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Protein

Superoxide dismutase [Cu-Zn]

Gene

sodA4

Organism
Rhodococcus equi (strain 103S) (Corynebacterium equi)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciREQU685727:GHKP-3763-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:sodA4Imported
Ordered Locus Names:REQ_38830Imported
OrganismiRhodococcus equi (strain 103S) (Corynebacterium equi)Imported
Taxonomic identifieri685727 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
ProteomesiUP000006892 Componenti: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000263448.
OMAiYNQTNGT.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4W8U3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPLVAIAAL GLTACSNNEE PTDVPGTTPP VWTGAPAPAG EHGESGSEHA
60 70 80 90 100
TTTGSADNVS VTLKDAKGSQ VGTATLAENG GFVQVTVDAQ GLTPGFHGLH
110 120 130 140 150
VHSVGKCEPN SVAPTGGEPG NFLSAGGHFQ VEGHTGHPAS GDLTSLEVRE
160 170 180 190 200
DGKGYLVTTT DAFTLEDLKN GGKGTALMIH ADADNFGNIP TRYALPDNAA
210 220
VPDQQTLSTG DAGGRVACGV IGG
Length:223
Mass (Da):22,263
Last modified:February 8, 2011 - v1
Checksum:iDE05822B873321E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN563149 Genomic DNA. Translation: CBH49868.1.
RefSeqiWP_013417078.1. NC_014659.1.
YP_004008547.1. NC_014659.1.

Genome annotation databases

EnsemblBacteriaiCBH49868; CBH49868; REQ_38830.
KEGGireq:REQ_38830.
PATRICi42665261. VBIRhoEqu141084_3890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN563149 Genomic DNA. Translation: CBH49868.1.
RefSeqiWP_013417078.1. NC_014659.1.
YP_004008547.1. NC_014659.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBH49868; CBH49868; REQ_38830.
KEGGireq:REQ_38830.
PATRICi42665261. VBIRhoEqu141084_3890.

Phylogenomic databases

HOGENOMiHOG000263448.
OMAiYNQTNGT.

Enzyme and pathway databases

BioCyciREQU685727:GHKP-3763-MONOMER.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 103SImported.

Entry informationi

Entry nameiE4W8U3_RHOE1
AccessioniPrimary (citable) accession number: E4W8U3
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: April 1, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.