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E4V6I8

- PDSA_ARTGP

UniProt

E4V6I8 - PDSA_ARTGP

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Protein
Protostadienol synthase A
Gene
PDSA, MGYG_08628
Organism
Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Protostadienol synthase which cyclizes (3S)-oxidosqualene to (17Z)-protosta-17(20),24-dien-3-beta-ol (protostadienol), the biosynthetic precursor of helvolic acid, a secundary metabolite which promotes virulence By similarity.

Catalytic activityi

(3S)-2,3-epoxy-2,3-dihydrosqualene = (17Z)-protosta-17(20),24-dien-3-beta-ol.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei237 – 2371Proton acceptor By similarity
Active sitei460 – 4601Proton donor By similarity

GO - Molecular functioni

  1. intramolecular transferase activity Source: InterPro

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
  2. steroid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Protostadienol synthase A (EC:5.4.99.32)
Gene namesi
Name:PDSA
ORF Names:MGYG_08628
OrganismiArthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum)
Taxonomic identifieri535722 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
ProteomesiUP000002669: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735Protostadienol synthase A
PRO_0000415498Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati129 – 17042PFTB 1
Add
BLAST
Repeati487 – 52842PFTB 2
Add
BLAST
Repeati564 – 60441PFTB 3
Add
BLAST
Repeati613 – 66048PFTB 4
Add
BLAST

Sequence similaritiesi

Contains 4 PFTB repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

OrthoDBiEOG70610B.

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00432. Prenyltrans. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.

Sequencei

Sequence statusi: Complete.

E4V6I8-1 [UniParc]FASTAAdd to Basket

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MPVADIEMVT GSAGHVDSKA ASEYGTDLRR WRLKVHEGRH MWEYVDEDVA    50
QTQQQTFAEN YWLGQEYELP KMSTPIFAQD ALDNGWAFFK RLQTQDGHWG 100
CHDDGPLFVT SGIVISSYIC GITLPDAMKN EMIRYLLNFV NEDGGWGLWI 150
NSPSTVFGTT MNYTMLRILG VPSTHPALLD ARDTLLKMGS ARALPTWGKF 200
WMCALGAYEW DGMIPLAPEP LLAPGFLPLN PGNWWVHTRN VFVSMSYLFG 250
HRFSAPMTPL IQELREELYD MPYHKIDWFA QQTNISDYDR LHPPTMLQKG 300
LANALCYYEY VKVPYLRRKA LDEALFQVEM EVHNTSYLCI APVSFASNML 350
VMFHAHGANS HWVKGMADRI IDPMWMCREG MAASGTNGTS VWDTALTVQA 400
ALDGGLAQRP ENHNTMLEAL KFIEVSQITE NPLGVSQGYR QPTKGAWPFS 450
TRDQAYAVSD TTAVTVRAVI QLQALKSMPK LVSDERLAEA VDLIIGMENK 500
CDGYSAFEPL RGPKALELLN ITELYDNVMT ESLYPECTSS VLLCLDTFTK 550
AYPHHRPVEI QSIMARCARY LIKAQFPCGG WLASWGVCFT YATMFALQGL 600
ETVGLRESNS ETCRNACSFL LQYQNDDGGW GEDLISIREK RYIQDPAGSQ 650
VTCTAYALMG LISAHCSNRD ALRRGIRWLM RAQQATGEWL PGSLEGIFAC 700
PGGMRYPNYK FHFTLSAIGR YIERYGDEAL YLKEQ 735
Length:735
Mass (Da):82,905
Last modified:February 8, 2011 - v1
Checksum:i263F8DEB2E3AA290
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS989831 Genomic DNA. Translation: EFQ96704.1.
RefSeqiXP_003169081.1. XM_003169033.1.

Genome annotation databases

GeneIDi10024264.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS989831 Genomic DNA. Translation: EFQ96704.1 .
RefSeqi XP_003169081.1. XM_003169033.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 10024264.

Phylogenomic databases

OrthoDBi EOG70610B.

Family and domain databases

Gene3Di 1.50.10.20. 2 hits.
InterProi IPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
Pfami PF00432. Prenyltrans. 1 hit.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 2 hits.
TIGRFAMsi TIGR01787. squalene_cyclas. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4604 / CBS 118893.

Entry informationi

Entry nameiPDSA_ARTGP
AccessioniPrimary (citable) accession number: E4V6I8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: February 8, 2011
Last modified: April 16, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi