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Protein

Alanine racemase

Gene

alr

Organism
Rhodococcus equi (strain 103S) (Corynebacterium equi)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei68 – 681Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei166 – 1661SubstrateUniRule annotation
Active sitei297 – 2971Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei345 – 3451Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciREQU685727:GHKP-3413-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:REQ_35320Imported
OrganismiRhodococcus equi (strain 103S) (Corynebacterium equi)Imported
Taxonomic identifieri685727 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
ProteomesiUP000006892 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei68 – 681N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE4WKR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiPSDWVRP.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

E4WKR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSKFVTTT AQEPDTAPTQ TSAPVAANTP PSAAAPQAEA VIDLDAVAYN
60 70 80 90 100
IGILREHAGG ATVMAVVKAD AYNHGAVPVA RAALAAGAGE LGVTTLAEGL
110 120 130 140 150
ELKNAGITAP VLSWLHTADS DFAPAVAAGV ELGLSSPRHL AAVAAAARQV
160 170 180 190 200
GTAATVTVKV DTGLNRNGVS REEWTDFLKD LARVEAEGAV RFKGVFSHLA
210 220 230 240 250
HADEPHHPVI DDQRERFTSA LEDAERIGLV PEAAHLSNSA ATLTRPDLRF
260 270 280 290 300
DMVRPGIAIY GLSPVPDLGT FGLRPVMTFR SRVALVKKVA AGEGVSYGHT
310 320 330 340 350
WVAPHDTTVA LLPVGYADGI PRALGGRFEV WLGDDRRPGI GRVCMDQVVV
360 370 380 390 400
DLGPDGAGVR EGDTAVFFGD GDGDRGVPHA QDWADALDTI HYEVVTSVRG
410
RTIRTYVGGP GGRS
Length:414
Mass (Da):43,083
Last modified:February 7, 2011 - v1
Checksum:i143297EB0B6FD28E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN563149 Genomic DNA. Translation: CBH49521.1.
RefSeqiWP_013416871.1. NC_014659.1.
YP_004008200.1. NC_014659.1.

Genome annotation databases

EnsemblBacteriaiCBH49521; CBH49521; REQ_35320.
KEGGireq:REQ_35320.
PATRICi42664543. VBIRhoEqu141084_3535.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN563149 Genomic DNA. Translation: CBH49521.1.
RefSeqiWP_013416871.1. NC_014659.1.
YP_004008200.1. NC_014659.1.

3D structure databases

ProteinModelPortaliE4WKR2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBH49521; CBH49521; REQ_35320.
KEGGireq:REQ_35320.
PATRICi42664543. VBIRhoEqu141084_3535.

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiPSDWVRP.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciREQU685727:GHKP-3413-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 103SImported.

Entry informationi

Entry nameiE4WKR2_RHOE1
AccessioniPrimary (citable) accession number: E4WKR2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 7, 2011
Last sequence update: February 7, 2011
Last modified: March 31, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.