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E4ZUB5

- LCPS_LEPMJ

UniProt

E4ZUB5 - LCPS_LEPMJ

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Protein

Bifunctional lycopene cyclase/phytoene synthase

Gene

Lema_P114090.1

Organism
Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase).By similarity

Catalytic activityi

Carotenoid psi-end group = carotenoid beta-end group.
2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathwayi

GO - Molecular functioni

  1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB-EC
  2. intramolecular lyase activity Source: InterPro

GO - Biological processi

  1. carotenoid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Transferase

Keywords - Biological processi

Carotenoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00799; UER00773.
UPA00802.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional lycopene cyclase/phytoene synthase
Including the following 2 domains:
Lycopene beta-cyclase (EC:5.5.1.19)
Alternative name(s):
Lycopene cyclase
Phytoene synthase (EC:2.5.1.32)
Gene namesi
ORF Names:Lema_P114090.1
OrganismiLeptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam)
Taxonomic identifieri985895 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaeLeptosphaeriaceaeLeptosphaeriaLeptosphaeria maculans complex
ProteomesiUP000002668: Whole genome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalSequence AnalysisAdd
BLAST
Transmembranei35 – 5521HelicalSequence AnalysisAdd
BLAST
Transmembranei65 – 8521HelicalSequence AnalysisAdd
BLAST
Transmembranei120 – 14021HelicalSequence AnalysisAdd
BLAST
Transmembranei152 – 17221HelicalSequence AnalysisAdd
BLAST
Transmembranei173 – 19321HelicalSequence AnalysisAdd
BLAST
Transmembranei221 – 24121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 581581Bifunctional lycopene cyclase/phytoene synthasePRO_0000409237Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliE4ZUB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 243243Lycopene beta-cyclaseAdd
BLAST
Regioni250 – 581332Phytoene synthaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the lycopene beta-cyclase family.Curated
In the C-terminal section; belongs to the phytoene/squalene synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiE4ZUB5.
OMAiYMEIGRV.
OrthoDBiEOG7RBZJ2.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
TIGRFAMsiTIGR03462. CarR_dom_SF. 2 hits.
PROSITEiPS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4ZUB5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGFDYALVHL KYTIPPAVLL TLLYRPLLTK IDVYKVAFLV TIAVVATIPW
60 70 80 90 100
DSYLIRNRIW SYPDHVIIGP TLFDIPLEEV FFFVVQTYNT SLLYLVLSKP
110 120 130 140 150
TFQPVYLCTE RDELHGSWRL KRLIGQAILL GAIAWGWFCV RERGLGTYTG
160 170 180 190 200
LILIWAGPFL LLLWSLAYQF IIGLPFTNTL LPIVLPTLYL WIVDTLALRR
210 220 230 240 250
GTWVISPGTK FGVHLWDGLE IEEALFFLLT NVLIVFGQLA FDNALAVLYA
260 270 280 290 300
FPHLFPDPSL LPSPATLIRS LLTSCAQYDE ARLTGFREAV SRLKRKSRSF
310 320 330 340 350
YLASSTFQGP LRMDLLLLYS FCRVADDLVD NAATTEEARQ WIAKLHKFLD
360 370 380 390 400
NVYRKDVVCS SVTDQVRKEF PLDTHSALLQ LPCCKLSAEP LRDLLRGFEM
410 420 430 440 450
DLEFNSTSPI QSTEDLVLYS ERVAGTVAQM CIQLIFHLYP SSLTAEKRHK
460 470 480 490 500
VVAAGNSMGV ALQYVNIARD IGVDAKIGRV YLPTDWLSEV GLNCDTVLKD
510 520 530 540 550
PKDPRIEALR GRLLDDAFSF YEEAKLAIAQ LPIEAQGPIR VAVESYMEIG
560 570 580
RTLKQDGFIV KAGRATVPKW RRVLVAWRTL N
Length:581
Mass (Da):65,807
Last modified:February 8, 2011 - v1
Checksum:iAE5B91B31A0FBDD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP929126 Genomic DNA. Translation: CBX94994.1.
RefSeqiXP_003838473.1. XM_003838425.1.

Genome annotation databases

EnsemblFungiiCBX94994; CBX94994; LEMA_P114090.1.
GeneIDi13287881.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP929126 Genomic DNA. Translation: CBX94994.1 .
RefSeqi XP_003838473.1. XM_003838425.1.

3D structure databases

ProteinModelPortali E4ZUB5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CBX94994 ; CBX94994 ; LEMA_P114090.1 .
GeneIDi 13287881.

Phylogenomic databases

InParanoidi E4ZUB5.
OMAi YMEIGRV.
OrthoDBi EOG7RBZJ2.

Enzyme and pathway databases

UniPathwayi UPA00799 ; UER00773 .
UPA00802 .

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view ]
Pfami PF00494. SQS_PSY. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
TIGRFAMsi TIGR03462. CarR_dom_SF. 2 hits.
PROSITEi PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8.

Entry informationi

Entry nameiLCPS_LEPMJ
AccessioniPrimary (citable) accession number: E4ZUB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: February 8, 2011
Last modified: October 29, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3