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E5KIY2 (E5KIY2_ECOLX) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

Metallo beta lactamase NDM-1 EMBL AGB57374.1

Metallo-beta-lactamase EMBL ADP20459.1

Metallo-beta-lactamase NDM-1 EMBL AHK80864.1

NDM-1 EMBL AFI72857.1

NDM-1 metallo-beta-lactamase EMBL AEN71485.1

New Delhi metallo-beta-lactamase EMBL ADY00041.1

New Delhi metallo-beta-lactamase-1 EMBL AFN73221.1
Gene names
Name:blaNDM-1 EMBL ADY00041.1
Synonyms:bla NDM-1 EMBL AFN73221.1
ORF Names:ECS01_0033 EMBL AHX39447.1, NDM1Dok01_N0175 EMBL BAK69668.1, pNDM102337_147 EMBL AEP32605.1, pNDM10505_149 EMBL AEN71485.1
Encoded onPlasmid p271A Ref.3 EMBL AEK64842.1
Plasmid pABC85 Ref.12 EMBL AGB57374.1
Plasmid pBJ01 Ref.13 EMBL AFU75168.1
Plasmid pGUE-NDM Ref.9 EMBL AFI72857.1
Plasmid pMC-NDM Ref.15 EMBL CDF66128.1
Plasmid pNDM-1_Dok01 Ref.6 EMBL BAK69668.1
Plasmid pNDM-ECS01 Ref.16 EMBL AHX39447.1
Plasmid pNDM-HK Ref.5 EMBL ADY00041.1
Plasmid pNDM102337 Ref.11 EMBL AEP32605.1
Plasmid pNDM10505 Ref.8 EMBL AEN71485.1
Plasmid unnamed Ref.10 EMBL AFN73221.1
OrganismEscherichia coli EMBL ADP20459.1
Taxonomic identifier562 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length270 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding1201Zinc; via tele nitrogen PDB 3S0Z
Metal binding1221Zinc PDB 3S0Z
Metal binding1891Zinc; via tele nitrogen PDB 3S0Z
Metal binding2081Zinc PDB 3S0Z

Sequences

Sequence LengthMass (Da)Tools
E5KIY2 [UniParc].

Last modified February 8, 2011. Version 1.
Checksum: 1B6009120B945F14

FASTA27028,499
        10         20         30         40         50         60 
MELPNIMHPV AKLSTALAAA LMLSGCMPGE IRPTIGQQME TGDQRFGDLV FRQLAPNVWQ 

        70         80         90        100        110        120 
HTSYLDMPGF GAVASNGLIV RDGGRVLVVD TAWTDDQTAQ ILNWIKQEIN LPVALAVVTH 

       130        140        150        160        170        180 
AHQDKMGGMD ALHAAGIATY ANALSNQLAP QEGMVAAQHS LTFAANGWVE PATAPNFGPL 

       190        200        210        220        230        240 
KVFYPGPGHT SDNITVGIDG TDIAFGGCLI KDSKAKSLGN LGDADTEHYA ASARAFGAAF 

