ID E5KIY2_ECOLX Unreviewed; 270 AA. AC E5KIY2; DT 08-FEB-2011, integrated into UniProtKB/TrEMBL. DT 08-FEB-2011, sequence version 1. DT 27-MAR-2024, entry version 115. DE RecName: Full=Metallo-beta-lactamase type 2 {ECO:0000256|ARBA:ARBA00017223}; DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865}; DE AltName: Full=B2 metallo-beta-lactamase {ECO:0000256|ARBA:ARBA00030107}; DE AltName: Full=Metallo-beta-lactamase type II {ECO:0000256|ARBA:ARBA00033087}; GN Name=blaNDM-1 {ECO:0000313|EMBL:ADY00041.1}; GN Synonyms=bla NDM-1 {ECO:0000313|EMBL:AFN73221.1}; GN ORFNames=A9X72_27270 {ECO:0000313|EMBL:AVU68806.1}, AZ95_0035 GN {ECO:0000313|EMBL:ALF35449.1}, BANRA_05542 GN {ECO:0000313|EMBL:VCZ28695.1}, E4K51_24975 GN {ECO:0000313|EMBL:MQS33320.1}, ECS01_0033 GN {ECO:0000313|EMBL:AHX39447.1}, G5603_25730 GN {ECO:0000313|EMBL:NGE91514.1}, G9448_24155 GN {ECO:0000313|EMBL:QLA46110.1}, NDM1Dok01_N0175 GN {ECO:0000313|EMBL:BAK69668.1}, pNDM102337_147 GN {ECO:0000313|EMBL:AEP32605.1}, pNDM10505_149 GN {ECO:0000313|EMBL:AEN71485.1}; OS Escherichia coli. OG Plasmid p271A {ECO:0000313|EMBL:AEK64842.1}, OG Plasmid pABC85 {ECO:0000313|EMBL:AGB57374.1}, OG Plasmid pACT1-EC-NDM-1 {ECO:0000313|EMBL:AKN35214.1}, OG Plasmid pACT2-NDM-1 {ECO:0000313|EMBL:AKN35231.1}, OG Plasmid pBJ01 {ECO:0000313|EMBL:AFU75168.1}, OG Plasmid pCO_Eco4457-1 {ECO:0000313|EMBL:QLA46110.1}, OG Plasmid pCR7-EC-NDM-1 {ECO:0000313|EMBL:AKN35341.1}, OG Plasmid pEc2A {ECO:0000313|EMBL:ALF35449.1}, OG Plasmid pGUE-NDM {ECO:0000313|EMBL:AFI72857.1}, OG Plasmid pHNEC55 {ECO:0000313|EMBL:ALP68872.1}, OG Plasmid pHNTS79-NDM {ECO:0000313|EMBL:ATB17817.1}, OG Plasmid pIMD989 {ECO:0000313|EMBL:CTQ31245.1}, OG Plasmid pLK75 {ECO:0000313|EMBL:AIU96948.1}, OG Plasmid pMC-NDM {ECO:0000313|EMBL:CDF66128.1}, OG Plasmid pNDM-1_Dok01 {ECO:0000313|EMBL:BAK69668.1}, OG Plasmid pNDM-ECS01 {ECO:0000313|EMBL:AHX39447.1}, OG Plasmid pNDM-EcoGN568 {ECO:0000313|EMBL:AIM48196.1}, OG Plasmid pNDM-HK {ECO:0000313|EMBL:ADY00041.1}, OG Plasmid pNDM-HU01 {ECO:0000313|EMBL:BAN37431.1}, OG Plasmid pNDM102337 {ECO:0000313|EMBL:AEP32605.1}, OG Plasmid pNDM10505 {ECO:0000313|EMBL:AEN71485.1}, OG Plasmid pPN66-ECL-NDM-1 {ECO:0000313|EMBL:ALD19858.1}, OG Plasmid pco_eco4457-1 {ECO:0000313|Proteomes:UP000509457}, OG Plasmid unnamed {ECO:0000313|EMBL:AFN73221.1}, and OG Plasmid unnamed1 {ECO:0000313|EMBL:AVU68806.1}. OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=562 {ECO:0000313|EMBL:ADP20459.1}; RN [1] {ECO:0000313|EMBL:ADP20459.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=271 {ECO:0000313|EMBL:ADP20459.1}; RX PubMed=20823289; DOI=10.1128/AAC.00878-10; RA Poirel L., Lagrutta E., Taylor P., Pham J., Nordmann P.; RT "Emergence of metallo-?-lactamase NDM-1-producing multidrug-resistant RT Escherichia coli in Australia."; RL Antimicrob. Agents Chemother. 54:4914-4916(2010). RN [2] {ECO:0000313|EMBL:BAK40112.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NDM-1 Dok01 {ECO:0000313|EMBL:BAK40112.1}; RA Yamamoto T.; RT "The entire NDM-1 gene sequence of NDM-1-positive E. coli isolated in RT Japan."; RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:AEK64842.