DNA ligase - Homo sapiens (Human)

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E5KLB5 (E5KLB5_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 20. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names	Recommended name: DNA ligase RuleBase RU000617 EC=6.5.1.1 RuleBase RU000617
Organism	Homo sapiens (Human) EMBL ADP89974.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1009 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). RuleBase RU000617
Sequence similarities	Belongs to the ATP-dependent DNA ligase family.

Ontologies

Keywords
Biological process	DNA damage DNA recombination RuleBase RU000617 DNA repair RuleBase RU000617 DNA replication RuleBase RU000617
Ligand	ATP-binding RuleBase RU000617 Nucleotide-binding
Molecular function	Ligase RuleBase RU000617 EMBL ADP89974.1
Gene Ontology (GO)
Biological_process	DNA ligation involved in DNA repair Inferred from electronic annotation. Source: InterPro DNA recombination Inferred from electronic annotation. Source: UniProtKB-KW DNA replication Inferred from electronic annotation. Source: UniProtKB-KW double-strand break repair via nonhomologous end joining Inferred from electronic annotation. Source: Compara mitochondrial DNA repair Inferred from electronic annotation. Source: Compara negative regulation of DNA recombination Inferred from electronic annotation. Source: Compara
Cellular_component	mitochondrion Inferred from electronic annotation. Source: Compara nucleus Inferred from direct assay. Source: HPA synaptonemal complex Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: InterPro DNA ligase (ATP) activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

E5KLB5 [UniParc].

Last modified February 8, 2011. Version 1.
Checksum: 0E4057E33C3F19A6
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FASTA

1,009

112,907

        10         20         30         40         50         60 
MSLAFKIFFP QTLRALSRKE LCLFRKHHWR DVRQFSQWSE TDLLHGHPLF LRRKPVLSFQ 

        70         80         90        100        110        120 
GSHLRSRATY LVFLPGLHVG LCSGPCEMAE QRFCVDYAKR GTAGCKKCKE KIVKGVCRIG 

       130        140        150        160        170        180 
KVVPNPFSES GGDMKEWYHI KCMFEKLERA RATTKKIEDL TELEGWEELE DNEKEQITQH 

       190        200        210        220        230        240 
IADLSSKAAG TPKKKAVVQA KLTTTGQVTS PVKGASFVTS TNPRKFSGFS AKPNNSGEAP 

       250        260        270        280        290        300 
SSPTPKRSLS SSKCDPRHKD CLLREFRKLC AMVADNPSYN TKTQIIQDFL RKGSAGDGFH 

       310        320        330        340        350        360 
GDVYLTVKLL LPGVIKTVYN LNDKQIVKLF SRIFNCNPDD MARDLEQGDV SETIRVFFEQ 

       370        380        390        400        410        420 
SKSFPPAAKS LLTIQEVDEF LLRLSKLTKE DEQQQALQDI ASRCTANDLK CIIRLIKHDL 

       430        440        450        460        470        480 
KMNSGAKHVL DALDPNAYEA FKASRNLQDV VERVLHNAQE VEKEPGQRRA LSVQASLMTP 

       490        500        510        520        530        540 
VQPMLAEACK SVEYAMKKCP NGMFSEIKYD GERVQVHKNG DHFSYFSRSL KPVLPHKVAH 

       550        560        570        580        590        600 
FKDYIPQAFP GGHSMILDSE VLLIDNKTGK PLPFGTLGVH KKAAFQDANV CLFVFDCIYF 

       610        620        630        640        650        660 
NDVSLMDRPL CERRKFLHDN MVEIPNRIMF SEMKRVTKAL DLADMITRVI QEGLEGLVLK 

       670        680        690        700        710        720 
DVKGTYEPGK RHWLKVKKDY LNEGAMADTA DLVVLGAFYG QGSKGGMMSI FLMGCYDPGS 

       730        740        750        760        770        780 
QKWCTVTKCA GGHDDATLAR LQNELDMVKI SKDPSKIPSW LKVNKIYYPD FIVPDPKKAA 

       790        800        810        820        830        840 
VWEITGAEFS KSEAHTADGI SIRFPRCTRI RDDKDWKSAT NLPQLKELYQ LSKEKADFTV 

       850        860        870        880        890        900 
VAGDEGSSTT GGSSEENKGP SGSAVSRKAP SKPSASTKKA EGKLSNSNSK DGNMQTAKPS 

       910        920        930        940        950        960 
AMKVGEKLAT KSSPVKVGEK RKAADETLCQ TKVLLDIFTG VRLYLPPSTP DFSRLRRYFV 

