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E4UYL6

- DAPB_ARTGP

UniProt

E4UYL6 - DAPB_ARTGP

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Protein
Probable dipeptidyl-aminopeptidase B
Gene
DAPB, MGYG_05182
Organism
Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei759 – 7591Charge relay system By similarity
Active sitei836 – 8361Charge relay system By similarity
Active sitei869 – 8691Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:DAPB
    ORF Names:MGYG_05182
    OrganismiArthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum)
    Taxonomic identifieri535722 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
    ProteomesiUP000002669: Unassembled WGS sequence

    Subcellular locationi

    Vacuole membrane; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles By similarity.

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9393Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei94 – 11421Helical; Signal-anchor for type II membrane protein; Reviewed prediction
    Add
    BLAST
    Topological domaini115 – 917803Vacuolar Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 917917Probable dipeptidyl-aminopeptidase B
    PRO_0000412130Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi206 – 2061N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi302 – 3021N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi354 – 3541N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi818 – 8181N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Glycoprotein

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E4UYL6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTVGRRLNDE EAIPLTAKEA GSRDSIDSSS TASVSLTLVD GTNHTTAKPS    50
    KSAHKGVSRD RYADEKYRDD VEEDWEEDRY IPSNAKPSQR RTQIVFWLLV 100
    ALCVGGWAVA FLFFVTSPGN TISTTPDTGS GSPDSDVIKP GSPPAGKKIP 150
    LDDVLGGAWS PTQHTISWIA GPKGEDGLLL QKSEGGTGPY LHVEDVRNIH 200
    GTQSNNKSMV LMKDSVFFVN DERISPEKVW PSPDLKTVLA MTRQKKNWRH 250
    SYTGLYWLFD VETQTAQPLD PGAPNGRIQL ATWSPTSDAV AFTRDNNLYI 300
    RNLTSKTVKA ITTDGGANLF YGIPDWVYEE EVFEGNSATW WSLDGKYISF 350
    LRTNETTVPE FPVDFYLSSP PDYAPKPGEE AYPYVQQIKY PKAGAPNPTV 400
    GLQFYDVERE ESFSVDVKDS LNDDDRIIIE VIPGSNGRIL VRETNRESYI 450
    VKVAAIDATK REGKIIRSDN IDEIDGGWVE PSHTTTYIPS DPASGRPNDG 500
    YIDTVIHEGY NHLAYFTPLE NPKPKMLTTG KWEVVAAPSG VDLKNNVIYF 550
    VATKESPIDR HVYSVKLDGS ELQLLKDSEK SAYYDVSFSH GAGYMLLQYQ 600
    GPKIPWQKLM NSPSNTDSYT EILEENKRLA KLSNEFALPS LHYSSITVDG 650
    FKLPVVERRP PNFDETKKYP VLFHLYGGPG SQTVNKKFLV NFQTYVASTL 700
    GYIVVTVDGR GTGFNGRKFR CIVRRNLGHY EAYDQIQTAK AWGRKPYVDK 750
    TRIAIWGWSY GGFMTLKTLE QDAGETFQYG MAVAPVTDWR YYDSIYTERY 800
    MHMPQNNEEG YETASVSNST ALSQNTRFLI MHGSADDNVH FQNTLTLLDK 850
    LDIMGVHNYD MHVFPDSNHG IYFHHAYKMV HQRLSDWLVN AFNGEWVRLR 900
    DPKPTIIKRV IRRLLHR 917
    Length:917
    Mass (Da):103,346
    Last modified:February 8, 2011 - v1
    Checksum:i68958EEB003D17D8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS989825 Genomic DNA. Translation: EFR02179.1.
    RefSeqiXP_003172590.1. XM_003172542.1.

    Genome annotation databases

    GeneIDi10027863.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS989825 Genomic DNA. Translation: EFR02179.1 .
    RefSeqi XP_003172590.1. XM_003172542.1.

    3D structure databases

    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 10027863.

    Phylogenomic databases

    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-4604 / CBS 118893.

    Entry informationi

    Entry nameiDAPB_ARTGP
    AccessioniPrimary (citable) accession number: E4UYL6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: February 8, 2011
    Last modified: June 11, 2014
    This is version 16 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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