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E4U4G9

- E4U4G9_OCEP5

UniProt

E4U4G9 - E4U4G9_OCEP5

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Protein

Probable DNA ligase

Gene
lig, Ocepr_0915
Organism
Oceanithermus profundus (strain DSM 14977 / NBRC 100410 / VKM B-2274 / 506)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei242 – 2421ATP By similarityUniRule annotation
Active sitei244 – 2441N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei249 – 2491ATP By similarityUniRule annotation
Binding sitei264 – 2641ATP By similarityUniRule annotation
Binding sitei293 – 2931ATP By similarityUniRule annotation
Binding sitei333 – 3331ATP By similarityUniRule annotation
Binding sitei408 – 4081ATP By similarityUniRule annotation
Binding sitei414 – 4141ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciOPRO670487:GH5I-931-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Ocepr_0915Imported
OrganismiOceanithermus profundus (strain DSM 14977 / NBRC 100410 / VKM B-2274 / 506)Imported
Taxonomic identifieri670487 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeOceanithermus
ProteomesiUP000008722: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE4U4G9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4U4G9-1 [UniParc]FASTAAdd to Basket

« Hide

MTFQRFVATL LEVERASSRI AMVKMLAEAF RELPPEEVPL AVLLLQGRVA    50
PEFEGLEFGV AEKEAAKALA LALGRDEAET VQAVKEKGDI GAYALEVLPR 100
RAGGLSLRHV YGELRAIAED AGPGSQARKR ERLSRLVAEA SPEEAAVILR 150
TVTGRLRLGV GDATVLEALA LAFLGDRAKK PLLERAYNLT SDLAYVARLA 200
LEGEEALRQV KLEVGKPVRM MLAERLPGPE QIMEKLGPHF AEHKYDGERV 250
QVHFDGERFW VYSRRLENIT HQYPDLLEAL REVQHGPFIL EAEAVVTDPV 300
TGEMRPFQNV LNRKVKHLTP ELLEKYPIKG FVFELLYADG EVLIERPYSE 350
RRERLERWFR PHERLELSTK RFVETTEELV QFFDASIEAG CEGLVCKKPD 400
GDYEAGKRGF KWVKYKRGIA GKLSDTLDLV IVGAWLGRGR RAGTYGSLLA 450
AAYNPDEDRF ETLTKVGSGF SDEDLNEVLP RRLDPYRRGE RHPRVWSLLE 500
PDVWFEPVQV IEVEAQEITL SPNHTCAFGA VQEGRGLALR FPRFVRYRDD 550
KSPEEATTTK EVVEMYKNQW A 571
Length:571
Mass (Da):64,634
Last modified:February 8, 2011 - v1
Checksum:iD64EF7D3C7741DED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002361 Genomic DNA. Translation: ADR36372.1.
RefSeqiWP_013457542.1. NC_014761.1.
YP_004057545.1. NC_014761.1.

Genome annotation databases

EnsemblBacteriaiADR36372; ADR36372; Ocepr_0915.
GeneIDi10015765.
KEGGiopr:Ocepr_0915.
PATRICi45305173. VBIOcePro145519_1040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002361 Genomic DNA. Translation: ADR36372.1 .
RefSeqi WP_013457542.1. NC_014761.1.
YP_004057545.1. NC_014761.1.

3D structure databases

ProteinModelPortali E4U4G9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADR36372 ; ADR36372 ; Ocepr_0915 .
GeneIDi 10015765.
KEGGi opr:Ocepr_0915.
PATRICi 45305173. VBIOcePro145519_1040.

Phylogenomic databases

HOGENOMi HOG000036008.
KOi K10747.

Enzyme and pathway databases

BioCyci OPRO670487:GH5I-931-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14977 / NBRC 100410 / VKM B-2274 / 506.

Entry informationi

Entry nameiE4U4G9_OCEP5
AccessioniPrimary (citable) accession number: E4U4G9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 3, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3