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E5KIY2

- E5KIY2_ECOLX

UniProt

E5KIY2 - E5KIY2_ECOLX

Protein
Submitted name:

Beta-lactamase

Gene

blaNDM-1

Organism
Escherichia coli
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi120 – 1201Zinc; via tele nitrogenImported
    Metal bindingi122 – 1221ZincImported
    Metal bindingi189 – 1891Zinc; via tele nitrogenImported
    Metal bindingi208 – 2081ZincImported

    GO - Molecular functioni

    1. hydrolase activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    Metal-bindingImported, ZincImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Beta-lactamaseImported
    Submitted name:
    Beta-lactamase NDM-1Imported
    Submitted name:
    BlaNDM-1Imported
    Submitted name:
    Metallo beta lactamase NDM-1Imported
    Submitted name:
    Metallo-beta-lactamaseImported
    Submitted name:
    Metallo-beta-lactamase NDM-1Imported
    Submitted name:
    NDM-1Imported
    Submitted name:
    NDM-1 metallo-beta-lactamaseImported
    Submitted name:
    New Delhi metallo-beta-lactamaseImported
    Submitted name:
    New Delhi metallo-beta-lactamase-1Imported
    Gene namesi
    Name:blaNDM-1Imported
    Synonyms:bla NDM-1Imported
    ORF Names:DP79_14850Imported, ECS01_0033Imported, NDM1Dok01_N0175Imported, pNDM102337_147Imported, pNDM10505_149Imported
    Encoded oniPlasmid p271AImported
    Plasmid pABC85Imported
    Plasmid pBJ01Imported
    Plasmid pGUE-NDMImported
    Plasmid pMC-NDMImported
    Plasmid pNDM-1_Dok01Imported
    Plasmid pNDM-ECS01Imported
    Plasmid pNDM-HKImported
    Plasmid pNDM-HU01Imported
    Plasmid pNDM102337Imported
    Plasmid pNDM10505Imported
    Plasmid unnamedImported
    OrganismiEscherichia coliImported
    Taxonomic identifieri562 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3S0ZX-ray2.50A/B47-270[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    Gene3Di3.60.15.10. 1 hit.
    InterProiIPR001279. Beta-lactamas-like.
    [Graphical view]
    PfamiPF00753. Lactamase_B. 1 hit.
    [Graphical view]
    SMARTiSM00849. Lactamase_B. 1 hit.
    [Graphical view]
    SUPFAMiSSF56281. SSF56281. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E5KIY2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELPNIMHPV AKLSTALAAA LMLSGCMPGE IRPTIGQQME TGDQRFGDLV    50
    FRQLAPNVWQ HTSYLDMPGF GAVASNGLIV RDGGRVLVVD TAWTDDQTAQ 100
    ILNWIKQEIN LPVALAVVTH AHQDKMGGMD ALHAAGIATY ANALSNQLAP 150
    QEGMVAAQHS LTFAANGWVE PATAPNFGPL KVFYPGPGHT SDNITVGIDG 200
    TDIAFGGCLI KDSKAKSLGN LGDADTEHYA ASARAFGAAF PKASMIVMSH 250
    SAPDSRAAIT HTARMADKLR 270
    Length:270
    Mass (Da):28,499
    Last modified:February 8, 2011 - v1
    Checksum:i1B6009120B945F14
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HQ162469 Genomic DNA. Translation: ADP20459.1.
    HQ451074 Genomic DNA. Translation: ADY00041.1.
    JF922606 Genomic DNA. Translation: AEH43774.1.
    JF785549 Genomic DNA. Translation: AEK64842.1.
    JF503991 Genomic DNA. Translation: AEN71485.1.
    JF714412 Genomic DNA. Translation: AEP32605.1.
    JQ364967 Genomic DNA. Translation: AFI72857.1.
    JX000475 Genomic DNA. Translation: AFN73221.1.
    JX296013 Genomic DNA. Translation: AFU75168.1.
    KC149527 Genomic DNA. Translation: AGB57374.1.
    KF951455 Genomic DNA. Translation: AHK80864.1.
    KF951456 Genomic DNA. Translation: AHK80865.1.
    KJ413946 Genomic DNA. Translation: AHX39447.1.
    KJ558506 Genomic DNA. Translation: AIA22330.1.
    AB604953 Genomic DNA. Translation: BAK40112.1.
    AP012208 Genomic DNA. Translation: BAK69668.1.
    AB769140 Genomic DNA. Translation: BAN37431.1.
    HG003695 Other DNA. Translation: CDF66128.1.
    JJNV01000040 Genomic DNA. Translation: KCW95010.1.
    RefSeqiYP_004765050.1. NC_015872.1.
    YP_006903357.1. NC_019045.2.
    YP_006939981.1. NC_018994.1.
    YP_006952434.1. NC_019063.1.
    YP_006953215.1. NC_019069.1.
    YP_006953875.1. NC_019089.1.

