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E5A7I6

- CBPYA_LEPMJ

UniProt

E5A7I6 - CBPYA_LEPMJ

Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.By similarity

    Catalytic activityi

    Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei269 – 2691PROSITE-ProRule annotation
    Active sitei460 – 4601PROSITE-ProRule annotation
    Active sitei519 – 5191PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Protein family/group databases

    MEROPSiS10.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase Y homolog A (EC:3.4.16.5)
    Gene namesi
    Name:CPYA
    ORF Names:Lema_P088200
    OrganismiLeptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam)
    Taxonomic identifieri985895 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaeLeptosphaeriaceaeLeptosphaeriaLeptosphaeria maculans complex
    ProteomesiUP000002668: Whole genome

    Subcellular locationi

    Vacuole By similarity

    GO - Cellular componenti

    1. vacuole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Propeptidei18 – 128111By similarityPRO_0000407451Add
    BLAST
    Chaini129 – 543415Carboxypeptidase Y homolog APRO_0000407452Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi182 ↔ 421By similarity
    Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi316 ↔ 330By similarity
    Disulfide bondi340 ↔ 363By similarity
    Disulfide bondi347 ↔ 356By similarity
    Disulfide bondi385 ↔ 391By similarity
    Glycosylationi508 – 5081N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    OMAiNCYDSGS.
    OrthoDBiEOG7XDBR1.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    E5A7I6-1 [UniParc]FASTAAdd to Basket

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    MKVATSALLV GAVSASVGPQ QQVLKFPDSF SELKEGAWSK PLHKLEESLK    50
    TLTGEARAVW DEVAMMFPES FEKAAFFSEP KPHTRKHDSE WDHIIKGADI 100
    QNVWVENKNG DKEREIDGKL ENYSMRTKKV DPSVLGVDKV KQYSGYLDDE 150
    EEDKHLFYWF FESRNDPKND PVVLWLNGGP GCSSLTGLFM ELGPASITKD 200
    GKIKHNPYSW NSNASVIFLD QPVNVGYSYS SGQVSNTVAA GKDIYALLTL 250
    FFKQFPEYAE QSFHISGESY AGHYIPVFAS EILSHKKRNI NLQSVLIGNG 300
    LTDGLTQYEY YRPMACGEGG WPAVLDESQC KAMDNAYPRC ASLIENCYNS 350
    ESVWSCVPAS IYCNNAMIGP YQRTGQNVYD IRKPCGSNSL CYDELDWIQA 400
    YLNKKEVMKA VGAEISSYES CNFDINRNFL LQGDWMKPFH RIVPGLLAEI 450
    PVLIYAGDAD YICNWLGNKA WTEALEWPGQ KDYNKAEMED FKIDGKGEAV 500
    GQVKSSGNFT FLKIHAGGHM VPYDQPEASL TMLNRWLAGD FWA 543
    Length:543
    Mass (Da):61,006
    Last modified:February 8, 2011 - v1
    Checksum:i9D60B7CBE773A600
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FP929136 Genomic DNA. Translation: CBX99581.1.
    RefSeqiXP_003843060.1. XM_003843012.1.

    Genome annotation databases

    EnsemblFungiiCBX99581; CBX99581; LEMA_P088200.1.
    GeneIDi13289211.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FP929136 Genomic DNA. Translation: CBX99581.1 .
    RefSeqi XP_003843060.1. XM_003843012.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CBX99581 ; CBX99581 ; LEMA_P088200.1 .
    GeneIDi 13289211.

    Phylogenomic databases

    OMAi NCYDSGS.
    OrthoDBi EOG7XDBR1.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8.

    Entry informationi

    Entry nameiCBPYA_LEPMJ
    AccessioniPrimary (citable) accession number: E5A7I6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3