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Protein

Alanine racemase

Gene

RBRH_00324

Organism
Burkholderia rhizoxinica (strain DSM 19002 / CIP 109453 / HKI 454)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei130 – 1301SubstrateUniRule annotation
Active sitei253 – 2531Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei301 – 3011Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBRHI882378:GJIB-3339-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:RBRH_00324Imported
Encoded oniPlasmid pBRH01Imported
OrganismiBurkholderia rhizoxinica (strain DSM 19002 / CIP 109453 / HKI 454)Imported
Taxonomic identifieri882378 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000007437: Plasmid pBRH01

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE5AUN4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031446.
KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E5AUN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRPLLATIH TAALANNLAV ARRHASKSKL WAVVKANAYG HGLARVFPGL
60 70 80 90 100
RSTDGFGLLD LEEAVKLREL GWAGPILLLE GFFRPTDIDV IDRYSLTTTV
110 120 130 140 150
HCDEQLRMLE MARLSKPVNI QLKMNSGMNR LGYVAGKYRA AWERARACPS
160 170 180 190 200
VGQITLMTHF SDADGEMGIR HQLEVFEHGA EGIAGSRSLA NSAATLWHPY
210 220 230 240 250
AHFDWVRPGI ILYGASPSGV SAAIEGLGLQ PAMTLSSELI AVQTVEPGDS
260 270 280 290 300
VGYGSAFKAR ERMRIGVVAC GYADGYPRCA PEGTPVQVGG VRTRVVGRVS
310 320 330 340 350
MDMLTVDLSS CPNAVIGSPV QLWGADVPID DVAAACGTVG YELMCAVAQR

VSVRAE
Length:356
Mass (Da):38,159
Last modified:February 8, 2011 - v1
Checksum:i4D2934A807762B66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR687360 Genomic DNA. Translation: CBW76808.1.
RefSeqiWP_013428669.1. NC_014718.1.
YP_004022327.1. NC_014718.1.

Genome annotation databases

EnsemblBacteriaiCBW76808; CBW76808; RBRH_00324.
GeneIDi9979238.
KEGGibrh:RBRH_00324.
PATRICi45181026. VBIBurRhi170666_0362.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR687360 Genomic DNA. Translation: CBW76808.1.
RefSeqiWP_013428669.1. NC_014718.1.
YP_004022327.1. NC_014718.1.

3D structure databases

ProteinModelPortaliE5AUN4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBW76808; CBW76808; RBRH_00324.
GeneIDi9979238.
KEGGibrh:RBRH_00324.
PATRICi45181026. VBIBurRhi170666_0362.

Phylogenomic databases

HOGENOMiHOG000031446.
KOiK01775.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciBRHI882378:GJIB-3339-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Burkholderia rhizoxinica, an endosymbiont of Rhizopus microsporus."
    Lackner G., Moebius N., Partida-Martinez L., Hertweck C.
    J. Bacteriol. 193:783-784(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HKI 454Imported.

Entry informationi

Entry nameiE5AUN4_BURRH
AccessioniPrimary (citable) accession number: E5AUN4
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: March 4, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, PlasmidImported, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.