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=271 {ECO:0000313|EMBL:AEK64842.1}; RC PLASMID=p271A {ECO:0000313|EMBL:AEK64842.1}; RX PubMed=21746951; DOI=10.1128/AAC.00165-11; RA Poirel L., Bonnin R.A., Nordmann P.; RT "Analysis of the Resistome of a Multidrug-Resistant NDM-1-Producing RT Escherichia coli Strain by High-Throughput Genome Sequencing."; RL Antimicrob. Agents Chemother. 55:4224-4229(2011). RN [4] {ECO:0000313|EMBL:AEH43774.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=DVR22 {ECO:0000313|EMBL:AEH43774.1}; RX PubMed=21730115; DOI=10.1128/AAC.00642-11; RA Sole M., Pitart C., Roca I., Fabrega A., Salvador P., Munoz L., RA Oliveira I., Gascon J., Marco F., Vila J.; RT "First Description of an Escherichia coli Strain Producing NDM-1 RT Carbapenemase in Spain."; RL Antimicrob. Agents Chemother. 55:4402-4404(2011). RN [5] {ECO:0000313|EMBL:ADY00041.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=HK-01 {ECO:0000313|EMBL:ADY00041.1}; RC PLASMID=pNDM-HK {ECO:0000313|EMBL:ADY00041.1}; RX PubMed=21445317; DOI=10.1371/journal.pone.0017989; RA Ho P.L., Lo W.U., Yeung M.K., Lin C.H., Chow K.H., Ang I., Tong A.H., RA Bao J.Y., Lok S., Lo J.Y.; RT "Complete sequencing of pNDM-HK encoding NDM-1 carbapenemase from a RT multidrug-resistant Escherichia coli strain isolated in Hong Kong."; RL PLoS ONE 6:E17989-E17989(2011). RN [6] {ECO:0000313|EMBL:BAK69668.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NDM-1 Dok01 {ECO:0000313|EMBL:BAK69668.1}; RC PLASMID=pNDM-1_Dok01 {ECO:0000313|EMBL:BAK69668.1}; RX PubMed=21966500; DOI=10.1371/journal.pone.0025334; RA Sekizuka T., Matsui M., Yamane K., Takeuchi F., Ohnishi M., Hishinuma A., RA Arakawa Y., Kuroda M.; RT "Complete Sequencing of the bla(NDM-1)-Positive IncA/C Plasmid from RT Escherichia coli ST38 Isolate Suggests a Possible Origin from Plant RT Pathogens."; RL PLoS ONE 6:e25334-e25334(2011). RN [7] {ECO:0007829|PDB:3S0Z} RP X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 47-270 IN COMPLEX WITH ZINC. RX PubMed=21637961; DOI=10.1007/s13238-011-1055-9; RA Guo Y., Wang J., Niu G., Shui W., Sun Y., Zhou H., Zhang Y., Yang C., RA Lou Z., Rao Z.; RT "A structural view of the antibiotic degradation enzyme NDM-1 from a RT superbug."; RL Protein Cell 2:384-394(2011). RN [8] {ECO:0000313|EMBL:AFI72857.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=GUE {ECO:0000313|EMBL:AFI72857.1}; RC PLASMID=pGUE-NDM {ECO:0000313|EMBL:AFI72857.1}; RX PubMed=22511964; DOI=10.1371/journal.pone.0034752; RA Bonnin R.A., Poirel L., Carattoli A., Nordmann P.; RT "Characterization of an IncFII Plasmid Encoding NDM-1 from Escherichia coli RT ST131."; RL PLoS ONE 7:E34752-E34752(2012). RN [9] {ECO:0000313|EMBL:AFN73221.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BJ01 {ECO:0000313|EMBL:AFN73221.1}; RC PLASMID=unnamed {ECO:0000313|EMBL:AFN73221.1}; RA Liu Z.; RT "First New Delhi Metallo-beta-Lactamase 1-Producing Escherichia coli RT isolated in China."; RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:AEP32605.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=N10-0505 {ECO:0000313|EMBL:AEN71485.1}, and N10-2337 RC {ECO:0000313|EMBL:AEP32605.1}; RC PLASMID=pNDM102337 {ECO:0000313|EMBL:AEP32605.1}, and pNDM10505 RC {ECO:0000313|EMBL:AEN71485.1}; RA Boyd D.A., Mataseje L.F., Mulvey M.R.; RT "Inc A/C plasmids harbouring the NDM-1 metallo-beta-lactamase."; RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|EMBL:BAN37431.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=MS5260 {ECO:0000313|EMBL:BAN37431.1}; RC PLASMID=pNDM-HU01 {ECO:0000313|EMBL:BAN37431.1}; RA Kayama S., Shigemoto N., Kuwahara R., Koba Y., Onodera M., Yokozaki M., RA Ohge H., Kato F., Hisatsune J., Sugai M.; RT "The first isolation of an NDM-1-producing Escherichia coli in West RT Japan."; RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:AGB57374.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ABC85 {ECO:0000313|EMBL:AGB57374.1}; RC PLASMID=pABC85 {ECO:0000313|EMBL:AGB57374.1}; RX PubMed=23579399; DOI=10.1099/jmm.0.059014-0; RA Sonnevend A., Al Baloushi A., Ghazawi A., Hashmey R., Girgis S., RA Hamadeh M.B., Al Haj M., Pal T.; RT "Emergence and spread of NDM-1 producer Enterobacteriaceae with RT contribution of IncX3 plasmids in the United Arab Emirates."; RL J. Med. Microbiol. 62:1044-1050(2013). RN [13] {ECO:0000313|EMBL:AFU75168.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BJ01 {ECO:0000313|EMBL:AFU75168.1}; RC PLASMID=pBJ01 {ECO:0000313|EMBL:AFU75168.1}; RX PubMed=23762496; RA Liu Z., Li W., Wang J., Pan J., Sun S., Yu Y., Zhao B., Ma Y., Zhang T., RA Qi J., Liu G., Lu F.; RT "Identification and Characterization of the First Escherichia coli Strain RT Carrying NDM-1 Gene in China."; RL PLoS ONE 8:E66666-E66666(2013). RN [14] {ECO:0000313|EMBL:AHK80864.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NF133 {ECO:0000313|EMBL:AHK80864.1}, and NF188 RC {ECO:0000313|EMBL:AHK80865.1}; RA Li W., Chetelat R.T.; RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|EMBL:CDF66128.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NMI5428/11 {ECO:0000313|EMBL:CDF66128.1}; RC PLASMID=pMC-NDM {ECO:0000313|EMBL:CDF66128.1}; RX PubMed=24247128; DOI=10.1128/AAC.01197-13; RA Fiett J., Baraniak A., Izdebski R., Sitkiewicz I., Zabicka D., Meler A., RA Filczak K., Hryniewicz W., Gniadkowski M.; RT "The First NDM Metallo-?-Lactamase-Producing Enterobacteriaceae Isolate in RT Poland: Evolution of IncFII-Type Plasmids Carrying the blaNDM-1 Gene."; RL Antimicrob. Agents Chemother. 58:1203-1207(2014). RN [16] {ECO:0000313|EMBL:AHX39447.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ECS01 {ECO:0000313|EMBL:AHX39447.1}; RC PLASMID=pNDM-ECS01 {ECO:0000313|EMBL:AHX39447.1}; RX PubMed=25096073; DOI=10.1093/jac/dku275; RA Netikul T., Sidjabat H.E., Paterson D.L., Kamolvit W., Tantisiriwat W., RA Steen J.A., Kiratisin P.; RT "Characterization of an IncN2-type blaNDM-1-carrying plasmid in Escherichia RT coli ST131 and Klebsiella pneumoniae ST11 and ST15 isolates in Thailand."; RL J. Antimicrob. Chemother. 69:3161-3163(2014). RN [17] {ECO:0000313|EMBL:AIU96948.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CGMHLK75 {ECO:0000313|EMBL:AIU96948.1}; RC PLASMID=pLK75 {ECO:0000313|EMBL:AIU96948.1}; RX PubMed=25144712; RA Chen C.J., Wu T.L., Lu P.L., Chen Y.T., Fung C.P., Chuang Y.C., Lin J.C., RA Siu L.K.; RT "Closely Related NDM-1-Encoding Plasmids from Escherichia coli and RT Klebsiella pneumoniae in Taiwan."; RL PLoS ONE 9:E104899-E104899(2014). RN [18] {ECO:0000313|EMBL:AIU96948.