Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

BlaNDM-1

Gene

blaNDM-1

Organism
Escherichia coli
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi120 – 1201Zinc; via tele nitrogenCombined sources
Metal bindingi122 – 1221ZincCombined sources
Metal bindingi189 – 1891Zinc; via tele nitrogenCombined sources
Metal bindingi208 – 2081ZincCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-bindingCombined sources, ZincCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
BlaNDM-1Imported
Submitted name:
BlaNDM-1 proteinImported
Submitted name:
Class B beta-lactamase NDM-1Imported
Submitted name:
Metallo beta lactamase NDM-1Imported
Submitted name:
Metallo-beta-lactamaseImported
Submitted name:
Metallo-beta-lactamase NDM-1Imported
Submitted name:
NDM-1Imported
Submitted name:
NDM-1 metallo-beta-lactamaseImported
Submitted name:
New Delhi metallo-beta-lactamaseImported
Submitted name:
New Delhi metallo-beta-lactamase NDM-1Imported
Gene namesi
Name:blaNDM-1Imported
Synonyms:bla NDM-1Imported
ORF Names:ECS01_0033Imported, NDM1Dok01_N0175Imported, pNDM102337_147Imported, pNDM10505_149Imported, RR31_25680Imported, RR31_25890Imported
Encoded oniPlasmid p271AImported
Plasmid p6409-202.186kbImported
Plasmid pABC85Imported
Plasmid pBJ01Imported
Plasmid pGUE-NDMImported
Plasmid pLK75Imported
Plasmid pMC-NDMImported
Plasmid pNDM-1_Dok01Imported
Plasmid pNDM-ECS01Imported
Plasmid pNDM-HKImported
Plasmid pNDM-HU01Imported
Plasmid pNDM102337Imported
Plasmid pNDM10505Imported
Plasmid unnamedImported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000031132 Componenti: Plasmid p6409-202.186kb

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3S0ZX-ray2.50A/B47-270[»]
ProteinModelPortaliE5KIY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

KOiK18780.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Beta-lactamas-like.
[Graphical view]
PfamiPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.

Sequencei

Sequence statusi: Complete.

E5KIY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELPNIMHPV AKLSTALAAA LMLSGCMPGE IRPTIGQQME TGDQRFGDLV
60 70 80 90 100
FRQLAPNVWQ HTSYLDMPGF GAVASNGLIV RDGGRVLVVD TAWTDDQTAQ
110 120 130 140 150
ILNWIKQEIN LPVALAVVTH AHQDKMGGMD ALHAAGIATY ANALSNQLAP
160 170 180 190 200
QEGMVAAQHS LTFAANGWVE PATAPNFGPL KVFYPGPGHT SDNITVGIDG
210 220 230 240 250
TDIAFGGCLI KDSKAKSLGN LGDADTEHYA ASARAFGAAF PKASMIVMSH
260 270
SAPDSRAAIT HTARMADKLR
Length:270
Mass (Da):28,499
Last modified:February 8, 2011 - v1
Checksum:i1B6009120B945F14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ162469 Genomic DNA. Translation: ADP20459.1.
HQ451074 Genomic DNA. Translation: ADY00041.1.
JF922606 Genomic DNA. Translation: AEH43774.1.
JF785549 Genomic DNA. Translation: AEK64842.1.
JF503991 Genomic DNA. Translation: AEN71485.1.
JF714412 Genomic DNA. Translation: AEP32605.1.
JQ364967 Genomic DNA. Translation: AFI72857.1.
JX000475 Genomic DNA. Translation: AFN73221.1.
JX296013 Genomic DNA. Translation: AFU75168.1.
KC149527 Genomic DNA. Translation: AGB57374.1.
KF951455 Genomic DNA. Translation: AHK80864.1.
KF951456 Genomic DNA. Translation: AHK80865.1.
KJ413946 Genomic DNA. Translation: AHX39447.1.
KJ558506 Genomic DNA. Translation: AIA22330.1.
KJ440076 Genomic DNA. Translation: AIU96948.1.
KM111580 Genomic DNA. Translation: AIZ65660.1.
KM111584 Genomic DNA. Translation: AIZ65664.1.
KM111585 Genomic DNA. Translation: AIZ65665.1.
KM485656 Genomic DNA. Translation: AIZ65943.1.
CP010373 Genomic DNA. Translation: AJB55021.1.
CP010373 Genomic DNA. Translation: AJB55029.1.
KP027046 Genomic DNA. Translation: AJL35292.1.
AB604953 Genomic DNA. Translation: BAK40112.1.
AP012208 Genomic DNA. Translation: BAK69668.1.
AB769140 Genomic DNA. Translation: BAN37431.1.
HG003695 Other DNA. Translation: CDF66128.1.
RefSeqiWP_004201164.1. NZ_JJNV01000040.1.
YP_004765050.1. NC_015872.1.
YP_006903357.1. NC_019045.2.
YP_006939981.1. NC_018994.1.
YP_006952434.1. NC_019063.1.
YP_006953215.1. NC_019069.1.
YP_006953875.1. NC_019089.1.
YP_009059936.1. NC_024954.1.
YP_009066439.1. NC_025106.1.
YP_009090519.1. NG_041604.1.
YP_009090743.1. NG_041630.1.

