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Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei269PROSITE-ProRule annotation1
Active sitei460PROSITE-ProRule annotation1
Active sitei519PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:CPYA
ORF Names:Lema_P088200
OrganismiLeptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam)
Taxonomic identifieri985895 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaeLeptosphaeriaceaeLeptosphaeriaLeptosphaeria maculans species complex
Proteomesi
  • UP000002668 Componenti: Genome

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000040745118 – 128By similarityAdd BLAST111
ChainiPRO_0000407452129 – 543Carboxypeptidase Y homolog AAdd BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi122N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi182 ↔ 421By similarity
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi316 ↔ 330By similarity
Disulfide bondi340 ↔ 363By similarity
Disulfide bondi347 ↔ 356By similarity
Disulfide bondi385 ↔ 391By similarity
Glycosylationi508N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PRIDEiE5A7I6

Interactioni

Protein-protein interaction databases

STRINGi5022.CBX99581

Structurei

3D structure databases

SMRiE5A7I6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiE5A7I6
OMAiMDNALPR
OrthoDBiEOG092C1EU7

Family and domain databases

Gene3Di3.40.50.1820, 2 hits
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR008442 Propeptide_carboxypepY
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF05388 Carbpep_Y_N, 1 hit
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00131 CARBOXYPEPT_SER_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E5A7I6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVATSALLV GAVSASVGPQ QQVLKFPDSF SELKEGAWSK PLHKLEESLK
60 70 80 90 100
TLTGEARAVW DEVAMMFPES FEKAAFFSEP KPHTRKHDSE WDHIIKGADI
110 120 130 140 150
QNVWVENKNG DKEREIDGKL ENYSMRTKKV DPSVLGVDKV KQYSGYLDDE
160 170 180 190 200
EEDKHLFYWF FESRNDPKND PVVLWLNGGP GCSSLTGLFM ELGPASITKD
210 220 230 240 250
GKIKHNPYSW NSNASVIFLD QPVNVGYSYS SGQVSNTVAA GKDIYALLTL
260 270 280 290 300
FFKQFPEYAE QSFHISGESY AGHYIPVFAS EILSHKKRNI NLQSVLIGNG
310 320 330 340 350
LTDGLTQYEY YRPMACGEGG WPAVLDESQC KAMDNAYPRC ASLIENCYNS
360 370 380 390 400
ESVWSCVPAS IYCNNAMIGP YQRTGQNVYD IRKPCGSNSL CYDELDWIQA
410 420 430 440 450
YLNKKEVMKA VGAEISSYES CNFDINRNFL LQGDWMKPFH RIVPGLLAEI
460 470 480 490 500
PVLIYAGDAD YICNWLGNKA WTEALEWPGQ KDYNKAEMED FKIDGKGEAV
510 520 530 540
GQVKSSGNFT FLKIHAGGHM VPYDQPEASL TMLNRWLAGD FWA
Length:543
Mass (Da):61,006
Last modified:February 8, 2011 - v1
Checksum:i9D60B7CBE773A600
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP929136 Genomic DNA Translation: CBX99581.1
RefSeqiXP_003843060.1, XM_003843012.1

Genome annotation databases

EnsemblFungiiCBX99581; CBX99581; LEMA_P088200.1
GeneIDi13289211

Similar proteinsi

Entry informationi

Entry nameiCBPYA_LEPMJ
AccessioniPrimary (citable) accession number: E5A7I6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: February 8, 2011
Last modified: May 23, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health