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E5KIY2

- E5KIY2_ECOLX

UniProt

E5KIY2 - E5KIY2_ECOLX

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Protein
Submitted name: Beta-lactamase
Gene
blaNDM-1, bla NDM-1, DP79_14850, ECS01_0033, NDM1Dok01_N0175, pNDM102337_147, pNDM10505_149
Organism
Escherichia coli
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi120 – 1201Zinc; via tele nitrogenImported
Metal bindingi122 – 1221ZincImported
Metal bindingi189 – 1891Zinc; via tele nitrogenImported
Metal bindingi208 – 2081ZincImported

GO - Molecular functioni

  1. hydrolase activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Metal-bindingImported, ZincImported

Names & Taxonomyi

Protein namesi
Submitted name:
Beta-lactamaseImported
Submitted name:
Beta-lactamase NDM-1Imported
Submitted name:
BlaNDM-1Imported
Submitted name:
Metallo beta lactamase NDM-1Imported
Submitted name:
Metallo-beta-lactamaseImported
Submitted name:
Metallo-beta-lactamase NDM-1Imported
Submitted name:
NDM-1Imported
Submitted name:
NDM-1 metallo-beta-lactamaseImported
Submitted name:
New Delhi metallo-beta-lactamaseImported
Submitted name:
New Delhi metallo-beta-lactamase-1Imported
Gene namesi
Name:blaNDM-1Imported
Synonyms:bla NDM-1Imported
ORF Names:DP79_14850Imported, ECS01_0033Imported, NDM1Dok01_N0175Imported, pNDM102337_147Imported, pNDM10505_149Imported
Encoded oniPlasmid p271AImported
Plasmid pABC85Imported
Plasmid pBJ01Imported
Plasmid pGUE-NDMImported
Plasmid pMC-NDMImported
Plasmid pNDM-1_Dok01Imported
Plasmid pNDM-ECS01Imported
Plasmid pNDM-HKImported
Plasmid pNDM-HU01Imported
Plasmid pNDM102337Imported
Plasmid pNDM10505Imported
Plasmid unnamedImported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3S0ZX-ray2.50A/B47-270[»]

Family & Domainsi

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Beta-lactamas-like.
[Graphical view]
PfamiPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.

Sequencei

Sequence statusi: Complete.

E5KIY2-1 [UniParc]FASTAAdd to Basket

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MELPNIMHPV AKLSTALAAA LMLSGCMPGE IRPTIGQQME TGDQRFGDLV    50
FRQLAPNVWQ HTSYLDMPGF GAVASNGLIV RDGGRVLVVD TAWTDDQTAQ 100
ILNWIKQEIN LPVALAVVTH AHQDKMGGMD ALHAAGIATY ANALSNQLAP 150
QEGMVAAQHS LTFAANGWVE PATAPNFGPL KVFYPGPGHT SDNITVGIDG 200
TDIAFGGCLI KDSKAKSLGN LGDADTEHYA ASARAFGAAF PKASMIVMSH 250
SAPDSRAAIT HTARMADKLR 270
Length:270
Mass (Da):28,499
Last modified:February 8, 2011 - v1
Checksum:i1B6009120B945F14
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HQ162469 Genomic DNA. Translation: ADP20459.1.
HQ451074 Genomic DNA. Translation: ADY00041.1.
JF922606 Genomic DNA. Translation: AEH43774.1.
JF785549 Genomic DNA. Translation: AEK64842.1.
JF503991 Genomic DNA. Translation: AEN71485.1.
JF714412 Genomic DNA. Translation: AEP32605.1.
JQ364967 Genomic DNA. Translation: AFI72857.1.
JX000475 Genomic DNA. Translation: AFN73221.1.
JX296013 Genomic DNA. Translation: AFU75168.1.
KC149527 Genomic DNA. Translation: AGB57374.1.
KF951455 Genomic DNA. Translation: AHK80864.1.
KF951456 Genomic DNA. Translation: AHK80865.1.
KJ413946 Genomic DNA. Translation: AHX39447.1.
KJ558506 Genomic DNA. Translation: AIA22330.1.
AB604953 Genomic DNA. Translation: BAK40112.1.
AP012208 Genomic DNA. Translation: BAK69668.1.
AB769140 Genomic DNA. Translation: BAN37431.1.
HG003695 Other DNA. Translation: CDF66128.1.
JJNV01000040 Genomic DNA. Translation: KCW95010.1.
RefSeqiYP_004765050.1. NC_015872.1.
YP_006903357.1. NC_019045.2.
YP_006939981.1. NC_018994.1.
YP_006952434.1. NC_019063.1.
YP_006953215.1. NC_019069.1.
YP_006953875.1. NC_019089.1.

Genome annotation databases

GeneIDi11027496.
13876866.
13903469.
13905367.
13906127.
13906812.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HQ162469 Genomic DNA. Translation: ADP20459.1 .
HQ451074 Genomic DNA. Translation: ADY00041.1 .
JF922606 Genomic DNA. Translation: AEH43774.1 .
JF785549 Genomic DNA. Translation: AEK64842.1 .
JF503991 Genomic DNA. Translation: AEN71485.1 .
JF714412 Genomic DNA. Translation: AEP32605.1 .
JQ364967 Genomic DNA. Translation: AFI72857.1 .
JX000475 Genomic DNA. Translation: AFN73221.1 .
JX296013 Genomic DNA. Translation: AFU75168.1 .
KC149527 Genomic DNA. Translation: AGB57374.1 .
KF951455 Genomic DNA. Translation: AHK80864.1 .
KF951456 Genomic DNA. Translation: AHK80865.1 .
KJ413946 Genomic DNA. Translation: AHX39447.1 .
KJ558506 Genomic DNA. Translation: AIA22330.1 .
AB604953 Genomic DNA. Translation: BAK40112.1 .
AP012208 Genomic DNA. Translation: BAK69668.1 .
AB769140 Genomic DNA. Translation: BAN37431.1 .
HG003695 Other DNA. Translation: CDF66128.1 .
JJNV01000040 Genomic DNA. Translation: KCW95010.1 .
RefSeqi YP_004765050.1. NC_015872.1.
YP_006903357.1. NC_019045.2.
YP_006939981.1. NC_018994.1.
YP_006952434.1. NC_019063.1.
YP_006953215.1. NC_019069.1.
YP_006953875.1. NC_019089.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3S0Z X-ray 2.50 A/B 47-270 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 11027496.
13876866.
13903469.
13905367.
13906127.
13906812.

