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Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei759 – 7591Charge relay systemBy similarity
Active sitei836 – 8361Charge relay systemBy similarity
Active sitei869 – 8691Charge relay systemBy similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:MGYG_05182
OrganismiArthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum)
Taxonomic identifieri535722 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeMicrosporum
ProteomesiUP000002669 Componenti: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9393CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei94 – 11421Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini115 – 917803VacuolarSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 917917Probable dipeptidyl-aminopeptidase BPRO_0000412130Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi354 – 3541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi818 – 8181N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiE4UYL6.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

E4UYL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVGRRLNDE EAIPLTAKEA GSRDSIDSSS TASVSLTLVD GTNHTTAKPS
60 70 80 90 100
KSAHKGVSRD RYADEKYRDD VEEDWEEDRY IPSNAKPSQR RTQIVFWLLV
110 120 130 140 150
ALCVGGWAVA FLFFVTSPGN TISTTPDTGS GSPDSDVIKP GSPPAGKKIP
160 170 180 190 200
LDDVLGGAWS PTQHTISWIA GPKGEDGLLL QKSEGGTGPY LHVEDVRNIH
210 220 230 240 250
GTQSNNKSMV LMKDSVFFVN DERISPEKVW PSPDLKTVLA MTRQKKNWRH
260 270 280 290 300
SYTGLYWLFD VETQTAQPLD PGAPNGRIQL ATWSPTSDAV AFTRDNNLYI
310 320 330 340 350
RNLTSKTVKA ITTDGGANLF YGIPDWVYEE EVFEGNSATW WSLDGKYISF
360 370 380 390 400
LRTNETTVPE FPVDFYLSSP PDYAPKPGEE AYPYVQQIKY PKAGAPNPTV
410 420 430 440 450
GLQFYDVERE ESFSVDVKDS LNDDDRIIIE VIPGSNGRIL VRETNRESYI
460 470 480 490 500
VKVAAIDATK REGKIIRSDN IDEIDGGWVE PSHTTTYIPS DPASGRPNDG
510 520 530 540 550
YIDTVIHEGY NHLAYFTPLE NPKPKMLTTG KWEVVAAPSG VDLKNNVIYF
560 570 580 590 600
VATKESPIDR HVYSVKLDGS ELQLLKDSEK SAYYDVSFSH GAGYMLLQYQ
610 620 630 640 650
GPKIPWQKLM NSPSNTDSYT EILEENKRLA KLSNEFALPS LHYSSITVDG
660 670 680 690 700
FKLPVVERRP PNFDETKKYP VLFHLYGGPG SQTVNKKFLV NFQTYVASTL
710 720 730 740 750
GYIVVTVDGR GTGFNGRKFR CIVRRNLGHY EAYDQIQTAK AWGRKPYVDK
760 770 780 790 800
TRIAIWGWSY GGFMTLKTLE QDAGETFQYG MAVAPVTDWR YYDSIYTERY
810 820 830 840 850
MHMPQNNEEG YETASVSNST ALSQNTRFLI MHGSADDNVH FQNTLTLLDK
860 870 880 890 900
LDIMGVHNYD MHVFPDSNHG IYFHHAYKMV HQRLSDWLVN AFNGEWVRLR
910
DPKPTIIKRV IRRLLHR
Length:917
Mass (Da):103,346
Last modified:February 8, 2011 - v1
Checksum:i68958EEB003D17D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS989825 Genomic DNA. Translation: EFR02179.1.
RefSeqiXP_003172590.1. XM_003172542.1.

Genome annotation databases

GeneIDi10027863.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS989825 Genomic DNA. Translation: EFR02179.1.
RefSeqiXP_003172590.1. XM_003172542.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi10027863.

Phylogenomic databases

InParanoidiE4UYL6.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4604 / CBS 118893.

Entry informationi

Entry nameiDAPB_ARTGP
AccessioniPrimary (citable) accession number: E4UYL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: February 8, 2011
Last modified: January 7, 2015
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.