Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

E4UDE4

- E4UDE4_LIBSC

UniProt

E4UDE4 - E4UDE4_LIBSC

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Isocitrate dehydrogenase [NADP]

Gene

CKC_04365

Organism
Liberibacter solanacearum (strain CLso-ZC1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771SubstrateUniRule annotation
Binding sitei82 – 821NADPUniRule annotation
Binding sitei109 – 1091SubstrateUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Sitei139 – 1391Critical for catalysisUniRule annotation
Sitei210 – 2101Critical for catalysisUniRule annotation
Metal bindingi250 – 2501Magnesium or manganese
Binding sitei258 – 2581NADPUniRule annotation
Metal bindingi273 – 2731Magnesium or manganese
Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADPUniRule annotation
Nucleotide bindingi308 – 3136NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciLSOL658172:GHHM-905-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:CKC_04365Imported
OrganismiLiberibacter solanacearum (strain CLso-ZC1)Imported
Taxonomic identifieri658172 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeCandidatus Liberibacter
ProteomesiUP000007038: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE4UDE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000019858.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4UDE4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKIKVINPV VSLDGDEMTR IIWQLIQEKL IHPYLDLKIE YFDLSIQNRD
60 70 80 90 100
LTNDQVTVDA ARAIKKCGVG VKCATITADK ERVKEFNLKE MWKSPNGTIR
110 120 130 140 150
NILGGTIFRE PIICKNVPRL VPGWKKPIII GRHAFGDQYR ATDFTFPGKG
160 170 180 190 200
KLILKFVGEN GETIEKEVFN SPSSGVAMAM YNLDNSIRDF ARAAMQYALT
210 220 230 240 250
RQLPLYLSTK NTILKTYDGQ FKNIFEEIYN NEFKHQFDEL GLTYTHRLID
260 270 280 290 300
DMVASSIKLS GGYVWACKNY DGDVQSDIVA QGFGSLGLMT SVLITADGKT
310 320 330 340 350
IESEAAHGTV TRHYRQHQKG EETSTNSIAS IFSWTRGLLH RAKLDENAEL
360 370 380 390 400
KKFAEKLEHV CIKTVEDGFM TKDLALLIGP EQDWLSTSGF IEKISHNLQD

NLQ
Length:403
Mass (Da):45,580
Last modified:February 8, 2011 - v1
Checksum:i3B336A1C431F6BEC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002371 Genomic DNA. Translation: ADR52622.1.
RefSeqiWP_013462278.1. NC_014774.1.
YP_004063110.1. NC_014774.1.

Genome annotation databases

EnsemblBacteriaiADR52622; ADR52622; CKC_04365.
GeneIDi10034246.
KEGGilso:CKC_04365.
PATRICi45199219. VBICanLib97138_0875.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002371 Genomic DNA. Translation: ADR52622.1 .
RefSeqi WP_013462278.1. NC_014774.1.
YP_004063110.1. NC_014774.1.

3D structure databases

ProteinModelPortali E4UDE4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADR52622 ; ADR52622 ; CKC_04365 .
GeneIDi 10034246.
KEGGi lso:CKC_04365.
PATRICi 45199219. VBICanLib97138_0875.

Phylogenomic databases

HOGENOMi HOG000019858.
KOi K00031.

Enzyme and pathway databases

BioCyci LSOL658172:GHHM-905-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Candidatus Liberibacter solanacearum CLso-ZC1."
    Lin H., Doddapaneni H.V., Lou B., Civerolo E.L., Chen C., Duan Y., Zhou L., Glynn J.
    Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLso-ZC1Imported.
  2. Lin H., Doddapaneni H.V., Lou B., Civerolo E.L., Chen C., Duan Y., Zhou L., Glynn J.
    Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CLso-ZC1.

Entry informationi

Entry nameiE4UDE4_LIBSC
AccessioniPrimary (citable) accession number: E4UDE4
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: October 29, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3