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E4V6I8

- PDSA_ARTGP

UniProt

E4V6I8 - PDSA_ARTGP

Protein

Protostadienol synthase A

Gene

PDSA

Organism
Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Protostadienol synthase which cyclizes (3S)-oxidosqualene to (17Z)-protosta-17(20),24-dien-3-beta-ol (protostadienol), the biosynthetic precursor of helvolic acid, a secundary metabolite which promotes virulence.By similarity

    Catalytic activityi

    (3S)-2,3-epoxy-2,3-dihydrosqualene = (17Z)-protosta-17(20),24-dien-3-beta-ol.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei237 – 2371Proton acceptorBy similarity
    Active sitei460 – 4601Proton donorBy similarity

    GO - Molecular functioni

    1. intramolecular transferase activity Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW
    2. steroid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Virulence

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protostadienol synthase A (EC:5.4.99.32)
    Gene namesi
    Name:PDSA
    ORF Names:MGYG_08628
    OrganismiArthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum)
    Taxonomic identifieri535722 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
    ProteomesiUP000002669: Unassembled WGS sequence

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 735735Protostadienol synthase APRO_0000415498Add
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati129 – 17042PFTB 1Add
    BLAST
    Repeati487 – 52842PFTB 2Add
    BLAST
    Repeati564 – 60441PFTB 3Add
    BLAST
    Repeati613 – 66048PFTB 4Add
    BLAST

    Sequence similaritiesi

    Belongs to the terpene cyclase/mutase family.Curated
    Contains 4 PFTB repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    OrthoDBiEOG70610B.

    Family and domain databases

    Gene3Di1.50.10.20. 2 hits.
    InterProiIPR001330. Prenyltrans.
    IPR018333. Squalene_cyclase.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view]
    PfamiPF00432. Prenyltrans. 1 hit.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 2 hits.
    TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E4V6I8-1 [UniParc]FASTAAdd to Basket

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    MPVADIEMVT GSAGHVDSKA ASEYGTDLRR WRLKVHEGRH MWEYVDEDVA    50
    QTQQQTFAEN YWLGQEYELP KMSTPIFAQD ALDNGWAFFK RLQTQDGHWG 100
    CHDDGPLFVT SGIVISSYIC GITLPDAMKN EMIRYLLNFV NEDGGWGLWI 150
    NSPSTVFGTT MNYTMLRILG VPSTHPALLD ARDTLLKMGS ARALPTWGKF 200
    WMCALGAYEW DGMIPLAPEP LLAPGFLPLN PGNWWVHTRN VFVSMSYLFG 250
    HRFSAPMTPL IQELREELYD MPYHKIDWFA QQTNISDYDR LHPPTMLQKG 300
    LANALCYYEY VKVPYLRRKA LDEALFQVEM EVHNTSYLCI APVSFASNML 350
    VMFHAHGANS HWVKGMADRI IDPMWMCREG MAASGTNGTS VWDTALTVQA 400
    ALDGGLAQRP ENHNTMLEAL KFIEVSQITE NPLGVSQGYR QPTKGAWPFS 450
    TRDQAYAVSD TTAVTVRAVI QLQALKSMPK LVSDERLAEA VDLIIGMENK 500
    CDGYSAFEPL RGPKALELLN ITELYDNVMT ESLYPECTSS VLLCLDTFTK 550
    AYPHHRPVEI QSIMARCARY LIKAQFPCGG WLASWGVCFT YATMFALQGL 600
    ETVGLRESNS ETCRNACSFL LQYQNDDGGW GEDLISIREK RYIQDPAGSQ 650
    VTCTAYALMG LISAHCSNRD ALRRGIRWLM RAQQATGEWL PGSLEGIFAC 700
    PGGMRYPNYK FHFTLSAIGR YIERYGDEAL YLKEQ 735
    Length:735
    Mass (Da):82,905
    Last modified:February 8, 2011 - v1
    Checksum:i263F8DEB2E3AA290
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS989831 Genomic DNA. Translation: EFQ96704.1.
    RefSeqiXP_003169081.1. XM_003169033.1.

    Genome annotation databases

    GeneIDi10024264.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS989831 Genomic DNA. Translation: EFQ96704.1 .
    RefSeqi XP_003169081.1. XM_003169033.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 10024264.

    Phylogenomic databases

    OrthoDBi EOG70610B.

    Family and domain databases

    Gene3Di 1.50.10.20. 2 hits.
    InterProi IPR001330. Prenyltrans.
    IPR018333. Squalene_cyclase.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view ]
    Pfami PF00432. Prenyltrans. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 2 hits.
    TIGRFAMsi TIGR01787. squalene_cyclas. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-4604 / CBS 118893.

    Entry informationi

    Entry nameiPDSA_ARTGP
    AccessioniPrimary (citable) accession number: E4V6I8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 22, 2012
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3