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Protein
Submitted name:

Beta-lactamase

Gene

blaNDM-1

Organism
Escherichia coli
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi120Zinc; via tele nitrogenCombined sources1
Metal bindingi122Zinc; via pros nitrogenCombined sources1
Metal bindingi189Zinc; via tele nitrogenCombined sources1

GO - Molecular functioni

Keywordsi

LigandMetal-bindingCombined sources, ZincCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Beta-lactamaseImported
Submitted name:
Beta-lactamase NDM-1Imported
Submitted name:
BlaNDM-1Imported
Submitted name:
BlaNDM-1 metallo beta lactamaseImported
Submitted name:
Metallo-beta-lactamase NDM-1Imported
Submitted name:
NDM-1Imported
Submitted name:
NDM-1 metallo-beta-lactamaseImported
Submitted name:
New Delhi metallo-beta-lactamase NDM-1Imported
Submitted name:
New Delhi metallo-beta-lactamase-1Imported
Submitted name:
Subclass B1 metallo-beta-lactamase NDM-1Imported
Gene namesi
Name:blaNDM-1Imported
Synonyms:bla NDM-1Imported
ORF Names:AM434_27040Imported, APU18_05360Imported, AZ95_0035Imported, BET08_16280Imported, BVL39_26630Imported, CA268_28970Imported, ECS01_0033Imported, MS6198_A142Imported, NDM1Dok01_N0175Imported, pNDM102337_147Imported, pNDM10505_149Imported
Encoded oniPlasmid p1002-NDM1Imported
Plasmid p1002-ndm1Imported
Plasmid p1540-2Imported
Plasmid p271AImported
Plasmid pABC85Imported
Plasmid pACT1-EC-NDM-1Imported
Plasmid pACT2-NDM-1Imported
Plasmid pBJ01Imported
Plasmid pCR7-EC-NDM-1Imported
Plasmid pEc2AImported
Plasmid pGUE-NDMImported
Plasmid pHNEC55Imported
Plasmid pHNTS79-NDMImported
Plasmid pIMD989Imported
Plasmid pLK75Imported
Plasmid pMC-NDMImported
Plasmid pMS6198AImported
Plasmid pNDM-1_Dok01Imported
Plasmid pNDM-ECS01Imported
Plasmid pNDM-EcoGN568Imported
Plasmid pNDM-HKImported
Plasmid pNDM-HU01Imported
Plasmid pNDM102337Imported
Plasmid pNDM10505Imported
Plasmid pPN66-ECL-NDM-1Imported
Plasmid pms6198aImported
Plasmid unitig_2Imported
Plasmid unnamedImported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000196793 Componenti: Plasmid unitig_2
  • UP000188465 Componenti: Unassembled WGS sequence
  • UP000094504 Componenti: Plasmid pms6198a
  • UP000194331 Componenti: Plasmid p1002-ndm1
  • UP000234906 Componenti: Plasmid p1540-2
  • UP000053450 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3S0ZX-ray2.50A/B47-270[»]
5YPIX-ray2.30A/B/C/D/E/F/G/H29-270[»]
5YPKX-ray2.00A/B/C/D/E/F/G/H29-270[»]
5YPLX-ray1.80A/B29-270[»]
5YPMX-ray2.15A/B/C/D/E/F/G/H29-270[»]
5YPNX-ray2.12A/B29-270[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 250Lactamase_BInterPro annotationAdd BLAST177

Family and domain databases

Gene3Di3.60.15.10, 1 hit
InterProiView protein in InterPro
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
PfamiView protein in Pfam
PF00753 Lactamase_B, 1 hit
SMARTiView protein in SMART
SM00849 Lactamase_B, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit

Sequencei

Sequence statusi: Complete.