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CGMHLK75 {ECO:0000313|EMBL:AIU96948.1}; RC PLASMID=pLK75 {ECO:0000313|EMBL:AIU96948.1}; RA Zou Y., Bi X., Huang L., Jing M.; RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases. RN [19] {ECO:0000313|EMBL:AIA22330.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NF741 {ECO:0000313|EMBL:AIA22330.1}; RA Liu L., Yang H., Zhao H., Sun J.; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [20] {ECO:0000313|EMBL:AIZ65660.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Res2011-159 {ECO:0000313|EMBL:AIZ65660.1}, Res2011-179 RC {ECO:0000313|EMBL:AIZ65664.1}, and Res2011-180 RC {ECO:0000313|EMBL:AIZ65665.1}; RA Cao V., Le T.L., Le H.T.D., Tran T.B.P., Mai V.N., Tran N.V.; RT "Detection of NDM-1 and NDM-4-producing Enterobacteriaceae isolates in RT Vietnam."; RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases. RN [21] {ECO:0000313|EMBL:AIZ65943.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=PI-E228 {ECO:0000313|EMBL:AIZ65943.1}; RA Kobayashi N., Kawaguchiya M., Ahmed S.; RT "Drug resistance of aerobic bacteria from puerperal infections in RT Bangladesh."; RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases. RN [22] {ECO:0000313|EMBL:AJL35292.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=GB102 {ECO:0000313|EMBL:AJL35292.1}; RA Robin F., Le Brun C.; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. RN [23] {ECO:0000313|EMBL:AIM48196.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=GN568 {ECO:0000313|EMBL:AIM48196.1}; RC PLASMID=pNDM-EcoGN568 {ECO:0000313|EMBL:AIM48196.1}; RX PubMed=25845877; DOI=10.1128/AAC.04862-14; RA Tijet N., Richardson D., MacMullin G., Patel S.N., Melano R.G.; RT "Characterization of multiple NDM-1-producing Enterobacteriaceae isolates RT from the same patient."; RL Antimicrob. Agents Chemother. 59:3648-3651(2015). RN [24] {ECO:0000313|EMBL:AJL35292.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=GB102 {ECO:0000313|EMBL:AJL35292.1}; RX PubMed=26055374; DOI=10.1128/AAC.04682-14; RA Huang Y.M., Zhong L.L., Zhang X.F., Hu H.T., Li Y.Q., Yang X.R., Feng L.Q., RA Huang X., Tian G.B.; RT "NDM-1-Producing Citrobacter freundii, Escherichia coli, and Acinetobacter RT baumannii Identified from a Single Patient in China."; RL Antimicrob. Agents Chemother. 59:5073-5077(2015). RN [25] {ECO:0000313|EMBL:ALF35449.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=E0083033-2 {ECO:0000313|EMBL:ALF35449.1}; RC PLASMID=pEc2A {ECO:0000313|EMBL:ALF35449.1}; RX PubMed=26392506; DOI=10.1128/AAC.01458-15; RA Campos J.C., Sampaio J.L.M.; RT "Characterization of Tn3000, a Transposon Responsible for blaNDM-1 RT Dissemination among Enterobacteriaceae in Brazil, Nepal, Morocco, and RT India."; RL Antimicrob. Agents Chemother. 59:7387-7395(2015). RN [26] {ECO:0000313|EMBL:AKN35214.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ACT1 {ECO:0000313|EMBL:AKN35214.1}, ACT2 RC {ECO:0000313|EMBL:AKN35231.1}, and CR7 {ECO:0000313|EMBL:AKN35341.1}; RC PLASMID=pACT1-EC-NDM-1 {ECO:0000313|EMBL:AKN35214.1}, pACT2-NDM-1 RC {ECO:0000313|EMBL:AKN35231.1}, and pCR7-EC-NDM-1 RC {ECO:0000313|EMBL:AKN35341.1}; RA Wailan A.M., Paterson D.L., Kennedy K., Ingram P., Paterson D.L., RA Sidjabat H.E.; RT "Genomic characteristics of NDM-producing Enterobacteriaceae in Australia RT and their blaNDM genetic contexts."; RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases. RN [27] {ECO:0000313|EMBL:ALD19858.