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E4ZUB5 (LCPS_LEPMJ) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional lycopene cyclase/phytoene synthase

Including the following 2 domains:

  1. Lycopene beta-cyclase
    EC=5.5.1.19
    Alternative name(s):
    Lycopene cyclase
  2. Phytoene synthase
    EC=2.5.1.32
Gene names
ORF Names:Lema_P114090.1
OrganismLeptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam) [Complete proteome]
Taxonomic identifier985895 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaeLeptosphaeriaceaeLeptosphaeriaLeptosphaeria maculans complex

Protein attributes

Sequence length581 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase) By similarity.

Catalytic activity

Carotenoid psi-end group = carotenoid beta-end group.

2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathway

Carotenoid biosynthesis; beta-carotene biosynthesis.

Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

In the N-terminal section; belongs to the lycopene beta-cyclase family.

In the C-terminal section; belongs to the phytoene/squalene synthase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 581581Bifunctional lycopene cyclase/phytoene synthase
PRO_0000409237

Regions

Transmembrane3 – 2321Helical; Potential
Transmembrane35 – 5521Helical; Potential
Transmembrane65 – 8521Helical; Potential
Transmembrane120 – 14021Helical; Potential
Transmembrane152 – 17221Helical; Potential
Transmembrane173 – 19321Helical; Potential
Transmembrane221 – 24121Helical; Potential
Region1 – 243243Lycopene beta-cyclase
Region250 – 581332Phytoene synthase

Sequences

Sequence LengthMass (Da)Tools
E4ZUB5 [UniParc].

Last modified February 8, 2011. Version 1.
Checksum: AE5B91B31A0FBDD1

FASTA58165,807
        10         20         30         40         50         60 
MGFDYALVHL KYTIPPAVLL TLLYRPLLTK IDVYKVAFLV TIAVVATIPW DSYLIRNRIW 

        70         80         90        100        110        120 
SYPDHVIIGP TLFDIPLEEV FFFVVQTYNT SLLYLVLSKP TFQPVYLCTE RDELHGSWRL 

       130        140        150        160        170        180 
KRLIGQAILL GAIAWGWFCV RERGLGTYTG LILIWAGPFL LLLWSLAYQF IIGLPFTNTL 

       190        200        210        220        230        240 
LPIVLPTLYL WIVDTLALRR GTWVISPGTK FGVHLWDGLE IEEALFFLLT NVLIVFGQLA 

       250        260        270        280        290        300 
FDNALAVLYA FPHLFPDPSL LPSPATLIRS LLTSCAQYDE ARLTGFREAV SRLKRKSRSF 

       310        320        330        340        350        360 
YLASSTFQGP LRMDLLLLYS FCRVADDLVD NAATTEEARQ WIAKLHKFLD NVYRKDVVCS 

       370        380        390        400        410        420 
SVTDQVRKEF PLDTHSALLQ LPCCKLSAEP LRDLLRGFEM DLEFNSTSPI QSTEDLVLYS 

       430        440        450        460        470        480 
ERVAGTVAQM CIQLIFHLYP SSLTAEKRHK VVAAGNSMGV ALQYVNIARD IGVDAKIGRV 

       490        500        510        520        530        540 
YLPTDWLSEV GLNCDTVLKD PKDPRIEALR GRLLDDAFSF YEEAKLAIAQ LPIEAQGPIR 

       550        560        570        580 
VAVESYMEIG RTLKQDGFIV KAGRATVPKW RRVLVAWRTL N 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FP929126 Genomic DNA. Translation: CBX94994.1.
RefSeqXP_003838473.1. XM_003838425.1.

3D structure databases

ProteinModelPortalE4ZUB5.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCBX94994; CBX94994; LEMA_P114090.1.
GeneID13287881.

Phylogenomic databases

OMAYMEIGRV.
OrthoDBEOG7RBZJ2.

Enzyme and pathway databases

UniPathwayUPA00799; UER00773.
UPA00802.

Family and domain databases

Gene3D1.10.600.10. 1 hit.
InterProIPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMSSF48576. SSF48576. 1 hit.
TIGRFAMsTIGR03462. CarR_dom_SF. 2 hits.
PROSITEPS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLCPS_LEPMJ
AccessionPrimary (citable) accession number: E4ZUB5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: February 8, 2011
Last modified: February 19, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways