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Protein
Submitted name:

Beta-lactamase NDM-1

Gene

bla NDM-1

Organism
Escherichia coli
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi120 – 1201Zinc; via tele nitrogenCombined sources
Metal bindingi122 – 1221ZincCombined sources
Metal bindingi189 – 1891Zinc; via tele nitrogenCombined sources
Metal bindingi208 – 2081ZincCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-bindingCombined sources, ZincCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Beta-lactamase NDM-1Imported
Submitted name:
BlaNDM-1Imported
Submitted name:
Metallo beta lactamase NDM-1Imported
Submitted name:
Metallo-beta-lactamase NDM-1Imported
Submitted name:
NDM-1Imported
Submitted name:
NDM-1 metallo-beta-lactamaseImported
Submitted name:
New Delhi metallo-beta-lactamaseImported
Submitted name:
New Delhi metallo-beta-lactamase NDM-1Imported
Submitted name:
New Delhi metallo-beta-lactamase-1Imported
Submitted name:
Subclass B1 metallo-beta-lactamaseImported
Gene namesi
Name:bla NDM-1Imported
Synonyms:blaNDM-1Imported
ORF Names:APU18_05360Imported, AZ95_0035Imported, ECS01_0033Imported, NDM1Dok01_N0175Imported, pNDM102337_147Imported, pNDM10505_149Imported
Encoded oniPlasmid p271AImported
Plasmid pABC85Imported
Plasmid pACT1-EC-NDM-1Imported
Plasmid pACT2-NDM-1Imported
Plasmid pBJ01Imported
Plasmid pCR7-EC-NDM-1Imported
Plasmid pEc2AImported
Plasmid pGUE-NDMImported
Plasmid pHNEC55Imported
Plasmid pIMD989Imported
Plasmid pLK75Imported
Plasmid pMC-NDMImported
Plasmid pNDM-1_Dok01Imported
Plasmid pNDM-ECS01Imported
Plasmid pNDM-EcoGN568Imported
Plasmid pNDM-HKImported
Plasmid pNDM-HU01Imported
Plasmid pNDM102337Imported
Plasmid pNDM10505Imported
Plasmid pPN66-ECL-NDM-1Imported
Plasmid unnamedImported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000053450 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3S0ZX-ray2.50A/B47-270[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 250177Lactamase_BInterPro annotationAdd
BLAST

Phylogenomic databases

KOiK18780.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Metallo-B-lactamas.
[Graphical view]
PfamiPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.

Sequencei

Sequence statusi: Complete.

E5KIY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELPNIMHPV AKLSTALAAA LMLSGCMPGE IRPTIGQQME TGDQRFGDLV
60 70 80 90 100
FRQLAPNVWQ HTSYLDMPGF GAVASNGLIV RDGGRVLVVD TAWTDDQTAQ
110 120 130 140 150
ILNWIKQEIN LPVALAVVTH AHQDKMGGMD ALHAAGIATY ANALSNQLAP
160 170 180 190 200
QEGMVAAQHS LTFAANGWVE PATAPNFGPL KVFYPGPGHT SDNITVGIDG
210 220 230 240 250
TDIAFGGCLI KDSKAKSLGN LGDADTEHYA ASARAFGAAF PKASMIVMSH
260 270
SAPDSRAAIT HTARMADKLR
Length:270
Mass (Da):28,499
Last modified:February 8, 2011 - v1
Checksum:i1B6009120B945F14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ162469 Genomic DNA. Translation: ADP20459.1.
HQ451074 Genomic DNA. Translation: ADY00041.1.
JF922606 Genomic DNA. Translation: AEH43774.1.
JF785549 Genomic DNA. Translation: AEK64842.1.
JF503991 Genomic DNA. Translation: AEN71485.1.
JF714412 Genomic DNA. Translation: AEP32605.1.
JQ364967 Genomic DNA. Translation: AFI72857.1.
JX000475 Genomic DNA. Translation: AFN73221.1.
JX296013 Genomic DNA. Translation: AFU75168.1.
KC149527 Genomic DNA. Translation: AGB57374.1.
KF951455 Genomic DNA. Translation: AHK80864.1.
KF951456 Genomic DNA. Translation: AHK80865.1.
KJ413946 Genomic DNA. Translation: AHX39447.1.
KJ558506 Genomic DNA. Translation: AIA22330.1.
KJ802404 Genomic DNA. Translation: AIM48196.1.
KJ440076 Genomic DNA. Translation: AIU96948.1.
KM111580 Genomic DNA. Translation: AIZ65660.1.
KM111584 Genomic DNA. Translation: AIZ65664.1.
KM111585 Genomic DNA. Translation: AIZ65665.1.
KM485656 Genomic DNA. Translation: AIZ65943.1.
KP027046 Genomic DNA. Translation: AJL35292.1.
KP826702 Genomic DNA. Translation: AKN35214.1.
KP826703 Genomic DNA. Translation: AKN35231.1.
KP826713 Genomic DNA. Translation: AKN35341.1.
KP772144 Genomic DNA. Translation: AKT45764.1.
KP772147 Genomic DNA. Translation: AKT45767.1.
KP772166 Genomic DNA. Translation: AKT45786.1.
KP772192 Genomic DNA. Translation: AKT45812.1.
KP770028 Genomic DNA. Translation: ALD19858.1.
KR822247 Genomic DNA. Translation: ALF35449.1.
KT879914 Genomic DNA. Translation: ALP68872.1.
AB604953 Genomic DNA. Translation: BAK40112.1.
AP012208 Genomic DNA. Translation: BAK69668.1.
AB769140 Genomic DNA. Translation: BAN37431.1.
HG003695 Other DNA. Translation: CDF66128.1.
LN871243 Genomic DNA. Translation: CTQ31245.1.
LNIP01000003 Genomic DNA. Translation: KSZ23519.1.
RefSeqiWP_004201164.1. NZ_LQWX01000118.1.
YP_004765050.1. NC_015872.1.
YP_006903357.1. NC_019045.2.
YP_006939981.1. NC_018994.1.
YP_006952434.1. NC_019063.1.
YP_006953215.1. NC_019069.1.
YP_006953875.1. NC_019089.1.
YP_009059936.1. NC_024954.1.
YP_009066439.1. NC_025106.1.

