. Translation: ADP90018.1 .
    HQ204849 Genomic DNA. Translation: ADP90020.1 .
    HQ204850 Genomic DNA. Translation: ADP90022.1 .
    HQ204851 Genomic DNA. Translation: ADP90024.1 .
    HQ204852 Genomic DNA. Translation: ADP90026.1 .
    HQ204853 Genomic DNA. Translation: ADP90028.1 .
    HQ204854 Genomic DNA. Translation: ADP90030.1 .
    HQ204855 Genomic DNA. Translation: ADP90032.1 .
    HQ204856 Genomic DNA. Translation: ADP90034.1 .
    HQ204857 Genomic DNA. Translation: ADP90036.1 .
    HQ204858 Genomic DNA. Translation: ADP90038.1 .
    HQ204859 Genomic DNA. Translation: ADP90040.1 .
    HQ204860 Genomic DNA. Translation: ADP90042.1 .
    HQ204861 Genomic DNA. Translation: ADP90044.1 .
    HQ204862 Genomic DNA. Translation: ADP90046.1 .
    HQ204863 Genomic DNA. Translation: ADP90048.1 .
    HQ204864 Genomic DNA. Translation: ADP90050.1 .
    HQ204865 Genomic DNA. Translation: ADP90052.1 .
    RefSeqi NP_039269.2. NM_013975.3.
    XP_005258028.1. XM_005257971.2.
    UniGenei Hs.100299.

    3D structure databases

    SMRi E5KLB5. Positions 88-204, 257-833, 928-1008.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 3980.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3980.
    KEGGi hsa:3980.

    Organism-specific databases

    CTDi 3980.

    Phylogenomic databases

    KOi K10776.
    OMAi LFSEMKH.
    PhylomeDBi E5KLB5.

    Miscellaneous databases

    GenomeRNAii 3980.
    NextBioi 15598.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1740.10. 1 hit.
    3.40.50.10190. 1 hit.
    InterProi IPR001357. BRCT_dom.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    IPR001510. Znf_PARP.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    PF00645. zf-PARP. 1 hit.
    [Graphical view ]
    SMARTi SM00292. BRCT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF52113. SSF52113. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS50172. BRCT. 1 hit.
    PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    PS00347. PARP_ZN_FINGER_1. 1 hit.
    PS50064. PARP_ZN_FINGER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing."
      Wang W., Shen P., Thiyagarajan S., Lin S., Palm C., Horvath R., Klopstock T., Cutler D., Pique L., Schrijver I., Davis R.W., Mindrinos M., Speed T.P., Scharfe C.
      Nucleic Acids Res. 39:44-58(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiE5KLB5_HUMAN
    AccessioniPrimary (citable) accession number: E5KLB5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 8, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.