E4USI8 (AMPP1_ARTGP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase P
Short name=AMPP
Short name=Aminopeptidase P
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	AMPP
ORF Names:	MGYG_04346

Organism

Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum) [Complete proteome]

Taxonomic identifier

535722 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Onygenales › Arthrodermataceae › Arthroderma › Arthroderma gypseum

Protein attributes

Sequence length	635 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 635	635	Probable Xaa-Pro aminopeptidase P		PRO_0000411776
Sites
	Metal binding	432	1	Manganese 2 By similarity
	Metal binding	443	1	Manganese 1 By similarity
	Metal binding	443	1	Manganese 2 By similarity
	Metal binding	541	1	Manganese 1 By similarity
	Metal binding	555	1	Manganese 1 By similarity
	Metal binding	555	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	E4USI8 [UniParc]. Last modified February 8, 2011. Version 1. Checksum: 4AE66BD1526D5587	FASTA	635	70,370
	10 20 30 40 50 60 MTILRHPLRF LFKPRFLYFQ SPSGQSSRPF STSQILRTAL DMPPPPVDTT QRLAKLRELM 70 80 90 100 110 120 AQNKVDVYTF ISSFTGSAGC AIVSMSKAAL STDGRYFSQA AKQLDSNWTL LKRGVEGVPT 130 140 150 160 170 180 WEEWTAEQAE NGKVVGVDPS LITAADARKL SQTLKTTGGS LIGIDQNLID AVWGDERPAR 190 200 210 220 230 240 PSNQITVQPV ERAGKSFEEK VEDLRKELAA KKRSAMVIST LDEIAWLFNL RGSDIPYNPV 250 260 270 280 290 300 FFSYAIVTPS VAELYVDENK LSPEARKHLE GKVVLKPYES IFQASKALAE SKASASSGSG 310 320 330 340 350 360 GKFLLSNKAS WSVSLALGGE QNVVEVRSPI TDAKAIKNEV ELEGFRKCHI RDGAALIEYF 370 380 390 400 410 420 AWLENALIKE GAKLDEVDGA NKLFEIRKKY DHFVGNSFDT ISSTGANGAT IHYKPEKSTC 430 440 450 460 470 480 AVIDPKAMYL CDSGGQYLDG TTDTTRTLHF GEPTEFQKKA YALVLKGHIS IDNAIFPKGT 490 500 510 520 530 540 TGYAIDSFAR QHLWKEGLDY LHGTGHGVGS FLNVHEGPMG IGSRAQYAEV PLSASNVLSN 550 560 570 580 590 600 EPGYYEDGNF GIRLENLVIC KEVKTPHKFG DKPFLGFEYI TLVPFCQKLL DASLLTEAER 610 620 630 KWVNDYHAKV WEKTSPFFEK DELTTNWLKR ETQPI

References

[1]

"Comparative genome analysis of Trichophyton rubrum and related dermatophytes reveals candidate genes involved in infection." Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W., Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E., Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I., Rossi A., Saif S. , Samalova M., Saunders C.W., Shea T., Summerbell R.C., Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C. MBio 3:E259-E259(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC MYA-4604 / CBS 118893.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS989824 Genomic DNA. Translation: EFR01339.1.
RefSeq	XP_003174169.1. XM_003174121.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	10029458.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR000587. Creatinase. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF01321. Creatinase_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP1_ARTGP

Accession

Primary (citable) accession number: E4USI8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	February 8, 2011
Last modified:	March 6, 2013
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program