ID   E4U870_OCEP5            Unreviewed;       872 AA.
AC   E4U870;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   RecName: Full=Phosphoenolpyruvate carboxylase {ECO:0000256|ARBA:ARBA00022419, ECO:0000256|HAMAP-Rule:MF_00595};
DE            Short=PEPC {ECO:0000256|HAMAP-Rule:MF_00595};
DE            Short=PEPCase {ECO:0000256|HAMAP-Rule:MF_00595};
DE            EC=4.1.1.31 {ECO:0000256|ARBA:ARBA00012305, ECO:0000256|HAMAP-Rule:MF_00595};
GN   Name=ppc {ECO:0000256|HAMAP-Rule:MF_00595};
GN   OrderedLocusNames=Ocepr_0828 {ECO:0000313|EMBL:ADR36285.1};
OS   Oceanithermus profundus (strain DSM 14977 / NBRC 100410 / VKM B-2274 /
OS   506).
OC   Bacteria; Deinococcota; Deinococci; Thermales; Thermaceae; Oceanithermus.
OX   NCBI_TaxID=670487 {ECO:0000313|EMBL:ADR36285.1, ECO:0000313|Proteomes:UP000008722};
RN   [1] {ECO:0000313|Proteomes:UP000008722}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14977 / NBRC 100410 / VKM B-2274 / 506
RC   {ECO:0000313|Proteomes:UP000008722};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA   Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Zhang X., Brettin T.,
RA   Detter J.C., Tapia R., Han C., Land M., Hauser L., Markowitz V.,
RA   Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Tindall B., Faehnrich R.,
RA   Brambilla E., Klenk H.-P., Eisen J.A.;
RT   "The complete sequence of chromosome of Oceanithermus profundus DSM
RT   14977.";
RL   Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADR36285.1, ECO:0000313|Proteomes:UP000008722}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14977 / NBRC 100410 / VKM B-2274 / 506
RC   {ECO:0000313|Proteomes:UP000008722};
RX   PubMed=21677858; DOI=10.4056/sigs.1734292;
RA   Pati A., Zhang X., Lapidus A., Nolan M., Lucas S., Del Rio T.G., Tice H.,
RA   Cheng J.F., Tapia R., Han C., Goodwin L., Pitluck S., Liolios K.,
RA   Pagani I., Ivanova N., Mavromatis K., Chen A., Palaniappan K., Hauser L.,
RA   Jeffries C.D., Brambilla E.M., Rohl A., Mwirichia R., Rohde M.,
RA   Tindall B.J., Sikorski J., Wirth R., Goker M., Woyke T., Detter J.C.,
RA   Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C.,
RA   Klenk H.P., Land M.;
RT   "Complete genome sequence of Oceanithermus profundus type strain (506).";
RL   Stand. Genomic Sci. 4:210-220(2011).
CC   -!- FUNCTION: Forms oxaloacetate, a four-carbon dicarboxylic acid source
CC       for the tricarboxylic acid cycle. {ECO:0000256|ARBA:ARBA00003670,
CC       ECO:0000256|HAMAP-Rule:MF_00595}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=oxaloacetate + phosphate = hydrogencarbonate +
CC         phosphoenolpyruvate; Xref=Rhea:RHEA:28370, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:17544, ChEBI:CHEBI:43474, ChEBI:CHEBI:58702; EC=4.1.1.31;
CC         Evidence={ECO:0000256|ARBA:ARBA00001071, ECO:0000256|HAMAP-
CC         Rule:MF_00595};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946, ECO:0000256|HAMAP-
CC         Rule:MF_00595};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00595}.
CC   -!- SIMILARITY: Belongs to the PEPCase type 1 family.
CC       {ECO:0000256|ARBA:ARBA00008346, ECO:0000256|HAMAP-Rule:MF_00595}.
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DR   EMBL; CP002361; ADR36285.1; -; Genomic_DNA.
DR   RefSeq; WP_013457455.1; NC_014761.1.
DR   AlphaFoldDB; E4U870; -.
DR   STRING; 670487.Ocepr_0828; -.
DR   KEGG; opr:Ocepr_0828; -.