E5KIY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELPNIMHPV AKLSTALAAA LMLSGCMPGE IRPTIGQQME TGDQRFGDLV
60 70 80 90 100
FRQLAPNVWQ HTSYLDMPGF GAVASNGLIV RDGGRVLVVD TAWTDDQTAQ
110 120 130 140 150
ILNWIKQEIN LPVALAVVTH AHQDKMGGMD ALHAAGIATY ANALSNQLAP
160 170 180 190 200
QEGMVAAQHS LTFAANGWVE PATAPNFGPL KVFYPGPGHT SDNITVGIDG
210 220 230 240 250
TDIAFGGCLI KDSKAKSLGN LGDADTEHYA ASARAFGAAF PKASMIVMSH
260 270
SAPDSRAAIT HTARMADKLR
Length:270
Mass (Da):28,499
Last modified:February 8, 2011 - v1
Checksum:i1B6009120B945F14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ162469 Genomic DNA Translation: ADP20459.1
HQ451074 Genomic DNA Translation: ADY00041.1
JF922606 Genomic DNA Translation: AEH43774.1
JF785549 Genomic DNA Translation: AEK64842.1
JF503991 Genomic DNA Translation: AEN71485.1
JF714412 Genomic DNA Translation: AEP32605.1
JQ364967 Genomic DNA Translation: AFI72857.1
JX000475 Genomic DNA Translation: AFN73221.1
JX296013 Genomic DNA Translation: AFU75168.1
KC149527 Genomic DNA Translation: AGB57374.1
KF951455 Genomic DNA Translation: AHK80864.1
KF951456 Genomic DNA Translation: AHK80865.1
KJ413946 Genomic DNA Translation: AHX39447.1
KJ558506 Genomic DNA Translation: AIA22330.1
KJ802404 Genomic DNA Translation: AIM48196.1
KJ440076 Genomic DNA Translation: AIU96948.1
KM111580 Genomic DNA Translation: AIZ65660.1
KM111584 Genomic DNA Translation: AIZ65664.1
KM111585 Genomic DNA Translation: AIZ65665.1
KM485656 Genomic DNA Translation: AIZ65943.1
KP027046 Genomic DNA Translation: AJL35292.1
KP826702 Genomic DNA Translation: AKN35214.1
KP826703 Genomic DNA Translation: AKN35231.1
KP826713 Genomic DNA Translation: AKN35341.1
KP772144 Genomic DNA Translation: AKT45764.1
KP772147 Genomic DNA Translation: AKT45767.1
KP772166 Genomic DNA Translation: AKT45786.1
KP772192 Genomic DNA Translation: AKT45812.1
KP770028 Genomic DNA Translation: ALD19858.1
KR822247 Genomic DNA Translation: ALF35449.1
KT879914 Genomic DNA Translation: ALP68872.1
CP015835 Genomic DNA Translation: AOM73211.1
CP021206 Genomic DNA Translation: ARR63277.1
CP021936 Genomic DNA Translation: ASC19938.1
MF383355 Genomic DNA Translation: ATB17817.1
CP019053 Genomic DNA Translation: AUL71622.1
AB604953 Genomic DNA Translation: BAK40112.1
AP012208 Genomic DNA Translation: BAK69668.1
AB769140 Genomic DNA Translation: BAN37431.1
HG003695 Other DNA Translation: CDF66128.1
LN871243 Genomic DNA Translation: CTQ31245.1
LNIP01000003 Genomic DNA Translation: KSZ23519.1
MCNL01000171 Genomic DNA Translation: ONK54431.1
RefSeqiWP_004201164.1, NZ_PISG01000161.1
YP_004765050.1, NC_015872.1
YP_006903357.1, NC_019045.2
YP_006939981.1, NC_018994.1
YP_006952434.1, NC_019063.1
YP_006953215.1, NC_019069.1
YP_006953875.1, NC_019089.1
YP_009059936.1, NC_024954.1
YP_009066439.1, NC_025106.1

Genome annotation databases

EnsemblBacteriaiANM85706; ANM85706; A8V37_24690
AOM73211; AOM73211; MS6198_A142
KSZ23519; KSZ23519; APU18_05360
GeneIDi11027496
13876866
13903469
13905367
13906127
13906812
20466712
20471936
PATRICifig|562.12826.peg.5242

Similar proteinsi

Entry informationi

Entry nameiE5KIY2_ECOLX
AccessioniPrimary (citable) accession number: E5KIY2
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported, PlasmidImported

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