    Genome annotation databases

    GeneIDi11027496.
    13876866.
    13903469.
    13905367.
    13906127.
    13906812.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HQ162469 Genomic DNA. Translation: ADP20459.1 .
    HQ451074 Genomic DNA. Translation: ADY00041.1 .
    JF922606 Genomic DNA. Translation: AEH43774.1 .
    JF785549 Genomic DNA. Translation: AEK64842.1 .
    JF503991 Genomic DNA. Translation: AEN71485.1 .
    JF714412 Genomic DNA. Translation: AEP32605.1 .
    JQ364967 Genomic DNA. Translation: AFI72857.1 .
    JX000475 Genomic DNA. Translation: AFN73221.1 .
    JX296013 Genomic DNA. Translation: AFU75168.1 .
    KC149527 Genomic DNA. Translation: AGB57374.1 .
    KF951455 Genomic DNA. Translation: AHK80864.1 .
    KF951456 Genomic DNA. Translation: AHK80865.1 .
    KJ413946 Genomic DNA. Translation: AHX39447.1 .
    KJ558506 Genomic DNA. Translation: AIA22330.1 .
    AB604953 Genomic DNA. Translation: BAK40112.1 .
    AP012208 Genomic DNA. Translation: BAK69668.1 .
    AB769140 Genomic DNA. Translation: BAN37431.1 .
    HG003695 Other DNA. Translation: CDF66128.1 .
    JJNV01000040 Genomic DNA. Translation: KCW95010.1 .
    RefSeqi YP_004765050.1. NC_015872.1.
    YP_006903357.1. NC_019045.2.
    YP_006939981.1. NC_018994.1.
    YP_006952434.1. NC_019063.1.
    YP_006953215.1. NC_019069.1.
    YP_006953875.1. NC_019089.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3S0Z X-ray 2.50 A/B 47-270 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 11027496.
    13876866.
    13903469.
    13905367.
    13906127.
    13906812.

