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E4USS9

- CBPYA_ARTGP

UniProt

E4USS9 - CBPYA_ARTGP

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Protein
Carboxypeptidase Y homolog A
Gene
CPYA, MGYG_03599
Organism
Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei266 – 2661 By similarity
Active sitei458 – 4581 By similarity
Active sitei520 – 5201 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:CPYA
ORF Names:MGYG_03599
OrganismiArthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum)
Taxonomic identifieri535722 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
ProteomesiUP000002669: Unassembled WGS sequence

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. vacuole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Propeptidei18 – 124107 By similarity
PRO_0000407426Add
BLAST
Chaini125 – 543419Carboxypeptidase Y homolog A
PRO_0000407427Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi179 ↔ 419 By similarity
Glycosylationi210 – 2101N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi313 ↔ 327 By similarity
Disulfide bondi337 ↔ 360 By similarity
Disulfide bondi344 ↔ 353 By similarity
Disulfide bondi382 ↔ 389 By similarity
Glycosylationi509 – 5091N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E4USS9-1 [UniParc]FASTAAdd to Basket

« Hide

MKLLTTGLLA SAALVAAQEQ QVLRADEVFG KAPLPDASIF DETIKQFQSS    50
IEDGISHFWS EMKTNFKDYL PMISLPKKHN RRPDSEWDHV VRGADVESVW 100
VQGADGEKRR EIDGKLKNYD LRVKSVDPSQ LGIDPGVKQY SGYLDDNDAD 150
KHLFYWFFES RNDPKNDPVV LWLNGGPGCS SLTGLFLELG PATIDKNLKV 200
VHNPYSWNSN ASVIFLDQPV NVGFSYSGSS VSDTVAAGKD VYALLTLFFK 250
QFPEYATQDF HISGESYAGH YIPVFAAEIL SHKNTNINLK SALIGNGLTD 300
PLTQYPHYRP MACGDGGYPA VLDQGTCRSM DNSLERCLSL IETCYSSESA 350
WVCVPAAMYC NSAILAPYQQ TGMNPYDVRS KCEDMGSLCY PQLNAITEWL 400
NQKSVMKALG VEVESYESCN SGINRDFLFH GDWMKPFHRL VPSVLEKIPV 450
LIYAGDADFI CNWLGNQAWT EALEWPGHKK FTEAKLQDLK IVDNKNKGKK 500
IGQVKSSGNF TFMRIFGAGH MVPLNQPEAS LEFFNRWLRG EWH 543
Length:543
Mass (Da):60,846
Last modified:February 8, 2011 - v1
Checksum:i01C8974ABAEC31F3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS989824 Genomic DNA. Translation: EFR00594.1.
RefSeqiXP_003173424.1. XM_003173376.1.

Genome annotation databases

GeneIDi10028703.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS989824 Genomic DNA. Translation: EFR00594.1 .
RefSeqi XP_003173424.1. XM_003173376.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 10028703.

Phylogenomic databases

OrthoDBi EOG7XDBR1.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4604 / CBS 118893.

Entry informationi

Entry nameiCBPYA_ARTGP
AccessioniPrimary (citable) accession number: E4USS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: February 8, 2011
Last modified: June 11, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi