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E5A7I6

- CBPYA_LEPMJ

UniProt

E5A7I6 - CBPYA_LEPMJ

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Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei269 – 2691PROSITE-ProRule annotation
Active sitei460 – 4601PROSITE-ProRule annotation
Active sitei519 – 5191PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:CPYA
ORF Names:Lema_P088200
OrganismiLeptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam)
Taxonomic identifieri985895 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaeLeptosphaeriaceaeLeptosphaeriaLeptosphaeria maculans complex
ProteomesiUP000002668: Whole genome

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. vacuole Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Propeptidei18 – 128111By similarityPRO_0000407451Add
BLAST
Chaini129 – 543415Carboxypeptidase Y homolog APRO_0000407452Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi182 ↔ 421By similarity
Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi316 ↔ 330By similarity
Disulfide bondi340 ↔ 363By similarity
Disulfide bondi347 ↔ 356By similarity
Disulfide bondi385 ↔ 391By similarity
Glycosylationi508 – 5081N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiE5A7I6.
OMAiNCYDSGS.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E5A7I6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVATSALLV GAVSASVGPQ QQVLKFPDSF SELKEGAWSK PLHKLEESLK
60 70 80 90 100
TLTGEARAVW DEVAMMFPES FEKAAFFSEP KPHTRKHDSE WDHIIKGADI
110 120 130 140 150
QNVWVENKNG DKEREIDGKL ENYSMRTKKV DPSVLGVDKV KQYSGYLDDE
160 170 180 190 200
EEDKHLFYWF FESRNDPKND PVVLWLNGGP GCSSLTGLFM ELGPASITKD
210 220 230 240 250
GKIKHNPYSW NSNASVIFLD QPVNVGYSYS SGQVSNTVAA GKDIYALLTL
260 270 280 290 300
FFKQFPEYAE QSFHISGESY AGHYIPVFAS EILSHKKRNI NLQSVLIGNG
310 320 330 340 350
LTDGLTQYEY YRPMACGEGG WPAVLDESQC KAMDNAYPRC ASLIENCYNS
360 370 380 390 400
ESVWSCVPAS IYCNNAMIGP YQRTGQNVYD IRKPCGSNSL CYDELDWIQA
410 420 430 440 450
YLNKKEVMKA VGAEISSYES CNFDINRNFL LQGDWMKPFH RIVPGLLAEI
460 470 480 490 500
PVLIYAGDAD YICNWLGNKA WTEALEWPGQ KDYNKAEMED FKIDGKGEAV
510 520 530 540
GQVKSSGNFT FLKIHAGGHM VPYDQPEASL TMLNRWLAGD FWA
Length:543
Mass (Da):61,006
Last modified:February 8, 2011 - v1
Checksum:i9D60B7CBE773A600
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP929136 Genomic DNA. Translation: CBX99581.1.
RefSeqiXP_003843060.1. XM_003843012.1.

Genome annotation databases

EnsemblFungiiCBX99581; CBX99581; LEMA_P088200.1.
GeneIDi13289211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP929136 Genomic DNA. Translation: CBX99581.1 .
RefSeqi XP_003843060.1. XM_003843012.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CBX99581 ; CBX99581 ; LEMA_P088200.1 .
GeneIDi 13289211.

Phylogenomic databases

InParanoidi E5A7I6.
OMAi NCYDSGS.
OrthoDBi EOG7XDBR1.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8.

Entry informationi

Entry nameiCBPYA_LEPMJ
AccessioniPrimary (citable) accession number: E5A7I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: February 8, 2011
Last modified: October 29, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3