Genome annotation databases

EnsemblBacteriaiAJB55021; AJB55021; RR31_25630.
AJB55029; AJB55029; RR31_25680.
KCW95010; KCW95010; DP79_14850.
GeneIDi11027496.
13876866.
13903469.
13905367.
13906127.
13906812.
20466712.
20471936.
KEGGipg:11027496.
pg:13876866.
pg:13903469.
pg:13905367.
pg:13906127.
pg:13906812.
pg:20466712.
pg:20471936.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ162469 Genomic DNA. Translation: ADP20459.1.
HQ451074 Genomic DNA. Translation: ADY00041.1.
JF922606 Genomic DNA. Translation: AEH43774.1.
JF785549 Genomic DNA. Translation: AEK64842.1.
JF503991 Genomic DNA. Translation: AEN71485.1.
JF714412 Genomic DNA. Translation: AEP32605.1.
JQ364967 Genomic DNA. Translation: AFI72857.1.
JX000475 Genomic DNA. Translation: AFN73221.1.
JX296013 Genomic DNA. Translation: AFU75168.1.
KC149527 Genomic DNA. Translation: AGB57374.1.
KF951455 Genomic DNA. Translation: AHK80864.1.
KF951456 Genomic DNA. Translation: AHK80865.1.
KJ413946 Genomic DNA. Translation: AHX39447.1.
KJ558506 Genomic DNA. Translation: AIA22330.1.
KJ440076 Genomic DNA. Translation: AIU96948.1.
KM111580 Genomic DNA. Translation: AIZ65660.1.
KM111584 Genomic DNA. Translation: AIZ65664.1.
KM111585 Genomic DNA. Translation: AIZ65665.1.
KM485656 Genomic DNA. Translation: AIZ65943.1.
CP010373 Genomic DNA. Translation: AJB55021.1.
CP010373 Genomic DNA. Translation: AJB55029.1.
KP027046 Genomic DNA. Translation: AJL35292.1.
AB604953 Genomic DNA. Translation: BAK40112.1.
AP012208 Genomic DNA. Translation: BAK69668.1.
AB769140 Genomic DNA. Translation: BAN37431.1.
HG003695 Other DNA. Translation: CDF66128.1.
RefSeqiWP_004201164.1. NZ_JJNV01000040.1.
YP_004765050.1. NC_015872.1.
YP_006903357.1. NC_019045.2.
YP_006939981.1. NC_018994.1.
YP_006952434.1. NC_019063.1.
YP_006953215.1. NC_019069.1.
YP_006953875.1. NC_019089.1.
YP_009059936.1. NC_024954.1.
YP_009066439.1. NC_025106.1.
YP_009090519.1. NG_041604.1.
YP_009090743.1. NG_041630.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3S0ZX-ray2.50A/B47-270[»]
ProteinModelPortaliE5KIY2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAJB55021; AJB55021; RR31_25630.
AJB55029; AJB55029; RR31_25680.
KCW95010; KCW95010; DP79_14850.
GeneIDi11027496.
13876866.
13903469.
13905367.
13906127.
13906812.
20466712.
20471936.
KEGGipg:11027496.
pg:13876866.
pg:13903469.
pg:13905367.
pg:13906127.
pg:13906812.
pg:20466712.
pg:20471936.

