E4UYL6 (DAPB_ARTGP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable dipeptidyl-aminopeptidase B
Short name=DPAP B
EC=3.4.14.5

Gene names

Name:	DAPB
ORF Names:	MGYG_05182

Organism

Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum) [Complete proteome]

Taxonomic identifier

535722 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Onygenales › Arthrodermataceae › Arthroderma › Arthroderma gypseum

Protein attributes

Sequence length	917 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.
Catalytic activity	Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Subcellular location	Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.
Sequence similarities	Belongs to the peptidase S9B family.

Ontologies

Keywords
Cellular component	Membrane Vacuole
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Aminopeptidase Hydrolase Protease Serine protease
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW vacuolar membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW serine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 917	917	Probable dipeptidyl-aminopeptidase B		PRO_0000412130
Regions
	Topological domain	1 – 93	93	Cytoplasmic Potential
	Transmembrane	94 – 114	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	115 – 917	803	Vacuolar Potential
Sites
	Active site	759	1	Charge relay system By similarity
	Active site	836	1	Charge relay system By similarity
	Active site	869	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	206	1	N-linked (GlcNAc...) Potential
	Glycosylation	302	1	N-linked (GlcNAc...) Potential
	Glycosylation	354	1	N-linked (GlcNAc...) Potential
	Glycosylation	818	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	E4UYL6 [UniParc]. Last modified February 8, 2011. Version 1. Checksum: 68958EEB003D17D8	FASTA	917	103,346
	10 20 30 40 50 60 MTVGRRLNDE EAIPLTAKEA GSRDSIDSSS TASVSLTLVD GTNHTTAKPS KSAHKGVSRD 70 80 90 100 110 120 RYADEKYRDD VEEDWEEDRY IPSNAKPSQR RTQIVFWLLV ALCVGGWAVA FLFFVTSPGN 130 140 150 160 170 180 TISTTPDTGS GSPDSDVIKP GSPPAGKKIP LDDVLGGAWS PTQHTISWIA GPKGEDGLLL 190 200 210 220 230 240 QKSEGGTGPY LHVEDVRNIH GTQSNNKSMV LMKDSVFFVN DERISPEKVW PSPDLKTVLA 250 260 270 280 290 300 MTRQKKNWRH SYTGLYWLFD VETQTAQPLD PGAPNGRIQL ATWSPTSDAV AFTRDNNLYI 310 320 330 340 350 360 RNLTSKTVKA ITTDGGANLF YGIPDWVYEE EVFEGNSATW WSLDGKYISF LRTNETTVPE 370 380 390 400 410 420 FPVDFYLSSP PDYAPKPGEE AYPYVQQIKY PKAGAPNPTV GLQFYDVERE ESFSVDVKDS 430 440 450 460 470 480 LNDDDRIIIE VIPGSNGRIL VRETNRESYI VKVAAIDATK REGKIIRSDN IDEIDGGWVE 490 500 510 520 530 540 PSHTTTYIPS DPASGRPNDG YIDTVIHEGY NHLAYFTPLE NPKPKMLTTG KWEVVAAPSG 550 560 570 580 590 600 VDLKNNVIYF VATKESPIDR HVYSVKLDGS ELQLLKDSEK SAYYDVSFSH GAGYMLLQYQ 610 620 630 640 650 660 GPKIPWQKLM NSPSNTDSYT EILEENKRLA KLSNEFALPS LHYSSITVDG FKLPVVERRP 670 680 690 700 710 720 PNFDETKKYP VLFHLYGGPG SQTVNKKFLV NFQTYVASTL GYIVVTVDGR GTGFNGRKFR 730 740 750 760 770 780 CIVRRNLGHY EAYDQIQTAK AWGRKPYVDK TRIAIWGWSY GGFMTLKTLE QDAGETFQYG 790 800 810 820 830 840 MAVAPVTDWR YYDSIYTERY MHMPQNNEEG YETASVSNST ALSQNTRFLI MHGSADDNVH 850 860 870 880 890 900 FQNTLTLLDK LDIMGVHNYD MHVFPDSNHG IYFHHAYKMV HQRLSDWLVN AFNGEWVRLR 910 DPKPTIIKRV IRRLLHR

References

[1]

"Comparative genome analysis of Trichophyton rubrum and related dermatophytes reveals candidate genes involved in infection." Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W., Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E., Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I., Rossi A., Saif S. , Samalova M., Saunders C.W., Shea T., Summerbell R.C., Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C. MBio 3:E259-E259(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC MYA-4604 / CBS 118893.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS989825 Genomic DNA. Translation: EFR02179.1.
RefSeq	XP_003172590.1. XM_003172542.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	10027863.
Family and domain databases
InterPro	IPR001375. Peptidase_S9. IPR002469. Peptidase_S9B. [Graphical view]
Pfam	PF00930. DPPIV_N. 1 hit. PF00326. Peptidase_S9. 1 hit. [Graphical view]
PROSITE	PS00708. PRO_ENDOPEP_SER. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_ARTGP

Accession

Primary (citable) accession number: E4UYL6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	February 8, 2011
Last modified:	March 6, 2013
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program