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E4ZCY5

- E4ZCY5_NEIL0

UniProt

E4ZCY5 - E4ZCY5_NEIL0

Protein

Phosphoadenosine phosphosulfate reductase

Gene

cysH

Organism
Neisseria lactamica (strain 020-06)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Reduction of activated sulfate into sulfite.UniRule annotation

    Catalytic activityi

    Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. phosphoadenylyl-sulfate reductase (thioredoxin) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cysteine biosynthetic process Source: InterPro
    2. hydrogen sulfide biosynthetic process Source: UniProtKB-UniPathway
    3. sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciNLAC489653:GJ91-1021-MONOMER.
    UniPathwayiUPA00140; UER00206.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoadenosine phosphosulfate reductaseUniRule annotation (EC:1.8.4.8UniRule annotation)
    Alternative name(s):
    3'-phosphoadenylylsulfate reductaseUniRule annotation
    PAPS reductase, thioredoxin dependentUniRule annotation
    PAPS sulfotransferaseUniRule annotation
    PAdoPS reductaseUniRule annotation
    Gene namesi
    Name:cysHUniRule annotationImported
    Ordered Locus Names:NLA_9920Imported
    OrganismiNeisseria lactamica (strain 020-06)Imported
    Taxonomic identifieri489653 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
    ProteomesiUP000008723: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PAPS reductase family. CysH subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000249395.
    KOiK00390.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00063. CysH.
    InterProiIPR011798. APS_reductase.
    IPR004511. PAPS/APS_Rdtase.
    IPR002500. PAPS_reduct.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF01507. PAPS_reduct. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000857. PAPS_reductase. 1 hit.
    TIGRFAMsiTIGR02055. APS_reductase. 1 hit.
    TIGR00434. cysH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E4ZCY5-1 [UniParc]FASTAAdd to Basket

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    MKIFKPALWK IPPIENGSET ALAEKTETLK QRLHRIAGSH RDARFASSLA    50
    AEDMVITDLI AGENLNIGIF TLDTGLLHAE TLNLLDRIER VYPHMQIKRF 100
    QPIREDALHY VESKGRFAFY DSVEARRECC RIRKIEPLDR AIAGADAWLT 150
    GQRREQSATR TELPFAEYDA GRGIGKYNPI FDWSEHDVWA YILANNVPYN 200
    DLYRQGFPSI GCDPCTRPVK AGEDIRAGRW WWEGRNSKEC GLHK 244
    Length:244
    Mass (Da):27,987
    Last modified:February 8, 2011 - v1
    Checksum:i21790ACF88B34F20
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN995097 Genomic DNA. Translation: CBN87218.1.
    RefSeqiYP_004048586.1. NC_014752.1.

    Genome annotation databases

    EnsemblBacteriaiCBN87218; CBN87218; NLA_9920.
    GeneIDi10006670.
    KEGGinla:NLA_9920.
    PATRICi45300320. VBINeiLac170077_1209.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN995097 Genomic DNA. Translation: CBN87218.1 .
    RefSeqi YP_004048586.1. NC_014752.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBN87218 ; CBN87218 ; NLA_9920 .
    GeneIDi 10006670.
    KEGGi nla:NLA_9920.
    PATRICi 45300320. VBINeiLac170077_1209.

    Phylogenomic databases

    HOGENOMi HOG000249395.
    KOi K00390.

    Enzyme and pathway databases

    UniPathwayi UPA00140 ; UER00206 .
    BioCyci NLAC489653:GJ91-1021-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00063. CysH.
    InterProi IPR011798. APS_reductase.
    IPR004511. PAPS/APS_Rdtase.
    IPR002500. PAPS_reduct.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF01507. PAPS_reduct. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000857. PAPS_reductase. 1 hit.
    TIGRFAMsi TIGR02055. APS_reductase. 1 hit.
    TIGR00434. cysH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Independent evolution of the core and accessory gene sets in the genus Neisseria: insights gained from the genome of Neisseria lactamica isolate 020-06."
      Bennett J.S., Bentley S.D., Vernikos G.S., Quail M.A., Cherevach I., White B., Parkhill J., Maiden M.C.
      BMC Genomics 11:652-652(2010)
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 020-06Imported.

    Entry informationi

    Entry nameiE4ZCY5_NEIL0
    AccessioniPrimary (citable) accession number: E4ZCY5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 8, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3