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Protein

Probable DNA ligase

Gene

lig

Organism
Oceanithermus profundus (strain DSM 14977 / NBRC 100410 / VKM B-2274 / 506)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei242 – 2421ATPUniRule annotation
Active sitei244 – 2441N6-AMP-lysine intermediateUniRule annotation
Binding sitei249 – 2491ATPUniRule annotation
Binding sitei264 – 2641ATPUniRule annotation
Binding sitei293 – 2931ATPUniRule annotation
Binding sitei333 – 3331ATPUniRule annotation
Binding sitei408 – 4081ATPUniRule annotation
Binding sitei414 – 4141ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciOPRO670487:GH5I-931-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Ocepr_0915Imported
OrganismiOceanithermus profundus (strain DSM 14977 / NBRC 100410 / VKM B-2274 / 506)Imported
Taxonomic identifieri670487 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeOceanithermus
ProteomesiUP000008722 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi670487.Ocepr_0915.

Structurei

3D structure databases

ProteinModelPortaliE4U4G9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4U4G9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFQRFVATL LEVERASSRI AMVKMLAEAF RELPPEEVPL AVLLLQGRVA
60 70 80 90 100
PEFEGLEFGV AEKEAAKALA LALGRDEAET VQAVKEKGDI GAYALEVLPR
110 120 130 140 150
RAGGLSLRHV YGELRAIAED AGPGSQARKR ERLSRLVAEA SPEEAAVILR
160 170 180 190 200
TVTGRLRLGV GDATVLEALA LAFLGDRAKK PLLERAYNLT SDLAYVARLA
210 220 230 240 250
LEGEEALRQV KLEVGKPVRM MLAERLPGPE QIMEKLGPHF AEHKYDGERV
260 270 280 290 300
QVHFDGERFW VYSRRLENIT HQYPDLLEAL REVQHGPFIL EAEAVVTDPV
310 320 330 340 350
TGEMRPFQNV LNRKVKHLTP ELLEKYPIKG FVFELLYADG EVLIERPYSE
360 370 380 390 400
RRERLERWFR PHERLELSTK RFVETTEELV QFFDASIEAG CEGLVCKKPD
410 420 430 440 450
GDYEAGKRGF KWVKYKRGIA GKLSDTLDLV IVGAWLGRGR RAGTYGSLLA
460 470 480 490 500
AAYNPDEDRF ETLTKVGSGF SDEDLNEVLP RRLDPYRRGE RHPRVWSLLE
510 520 530 540 550
PDVWFEPVQV IEVEAQEITL SPNHTCAFGA VQEGRGLALR FPRFVRYRDD
560 570
KSPEEATTTK EVVEMYKNQW A
Length:571
Mass (Da):64,634
Last modified:February 8, 2011 - v1
Checksum:iD64EF7D3C7741DED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002361 Genomic DNA. Translation: ADR36372.1.
RefSeqiWP_013457542.1. NC_014761.1.
YP_004057545.1. NC_014761.1.

Genome annotation databases

EnsemblBacteriaiADR36372; ADR36372; Ocepr_0915.
KEGGiopr:Ocepr_0915.
PATRICi45305173. VBIOcePro145519_1040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002361 Genomic DNA. Translation: ADR36372.1.
RefSeqiWP_013457542.1. NC_014761.1.
YP_004057545.1. NC_014761.1.

3D structure databases

ProteinModelPortaliE4U4G9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi670487.Ocepr_0915.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADR36372; ADR36372; Ocepr_0915.
KEGGiopr:Ocepr_0915.
PATRICi45305173. VBIOcePro145519_1040.

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.

Enzyme and pathway databases

BioCyciOPRO670487:GH5I-931-MONOMER.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14977 / NBRC 100410 / VKM B-2274 / 506Imported.

Entry informationi

Entry nameiE4U4G9_OCEP5
AccessioniPrimary (citable) accession number: E4U4G9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: June 24, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.