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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Neisseria lactamica (strain 020-06)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotationSAAS annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei158 – 1581UniRule annotation
Active sitei586 – 5861UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciNLAC489653:GJ91-275-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotationImported
Ordered Locus Names:NLA_2620Imported
OrganismiNeisseria lactamica (strain 020-06)Imported
Taxonomic identifieri489653 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000008723: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000238647.
KOiK01595.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4ZAX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHLGYIYNI YGKRERKIMQ LHILNNPKDA ALAADAEFLK QSLFNLLHEE
60 70 80 90 100
ASPLVVETVK LLSTSDDSAA LIEKVLPQLD ERQTYDLTLA CGLFAQILNI
110 120 130 140 150
AEDVHHERRR QIHEDAGHNA AEGSLTETVR RLKAGKADDK SVQRQLDNTS
160 170 180 190 200
VTAVLTAHPT EVQRQTVLNF NRRIRALLPQ RERCTNADAL ARLRREIDTV
210 220 230 240 250
LLGLWQTSET RRHKLSVNDE INNGVSIFPM SFFEALPKLY RKMEHDFQTA
260 270 280 290 300
YPDVRVPDIL KIGGWIGGDR DGNPFVSAET LRFAFRRHAD AVFRFYRGEL
310 320 330 340 350
DKLYRELPLS IRRVKVNGDV MALSDKSPDE EIARTEEPYR RAIAYIMARA
360 370 380 390 400
MGKARALGLG MGCKFGFLEP YASAQEFLDD LKKLQRSLID NGSRLLAEGR
410 420 430 440 450
LADLIRSVSV FGFHMMPLDL RQHAGKHADV VAELFQHAGL EDYNSLNEEQ
460 470 480 490 500
KQAALLRELS HQRPLYSPFI TYSDHTRHEL AIFNEARKIK DEFGEDAVTQ
510 520 530 540 550
SIISNCEQPG DLLALALLLK ESGLLAVENG KPKSRINIVP LFETIEALEN
560 570 580 590 600
ACPVMETMFR LDWYGALLES RGNIQEIMLG YSDSNKDGGY VTSSWCLYQA
610 620 630 640 650
ELGLVELFKK YGVRMRLFHG RGGSVGRGGG PSYQAILAQP AGSVAGQIRI
660 670 680 690 700
TEQGEVITAK YADPGNAQRN LETLVAATLE AGIPTDKKDP DAKLMQALSD
710 720 730 740 750
VSFKYYRELI THPDFIDYFL QTSPIQEIAT LNLGSRPASR KTLARIQDLR
760 770 780 790 800
AIPWVFSWMQ NRLMLPAWYG FGSAVETLCE GSPETLAALR GHARNNPFFQ
810 820 830 840 850
AMLSNMEQVM AKTDITLAEN YAGLSESPDK AKIIFGMIKE EYRRSRKALL
860 870 880 890 900
DLLQTEELLR DNRSLARSLA LRIPYLNALN GLQVAMLKRL RKEPDNPHAL
910
LMVHLTINGV AQGLRNTG
Length:918
Mass (Da):103,357
Last modified:February 8, 2011 - v1
Checksum:iE9694AEC19E3969A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN995097 Genomic DNA. Translation: CBN86503.1.
RefSeqiWP_013448328.1. NC_014752.1.
YP_004047893.1. NC_014752.1.

Genome annotation databases

EnsemblBacteriaiCBN86503; CBN86503; NLA_2620.
GeneIDi10007275.
KEGGinla:NLA_2620.
PATRICi45298428. VBINeiLac170077_0305.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN995097 Genomic DNA. Translation: CBN86503.1.
RefSeqiWP_013448328.1. NC_014752.1.
YP_004047893.1. NC_014752.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBN86503; CBN86503; NLA_2620.
GeneIDi10007275.
KEGGinla:NLA_2620.
PATRICi45298428. VBINeiLac170077_0305.

Phylogenomic databases

HOGENOMiHOG000238647.
KOiK01595.

Enzyme and pathway databases

BioCyciNLAC489653:GJ91-275-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Independent evolution of the core and accessory gene sets in the genus Neisseria: insights gained from the genome of Neisseria lactamica isolate 020-06."
    Bennett J.S., Bentley S.D., Vernikos G.S., Quail M.A., Cherevach I., White B., Parkhill J., Maiden M.C.
    BMC Genomics 11:652-652(2010)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 020-06Imported.

Entry informationi

Entry nameiE4ZAX6_NEIL0
AccessioniPrimary (citable) accession number: E4ZAX6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: March 4, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.