       250        260        270 
PKASMIVMSH SAPDSRAAIT HTARMADKLR 

« Hide

References

[1]"Emergence of metallo-?-lactamase NDM-1-producing multidrug-resistant Escherichia coli in Australia."
Poirel L., Lagrutta E., Taylor P., Pham J., Nordmann P.
Antimicrob. Agents Chemother. 54:4914-4916(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 271 EMBL ADP20459.1.
[2]"The entire NDM-1 gene sequence of NDM-1-positive E. coli isolated in Japan."
Yamamoto T.
Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NDM-1 Dok01 EMBL BAK40112.1.
[3]"Analysis of the Resistome of a Multidrug-Resistant NDM-1-Producing Escherichia coli Strain by High-Throughput Genome Sequencing."
Poirel L., Bonnin R.A., Nordmann P.
Antimicrob. Agents Chemother. 55:4224-4229(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 271 EMBL AEK64842.1.
[4]"First Description of an Escherichia coli Strain Producing NDM-1 Carbapenemase in Spain."
Sole M., Pitart C., Roca I., Fabrega A., Salvador P., Munoz L., Oliveira I., Gascon J., Marco F., Vila J.
Antimicrob. Agents Chemother. 55:4402-4404(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: DVR22 EMBL AEH43774.1.
[5]"Complete sequencing of pNDM-HK encoding NDM-1 carbapenemase from a multidrug-resistant Escherichia coli strain isolated in Hong Kong."
Ho P.L., Lo W.U., Yeung M.K., Lin C.H., Chow K.H., Ang I., Tong A.H., Bao J.Y., Lok S., Lo J.Y.
PLoS ONE 6:E17989-E17989(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: HK-01 EMBL ADY00041.1.
[6]"Complete Sequencing of the bla(NDM-1)-Positive IncA/C Plasmid from Escherichia coli ST38 Isolate Suggests a Possible Origin from Plant Pathogens."
Sekizuka T., Matsui M., Yamane K., Takeuchi F., Ohnishi M., Hishinuma A., Arakawa Y., Kuroda M.
PLoS ONE 6:e25334-e25334(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NDM-1 Dok01 EMBL BAK69668.1.
[7]"A structural view of the antibiotic degradation enzyme NDM-1 from a superbug."
Guo Y., Wang J., Niu G., Shui W., Sun Y., Zhou H., Zhang Y., Yang C., Lou Z., Rao Z.
Protein Cell 2:384-394(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 47-270 IN COMPLEX WITH ZINC.
[8]"Inc A/C plasmids harbouring the NDM-1 metallo-beta-lactamase."
Boyd D.A., Mataseje L.F., Mulvey M.R.
Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: N10-0505 EMBL AEN71485.1.
[9]"Characterization of an IncFII Plasmid Encoding NDM-1 from Escherichia coli ST131."
Bonnin R.A., Poirel L., Carattoli A., Nordmann P.
PLoS ONE 7:E34752-E34752(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: GUE EMBL AFI72857.1.
[10]"First New Delhi Metallo-beta-Lactamase 1-Producing Escherichia coli isolated in China."
Liu Z.
Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BJ01 EMBL AFN73221.1.
[11]"Inc A/C plasmids harbouring the NDM-1 metallo-beta-lactamase."
Boyd D.A., Mataseje L.F., Mulvey M.R.
Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: N10-2337 EMBL AEP32605.1.
[12]"Emergence and spread of NDM-1 producer Enterobacteriaceae with contribution of IncX3 plasmids in the United Arab Emirates."
Sonnevend A., Al Baloushi A., Ghazawi A., Hashmey R., Girgis S., Hamadeh M.B., Al Haj M., Pal T.
J. Med. Microbiol. 62:1044-1050(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: ABC85 EMBL AGB57374.1.
[13]"Identification and Characterization of the First Escherichia coli Strain Carrying NDM-1 Gene in China."
Liu Z., Li W., Wang J., Pan J., Sun S., Yu Y., Zhao B., Ma Y., Zhang T., Qi J., Liu G., Lu F.
PLoS ONE 8:E66666-E66666(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BJ01 EMBL AFU75168.1.
[14]Lu W., Cheng C., Rui Y.
Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NF133 EMBL AHK80864.1 and NF188 EMBL AHK80865.1.
[15]"The First NDM Metallo-?-Lactamase-Producing Enterobacteriaceae Isolate in Poland: Evolution of IncFII-Type Plasmids Carrying the blaNDM-1 Gene."
Fiett J., Baraniak A., Izdebski R., Sitkiewicz I., Zabicka D., Meler A., Filczak K., Hryniewicz W., Gniadkowski M.
Antimicrob. Agents Chemother. 58:1203-1207(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NMI5428/11 EMBL CDF66128.1.
[16]"Emergence and characterisation of blaNDM-1-carrying IncN2-type plasmid in Escherichia coli ST131 isolate in Thailand."
Netikul T., Sidjabat H.E., Paterson D.L., Kamolwit W., Tantisiriwat W., Kiratisin P.
Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: ECS01 EMBL AHX39447.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HQ162469 Genomic DNA. Translation: ADP20459.1.
HQ451074 Genomic DNA. Translation: ADY00041.1.
JF922606 Genomic DNA. Translation: AEH43774.1.
JF785549 Genomic DNA. Translation: AEK64842.1.
JF503991 Genomic DNA. Translation: AEN71485.1.
JF714412 Genomic DNA. Translation: AEP32605.1.
JQ364967 Genomic DNA. Translation: AFI72857.1.
JX000475 Genomic DNA. Translation: AFN73221.1.
JX296013 Genomic DNA. Translation: AFU75168.1.
KC149527 Genomic DNA. Translation: AGB57374.1.
KF951455 Genomic DNA. Translation: AHK80864.1.
KF951456 Genomic DNA. Translation: AHK80865.1.
KJ413946 Genomic DNA. Translation: AHX39447.1.
AB604953 Genomic DNA. Translation: BAK40112.1.
AP012208 Genomic DNA. Translation: BAK69668.1.
HG003695 Other DNA. Translation: CDF66128.1.
RefSeqYP_004765050.1. NC_015872.1.
YP_006903357.1. NC_019045.2.
YP_006939981.1. NC_018994.1.
YP_006952434.1. NC_019063.1.
YP_006953215.1. NC_019069.1.
YP_006953875.1. NC_019089.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3S0ZX-ray2.50A/B47-270[»]
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID11027496.
13876866.
13903469.
13905367.
13906127.
13906812.

Family and domain databases

Gene3D3.60.15.10. 1 hit.
InterProIPR001279. Beta-lactamas-like.
[Graphical view]
PfamPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMSSF56281. SSF56281. 1 hit.
ProtoNetSearch...

Entry information

Entry nameE5KIY2_ECOLX
AccessionPrimary (citable) accession number: E5KIY2
Entry history
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: July 9, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)