Family and domain databases

Gene3Di 3.60.15.10. 1 hit.
InterProi IPR001279. Beta-lactamas-like.
[Graphical view ]
Pfami PF00753. Lactamase_B. 1 hit.
[Graphical view ]
SMARTi SM00849. Lactamase_B. 1 hit.
[Graphical view ]
SUPFAMi SSF56281. SSF56281. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Emergence of metallo-?-lactamase NDM-1-producing multidrug-resistant Escherichia coli in Australia."
    Poirel L., Lagrutta E., Taylor P., Pham J., Nordmann P.
    Antimicrob. Agents Chemother. 54:4914-4916(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 271Imported.
  2. "The entire NDM-1 gene sequence of NDM-1-positive E. coli isolated in Japan."
    Yamamoto T.
    Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NDM-1 Dok01Imported.
  3. "Analysis of the Resistome of a Multidrug-Resistant NDM-1-Producing Escherichia coli Strain by High-Throughput Genome Sequencing."
    Poirel L., Bonnin R.A., Nordmann P.
    Antimicrob. Agents Chemother. 55:4224-4229(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 271Imported.
    Plasmid: p271A
  4. "First Description of an Escherichia coli Strain Producing NDM-1 Carbapenemase in Spain."
    Sole M., Pitart C., Roca I., Fabrega A., Salvador P., Munoz L., Oliveira I., Gascon J., Marco F., Vila J.
    Antimicrob. Agents Chemother. 55:4402-4404(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DVR22Imported.
  5. "Complete sequencing of pNDM-HK encoding NDM-1 carbapenemase from a multidrug-resistant Escherichia coli strain isolated in Hong Kong."
    Ho P.L., Lo W.U., Yeung M.K., Lin C.H., Chow K.H., Ang I., Tong A.H., Bao J.Y., Lok S., Lo J.Y.
    PLoS ONE 6:E17989-E17989(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HK-01Imported.
    Plasmid: pNDM-HK
  6. "Complete Sequencing of the bla(NDM-1)-Positive IncA/C Plasmid from Escherichia coli ST38 Isolate Suggests a Possible Origin from Plant Pathogens."
    Sekizuka T., Matsui M., Yamane K., Takeuchi F., Ohnishi M., Hishinuma A., Arakawa Y., Kuroda M.
    PLoS ONE 6:e25334-e25334(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NDM-1 Dok01Imported.
    Plasmid: pNDM-1_Dok01
  7. "A structural view of the antibiotic degradation enzyme NDM-1 from a superbug."
    Guo Y., Wang J., Niu G., Shui W., Sun Y., Zhou H., Zhang Y., Yang C., Lou Z., Rao Z.
    Protein Cell 2:384-394(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 47-270 IN COMPLEX WITH ZINC.
  8. "Inc A/C plasmids harbouring the NDM-1 metallo-beta-lactamase."
    Boyd D.A., Mataseje L.F., Mulvey M.R.
    Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: N10-0505Imported.
    Plasmid: pNDM10505
  9. "Characterization of an IncFII Plasmid Encoding NDM-1 from Escherichia coli ST131."
    Bonnin R.A., Poirel L., Carattoli A., Nordmann P.
    PLoS ONE 7:E34752-E34752(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: GUEImported.
    Plasmid: pGUE-NDM
  10. "First New Delhi Metallo-beta-Lactamase 1-Producing Escherichia coli isolated in China."
    Liu Z.
    Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BJ01Imported.
    Plasmid: unnamed
  11. "Inc A/C plasmids harbouring the NDM-1 metallo-beta-lactamase."
    Boyd D.A., Mataseje L.F., Mulvey M.R.
    Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: N10-2337Imported.
    Plasmid: pNDM102337
  12. "The first isolation of an NDM-1-producing Escherichia coli in West Japan."
    Kayama S., Shigemoto N., Kuwahara R., Koba Y., Onodera M., Yokozaki M., Ohge H., Kato F., Hisatsune J., Sugai M.
    Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MS5260Imported.
    Plasmid: pNDM-HU01
  13. "Emergence and spread of NDM-1 producer Enterobacteriaceae with contribution of IncX3 plasmids in the United Arab Emirates."
    Sonnevend A., Al Baloushi A., Ghazawi A., Hashmey R., Girgis S., Hamadeh M.B., Al Haj M., Pal T.
    J. Med. Microbiol. 62:1044-1050(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ABC85Imported.
    Plasmid: pABC85
  14. "Identification and Characterization of the First Escherichia coli Strain Carrying NDM-1 Gene in China."
    Liu Z., Li W., Wang J., Pan J., Sun S., Yu Y., Zhao B., Ma Y., Zhang T., Qi J., Liu G., Lu F.
    PLoS ONE 8:E66666-E66666(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BJ01Imported.
    Plasmid: pBJ01
  15. Lu W., Cheng C., Rui Y.
    Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NF133Imported and NF188Imported.
  16. "The First NDM Metallo-?-Lactamase-Producing Enterobacteriaceae Isolate in Poland: Evolution of IncFII-Type Plasmids Carrying the blaNDM-1 Gene."
    Fiett J., Baraniak A., Izdebski R., Sitkiewicz I., Zabicka D., Meler A., Filczak K., Hryniewicz W., Gniadkowski M.
    Antimicrob. Agents Chemother. 58:1203-1207(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NMI5428/11Imported.
    Plasmid: pMC-NDM
  17. "Emergence and characterisation of blaNDM-1-carrying IncN2-type plasmid in Escherichia coli ST131 isolate in Thailand."
    Netikul T., Sidjabat H.E., Paterson D.L., Kamolwit W., Tantisiriwat W., Kiratisin P.
    Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ECS01Imported.
    Plasmid: pNDM-ECS01
  18. Lu W.
    Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NF741Imported.
  19. "Draft Genome Sequence of blaNDM-1 positive Escherichia coli O25b-ST131 clone isolated from an environmental sample."
    Kutumbaka K., Han S., Mategko J., Nadala C., Buser G.L., Cassidy M.P., Beldavs Z.G., Weissman S.J., Morey K.E., Vega R., Samadpour M.
    Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: O25b-ST131Imported.

Entry informationi

Entry nameiE5KIY2_ECOLX
AccessioniPrimary (citable) accession number: E5KIY2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 3, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, PlasmidImported

External Data

Dasty 3

Similar proteinsi