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E5KLB5

- E5KLB5_HUMAN

UniProt

E5KLB5 - E5KLB5_HUMAN

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Protein

DNA ligase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. base-excision repair, DNA ligation Source: Ensembl
  2. DNA biosynthetic process Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
  5. double-strand break repair via nonhomologous end joining Source: Ensembl
  6. mitochondrial DNA repair Source: Ensembl
  7. negative regulation of DNA recombination Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: HPA
  2. synaptonemal complex Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiE5KLB5. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE5KLB5.
SMRiE5KLB5. Positions 88-204, 257-833, 928-1008.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10776.
OMAiLFSEMKH.
PhylomeDBiE5KLB5.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.30.1740.10. 1 hit.
3.40.50.10190. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
IPR001510. Znf_PARP.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF00645. zf-PARP. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
PS00347. PARP_ZN_FINGER_1. 1 hit.
PS50064. PARP_ZN_FINGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E5KLB5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLAFKIFFP QTLRALSRKE LCLFRKHHWR DVRQFSQWSE TDLLHGHPLF
60 70 80 90 100
LRRKPVLSFQ GSHLRSRATY LVFLPGLHVG LCSGPCEMAE QRFCVDYAKR
110 120 130 140 150
GTAGCKKCKE KIVKGVCRIG KVVPNPFSES GGDMKEWYHI KCMFEKLERA
160 170 180 190 200
RATTKKIEDL TELEGWEELE DNEKEQITQH IADLSSKAAG TPKKKAVVQA
210 220 230 240 250
KLTTTGQVTS PVKGASFVTS TNPRKFSGFS AKPNNSGEAP SSPTPKRSLS
260 270 280 290 300
SSKCDPRHKD CLLREFRKLC AMVADNPSYN TKTQIIQDFL RKGSAGDGFH
310 320 330 340 350
GDVYLTVKLL LPGVIKTVYN LNDKQIVKLF SRIFNCNPDD MARDLEQGDV
360 370 380 390 400
SETIRVFFEQ SKSFPPAAKS LLTIQEVDEF LLRLSKLTKE DEQQQALQDI
410 420 430 440 450
ASRCTANDLK CIIRLIKHDL KMNSGAKHVL DALDPNAYEA FKASRNLQDV
460 470 480 490 500
VERVLHNAQE VEKEPGQRRA LSVQASLMTP VQPMLAEACK SVEYAMKKCP
510 520 530 540 550
NGMFSEIKYD GERVQVHKNG DHFSYFSRSL KPVLPHKVAH FKDYIPQAFP
560 570 580 590 600
GGHSMILDSE VLLIDNKTGK PLPFGTLGVH KKAAFQDANV CLFVFDCIYF
610 620 630 640 650
NDVSLMDRPL CERRKFLHDN MVEIPNRIMF SEMKRVTKAL DLADMITRVI
660 670 680 690 700
QEGLEGLVLK DVKGTYEPGK RHWLKVKKDY LNEGAMADTA DLVVLGAFYG
710 720 730 740 750
QGSKGGMMSI FLMGCYDPGS QKWCTVTKCA GGHDDATLAR LQNELDMVKI
760 770 780 790 800
SKDPSKIPSW LKVNKIYYPD FIVPDPKKAA VWEITGAEFS KSEAHTADGI
810 820 830 840 850
SIRFPRCTRI RDDKDWKSAT NLPQLKELYQ LSKEKADFTV VAGDEGSSTT
860 870 880 890 900
GGSSEENKGP SGSAVSRKAP SKPSASTKKA EGKLSNSNSK DGNMQTAKPS
910 920 930 940 950
AMKVGEKLAT KSSPVKVGEK RKAADETLCQ TKVLLDIFTG VRLYLPPSTP
960 970 980 990 1000
DFSRLRRYFV AFDGDLVQEF DMTSATHVLG SRDKNPAAQQ VSPEWIWACI

RKRRLVAPC
Length:1,009
Mass (Da):112,907
Last modified:February 8, 2011 - v1
Checksum:i0E4057E33C3F19A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HQ204826 Genomic DNA. Translation: ADP89974.1.
HQ204827 Genomic DNA. Translation: ADP89976.1.
HQ204828 Genomic DNA. Translation: ADP89978.1.
HQ204829 Genomic DNA. Translation: ADP89980.1.
HQ204830 Genomic DNA. Translation: ADP89982.1.
HQ204831 Genomic DNA. Translation: ADP89984.1.
HQ204832 Genomic DNA. Translation: ADP89986.1.
HQ204833 Genomic DNA. Translation: ADP89988.1.
HQ204834 Genomic DNA. Translation: ADP89990.1.
HQ204835 Genomic DNA. Translation: ADP89992.1.
HQ204836 Genomic DNA. Translation: ADP89994.1.
HQ204837 Genomic DNA. Translation: ADP89996.1.
HQ204838 Genomic DNA. Translation: ADP89998.1.
HQ204839 Genomic DNA. Translation: ADP90000.1.
HQ204840 Genomic DNA. Translation: ADP90002.1.
HQ204841 Genomic DNA. Translation: ADP90004.1.
HQ204842 Genomic DNA. Translation: ADP90006.1.
HQ204843 Genomic DNA. Translation: ADP90008.1.
HQ204844 Genomic DNA. Translation: ADP90010.1.
HQ204845 Genomic DNA. Translation: ADP90012.1.
HQ204846 Genomic DNA. Translation: ADP90014.1.
HQ204847 Genomic DNA. Translation: ADP90016.1.
HQ204848 Genomic DNA. Translation: ADP90018.1.
HQ204849 Genomic DNA. Translation: ADP90020.1.
HQ204850 Genomic DNA. Translation: ADP90022.1.
HQ204851 Genomic DNA. Translation: ADP90024.1.
HQ204852 Genomic DNA. Translation: ADP90026.1.
HQ204853 Genomic DNA. Translation: ADP90028.1.
HQ204854 Genomic DNA. Translation: ADP90030.1.
HQ204855 Genomic DNA. Translation: ADP90032.1.
HQ204856 Genomic DNA. Translation: ADP90034.1.
HQ204857 Genomic DNA. Translation: ADP90036.1.
HQ204858 Genomic DNA. Translation: ADP90038.1.
HQ204859 Genomic DNA. Translation: ADP90040.1.
HQ204860 Genomic DNA. Translation: ADP90042.1.
HQ204861 Genomic DNA. Translation: ADP90044.1.
HQ204862 Genomic DNA. Translation: ADP90046.1.
HQ204863 Genomic DNA. Translation: ADP90048.1.
HQ204864 Genomic DNA. Translation: ADP90050.1.
HQ204865 Genomic DNA. Translation: ADP90052.1.
RefSeqiNP_039269.2. NM_013975.3.
XP_005258028.1. XM_005257971.2.
UniGeneiHs.100299.

