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E4ZUB5

- LCPS_LEPMJ

UniProt

E4ZUB5 - LCPS_LEPMJ

Protein

Bifunctional lycopene cyclase/phytoene synthase

Gene

Lema_P114090.1

Organism
Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase).By similarity

    Catalytic activityi

    Carotenoid psi-end group = carotenoid beta-end group.
    2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

    Pathwayi

    GO - Molecular functioni

    1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB-EC
    2. intramolecular lyase activity Source: InterPro

    GO - Biological processi

    1. carotenoid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, Transferase

    Keywords - Biological processi

    Carotenoid biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00799; UER00773.
    UPA00802.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional lycopene cyclase/phytoene synthase
    Including the following 2 domains:
    Lycopene beta-cyclase (EC:5.5.1.19)
    Alternative name(s):
    Lycopene cyclase
    Phytoene synthase (EC:2.5.1.32)
    Gene namesi
    ORF Names:Lema_P114090.1
    OrganismiLeptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam)
    Taxonomic identifieri985895 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaeLeptosphaeriaceaeLeptosphaeriaLeptosphaeria maculans complex
    ProteomesiUP000002668: Whole genome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 581581Bifunctional lycopene cyclase/phytoene synthasePRO_0000409237Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliE4ZUB5.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3 – 2321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei35 – 5521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei65 – 8521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei120 – 14021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei152 – 17221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei221 – 24121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 243243Lycopene beta-cyclaseAdd
    BLAST
    Regioni250 – 581332Phytoene synthaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the lycopene beta-cyclase family.Curated
    In the C-terminal section; belongs to the phytoene/squalene synthase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    OMAiYMEIGRV.
    OrthoDBiEOG7RBZJ2.

    Family and domain databases

    Gene3Di1.10.600.10. 1 hit.
    InterProiIPR017825. Lycopene_cyclase_dom.
    IPR002060. Squ/phyt_synthse.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    [Graphical view]
    PfamiPF00494. SQS_PSY. 1 hit.
    [Graphical view]
    SUPFAMiSSF48576. SSF48576. 1 hit.
    TIGRFAMsiTIGR03462. CarR_dom_SF. 2 hits.
    PROSITEiPS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E4ZUB5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGFDYALVHL KYTIPPAVLL TLLYRPLLTK IDVYKVAFLV TIAVVATIPW    50
    DSYLIRNRIW SYPDHVIIGP TLFDIPLEEV FFFVVQTYNT SLLYLVLSKP 100
    TFQPVYLCTE RDELHGSWRL KRLIGQAILL GAIAWGWFCV RERGLGTYTG 150
    LILIWAGPFL LLLWSLAYQF IIGLPFTNTL LPIVLPTLYL WIVDTLALRR 200
    GTWVISPGTK FGVHLWDGLE IEEALFFLLT NVLIVFGQLA FDNALAVLYA 250
    FPHLFPDPSL LPSPATLIRS LLTSCAQYDE ARLTGFREAV SRLKRKSRSF 300
    YLASSTFQGP LRMDLLLLYS FCRVADDLVD NAATTEEARQ WIAKLHKFLD 350
    NVYRKDVVCS SVTDQVRKEF PLDTHSALLQ LPCCKLSAEP LRDLLRGFEM 400
    DLEFNSTSPI QSTEDLVLYS ERVAGTVAQM CIQLIFHLYP SSLTAEKRHK 450
    VVAAGNSMGV ALQYVNIARD IGVDAKIGRV YLPTDWLSEV GLNCDTVLKD 500
    PKDPRIEALR GRLLDDAFSF YEEAKLAIAQ LPIEAQGPIR VAVESYMEIG 550
    RTLKQDGFIV KAGRATVPKW RRVLVAWRTL N 581
    Length:581
    Mass (Da):65,807
    Last modified:February 8, 2011 - v1
    Checksum:iAE5B91B31A0FBDD1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FP929126 Genomic DNA. Translation: CBX94994.1.
    RefSeqiXP_003838473.1. XM_003838425.1.

    Genome annotation databases

    EnsemblFungiiCBX94994; CBX94994; LEMA_P114090.1.
    GeneIDi13287881.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FP929126 Genomic DNA. Translation: CBX94994.1 .
    RefSeqi XP_003838473.1. XM_003838425.1.

    3D structure databases

    ProteinModelPortali E4ZUB5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CBX94994 ; CBX94994 ; LEMA_P114090.1 .
    GeneIDi 13287881.

    Phylogenomic databases

    OMAi YMEIGRV.
    OrthoDBi EOG7RBZJ2.

    Enzyme and pathway databases

    UniPathwayi UPA00799 ; UER00773 .
    UPA00802 .

    Family and domain databases

    Gene3Di 1.10.600.10. 1 hit.
    InterProi IPR017825. Lycopene_cyclase_dom.
    IPR002060. Squ/phyt_synthse.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    [Graphical view ]
    Pfami PF00494. SQS_PSY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48576. SSF48576. 1 hit.
    TIGRFAMsi TIGR03462. CarR_dom_SF. 2 hits.
    PROSITEi PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8.

    Entry informationi

    Entry nameiLCPS_LEPMJ
    AccessioniPrimary (citable) accession number: E4ZUB5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 31, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3