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E4WKR2 (E4WKR2_RHOE1) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein attributes

Sequence length414 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201 SAAS SAAS001608

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family. HAMAP-Rule MF_01201 RuleBase RU004188

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site681Proton acceptor; specific for D-alanine By similarity HAMAP-Rule MF_01201
Active site2971Proton acceptor; specific for L-alanine By similarity HAMAP-Rule MF_01201
Binding site1661Substrate By similarity HAMAP-Rule MF_01201
Binding site3451Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01201

Amino acid modifications

Modified residue681N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01201

Sequences

Sequence LengthMass (Da)Tools
E4WKR2 [UniParc].

Last modified February 8, 2011. Version 1.
Checksum: 143297EB0B6FD28E

FASTA41443,083
        10         20         30         40         50         60 
MAGSKFVTTT AQEPDTAPTQ TSAPVAANTP PSAAAPQAEA VIDLDAVAYN IGILREHAGG 

        70         80         90        100        110        120 
ATVMAVVKAD AYNHGAVPVA RAALAAGAGE LGVTTLAEGL ELKNAGITAP VLSWLHTADS 

       130        140        150        160        170        180 
DFAPAVAAGV ELGLSSPRHL AAVAAAARQV GTAATVTVKV DTGLNRNGVS REEWTDFLKD 

       190        200        210        220        230        240 
LARVEAEGAV RFKGVFSHLA HADEPHHPVI DDQRERFTSA LEDAERIGLV PEAAHLSNSA 

       250        260        270        280        290        300 
ATLTRPDLRF DMVRPGIAIY GLSPVPDLGT FGLRPVMTFR SRVALVKKVA AGEGVSYGHT 

       310        320        330        340        350        360 
WVAPHDTTVA LLPVGYADGI PRALGGRFEV WLGDDRRPGI GRVCMDQVVV DLGPDGAGVR 

       370        380        390        400        410 
EGDTAVFFGD GDGDRGVPHA QDWADALDTI HYEVVTSVRG RTIRTYVGGP GGRS 

« Hide

References

[1]"The genome of a pathogenic rhodococcus: cooptive virulence underpinned by key gene acquisitions."
Letek M., Gonzalez P., Macarthur I., Rodriguez H., Freeman T.C., Valero-Rello A., Blanco M., Buckley T., Cherevach I., Fahey R., Hapeshi A., Holdstock J., Leadon D., Navas J., Ocampo A., Quail M.A., Sanders M., Scortti M.M. expand/collapse author list , Prescott J.F., Fogarty U., Meijer W.G., Parkhill J., Bentley S.D., Vazquez-Boland J.A.
PLoS Genet. 6:E1001145-E1001145(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 103S.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FN563149 Genomic DNA. Translation: CBH49521.1.
RefSeqYP_004008200.1. NC_014659.1.

3D structure databases

ProteinModelPortalE4WKR2.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBH49521; CBH49521; REQ_35320.
GeneID9965860.
KEGGreq:REQ_35320.
PATRIC42664543. VBIRhoEqu141084_3535.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000031444.
KOK01775.
OMAISHFACA.

Enzyme and pathway databases

BioCycREQU685727:GHKP-3413-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
ProtoNetSearch...

Entry information

Entry nameE4WKR2_RHOE1
AccessionPrimary (citable) accession number: E4WKR2
Entry history
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: July 9, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)