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E4ZUB5

- LCPS_LEPMJ

UniProt

E4ZUB5 - LCPS_LEPMJ

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Protein
Bifunctional lycopene cyclase/phytoene synthase
Gene
Lema_P114090.1
Organism
Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase) By similarity.

Catalytic activityi

Carotenoid psi-end group = carotenoid beta-end group.
2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathwayi

GO - Molecular functioni

  1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB-EC
  2. intramolecular lyase activity Source: InterPro

GO - Biological processi

  1. carotenoid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Transferase

Keywords - Biological processi

Carotenoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00799; UER00773.
UPA00802.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional lycopene cyclase/phytoene synthase
Including the following 2 domains:
Lycopene beta-cyclase (EC:5.5.1.19)
Alternative name(s):
Lycopene cyclase
Phytoene synthase (EC:2.5.1.32)
Gene namesi
ORF Names:Lema_P114090.1
OrganismiLeptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam)
Taxonomic identifieri985895 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaeLeptosphaeriaceaeLeptosphaeriaLeptosphaeria maculans complex
ProteomesiUP000002668: Whole genome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321Helical; Reviewed prediction
Add
BLAST
Transmembranei35 – 5521Helical; Reviewed prediction
Add
BLAST
Transmembranei65 – 8521Helical; Reviewed prediction
Add
BLAST
Transmembranei120 – 14021Helical; Reviewed prediction
Add
BLAST
Transmembranei152 – 17221Helical; Reviewed prediction
Add
BLAST
Transmembranei173 – 19321Helical; Reviewed prediction
Add
BLAST
Transmembranei221 – 24121Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 581581Bifunctional lycopene cyclase/phytoene synthase
PRO_0000409237Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliE4ZUB5.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 243243Lycopene beta-cyclase
Add
BLAST
Regioni250 – 581332Phytoene synthase
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the lycopene beta-cyclase family.
In the C-terminal section; belongs to the phytoene/squalene synthase family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OMAiYMEIGRV.
OrthoDBiEOG7RBZJ2.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
TIGRFAMsiTIGR03462. CarR_dom_SF. 2 hits.
PROSITEiPS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4ZUB5-1 [UniParc]FASTAAdd to Basket

« Hide

MGFDYALVHL KYTIPPAVLL TLLYRPLLTK IDVYKVAFLV TIAVVATIPW    50
DSYLIRNRIW SYPDHVIIGP TLFDIPLEEV FFFVVQTYNT SLLYLVLSKP 100
TFQPVYLCTE RDELHGSWRL KRLIGQAILL GAIAWGWFCV RERGLGTYTG 150
LILIWAGPFL LLLWSLAYQF IIGLPFTNTL LPIVLPTLYL WIVDTLALRR 200
GTWVISPGTK FGVHLWDGLE IEEALFFLLT NVLIVFGQLA FDNALAVLYA 250
FPHLFPDPSL LPSPATLIRS LLTSCAQYDE ARLTGFREAV SRLKRKSRSF 300
YLASSTFQGP LRMDLLLLYS FCRVADDLVD NAATTEEARQ WIAKLHKFLD 350
NVYRKDVVCS SVTDQVRKEF PLDTHSALLQ LPCCKLSAEP LRDLLRGFEM 400
DLEFNSTSPI QSTEDLVLYS ERVAGTVAQM CIQLIFHLYP SSLTAEKRHK 450
VVAAGNSMGV ALQYVNIARD IGVDAKIGRV YLPTDWLSEV GLNCDTVLKD 500
PKDPRIEALR GRLLDDAFSF YEEAKLAIAQ LPIEAQGPIR VAVESYMEIG 550
RTLKQDGFIV KAGRATVPKW RRVLVAWRTL N 581
Length:581
Mass (Da):65,807
Last modified:February 8, 2011 - v1
Checksum:iAE5B91B31A0FBDD1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FP929126 Genomic DNA. Translation: CBX94994.1.
RefSeqiXP_003838473.1. XM_003838425.1.

Genome annotation databases

EnsemblFungiiCBX94994; CBX94994; LEMA_P114090.1.
GeneIDi13287881.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FP929126 Genomic DNA. Translation: CBX94994.1 .
RefSeqi XP_003838473.1. XM_003838425.1.

3D structure databases

ProteinModelPortali E4ZUB5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CBX94994 ; CBX94994 ; LEMA_P114090.1 .
GeneIDi 13287881.

Phylogenomic databases

OMAi YMEIGRV.
OrthoDBi EOG7RBZJ2.

Enzyme and pathway databases

UniPathwayi UPA00799 ; UER00773 .
UPA00802 .

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view ]
Pfami PF00494. SQS_PSY. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
TIGRFAMsi TIGR03462. CarR_dom_SF. 2 hits.
PROSITEi PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8.

Entry informationi

Entry nameiLCPS_LEPMJ
AccessioniPrimary (citable) accession number: E4ZUB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: February 8, 2011
Last modified: February 19, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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