Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Aconitate hydratase

Gene

RBRH_00163

Organism
Burkholderia rhizoxinica (strain DSM 19002 / CIP 109453 / HKI 454)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.UniRule annotation

Catalytic activityi

Citrate = isocitrate.UniRule annotation

Cofactori

Note: Binds 1 [4Fe-4S] cluster per subunit.UniRule annotation

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. aconitate hydratase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Ligandi

4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciBRHI882378:GJIB-2158-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aconitate hydrataseUniRule annotation (EC:4.2.1.3UniRule annotation)
Short name:
AconitaseUniRule annotation
Gene namesi
Ordered Locus Names:RBRH_00163Imported
OrganismiBurkholderia rhizoxinica (strain DSM 19002 / CIP 109453 / HKI 454)Imported
Taxonomic identifieri882378 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000007437 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE5ASP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aconitase/IPM isomerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000025703.
KOiK01681.

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
3.30.499.10. 2 hits.
3.40.1060.10. 1 hit.
InterProiIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR015934. Aconitase/AcnD.
IPR006249. Aconitase/Fe_reg_2.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 1 hit.
PTHR11670:SF1. PTHR11670:SF1. 1 hit.
PfamiPF00330. Aconitase. 1 hit.
PF00694. Aconitase_C. 1 hit.
[Graphical view]
PRINTSiPR00415. ACONITASE.
SUPFAMiSSF52016. SSF52016. 1 hit.
SSF53732. SSF53732. 1 hit.
TIGRFAMsiTIGR01341. aconitase_1. 1 hit.
PROSITEiPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E5ASP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHNLHKTLK EFDSGSGKGK YYSLPQLGKA LGIKIDRLPV SIRIVLESVL
60 70 80 90 100
RNYDGKKISE EHVKQLAKWQ PNAARTDEIP FVVSRVVLQD FTGVPLLADI
110 120 130 140 150
AAMRGVAQRA GKNPKRIEPL VPVDLVVDHS VQIDYFRQKD ALDLNMKLEF
160 170 180 190 200
ERNKERYQFM KWGMQAFDTF KVVPPGVGIV HQVNLEYLAR GVHKKSVDGD
210 220 230 240 250
TVYYPDTLVG TDSHTTMING IGVVGWGVGG IEAEAGMLGQ PVYFLTPDVV
260 270 280 290 300
GVELKGRLRE GVTATDLVLT ITEMLRKEKV VGKFVEFFGE GTASLTLPDR
310 320 330 340 350
ATIGNMAPEY GATMGFFPVD NKTIDYFKGT GRTKEEIAAF ENYFKAQELY
360 370 380 390 400
GIPSAGQIDY TKTLTLDLST VAPSLAGPKR PQDRIEIGNV KSTFADLFSL
410 420 430 440 450
PVAQNGFAKK ADDLGKVYKT TDGVELKNGD VLIAAITSCT NTSNPSVLIA
460 470 480 490 500
AGLLAKKAVD AGLTVAPHIK TSLAPGSRIV TEYLSATGLL PYLEKLGFTV
510 520 530 540 550
AAYGCTTCIG NAGDLTAPLN EAIVKHDVVA AAVLSGNRNF EARIHPNIRA
560 570 580 590 600
NFLASPPLVV AYAIAGTITR DLMTEPVGKG KGDRDIYLGD IWPSSDEVNQ
610 620 630 640 650
LLKYALDAKK FKEDYSQLTK NGDLWSQIEG AEGQVYNWPK STYIAEPPFF
660 670 680 690 700
GEHFSMQPAK SITPVKNARA LGIFGDSVTT DHISPAGSIK EDSPAGRWLK
710 720 730 740 750
ENGVQKADFN SYGSRRGNHD VMMRGTFANV RIKNLMIPAK PDGSRVEGGL
760 770 780 790 800
TIHQPSGEQT SIYDAAIKYI AEGTPTIVFA GEEYGTGSSR DWAAKGTYLL
810 820 830 840 850
GVKAVVARSF ERIHRSNLVG MGVLPLQFEN EDSVQSLGIT GEEIYDIEGL
860 870 880 890 900
TDDFKPQQEV TLVIRGKNGV KKVPVLLRID TPIEVDYYKH GGILPFVLRQ

LLAA
Length:904
Mass (Da):98,513
Last modified:February 8, 2011 - v1
Checksum:i4A13FBA69F00A93C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR687359 Genomic DNA. Translation: CBW75626.1.
RefSeqiYP_004029770.1. NC_014722.1.

Genome annotation databases

EnsemblBacteriaiCBW75626; CBW75626; RBRH_00163.
KEGGibrh:RBRH_00163.
PATRICi45185932. VBIBurRhi170666_2737.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR687359 Genomic DNA. Translation: CBW75626.1.
RefSeqiYP_004029770.1. NC_014722.1.

3D structure databases

ProteinModelPortaliE5ASP4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBW75626; CBW75626; RBRH_00163.
KEGGibrh:RBRH_00163.
PATRICi45185932. VBIBurRhi170666_2737.

Phylogenomic databases

HOGENOMiHOG000025703.
KOiK01681.

Enzyme and pathway databases

BioCyciBRHI882378:GJIB-2158-MONOMER.

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
3.30.499.10. 2 hits.
3.40.1060.10. 1 hit.
InterProiIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR015934. Aconitase/AcnD.
IPR006249. Aconitase/Fe_reg_2.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 1 hit.
PTHR11670:SF1. PTHR11670:SF1. 1 hit.
PfamiPF00330. Aconitase. 1 hit.
PF00694. Aconitase_C. 1 hit.
[Graphical view]
PRINTSiPR00415. ACONITASE.
SUPFAMiSSF52016. SSF52016. 1 hit.
SSF53732. SSF53732. 1 hit.
TIGRFAMsiTIGR01341. aconitase_1. 1 hit.
PROSITEiPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Burkholderia rhizoxinica, an endosymbiont of Rhizopus microsporus."
    Lackner G., Moebius N., Partida-Martinez L., Hertweck C.
    J. Bacteriol. 193:783-784(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 19002 / CIP 109453 / HKI 454Imported.

Entry informationi

Entry nameiE5ASP4_BURRH
AccessioniPrimary (citable) accession number: E5ASP4
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: April 29, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.