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Protein

Isocitrate dehydrogenase [NADP]

Gene

REQ_34420

Organism
Rhodococcus hoagii (strain 103S) (Rhodococcus equi)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg2+ or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei77SubstrateUniRule annotation1
Binding sitei82NADPUniRule annotation1
Binding sitei109SubstrateUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Sitei139Critical for catalysisUniRule annotation1
Sitei212Critical for catalysisUniRule annotation1
Metal bindingi252Magnesium or manganeseUniRule annotation1
Binding sitei260NADPUniRule annotation1
Metal bindingi275Magnesium or manganeseUniRule annotation1
Binding sitei328NADP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi75 – 77NADPUniRule annotation3
Nucleotide bindingi310 – 315NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processTricarboxylic acid cycleUniRule annotation
LigandMagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:REQ_34420Imported
OrganismiRhodococcus hoagii (strain 103S) (Rhodococcus equi)Imported
Taxonomic identifieri685727 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
Proteomesi
  • UP000006892 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi685727.REQ_34420

Structurei

3D structure databases

ProteinModelPortaliE4WKH8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 396Iso_dhInterPro annotationAdd BLAST388

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni94 – 100Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D5N Bacteria
COG0538 LUCA
HOGENOMiHOG000019858
KOiK00031
OrthoDBiPOG091H0JP0

Family and domain databases

InterProiView protein in InterPro
IPR019818 IsoCit/isopropylmalate_DH_CS
IPR004790 Isocitrate_DH_NADP
IPR024084 IsoPropMal-DH-like_dom
PANTHERiPTHR11822 PTHR11822, 1 hit
PfamiView protein in Pfam
PF00180 Iso_dh, 1 hit
PIRSFiPIRSF000108 IDH_NADP, 1 hit
SMARTiView protein in SMART
SM01329 Iso_dh, 1 hit
TIGRFAMsiTIGR00127 nadp_idh_euk, 1 hit
PROSITEiView protein in PROSITE
PS00470 IDH_IMDH, 1 hit

Sequencei

Sequence statusi: Complete.

E4WKH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKIKVEGKV VELDGDEMTR IIWQFIKDKL IHPYLDVDLE YYDLGIEHRD
60 70 80 90 100
ATDDQVTIDA AEAIKKHGVG VKCATITPDE ARVEEFGLKK MWRSPNGTIR
110 120 130 140 150
NILGGTIFRA PILISNVPRL VPGWTKPVIV GRHAFGDQYR ATDFKAPGAG
160 170 180 190 200
TVTITYTPDD GSEPIQHEVC RLPEDGGVVM GMYNYKKSIQ DFARASLSYG
210 220 230 240 250
LQQNYPVYLS TKNTILKAYD GMFKDEFQRI YEDEFKAEFD AAGLHYEHRL
260 270 280 290 300
IDDMVASSLK WEGGYVWACK NYDGDVQSDT VAQGYGSLGL MTSVLMTPDG
310 320 330 340 350
RTVEAEAAHG TVTRHYRQHQ QGKPTSTNPI ASIFAWTRGL EHRGKLDNTP
360 370 380 390 400
ELIEFAQQLE DVVIKTVENG QMTKDLALLV GPDQAWQTTE EFLATLDENL

QKARA
Length:405
Mass (Da):45,431
Last modified:February 8, 2011 - v1
Checksum:i8D7179D70CD0CF22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN563149 Genomic DNA Translation: CBH49437.1
RefSeqiWP_005518554.1, NC_014659.1

Genome annotation databases

EnsemblBacteriaiCBH49437; CBH49437; REQ_34420
GeneIDi32495363
KEGGireq:REQ_34420

Similar proteinsi

Entry informationi

Entry nameiE4WKH8_RHOH1
AccessioniPrimary (citable) accession number: E4WKH8
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: March 28, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health