DR   eggNOG; COG2352; Bacteria.
DR   HOGENOM; CLU_006557_2_0_0; -.
DR   Proteomes; UP000008722; Chromosome.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008964; F:phosphoenolpyruvate carboxylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015977; P:carbon fixation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006107; P:oxaloacetate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   Gene3D; 1.20.1440.90; Phosphoenolpyruvate/pyruvate domain; 1.
DR   HAMAP; MF_00595; PEPcase_type1; 1.
DR   InterPro; IPR021135; PEP_COase.
DR   InterPro; IPR022805; PEP_COase_bac/pln-type.
DR   InterPro; IPR018129; PEP_COase_Lys_AS.
DR   InterPro; IPR033129; PEPCASE_His_AS.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   PANTHER; PTHR30523; PHOSPHOENOLPYRUVATE CARBOXYLASE; 1.
DR   PANTHER; PTHR30523:SF6; PHOSPHOENOLPYRUVATE CARBOXYLASE; 1.
DR   Pfam; PF00311; PEPcase; 1.
DR   PRINTS; PR00150; PEPCARBXLASE.
DR   SUPFAM; SSF51621; Phosphoenolpyruvate/pyruvate domain; 1.
DR   PROSITE; PS00781; PEPCASE_1; 1.
DR   PROSITE; PS00393; PEPCASE_2; 1.
PE   3: Inferred from homology;
KW   Carbon dioxide fixation {ECO:0000256|ARBA:ARBA00023300, ECO:0000256|HAMAP-
KW   Rule:MF_00595};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_00595};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|HAMAP-Rule:MF_00595};
KW   Pyruvate {ECO:0000313|EMBL:ADR36285.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008722}.
FT   ACT_SITE        134
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00595,
FT                   ECO:0000256|PROSITE-ProRule:PRU10111"
FT   ACT_SITE        534
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00595,
FT                   ECO:0000256|PROSITE-ProRule:PRU10112"
SQ   SEQUENCE   872 AA;  96987 MW;  33F046DB6FEB25AB CRC64;
     MTLPEALRRD VDRLGRALGE AIREVSGERL YELVEEVRAR TKRLRQRPDD AERAALVRLV
     ASLDLHRAEG LTRAFTSFFY LANLAESYHR VHTAADAKGE FARAARTLAS WGVPPEEAAR
     LARSMRLWLT FTAHPTEARR RTVRHHLERL RDALARGDRA AVRERVKLLW ATEELRRTQP
     TVEDEVKGAL YYLPESLWSA QARLVERIEA ALEQAFGKRF EAESPVRTRS WIGGDRDGNP
     AVTPEVTAWA QDHARRLYVE HFCRELDELV RDLSVSERRL PVPRELREAA ERALALIERA
     PRFEGEPLRR YLMGVYYRLE HTLGSGPGAY GDAGELAGDL ERLRRTLEAM GFSAFAARGV
     RPLEEAARTF GLSFADLDLR EEASEHREAV AELVAAAGLA DDYPEWSDDR REAWLTGELA
     SARPLAPVGY RPRGKALRRA LGALEVWDGR GAYVVSMTKS PADLLEVLLL AREAGRYRPD
     RGAPFDVVPL FETLADLDAA GRTVERLLAN PVFRRQVEAR GALEVMIGYS DSNKDAGYLA
     ANWALYTAQQ RIAEAARAAG VSVRFFHGRG TSTARGGGPA GRAIAALPVG TVGREIRITE
     QGEALADKYA HPDLALRSLE ETIAHLWLAA ARDAGYGPEA AFAPEPAWVA AIEAAAARSA
     QVYRELLGSE GFLAFFEQLT PIREIAALKI ASRPVYRHGR IQEIRDLRAI PWVMAWTQVR
     ANLPGWYGLG EGLSAIDPAL LGEMHDGWPF FRSVLEGAEL SLAKTDLEVT RGYLRLVDPE
     LAGRFFSAIE RAHEAALSTL EKARGRPLLA DAPGLARSLE LRNPYLDPIN HLQIELLYRY
     RRLPPESPDR ESTTRALLST ILGIAAGMRN TG
//