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Protein

Phosphoadenosine phosphosulfate reductase

Gene

cysH

Organism
Neisseria lactamica (strain 020-06)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Reduction of activated sulfate into sulfite.UniRule annotationSAAS annotation

Catalytic activityi

Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin.UniRule annotation

Pathwayi: hydrogen sulfide biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes sulfite from sulfate.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Sulfate adenylyltransferase subunit 1 (cysN)
  2. no protein annotated in this organism
  3. Phosphoadenosine phosphosulfate reductase (cysH)
This subpathway is part of the pathway hydrogen sulfide biosynthesis, which is itself part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sulfite from sulfate, the pathway hydrogen sulfide biosynthesis and in Sulfur metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00140; UER00206.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoadenosine phosphosulfate reductaseUniRule annotation (EC:1.8.4.8UniRule annotation)
Alternative name(s):
3'-phosphoadenylylsulfate reductaseUniRule annotation
PAPS reductase, thioredoxin dependentUniRule annotation
PAPS sulfotransferaseUniRule annotation
PAdoPS reductaseUniRule annotation
Gene namesi
Name:cysHUniRule annotationImported
Ordered Locus Names:NLA_9920Imported
OrganismiNeisseria lactamica (strain 020-06)Imported
Taxonomic identifieri489653 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000008723 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi489653.NLA_9920.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 218PAPS_reductInterPro annotationAdd BLAST173

Sequence similaritiesi

Belongs to the PAPS reductase family. CysH subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105ET3. Bacteria.
COG0175. LUCA.
HOGENOMiHOG000249395.
KOiK00390.

Family and domain databases

CDDicd01713. PAPS_reductase. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00063. CysH. 1 hit.
InterProiView protein in InterPro
IPR011798. APS_reductase.
IPR004511. PAPS/APS_Rdtase.
IPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
PfamiView protein in Pfam
PF01507. PAPS_reduct. 1 hit.
PIRSFiPIRSF000857. PAPS_reductase. 1 hit.
TIGRFAMsiTIGR02055. APS_reductase. 1 hit.
TIGR00434. cysH. 1 hit.

Sequencei

Sequence statusi: Complete.

E4ZCY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIFKPALWK IPPIENGSET ALAEKTETLK QRLHRIAGSH RDARFASSLA
60 70 80 90 100
AEDMVITDLI AGENLNIGIF TLDTGLLHAE TLNLLDRIER VYPHMQIKRF
110 120 130 140 150
QPIREDALHY VESKGRFAFY DSVEARRECC RIRKIEPLDR AIAGADAWLT
160 170 180 190 200
GQRREQSATR TELPFAEYDA GRGIGKYNPI FDWSEHDVWA YILANNVPYN
210 220 230 240
DLYRQGFPSI GCDPCTRPVK AGEDIRAGRW WWEGRNSKEC GLHK
Length:244
Mass (Da):27,987
Last modified:February 8, 2011 - v1
Checksum:i21790ACF88B34F20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN995097 Genomic DNA. Translation: CBN87218.1.
RefSeqiWP_013448886.1. NC_014752.1.

Genome annotation databases

EnsemblBacteriaiCBN87218; CBN87218; NLA_9920.
KEGGinla:NLA_9920.

Similar proteinsi

Entry informationi

Entry nameiE4ZCY5_NEIL0
AccessioniPrimary (citable) accession number: E4ZCY5
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 27, 2017
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported