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E5A7I6

- CBPYA_LEPMJ

UniProt

E5A7I6 - CBPYA_LEPMJ

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Protein

Carboxypeptidase Y homolog A

Gene
CPYA, Lema_P088200
Organism
Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei269 – 2691 By similarity
Active sitei460 – 4601 By similarity
Active sitei519 – 5191 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:CPYA
ORF Names:Lema_P088200
OrganismiLeptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam)
Taxonomic identifieri985895 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaeLeptosphaeriaceaeLeptosphaeriaLeptosphaeria maculans complex
ProteomesiUP000002668: Whole genome

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. vacuole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Propeptidei18 – 128111 By similarityPRO_0000407451Add
BLAST
Chaini129 – 543415Carboxypeptidase Y homolog APRO_0000407452Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi122 – 1221N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi182 ↔ 421 By similarity
Glycosylationi213 – 2131N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi316 ↔ 330 By similarity
Disulfide bondi340 ↔ 363 By similarity
Disulfide bondi347 ↔ 356 By similarity
Disulfide bondi385 ↔ 391 By similarity
Glycosylationi508 – 5081N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal

Phylogenomic databases

OMAiNCYDSGS.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E5A7I6-1 [UniParc]FASTAAdd to Basket

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MKVATSALLV GAVSASVGPQ QQVLKFPDSF SELKEGAWSK PLHKLEESLK    50
TLTGEARAVW DEVAMMFPES FEKAAFFSEP KPHTRKHDSE WDHIIKGADI 100
QNVWVENKNG DKEREIDGKL ENYSMRTKKV DPSVLGVDKV KQYSGYLDDE 150
EEDKHLFYWF FESRNDPKND PVVLWLNGGP GCSSLTGLFM ELGPASITKD 200
GKIKHNPYSW NSNASVIFLD QPVNVGYSYS SGQVSNTVAA GKDIYALLTL 250
FFKQFPEYAE QSFHISGESY AGHYIPVFAS EILSHKKRNI NLQSVLIGNG 300
LTDGLTQYEY YRPMACGEGG WPAVLDESQC KAMDNAYPRC ASLIENCYNS 350
ESVWSCVPAS IYCNNAMIGP YQRTGQNVYD IRKPCGSNSL CYDELDWIQA 400
YLNKKEVMKA VGAEISSYES CNFDINRNFL LQGDWMKPFH RIVPGLLAEI 450
PVLIYAGDAD YICNWLGNKA WTEALEWPGQ KDYNKAEMED FKIDGKGEAV 500
GQVKSSGNFT FLKIHAGGHM VPYDQPEASL TMLNRWLAGD FWA 543
Length:543
Mass (Da):61,006
Last modified:February 8, 2011 - v1
Checksum:i9D60B7CBE773A600
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FP929136 Genomic DNA. Translation: CBX99581.1.
RefSeqiXP_003843060.1. XM_003843012.1.

Genome annotation databases

EnsemblFungiiCBX99581; CBX99581; LEMA_P088200.1.
GeneIDi13289211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FP929136 Genomic DNA. Translation: CBX99581.1 .
RefSeqi XP_003843060.1. XM_003843012.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CBX99581 ; CBX99581 ; LEMA_P088200.1 .
GeneIDi 13289211.

Phylogenomic databases

OMAi NCYDSGS.
OrthoDBi EOG7XDBR1.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8.

Entry informationi

Entry nameiCBPYA_LEPMJ
AccessioniPrimary (citable) accession number: E5A7I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: February 8, 2011
Last modified: June 11, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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