Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

E4UDE4 (E4UDE4_LIBSC) Unreviewed, UniProtKB/TrEMBL

Last modified October 16, 2013. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
Ordered Locus Names:CKC_04365 EMBL ADR52622.1
OrganismLiberibacter solanacearum (strain CLso-ZC1) [Complete proteome] [HAMAP] EMBL ADR52622.1
Taxonomic identifier658172 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeCandidatus Liberibacter

Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding308 – 3136NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity

Sites

Metal binding2501Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2731Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity
Binding site1321Substrate By similarity
Binding site2581NADP By similarity PIRSR PIRSR000108-4
Binding site3261NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2101Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
E4UDE4 [UniParc].

Last modified February 8, 2011. Version 1.
Checksum: 3B336A1C431F6BEC

FASTA40345,580
        10         20         30         40         50         60 
MKKIKVINPV VSLDGDEMTR IIWQLIQEKL IHPYLDLKIE YFDLSIQNRD LTNDQVTVDA 

        70         80         90        100        110        120 
ARAIKKCGVG VKCATITADK ERVKEFNLKE MWKSPNGTIR NILGGTIFRE PIICKNVPRL 

       130        140        150        160        170        180 
VPGWKKPIII GRHAFGDQYR ATDFTFPGKG KLILKFVGEN GETIEKEVFN SPSSGVAMAM 

       190        200        210        220        230        240 
YNLDNSIRDF ARAAMQYALT RQLPLYLSTK NTILKTYDGQ FKNIFEEIYN NEFKHQFDEL 

       250        260        270        280        290        300 
GLTYTHRLID DMVASSIKLS GGYVWACKNY DGDVQSDIVA QGFGSLGLMT SVLITADGKT 

       310        320        330        340        350        360 
IESEAAHGTV TRHYRQHQKG EETSTNSIAS IFSWTRGLLH RAKLDENAEL KKFAEKLEHV 

       370        380        390        400 
CIKTVEDGFM TKDLALLIGP EQDWLSTSGF IEKISHNLQD NLQ 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Candidatus Liberibacter solanacearum CLso-ZC1."
Lin H., Doddapaneni H.V., Lou B., Civerolo E.L., Chen C., Duan Y., Zhou L., Glynn J.
Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CLso-ZC1.
[2]Lin H., Doddapaneni H.V., Lou B., Civerolo E.L., Chen C., Duan Y., Zhou L., Glynn J.
Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: CLso-ZC1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002371 Genomic DNA. Translation: ADR52622.1.
RefSeqYP_004063110.1. NC_014774.1.

3D structure databases

ProteinModelPortalE4UDE4.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADR52622; ADR52622; CKC_04365.
GeneID10034246.
KEGGlso:CKC_04365.
PATRIC45199219. VBICanLib97138_0875.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000019858.
KOK00031.

Enzyme and pathway databases

BioCycLSOL658172:GHHM-905-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE4UDE4_LIBSC
AccessionPrimary (citable) accession number: E4UDE4
Entry history
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: October 16, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)