       970        980        990       1000 
AFDGDLVQEF DMTSATHVLG SRDKNPAAQQ VSPEWIWACI RKRRLVAPC

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References

[1]	"Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing." Wang W., Shen P., Thiyagarajan S., Lin S., Palm C., Horvath R., Klopstock T., Cutler D., Pique L., Schrijver I., Davis R.W., Mindrinos M., Speed T.P., Scharfe C. Nucleic Acids Res. 39:44-58(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	HQ204826 Genomic DNA. Translation: ADP89974.1. HQ204827 Genomic DNA. Translation: ADP89976.1. HQ204828 Genomic DNA. Translation: ADP89978.1. HQ204829 Genomic DNA. Translation: ADP89980.1. HQ204830 Genomic DNA. Translation: ADP89982.1. HQ204831 Genomic DNA. Translation: ADP89984.1. HQ204832 Genomic DNA. Translation: ADP89986.1. HQ204833 Genomic DNA. Translation: ADP89988.1. HQ204834 Genomic DNA. Translation: ADP89990.1. HQ204835 Genomic DNA. Translation: ADP89992.1. HQ204836 Genomic DNA. Translation: ADP89994.1. HQ204837 Genomic DNA. Translation: ADP89996.1. HQ204838 Genomic DNA. Translation: ADP89998.1. HQ204839 Genomic DNA. Translation: ADP90000.1. HQ204840 Genomic DNA. Translation: ADP90002.1. HQ204841 Genomic DNA. Translation: ADP90004.1. HQ204842 Genomic DNA. Translation: ADP90006.1. HQ204843 Genomic DNA. Translation: ADP90008.1. HQ204844 Genomic DNA. Translation: ADP90010.1. HQ204845 Genomic DNA. Translation: ADP90012.1. HQ204846 Genomic DNA. Translation: ADP90014.1. HQ204847 Genomic DNA. Translation: ADP90016.1. HQ204848 Genomic DNA. Translation: ADP90018.1. HQ204849 Genomic DNA. Translation: ADP90020.1. HQ204850 Genomic DNA. Translation: ADP90022.1. HQ204851 Genomic DNA. Translation: ADP90024.1. HQ204852 Genomic DNA. Translation: ADP90026.1. HQ204853 Genomic DNA. Translation: ADP90028.1. HQ204854 Genomic DNA. Translation: ADP90030.1. HQ204855 Genomic DNA. Translation: ADP90032.1. HQ204856 Genomic DNA. Translation: ADP90034.1. HQ204857 Genomic DNA. Translation: ADP90036.1. HQ204858 Genomic DNA. Translation: ADP90038.1. HQ204859 Genomic DNA. Translation: ADP90040.1. HQ204860 Genomic DNA. Translation: ADP90042.1. HQ204861 Genomic DNA. Translation: ADP90044.1. HQ204862 Genomic DNA. Translation: ADP90046.1. HQ204863 Genomic DNA. Translation: ADP90048.1. HQ204864 Genomic DNA. Translation: ADP90050.1. HQ204865 Genomic DNA. Translation: ADP90052.1.
IPI	IPI00029081.
RefSeq	NP_039269.2. NM_013975.3.
UniGene	Hs.100299.
3D structure databases
ProteinModelPortal	E5KLB5.
ModBase	Search...
Proteomic databases
PRIDE	E5KLB5.
Protocols and materials databases
DNASU	3980.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3980.
KEGG	hsa:3980.
Organism-specific databases
CTD	3980.
Phylogenomic databases
KO	K10776.
OMA	WSETDLL.
Gene expression databases
ArrayExpress	E5KLB5.
Bgee	E5KLB5.
Family and domain databases
Gene3D	1.10.3260.10. 1 hit. 2.40.50.140. 1 hit. 3.30.1740.10. 1 hit.
InterPro	IPR001357. BRCT_dom. IPR000977. DNA_ligase_ATP-dep. IPR012309. DNA_ligase_ATP-dep_C. IPR012310. DNA_ligase_ATP-dep_cent. IPR016059. DNA_ligase_ATP-dep_CS. IPR012308. DNA_ligase_ATP-dep_N. IPR012340. NA-bd_OB-fold. IPR001510. Znf_PARP. [Graphical view]
Pfam	PF04679. DNA_ligase_A_C. 1 hit. PF01068. DNA_ligase_A_M. 1 hit. PF04675. DNA_ligase_A_N. 1 hit. PF00645. zf-PARP. 1 hit. [Graphical view]
SMART	SM00292. BRCT. 1 hit. [Graphical view]
SUPFAM	SSF52113. BRCT. 1 hit. SSF50249. Nucleic_acid_OB. 1 hit. SSF117018. SSF117018. 1 hit.
TIGRFAMs	TIGR00574. dnl1. 1 hit.
PROSITE	PS50172. BRCT. 1 hit. PS00697. DNA_LIGASE_A1. 1 hit. PS00333. DNA_LIGASE_A2. 1 hit. PS50160. DNA_LIGASE_A3. 1 hit. PS00347. PARP_ZN_FINGER_1. 1 hit. PS50064. PARP_ZN_FINGER_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	3980.
NextBio	15598.

Entry information

Entry name

E5KLB5_HUMAN

Accession

Primary (citable) accession number: E5KLB5

Entry history

Integrated into UniProtKB/TrEMBL:	February 8, 2011
Last sequence update:	February 8, 2011
Last modified:	May 1, 2013
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information