Genome annotation databases

EnsemblBacteriaiAJB55021; AJB55021; RR31_25890.
AJB55029; AJB55029; RR31_25680.
GeneIDi11027496.
13876866.
13903469.
13905367.
13906127.
13906812.
20466712.
20471936.
KEGGipg:11027496.
pg:13876866.
pg:13903469.
pg:13905367.
pg:13906127.
pg:13906812.
pg:20466712.
pg:20471936.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ162469 Genomic DNA. Translation: ADP20459.1.
HQ451074 Genomic DNA. Translation: ADY00041.1.
JF922606 Genomic DNA. Translation: AEH43774.1.
JF785549 Genomic DNA. Translation: AEK64842.1.
JF503991 Genomic DNA. Translation: AEN71485.1.
JF714412 Genomic DNA. Translation: AEP32605.1.
JQ364967 Genomic DNA. Translation: AFI72857.1.
JX000475 Genomic DNA. Translation: AFN73221.1.
JX296013 Genomic DNA. Translation: AFU75168.1.
KC149527 Genomic DNA. Translation: AGB57374.1.
KF951455 Genomic DNA. Translation: AHK80864.1.
KF951456 Genomic DNA. Translation: AHK80865.1.
KJ413946 Genomic DNA. Translation: AHX39447.1.
KJ558506 Genomic DNA. Translation: AIA22330.1.
KJ802404 Genomic DNA. Translation: AIM48196.1.
KJ440076 Genomic DNA. Translation: AIU96948.1.
KM111580 Genomic DNA. Translation: AIZ65660.1.
KM111584 Genomic DNA. Translation: AIZ65664.1.
KM111585 Genomic DNA. Translation: AIZ65665.1.
KM485656 Genomic DNA. Translation: AIZ65943.1.
KP027046 Genomic DNA. Translation: AJL35292.1.
KP826702 Genomic DNA. Translation: AKN35214.1.
KP826703 Genomic DNA. Translation: AKN35231.1.
KP826713 Genomic DNA. Translation: AKN35341.1.
KP772144 Genomic DNA. Translation: AKT45764.1.
KP772147 Genomic DNA. Translation: AKT45767.1.
KP772166 Genomic DNA. Translation: AKT45786.1.
KP772192 Genomic DNA. Translation: AKT45812.1.
KP770028 Genomic DNA. Translation: ALD19858.1.
KR822247 Genomic DNA. Translation: ALF35449.1.
KT879914 Genomic DNA. Translation: ALP68872.1.
AB604953 Genomic DNA. Translation: BAK40112.1.
AP012208 Genomic DNA. Translation: BAK69668.1.
AB769140 Genomic DNA. Translation: BAN37431.1.
HG003695 Other DNA. Translation: CDF66128.1.
LN871243 Genomic DNA. Translation: CTQ31245.1.
LNIP01000003 Genomic DNA. Translation: KSZ23519.1.
RefSeqiWP_004201164.1. NZ_LQWX01000118.1.
YP_004765050.1. NC_015872.1.
YP_006903357.1. NC_019045.2.
YP_006939981.1. NC_018994.1.
YP_006952434.1. NC_019063.1.
YP_006953215.1. NC_019069.1.
YP_006953875.1. NC_019089.1.
YP_009059936.1. NC_024954.1.
YP_009066439.1. NC_025106.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3S0ZX-ray2.50A/B47-270[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAJB55021; AJB55021; RR31_25890.
AJB55029; AJB55029; RR31_25680.
GeneIDi11027496.
13876866.
13903469.
13905367.
13906127.
13906812.
20466712.
20471936.
KEGGipg:11027496.
pg:13876866.
pg:13903469.
pg:13905367.
pg:13906127.
pg:13906812.
pg:20466712.
pg:20471936.

Phylogenomic databases

KOiK18780.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Metallo-B-lactamas.
[Graphical view]
PfamiPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiE5KIY2_ECOLX
AccessioniPrimary (citable) accession number: E5KIY2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 7, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported, PlasmidImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.