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Pn66 {ECO:0000313|EMBL:ALD19858.1}; RC PLASMID=pPN66-ECL-NDM-1 {ECO:0000313|EMBL:ALD19858.1}; RA Wailan A.M., Sartor A.L., Zowawi H.M., Perry J.D., Paterson D.L., RA Sidjabat H.E.; RT "The genetic characterization of NDM-1 producing Enterobacteriaceae and RT Acinetobacter baumannii from Pakistan hospitals for an insight of blaNDM RT acquisition via plasmids."; RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases. RN [28] {ECO:0000313|EMBL:AKT45764.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NF113 {ECO:0000313|EMBL:AKT45812.1}, NF50 RC {ECO:0000313|EMBL:AKT45764.1}, NF54 {ECO:0000313|EMBL:AKT45767.1}, and RC NF76 {ECO:0000313|EMBL:AKT45786.1}; RA Torres C.; RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases. RN [29] {ECO:0000313|EMBL:CTQ31245.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=IMD989 {ECO:0000313|EMBL:CTQ31245.1}; RC PLASMID=pIMD989 {ECO:0000313|EMBL:CTQ31245.1}; RA Novovic K., Kojic M., Jovcic B.; RT "blaNDM-1 metallobeta lactamase in Escherichia coli from Serbia."; RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases. RN [30] {ECO:0000313|EMBL:ALP68872.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=HNEC55 {ECO:0000313|EMBL:ALP68872.1}; RC PLASMID=pHNEC55 {ECO:0000313|EMBL:ALP68872.1}; RA Lin D.; RT "Complete Nucleotide Sequence of a Conjugative Plasmid Carrying blaNDM-1."; RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases. RN [31] {ECO:0000313|EMBL:ATB17817.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=TS79e {ECO:0000313|EMBL:ATB17817.1}; RC PLASMID=pHNTS79-NDM {ECO:0000313|EMBL:ATB17817.1}; RX PubMed=29029065; RA Wang J., Yao X., Luo J., Lv L., Zeng Z., Liu J.H.; RT "Emergence of Escherichia coli co-producing NDM-1 and KPC-2 carbapenemases RT from a retail vegetable, China."; RL J. Antimicrob. Chemother. 0:0-0(2017). RN [32] {ECO:0007829|PDB:5YPI, ECO:0007829|PDB:5YPK} RP X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 29-270 IN COMPLEX WITH ZN(2+). RX PubMed=29269938; DOI=10.1038/s41467-017-02339-w; RA Feng H., Liu X., Wang S., Fleming J., Wang D.C., Liu W.; RT "The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from RT that of penicillin or cephalosporin hydrolysis."; RL Nat. Commun. 8:2242-2242(2017). RN [33] {ECO:0000313|EMBL:AVU68806.1, ECO:0000313|Proteomes:UP000325046} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=190 {ECO:0000313|EMBL:AVU68806.1, RC ECO:0000313|Proteomes:UP000325046}; RC PLASMID=unnamed1 {ECO:0000313|EMBL:AVU68806.1, RC ECO:0000313|Proteomes:UP000325046}; RA Hoffmann M., Sanchez M., Timme R., Bry L.; RT "Whole genome sequencing of cultured foodborne pathogen."; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. RN [34] {ECO:0007829|PDB:6C89} RP X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 40-270 IN COMPLEX WITH ZN(2+). RX PubMed=30375382; DOI=10.1038/s41467-018-06839-1; RA Sun Z., Hu L., Sankaran B., Prasad B.V.V., Palzkill T.; RT "Differential active site requirements for NDM-1 beta-lactamase hydrolysis RT of carbapenem versus penicillin and cephalosporin antibiotics."; RL Nat. Commun. 