Genome annotation databases

GeneIDi3980.
KEGGihsa:3980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HQ204826 Genomic DNA. Translation: ADP89974.1 .
HQ204827 Genomic DNA. Translation: ADP89976.1 .
HQ204828 Genomic DNA. Translation: ADP89978.1 .
HQ204829 Genomic DNA. Translation: ADP89980.1 .
HQ204830 Genomic DNA. Translation: ADP89982.1 .
HQ204831 Genomic DNA. Translation: ADP89984.1 .
HQ204832 Genomic DNA. Translation: ADP89986.1 .
HQ204833 Genomic DNA. Translation: ADP89988.1 .
HQ204834 Genomic DNA. Translation: ADP89990.1 .
HQ204835 Genomic DNA. Translation: ADP89992.1 .
HQ204836 Genomic DNA. Translation: ADP89994.1 .
HQ204837 Genomic DNA. Translation: ADP89996.1 .
HQ204838 Genomic DNA. Translation: ADP89998.1 .
HQ204839 Genomic DNA. Translation: ADP90000.1 .
HQ204840 Genomic DNA. Translation: ADP90002.1 .
HQ204841 Genomic DNA. Translation: ADP90004.1 .
HQ204842 Genomic DNA. Translation: ADP90006.1 .
HQ204843 Genomic DNA. Translation: ADP90008.1 .
HQ204844 Genomic DNA. Translation: ADP90010.1 .
HQ204845 Genomic DNA. Translation: ADP90012.1 .
HQ204846 Genomic DNA. Translation: ADP90014.1 .
HQ204847 Genomic DNA. Translation: ADP90016.1 .
HQ204848 Genomic DNA. Translation: ADP90018.1 .
HQ204849 Genomic DNA. Translation: ADP90020.1 .
HQ204850 Genomic DNA. Translation: ADP90022.1 .
HQ204851 Genomic DNA. Translation: ADP90024.1 .
HQ204852 Genomic DNA. Translation: ADP90026.1 .
HQ204853 Genomic DNA. Translation: ADP90028.1 .
HQ204854 Genomic DNA. Translation: ADP90030.1 .
HQ204855 Genomic DNA. Translation: ADP90032.1 .
HQ204856 Genomic DNA. Translation: ADP90034.1 .
HQ204857 Genomic DNA. Translation: ADP90036.1 .
HQ204858 Genomic DNA. Translation: ADP90038.1 .
HQ204859 Genomic DNA. Translation: ADP90040.1 .
HQ204860 Genomic DNA. Translation: ADP90042.1 .
HQ204861 Genomic DNA. Translation: ADP90044.1 .
HQ204862 Genomic DNA. Translation: ADP90046.1 .
HQ204863 Genomic DNA. Translation: ADP90048.1 .
HQ204864 Genomic DNA. Translation: ADP90050.1 .
HQ204865 Genomic DNA. Translation: ADP90052.1 .
RefSeqi NP_039269.2. NM_013975.3.
XP_005258028.1. XM_005257971.2.
UniGenei Hs.100299.

3D structure databases

ProteinModelPortali E5KLB5.
SMRi E5KLB5. Positions 88-204, 257-833, 928-1008.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

DNASUi 3980.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3980.
KEGGi hsa:3980.

Organism-specific databases

CTDi 3980.

Phylogenomic databases

KOi K10776.
OMAi LFSEMKH.
PhylomeDBi E5KLB5.

Miscellaneous databases

GenomeRNAii 3980.
NextBioi 15598.

Gene expression databases

ExpressionAtlasi E5KLB5. baseline and differential.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.30.1740.10. 1 hit.
3.40.50.10190. 1 hit.
InterProi IPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
IPR001510. Znf_PARP.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF00645. zf-PARP. 1 hit.
[Graphical view ]
SMARTi SM00292. BRCT. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
PS00347. PARP_ZN_FINGER_1. 1 hit.
PS50064. PARP_ZN_FINGER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing."
    Wang W., Shen P., Thiyagarajan S., Lin S., Palm C., Horvath R., Klopstock T., Cutler D., Pique L., Schrijver I., Davis R.W., Mindrinos M., Speed T.P., Scharfe C.
    Nucleic Acids Res. 39:44-58(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiE5KLB5_HUMAN
AccessioniPrimary (citable) accession number: E5KLB5
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: October 29, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.