    Family and domain databases

    Gene3Di 3.60.15.10. 1 hit.
    InterProi IPR001279. Beta-lactamas-like.
    [Graphical view ]
    Pfami PF00753. Lactamase_B. 1 hit.
    [Graphical view ]
    SMARTi SM00849. Lactamase_B. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56281. SSF56281. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Emergence of metallo-?-lactamase NDM-1-producing multidrug-resistant Escherichia coli in Australia."
      Poirel L., Lagrutta E., Taylor P., Pham J., Nordmann P.
      Antimicrob. Agents Chemother. 54:4914-4916(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 271Imported.
    2. "The entire NDM-1 gene sequence of NDM-1-positive E. coli isolated in Japan."
      Yamamoto T.
      Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NDM-1 Dok01Imported.
    3. "Analysis of the Resistome of a Multidrug-Resistant NDM-1-Producing Escherichia coli Strain by High-Throughput Genome Sequencing."
      Poirel L., Bonnin R.A., Nordmann P.
      Antimicrob. Agents Chemother. 55:4224-4229(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 271Imported.
      Plasmid: p271A
    4. "First Description of an Escherichia coli Strain Producing NDM-1 Carbapenemase in Spain."
      Sole M., Pitart C., Roca I., Fabrega A., Salvador P., Munoz L., Oliveira I., Gascon J., Marco F., Vila J.
      Antimicrob. Agents Chemother. 55:4402-4404(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DVR22Imported.
    5. "Complete sequencing of pNDM-HK encoding NDM-1 carbapenemase from a multidrug-resistant Escherichia coli strain isolated in Hong Kong."
      Ho P.L., Lo W.U., Yeung M.K., Lin C.H., Chow K.H., Ang I., Tong A.H., Bao J.Y., Lok S., Lo J.Y.
      PLoS ONE 6:E17989-E17989(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: HK-01Imported.
      Plasmid: pNDM-HK
    6. "Complete Sequencing of the bla(NDM-1)-Positive IncA/C Plasmid from Escherichia coli ST38 Isolate Suggests a Possible Origin from Plant Pathogens."
      Sekizuka T., Matsui M., Yamane K., Takeuchi F., Ohnishi M., Hishinuma A., Arakawa Y., Kuroda M.
      PLoS ONE 6:e25334-e25334(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NDM-1 Dok01Imported.
      Plasmid: pNDM-1_Dok01
    7. "A structural view of the antibiotic degradation enzyme NDM-1 from a superbug."
      Guo Y., Wang J., Niu G., Shui W., Sun Y., Zhou H., Zhang Y., Yang C., Lou Z., Rao Z.
      Protein Cell 2:384-394(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 47-270 IN COMPLEX WITH ZINC.
    8. "Inc A/C plasmids harbouring the NDM-1 metallo-beta-lactamase."
      Boyd D.A., Mataseje L.F., Mulvey M.R.
      Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: N10-0505Imported.
      Plasmid: pNDM10505
    9. "Characterization of an IncFII Plasmid Encoding NDM-1 from Escherichia coli ST131."
      Bonnin R.A., Poirel L., Carattoli A., Nordmann P.
      PLoS ONE 7:E34752-E34752(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: GUEImported.
      Plasmid: pGUE-NDM
    10. "First New Delhi Metallo-beta-Lactamase 1-Producing Escherichia coli isolated in China."
      Liu Z.
      Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BJ01Imported.
      Plasmid: unnamed
    11. "Inc A/C plasmids harbouring the NDM-1 metallo-beta-lactamase."
      Boyd D.A., Mataseje L.F., Mulvey M.R.
      Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: N10-2337Imported.
      Plasmid: pNDM102337
    12. "The first isolation of an NDM-1-producing Escherichia coli in West Japan."
      Kayama S., Shigemoto N., Kuwahara R., Koba Y., Onodera M., Yokozaki M., Ohge H., Kato F., Hisatsune J., Sugai M.
      Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MS5260Imported.
      Plasmid: pNDM-HU01
    13. "Emergence and spread of NDM-1 producer Enterobacteriaceae with contribution of IncX3 plasmids in the United Arab Emirates."
      Sonnevend A., Al Baloushi A., Ghazawi A., Hashmey R., Girgis S., Hamadeh M.B., Al Haj M., Pal T.
      J. Med. Microbiol. 62:1044-1050(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ABC85Imported.
      Plasmid: pABC85
    14. "Identification and Characterization of the First Escherichia coli Strain Carrying NDM-1 Gene in China."
      Liu Z., Li W., Wang J., Pan J., Sun S., Yu Y., Zhao B., Ma Y., Zhang T., Qi J., Liu G., Lu F.
      PLoS ONE 8:E66666-E66666(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BJ01Imported.
      Plasmid: pBJ01
    15. Lu W., Cheng C., Rui Y.
      Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NF133Imported and NF188Imported.
    16. "The First NDM Metallo-?-Lactamase-Producing Enterobacteriaceae Isolate in Poland: Evolution of IncFII-Type Plasmids Carrying the blaNDM-1 Gene."
      Fiett J., Baraniak A., Izdebski R., Sitkiewicz I., Zabicka D., Meler A., Filczak K., Hryniewicz W., Gniadkowski M.
      Antimicrob. Agents Chemother. 58:1203-1207(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NMI5428/11Imported.
      Plasmid: pMC-NDM
    17. "Emergence and characterisation of blaNDM-1-carrying IncN2-type plasmid in Escherichia coli ST131 isolate in Thailand."
      Netikul T., Sidjabat H.E., Paterson D.L., Kamolwit W., Tantisiriwat W., Kiratisin P.
      Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ECS01Imported.
      Plasmid: pNDM-ECS01
    18. Lu W.
      Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NF741Imported.
    19. "Draft Genome Sequence of blaNDM-1 positive Escherichia coli O25b-ST131 clone isolated from an environmental sample."
      Kutumbaka K., Han S., Mategko J., Nadala C., Buser G.L., Cassidy M.P., Beldavs Z.G., Weissman S.J., Morey K.E., Vega R., Samadpour M.
      Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: O25b-ST131Imported.

    Entry informationi

    Entry nameiE5KIY2_ECOLX
    AccessioniPrimary (citable) accession number: E5KIY2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 8, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, PlasmidImported

    External Data

    Dasty 3