9:4524-4524(2018). RN [35] {ECO:0007829|PDB:5ZR8} RP X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 29-270 IN COMPLEX WITH ZN(2+). RA Wachino J.; RT "Crystal Structure Of NDM-1 Metallo-beta-lactamase."; RL Submitted (APR-2018) to the PDB data bank. RN [36] {ECO:0000313|EMBL:VCZ28695.1, ECO:0000313|Proteomes:UP000281521} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Ecoli022 {ECO:0000313|EMBL:VCZ28695.1}; RA Noll B N.; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. RN [37] {ECO:0007829|PDB:6OVZ} RP X-RAY CRYSTALLOGRAPHY (2.02 ANGSTROMS) OF 36-270 IN COMPLEX WITH CA(2+) AND RP ZN(2+). RX PubMed=31145588; DOI=10.1021/acs.biochem.9b00393; RA Thomas P.W., Cammarata M., Brodbelt J.S., Monzingo A.F., Pratt R.F., RA Fast W.; RT "A Lysine-Targeted Affinity Label for Serine-beta-Lactamase Also Covalently RT Modifies New Delhi Metallo-beta-lactamase-1 (NDM-1)."; RL Biochemistry 58:2834-2843(2019). RN [38] {ECO:0000313|EMBL:MQS33320.1, ECO:0000313|Proteomes:UP000460351} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=RXD010 {ECO:0000313|EMBL:MQS33320.1, RC ECO:0000313|Proteomes:UP000460351}; RX PubMed=31652858; RA Peng Z., Li X., Hu Z., Li Z., Lv Y., Lei M., Wu B., Chen H., Wang X.; RT "Characteristics of Carbapenem-Resistant and Colistin-Resistant Escherichia RT coli Co-Producing NDM-1 and MCR-1 from Pig Farms in China."; RL Microorganisms 7:0-E482(2019). RN [39] {ECO:0007829|PDB:6KXI, ECO:0007829|PDB:6KZL} RP X-RAY CRYSTALLOGRAPHY (1.38 ANGSTROMS) OF 29-270 IN COMPLEX WITH ZN(2+). RX PubMed=32184250; DOI=10.1128/mbio.03144-19; RA Wachino J.I., Jin W., Kimura K., Kurosaki H., Sato A., Arakawa Y.; RT "Sulfamoyl Heteroarylcarboxylic Acids as Promising Metallo-beta-Lactamase RT Inhibitors for Controlling Bacterial Carbapenem Resistance. ."; RL MBio 11:e03144-e03119(2020). RN [40] {ECO:0000313|EMBL:NGE91514.1, ECO:0000313|Proteomes:UP000472856} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ECM_75 {ECO:0000313|EMBL:NGE91514.1, RC ECO:0000313|Proteomes:UP000472856}; RA Tokajian S., El Chaar M., El Khoury M.; RT "WGS of Carbapenem-Resistant Enterobacteriaceae."; RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases. RN [41] {ECO:0000313|EMBL:QLA46110.1, ECO:0000313|Proteomes:UP000509457} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ARL09/232 {ECO:0000313|EMBL:QLA46110.1, RC ECO:0000313|Proteomes:UP000509457}; RC PLASMID=pCO_Eco4457-1 {ECO:0000313|EMBL:QLA46110.1}, and pco_eco4457-1 RC {ECO:0000313|Proteomes:UP000509457}; RA Olivera C.D., Rakonjac J.; RT "Complete genome assembly of New Delhi metallo-beta-lactamase-1 (NDM- RT 1)- producing Escherichia coli human isolate from New Zealand."; RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid; CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627, CC ChEBI:CHEBI:140347; EC=3.5.2.6; CC Evidence={ECO:0000256|ARBA:ARBA00001526}; CC -!