Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

E4UA11 (E4UA11_OCEP5) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Ocepr_1936 EMBL ADR37388.1
OrganismOceanithermus profundus (strain DSM 14977 / NBRC 100410 / VKM B-2274 / 506) [Complete proteome] [HAMAP] EMBL ADR37388.1
Taxonomic identifier670487 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeOceanithermus

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain123 – 319197ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding152 – 20150ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2731Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2861Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2861Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2881Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
E4UA11 [UniParc].

Last modified February 8, 2011. Version 1.
Checksum: CBF3840E0E34A915

FASTA32335,328
        10         20         30         40         50         60 
MKPKRILLVA GGRSGEHEVS LQSAQGVLEA LPFDADPAVI AKDGRWLLGR LALDAIEAGR 

        70         80         90        100        110        120 
APRGDHPFPP PVAWRDYDVV FPLLHGRWGE DGTIQGFFEM LGVPYVGADV TASAVCMDKD 

       130        140        150        160        170        180 
LSKRILAQAG LPVVPWEVLR KGEPVFVGLE PPFFVKPARA GSSVGIAKVR RYAELRPALD 

       190        200        210        220        230        240 
EAFRHDDKVV IEQAVPGVRE LEVALLGNVE AEASVVGEVR YQAEFYDYAT KYTAGAAELD 

       250        260        270        280        290        300 
IPAALDPGTQ ETVQEMAVRA YRVLGVRGMA RVDFFLAESG EIYLNELNTI PGFTPFSMYP 

       310        320 
KLWQASGLPY PELLTRLVEL ALE 

« Hide

References

[1]"The complete sequence of chromosome of Oceanithermus profundus DSM 14977."
US DOE Joint Genome Institute (JGI-PGF)
Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Zhang X., Brettin T., Detter J.C., Tapia R., Han C., Land M., Hauser L., Markowitz V. expand/collapse author list , Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Tindall B., Faehnrich R., Brambilla E., Klenk H.-P., Eisen J.A.
Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 14977 / NBRC 100410 / VKM B-2274 / 506.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002361 Genomic DNA. Translation: ADR37388.1.
RefSeqYP_004058561.1. NC_014761.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADR37388; ADR37388; Ocepr_1936.
GeneID10016812.
KEGGopr:Ocepr_1936.
PATRIC45307275. VBIOcePro145519_2063.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011593.
KOK01921.

Enzyme and pathway databases

BioCycOPRO670487:GH5I-1978-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE4UA11_OCEP5
AccessionPrimary (citable) accession number: E4UA11
Entry history
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: June 11, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)