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E4ZCY5

- E4ZCY5_NEIL0

UniProt

E4ZCY5 - E4ZCY5_NEIL0

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Protein

Phosphoadenosine phosphosulfate reductase

Gene

cysH

Organism
Neisseria lactamica (strain 020-06)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Reduction of activated sulfate into sulfite.UniRule annotation

Catalytic activityi

Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. phosphoadenylyl-sulfate reductase (thioredoxin) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cysteine biosynthetic process Source: InterPro
  2. hydrogen sulfide biosynthetic process Source: UniProtKB-UniPathway
  3. sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciNLAC489653:GJ91-1021-MONOMER.
UniPathwayiUPA00140; UER00206.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoadenosine phosphosulfate reductaseUniRule annotation (EC:1.8.4.8UniRule annotation)
Alternative name(s):
3'-phosphoadenylylsulfate reductaseUniRule annotation
PAPS reductase, thioredoxin dependentUniRule annotation
PAPS sulfotransferaseUniRule annotation
PAdoPS reductaseUniRule annotation
Gene namesi
Name:cysHUniRule annotationImported
Ordered Locus Names:NLA_9920Imported
OrganismiNeisseria lactamica (strain 020-06)Imported
Taxonomic identifieri489653 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000008723: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PAPS reductase family. CysH subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000249395.
KOiK00390.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00063. CysH.
InterProiIPR011798. APS_reductase.
IPR004511. PAPS/APS_Rdtase.
IPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01507. PAPS_reduct. 1 hit.
[Graphical view]
PIRSFiPIRSF000857. PAPS_reductase. 1 hit.
TIGRFAMsiTIGR02055. APS_reductase. 1 hit.
TIGR00434. cysH. 1 hit.

Sequencei

Sequence statusi: Complete.

E4ZCY5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIFKPALWK IPPIENGSET ALAEKTETLK QRLHRIAGSH RDARFASSLA
60 70 80 90 100
AEDMVITDLI AGENLNIGIF TLDTGLLHAE TLNLLDRIER VYPHMQIKRF
110 120 130 140 150
QPIREDALHY VESKGRFAFY DSVEARRECC RIRKIEPLDR AIAGADAWLT
160 170 180 190 200
GQRREQSATR TELPFAEYDA GRGIGKYNPI FDWSEHDVWA YILANNVPYN
210 220 230 240
DLYRQGFPSI GCDPCTRPVK AGEDIRAGRW WWEGRNSKEC GLHK
Length:244
Mass (Da):27,987
Last modified:February 8, 2011 - v1
Checksum:i21790ACF88B34F20
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN995097 Genomic DNA. Translation: CBN87218.1.
RefSeqiYP_004048586.1. NC_014752.1.

Genome annotation databases

EnsemblBacteriaiCBN87218; CBN87218; NLA_9920.
GeneIDi10006670.
KEGGinla:NLA_9920.
PATRICi45300320. VBINeiLac170077_1209.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN995097 Genomic DNA. Translation: CBN87218.1 .
RefSeqi YP_004048586.1. NC_014752.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBN87218 ; CBN87218 ; NLA_9920 .
GeneIDi 10006670.
KEGGi nla:NLA_9920.
PATRICi 45300320. VBINeiLac170077_1209.

Phylogenomic databases

HOGENOMi HOG000249395.
KOi K00390.

Enzyme and pathway databases

UniPathwayi UPA00140 ; UER00206 .
BioCyci NLAC489653:GJ91-1021-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00063. CysH.
InterProi IPR011798. APS_reductase.
IPR004511. PAPS/APS_Rdtase.
IPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF01507. PAPS_reduct. 1 hit.
[Graphical view ]
PIRSFi PIRSF000857. PAPS_reductase. 1 hit.
TIGRFAMsi TIGR02055. APS_reductase. 1 hit.
TIGR00434. cysH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Independent evolution of the core and accessory gene sets in the genus Neisseria: insights gained from the genome of Neisseria lactamica isolate 020-06."
    Bennett J.S., Bentley S.D., Vernikos G.S., Quail M.A., Cherevach I., White B., Parkhill J., Maiden M.C.
    BMC Genomics 11:652-652(2010)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 020-06Imported.

Entry informationi

Entry nameiE4ZCY5_NEIL0
AccessioniPrimary (citable) accession number: E4ZCY5
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: October 1, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3