- COFACTOR: CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; CC Evidence={ECO:0000256|ARBA:ARBA00001947}; CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}. CC -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. Class-B CC beta-lactamase family. {ECO:0000256|ARBA:ARBA00005250}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HQ162469; ADP20459.1; -; Genomic_DNA. DR EMBL; HQ451074; ADY00041.1; -; Genomic_DNA. DR EMBL; JF922606; AEH43774.1; -; Genomic_DNA. DR EMBL; JF785549; AEK64842.1; -; Genomic_DNA. DR EMBL; JF503991; AEN71485.1; -; Genomic_DNA. DR EMBL; JF714412; AEP32605.1; -; Genomic_DNA. DR EMBL; JQ364967; AFI72857.1; -; Genomic_DNA. DR EMBL; JX000475; AFN73221.1; -; Genomic_DNA. DR EMBL; JX296013; AFU75168.1; -; Genomic_DNA. DR EMBL; KC149527; AGB57374.1; -; Genomic_DNA. DR EMBL; KF951455; AHK80864.1; -; Genomic_DNA. DR EMBL; KF951456; AHK80865.1; -; Genomic_DNA. DR EMBL; KJ413946; AHX39447.1; -; Genomic_DNA. DR EMBL; KJ558506; AIA22330.1; -; Genomic_DNA. DR EMBL; KJ802404; AIM48196.1; -; Genomic_DNA. DR EMBL; KJ440076; AIU96948.1; -; Genomic_DNA. DR EMBL; KM111580; AIZ65660.1; -; Genomic_DNA. DR EMBL; KM111584; AIZ65664.1; -; Genomic_DNA. DR EMBL; KM111585; AIZ65665.1; -; Genomic_DNA. DR EMBL; KM485656; AIZ65943.1; -; Genomic_DNA. DR EMBL; KP027046; AJL35292.1; -; Genomic_DNA. DR EMBL; KP826702; AKN35214.1; -; Genomic_DNA. DR EMBL; KP826703; AKN35231.1; -; Genomic_DNA. DR EMBL; KP826713; AKN35341.1; -; Genomic_DNA. DR EMBL; KP772144; AKT45764.1; -; Genomic_DNA. DR EMBL; KP772147; AKT45767.1; -; Genomic_DNA. DR EMBL; KP772166; AKT45786.1; -; Genomic_DNA. DR EMBL; KP772192; AKT45812.1; -; Genomic_DNA. DR EMBL; KP770028; ALD19858.1; -; Genomic_DNA. DR EMBL; KR822247; ALF35449.1; -; Genomic_DNA. DR EMBL; KT879914; ALP68872.1; -; Genomic_DNA. DR EMBL; MF383355; ATB17817.1; -; Genomic_DNA. DR EMBL; CP020524; AVU68806.1; -; Genomic_DNA. DR EMBL; AB604953; BAK40112.1; -; Genomic_DNA. DR EMBL; AP012208; BAK69668.1; -; Genomic_DNA. DR EMBL; AB769140; BAN37431.1; -; Genomic_DNA. DR EMBL; HG003695; CDF66128.1; -; Other_DNA. DR EMBL; LN871243; CTQ31245.1; -; Genomic_DNA. DR EMBL; SQQU01000064; MQS33320.1; -; Genomic_DNA. DR EMBL; JAAJRI010000046; NGE91514.1; -; Genomic_DNA. DR EMBL; CP049968; QLA46110.1; -; Genomic_DNA. DR EMBL; UWXJ01000003; VCZ28695.1; -; Genomic_DNA. DR RefSeq; WP_004201164.1; NZ_WUUG01000022.1. DR RefSeq; YP_004765050.1; NC_015872.1. DR RefSeq; YP_006903357.1; NC_019045.2. DR RefSeq; YP_006939981.1; NC_018994.1. DR RefSeq; YP_006952434.1; NC_019063.1. DR RefSeq; YP_006953215.1; NC_019069.1. DR RefSeq; YP_006953875.1; NC_019089.1. DR RefSeq; YP_009059936.1; NC_024954.1. DR RefSeq; YP_009066439.1; NC_025106.1. DR PDB; 3S0Z; X-ray; 2.50 A; A/B=47-270. DR PDB; 5YPI; X-ray; 2.30 A; A/B/C/D/E/F/G/H=29-270. DR PDB; 5YPK; X-ray; 2.00 A; A/B/C/D/E/F/G/H=29-270. DR PDB; 5YPL; X-ray; 1.80 A; A/B=29-270. DR PDB; 5YPM; X-ray; 2.15 A; A/B/C/D/E/F/G/H=29-270. DR PDB; 5YPN; X-ray; 2.12 A; A/B=29-270. DR PDB; 5ZR8; X-ray; 1.50 A; A/E=29-270. DR PDB; 6C89; X-ray; 1.75 A; A/B/C/D=40-270. DR PDB; 6KXI; X-ray; 1.38 A; A/B=29-270. DR PDB; 6KZL; X-ray; 1.76 A; A/B=29-270. DR PDB; 6OVZ; X-ray; 2.02 A; A/B=36-270. DR PDBsum; 3S0Z; -. DR PDBsum; 5YPI; -. DR PDBsum; 5YPK; -. DR PDBsum; 5YPL; -. DR PDBsum; 5YPM; -. DR PDBsum; 5YPN; -. DR PDBsum; 5ZR8; -. DR PDBsum; 6C89; -. DR PDBsum; 6KXI; -. DR PDBsum; 6KZL; -. DR PDBsum; 6OVZ; -. DR ChEMBL; CHEMBL4295540; -. DR GeneID; 84239019; -. DR PATRIC; fig|562.12826.peg.5242; -. DR Proteomes; UP000281521; Unassembled WGS sequence. DR Proteomes; UP000325046; Plasmid unnamed1. DR Proteomes; UP000460351; Unassembled WGS sequence. DR Proteomes; UP000472856; Unassembled WGS sequence. DR Proteomes; UP000509457; Plasmid pco_eco4457-1. