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Protein

Phosphoadenosine phosphosulfate reductase

Gene

cysH

Organism
Neisseria lactamica (strain 020-06)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Reduction of activated sulfate into sulfite.UniRule annotation

Catalytic activityi

Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin.UniRule annotation

Pathwayi

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciNLAC489653:GJ91-1021-MONOMER.
UniPathwayiUPA00140; UER00206.
UPA00140; UER00206.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoadenosine phosphosulfate reductaseUniRule annotation (EC:1.8.4.8UniRule annotation)
Alternative name(s):
3'-phosphoadenylylsulfate reductaseUniRule annotation
PAPS reductase, thioredoxin dependentUniRule annotation
PAPS sulfotransferaseUniRule annotation
PAdoPS reductaseUniRule annotation
Gene namesi
Name:cysHUniRule annotationImported
Ordered Locus Names:NLA_9920Imported
OrganismiNeisseria lactamica (strain 020-06)Imported
Taxonomic identifieri489653 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000008723 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PAPS reductase family. CysH subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000249395.
KOiK00390.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00063. CysH.
InterProiIPR011798. APS_reductase.
IPR004511. PAPS/APS_Rdtase.
IPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01507. PAPS_reduct. 1 hit.
[Graphical view]
PIRSFiPIRSF000857. PAPS_reductase. 1 hit.
TIGRFAMsiTIGR02055. APS_reductase. 1 hit.
TIGR00434. cysH. 1 hit.

Sequencei

Sequence statusi: Complete.

E4ZCY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIFKPALWK IPPIENGSET ALAEKTETLK QRLHRIAGSH RDARFASSLA
60 70 80 90 100
AEDMVITDLI AGENLNIGIF TLDTGLLHAE TLNLLDRIER VYPHMQIKRF
110 120 130 140 150
QPIREDALHY VESKGRFAFY DSVEARRECC RIRKIEPLDR AIAGADAWLT
160 170 180 190 200
GQRREQSATR TELPFAEYDA GRGIGKYNPI FDWSEHDVWA YILANNVPYN
210 220 230 240
DLYRQGFPSI GCDPCTRPVK AGEDIRAGRW WWEGRNSKEC GLHK
Length:244
Mass (Da):27,987
Last modified:February 8, 2011 - v1
Checksum:i21790ACF88B34F20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN995097 Genomic DNA. Translation: CBN87218.1.
RefSeqiWP_013448886.1. NC_014752.1.
YP_004048586.1. NC_014752.1.

Genome annotation databases

EnsemblBacteriaiCBN87218; CBN87218; NLA_9920.
KEGGinla:NLA_9920.
PATRICi45300320. VBINeiLac170077_1209.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN995097 Genomic DNA. Translation: CBN87218.1.
RefSeqiWP_013448886.1. NC_014752.1.
YP_004048586.1. NC_014752.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBN87218; CBN87218; NLA_9920.
KEGGinla:NLA_9920.
PATRICi45300320. VBINeiLac170077_1209.

Phylogenomic databases

HOGENOMiHOG000249395.
KOiK00390.

Enzyme and pathway databases

UniPathwayiUPA00140; UER00206.
UPA00140; UER00206.
BioCyciNLAC489653:GJ91-1021-MONOMER.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00063. CysH.
InterProiIPR011798. APS_reductase.
IPR004511. PAPS/APS_Rdtase.
IPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01507. PAPS_reduct. 1 hit.
[Graphical view]
PIRSFiPIRSF000857. PAPS_reductase. 1 hit.
TIGRFAMsiTIGR02055. APS_reductase. 1 hit.
TIGR00434. cysH. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Independent evolution of the core and accessory gene sets in the genus Neisseria: insights gained from the genome of Neisseria lactamica isolate 020-06."
    Bennett J.S., Bentley S.D., Vernikos G.S., Quail M.A., Cherevach I., White B., Parkhill J., Maiden M.C.
    BMC Genomics 11:652-652(2010)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 020-06Imported.

Entry informationi

Entry nameiE4ZCY5_NEIL0
AccessioniPrimary (citable) accession number: E4ZCY5
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: May 27, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.