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E4UYL6 (DAPB_ARTGP) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl-aminopeptidase B

Short name=DPAP B
EC=3.4.14.5
Gene names
Name:DAPB
ORF Names:MGYG_05182
OrganismArthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum) [Complete proteome]
Taxonomic identifier535722 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma

Protein attributes

Sequence length917 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Ontologies

Keywords
   Cellular componentMembrane
Vacuole
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   Molecular functionAminopeptidase
Hydrolase
Protease
Serine protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

vacuolar membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaminopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

serine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 917917Probable dipeptidyl-aminopeptidase B
PRO_0000412130

Regions

Topological domain1 – 9393Cytoplasmic Potential
Transmembrane94 – 11421Helical; Signal-anchor for type II membrane protein; Potential
Topological domain115 – 917803Vacuolar Potential

Sites

Active site7591Charge relay system By similarity
Active site8361Charge relay system By similarity
Active site8691Charge relay system By similarity

Amino acid modifications

Glycosylation2061N-linked (GlcNAc...) Potential
Glycosylation3021N-linked (GlcNAc...) Potential
Glycosylation3541N-linked (GlcNAc...) Potential
Glycosylation8181N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
E4UYL6 [UniParc].

Last modified February 8, 2011. Version 1.
Checksum: 68958EEB003D17D8

FASTA917103,346
        10         20         30         40         50         60 
MTVGRRLNDE EAIPLTAKEA GSRDSIDSSS TASVSLTLVD GTNHTTAKPS KSAHKGVSRD 

        70         80         90        100        110        120 
RYADEKYRDD VEEDWEEDRY IPSNAKPSQR RTQIVFWLLV ALCVGGWAVA FLFFVTSPGN 

       130        140        150        160        170        180 
TISTTPDTGS GSPDSDVIKP GSPPAGKKIP LDDVLGGAWS PTQHTISWIA GPKGEDGLLL 

       190        200        210        220        230        240 
QKSEGGTGPY LHVEDVRNIH GTQSNNKSMV LMKDSVFFVN DERISPEKVW PSPDLKTVLA 

       250        260        270        280        290        300 
MTRQKKNWRH SYTGLYWLFD VETQTAQPLD PGAPNGRIQL ATWSPTSDAV AFTRDNNLYI 

       310        320        330        340        350        360 
RNLTSKTVKA ITTDGGANLF YGIPDWVYEE EVFEGNSATW WSLDGKYISF LRTNETTVPE 

       370        380        390        400        410        420 
FPVDFYLSSP PDYAPKPGEE AYPYVQQIKY PKAGAPNPTV GLQFYDVERE ESFSVDVKDS 

       430        440        450        460        470        480 
LNDDDRIIIE VIPGSNGRIL VRETNRESYI VKVAAIDATK REGKIIRSDN IDEIDGGWVE 

       490        500        510        520        530        540 
PSHTTTYIPS DPASGRPNDG YIDTVIHEGY NHLAYFTPLE NPKPKMLTTG KWEVVAAPSG 

       550        560        570        580        590        600 
VDLKNNVIYF VATKESPIDR HVYSVKLDGS ELQLLKDSEK SAYYDVSFSH GAGYMLLQYQ 

       610        620        630        640        650        660 
GPKIPWQKLM NSPSNTDSYT EILEENKRLA KLSNEFALPS LHYSSITVDG FKLPVVERRP 

       670        680        690        700        710        720 
PNFDETKKYP VLFHLYGGPG SQTVNKKFLV NFQTYVASTL GYIVVTVDGR GTGFNGRKFR 

       730        740        750        760        770        780 
CIVRRNLGHY EAYDQIQTAK AWGRKPYVDK TRIAIWGWSY GGFMTLKTLE QDAGETFQYG 

       790        800        810        820        830        840 
MAVAPVTDWR YYDSIYTERY MHMPQNNEEG YETASVSNST ALSQNTRFLI MHGSADDNVH 

       850        860        870        880        890        900 
FQNTLTLLDK LDIMGVHNYD MHVFPDSNHG IYFHHAYKMV HQRLSDWLVN AFNGEWVRLR 

       910 
DPKPTIIKRV IRRLLHR 

« Hide

References

[1]"Comparative genome analysis of Trichophyton rubrum and related dermatophytes reveals candidate genes involved in infection."
Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W., Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E., Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I., Rossi A., Saif S. expand/collapse author list , Samalova M., Saunders C.W., Shea T., Summerbell R.C., Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.
MBio 3:E259-E259(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-4604 / CBS 118893.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS989825 Genomic DNA. Translation: EFR02179.1.
RefSeqXP_003172590.1. XM_003172542.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID10027863.

Phylogenomic databases

OrthoDBEOG72VHFG.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
InterProIPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPB_ARTGP
AccessionPrimary (citable) accession number: E4UYL6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: February 8, 2011
Last modified: April 16, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries