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E4WKH8

- E4WKH8_RHOE1

UniProt

E4WKH8 - E4WKH8_RHOE1

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Protein

Isocitrate dehydrogenase [NADP]

Gene

REQ_34420

Organism
Rhodococcus equi (strain 103S) (Corynebacterium equi)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771SubstrateUniRule annotation
Binding sitei82 – 821NADPUniRule annotation
Binding sitei109 – 1091SubstrateUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Sitei139 – 1391Critical for catalysisUniRule annotation
Sitei212 – 2121Critical for catalysisUniRule annotation
Binding sitei260 – 2601NADPUniRule annotation
Binding sitei328 – 3281NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADPUniRule annotation
Nucleotide bindingi310 – 3156NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciREQU685727:GHKP-3329-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:REQ_34420Imported
OrganismiRhodococcus equi (strain 103S) (Corynebacterium equi)Imported
Taxonomic identifieri685727 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
ProteomesiUP000006892: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE4WKH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000019858.
KOiK00031.
OMAiFKDEFQR.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4WKH8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKIKVEGKV VELDGDEMTR IIWQFIKDKL IHPYLDVDLE YYDLGIEHRD
60 70 80 90 100
ATDDQVTIDA AEAIKKHGVG VKCATITPDE ARVEEFGLKK MWRSPNGTIR
110 120 130 140 150
NILGGTIFRA PILISNVPRL VPGWTKPVIV GRHAFGDQYR ATDFKAPGAG
160 170 180 190 200
TVTITYTPDD GSEPIQHEVC RLPEDGGVVM GMYNYKKSIQ DFARASLSYG
210 220 230 240 250
LQQNYPVYLS TKNTILKAYD GMFKDEFQRI YEDEFKAEFD AAGLHYEHRL
260 270 280 290 300
IDDMVASSLK WEGGYVWACK NYDGDVQSDT VAQGYGSLGL MTSVLMTPDG
310 320 330 340 350
RTVEAEAAHG TVTRHYRQHQ QGKPTSTNPI ASIFAWTRGL EHRGKLDNTP
360 370 380 390 400
ELIEFAQQLE DVVIKTVENG QMTKDLALLV GPDQAWQTTE EFLATLDENL

QKARA
Length:405
Mass (Da):45,431
Last modified:February 8, 2011 - v1
Checksum:i8D7179D70CD0CF22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN563149 Genomic DNA. Translation: CBH49437.1.
RefSeqiWP_005518554.1. NC_014659.1.
YP_004008116.1. NC_014659.1.

Genome annotation databases

EnsemblBacteriaiCBH49437; CBH49437; REQ_34420.
GeneIDi9965784.
KEGGireq:REQ_34420.
PATRICi42664361. VBIRhoEqu141084_3444.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN563149 Genomic DNA. Translation: CBH49437.1 .
RefSeqi WP_005518554.1. NC_014659.1.
YP_004008116.1. NC_014659.1.

3D structure databases

ProteinModelPortali E4WKH8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBH49437 ; CBH49437 ; REQ_34420 .
GeneIDi 9965784.
KEGGi req:REQ_34420.
PATRICi 42664361. VBIRhoEqu141084_3444.

Phylogenomic databases

HOGENOMi HOG000019858.
KOi K00031.
OMAi FKDEFQR.

Enzyme and pathway databases

BioCyci REQU685727:GHKP-3329-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 103SImported.

Entry informationi

Entry nameiE4WKH8_RHOE1
AccessioniPrimary (citable) accession number: E4WKH8
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: November 26, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3