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR CDD; cd16300; NDM_FIM-like_MBL-B1; 1. DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1. DR InterPro; IPR001279; Metallo-B-lactamas. DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro. DR PANTHER; PTHR42951:SF20; BETA LACTAMASE; 1. DR PANTHER; PTHR42951; METALLO-BETA-LACTAMASE DOMAIN-CONTAINING; 1. DR Pfam; PF00753; Lactamase_B; 1. DR SMART; SM00849; Lactamase_B; 1. DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:3S0Z, ECO:0007829|PDB:5YPI}; KW Calcium {ECO:0007829|PDB:6OVZ}; Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Metal-binding {ECO:0007829|PDB:3S0Z, ECO:0007829|PDB:5YPI}; KW Plasmid {ECO:0000313|EMBL:ADY00041.1}; KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0007829|PDB:3S0Z}. FT DOMAIN 74..250 FT /note="Metallo-beta-lactamase" FT /evidence="ECO:0000259|SMART:SM00849" FT BINDING 95 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /evidence="ECO:0007829|PDB:6OVZ" FT BINDING 120 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="1" FT /evidence="ECO:0007829|PDB:5YPI, ECO:0007829|PDB:5YPK" FT BINDING 122 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="1" FT /evidence="ECO:0007829|PDB:5YPN" FT BINDING 124 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="2" FT /evidence="ECO:0007829|PDB:3S0Z" FT BINDING 124 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="4" FT /evidence="ECO:0007829|PDB:5YPI, ECO:0007829|PDB:5YPK" FT BINDING 124 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="1" FT /evidence="ECO:0007829|PDB:6KXI, ECO:0007829|PDB:6KZL" FT BINDING 130 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /evidence="ECO:0007829|PDB:6OVZ" FT BINDING 152 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="6" FT /evidence="ECO:0007829|PDB:5ZR8, ECO:0007829|PDB:6KXI" FT BINDING 152 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="5" FT /evidence="ECO:0007829|PDB:6OVZ" FT BINDING 189 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="1" FT /evidence="ECO:0007829|PDB:5YPI, ECO:0007829|PDB:5YPK" FT BINDING 189 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="2" FT /evidence="ECO:0007829|PDB:3S0Z" FT BINDING 208 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="4" FT /evidence="ECO:0007829|PDB:5YPI, ECO:0007829|PDB:5YPK" FT BINDING 208 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="3" FT /evidence="ECO:0007829|PDB:3S0Z" FT BINDING 223 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="6" FT /evidence="ECO:0007829|PDB:5ZR8, ECO:0007829|PDB:6KXI" FT BINDING 223 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="5" FT /evidence="ECO:0007829|PDB:6OVZ" FT BINDING 227 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="6" FT /evidence="ECO:0007829|PDB:5ZR8, ECO:0007829|PDB:6KXI" FT BINDING 250 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="4" FT /evidence="ECO:0007829|PDB:5YPN" SQ SEQUENCE 270 AA; 28499 MW; 1B6009120B945F14 CRC64; MELPNIMHPV AKLSTALAAA LMLSGCMPGE IRPTIGQQME TGDQRFGDLV FRQLAPNVWQ HTSYLDMPGF GAVASNGLIV RDGGRVLVVD TAWTDDQTAQ ILNWIKQEIN LPVALAVVTH AHQDKMGGMD ALHAAGIATY ANALSNQLAP QEGMVAAQHS LTFAANGWVE PATAPNFGPL KVFYPGPGHT SDNITVGIDG TDIAFGGCLI KDSKAKSLGN LGDADTEHYA ASARAFGAAF PKASMIVMSH SAPDSRAAIT HTARMADKLR //