Phylogenomic databases

KOiK18780.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Beta-lactamas-like.
[Graphical view]
PfamiPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Emergence of metallo-?-lactamase NDM-1-producing multidrug-resistant Escherichia coli in Australia."
    Poirel L., Lagrutta E., Taylor P., Pham J., Nordmann P.
    Antimicrob. Agents Chemother. 54:4914-4916(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 271Imported.
  2. "The entire NDM-1 gene sequence of NDM-1-positive E. coli isolated in Japan."
    Yamamoto T.
    Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NDM-1 Dok01Imported.
  3. "Analysis of the Resistome of a Multidrug-Resistant NDM-1-Producing Escherichia coli Strain by High-Throughput Genome Sequencing."
    Poirel L., Bonnin R.A., Nordmann P.
    Antimicrob. Agents Chemother. 55:4224-4229(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 271Imported.
    Plasmid: p271A
  4. "First Description of an Escherichia coli Strain Producing NDM-1 Carbapenemase in Spain."
    Sole M., Pitart C., Roca I., Fabrega A., Salvador P., Munoz L., Oliveira I., Gascon J., Marco F., Vila J.
    Antimicrob. Agents Chemother. 55:4402-4404(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DVR22Imported.
  5. "Complete sequencing of pNDM-HK encoding NDM-1 carbapenemase from a multidrug-resistant Escherichia coli strain isolated in Hong Kong."
    Ho P.L., Lo W.U., Yeung M.K., Lin C.H., Chow K.H., Ang I., Tong A.H., Bao J.Y., Lok S., Lo J.Y.
    PLoS ONE 6:E17989-E17989(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HK-01Imported.
    Plasmid: pNDM-HK
  6. "Complete Sequencing of the bla(NDM-1)-Positive IncA/C Plasmid from Escherichia coli ST38 Isolate Suggests a Possible Origin from Plant Pathogens."
    Sekizuka T., Matsui M., Yamane K., Takeuchi F., Ohnishi M., Hishinuma A., Arakawa Y., Kuroda M.
    PLoS ONE 6:e25334-e25334(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NDM-1 Dok01Imported.
    Plasmid: pNDM-1_Dok01
  7. "A structural view of the antibiotic degradation enzyme NDM-1 from a superbug."
    Guo Y., Wang J., Niu G., Shui W., Sun Y., Zhou H., Zhang Y., Yang C., Lou Z., Rao Z.
    Protein Cell 2:384-394(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 47-270 IN COMPLEX WITH ZINC.
  8. "Inc A/C plasmids harbouring the NDM-1 metallo-beta-lactamase."
    Boyd D.A., Mataseje L.F., Mulvey M.R.
    Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: N10-0505Imported.
    Plasmid: pNDM10505
  9. "Characterization of an IncFII Plasmid Encoding NDM-1 from Escherichia coli ST131."
    Bonnin R.A., Poirel L., Carattoli A., Nordmann P.
    PLoS ONE 7:E34752-E34752(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: GUEImported.
    Plasmid: pGUE-NDM
  10. "First New Delhi Metallo-beta-Lactamase 1-Producing Escherichia coli isolated in China."
    Liu Z.
    Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BJ01Imported.
    Plasmid: unnamed
  11. "Inc A/C plasmids harbouring the NDM-1 metallo-beta-lactamase."
    Boyd D.A., Mataseje L.F., Mulvey M.R.
    Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: N10-2337Imported.
    Plasmid: pNDM102337
  12. "The first isolation of an NDM-1-producing Escherichia coli in West Japan."
    Kayama S., Shigemoto N., Kuwahara R., Koba Y., Onodera M., Yokozaki M., Ohge H., Kato F., Hisatsune J., Sugai M.
    Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MS5260Imported.
    Plasmid: pNDM-HU01
  13. "Emergence and spread of NDM-1 producer Enterobacteriaceae with contribution of IncX3 plasmids in the United Arab Emirates."
    Sonnevend A., Al Baloushi A., Ghazawi A., Hashmey R., Girgis S., Hamadeh M.B., Al Haj M., Pal T.
    J. Med. Microbiol. 62:1044-1050(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ABC85Imported.
    Plasmid: pABC85
  14. "Identification and Characterization of the First Escherichia coli Strain Carrying NDM-1 Gene in China."
    Liu Z., Li W., Wang J., Pan J., Sun S., Yu Y., Zhao B., Ma Y., Zhang T., Qi J., Liu G., Lu F.
    PLoS ONE 8:E66666-E66666(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BJ01Imported.
    Plasmid: pBJ01
  15. Lu W., Cheng C., Rui Y.
    Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NF133Imported and NF188Imported.
  16. "The First NDM Metallo-?-Lactamase-Producing Enterobacteriaceae Isolate in Poland: Evolution of IncFII-Type Plasmids Carrying the blaNDM-1 Gene."
    Fiett J., Baraniak A., Izdebski R., Sitkiewicz I., Zabicka D., Meler A., Filczak K., Hryniewicz W., Gniadkowski M.
    Antimicrob. Agents Chemother. 58:1203-1207(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NMI5428/11Imported.
    Plasmid: pMC-NDM
  17. "Characterization of an IncN2-type blaNDM-1-carrying plasmid in Escherichia coli ST131 and Klebsiella pneumoniae ST11 and ST15 isolates in Thailand."
    Netikul T., Sidjabat H.E., Paterson D.L., Kamolvit W., Tantisiriwat W., Steen J.A., Kiratisin P.
    J. Antimicrob. Chemother. 69:3161-3163(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ECS01Imported.
    Plasmid: pNDM-ECS01
  18. "Closely Related NDM-1-Encoding Plasmids from Escherichia coli and Klebsiella pneumoniae in Taiwan."
    Chen C.J., Wu T.L., Lu P.L., Chen Y.T., Fung C.P., Chuang Y.C., Lin J.C., Siu L.K.
    PLoS ONE 9:E104899-E104899(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CGMHLK75Imported.
    Plasmid: pLK75
  19. Chen Y.-T., Lin A.-C., Siu K.
    Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CGMHLK75Imported.
    Plasmid: pLK75
  20. Lu W.
    Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NF741Imported.
  21. "Detection of NDM-1 and NDM-4-producing Enterobacteriaceae isolates in Vietnam."
    Cao V., Le T.L., Le H.T.D., Tran T.B.P., Mai V.N., Tran N.V.
    Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Res2011-159Imported, Res2011-179Imported and Res2011-180Imported.
  22. "Drug resistance of aerobic bacteria from puerperal infections in Bangladesh."
    Kobayashi N., Kawaguchiya M., Ahmed S.
    Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: PI-E228Imported.
  23. "NDM-1-Producing Citrobacter freundii, Escherichia coli and Acinetobacter baumannii Identified from a Single Patient in China."
    Tian G.-B.
    Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: GB102Imported.
  24. McCorrison J., Sanka R., Adams M., Brinkac L., Sutton G., Bonomo R., Rojas L.
    Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 6409Imported.
    Plasmid: p6409-202.186kb

Entry informationi

Entry nameiE5KIY2_ECOLX
AccessioniPrimary (citable) accession number: E5KIY2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: May 27, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported, PlasmidImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.