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E4U4G9

- E4U4G9_OCEP5

UniProt

E4U4G9 - E4U4G9_OCEP5

Protein

Probable DNA ligase

Gene

lig

Organism
Oceanithermus profundus (strain DSM 14977 / NBRC 100410 / VKM B-2274 / 506)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei242 – 2421ATPUniRule annotation
    Active sitei244 – 2441N6-AMP-lysine intermediateUniRule annotation
    Binding sitei249 – 2491ATPUniRule annotation
    Binding sitei264 – 2641ATPUniRule annotation
    Binding sitei293 – 2931ATPUniRule annotation
    Binding sitei333 – 3331ATPUniRule annotation
    Binding sitei408 – 4081ATPUniRule annotation
    Binding sitei414 – 4141ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciOPRO670487:GH5I-931-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Ocepr_0915Imported
    OrganismiOceanithermus profundus (strain DSM 14977 / NBRC 100410 / VKM B-2274 / 506)Imported
    Taxonomic identifieri670487 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeOceanithermus
    ProteomesiUP000008722: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliE4U4G9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000036008.
    KOiK10747.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E4U4G9-1 [UniParc]FASTAAdd to Basket

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    MTFQRFVATL LEVERASSRI AMVKMLAEAF RELPPEEVPL AVLLLQGRVA    50
    PEFEGLEFGV AEKEAAKALA LALGRDEAET VQAVKEKGDI GAYALEVLPR 100
    RAGGLSLRHV YGELRAIAED AGPGSQARKR ERLSRLVAEA SPEEAAVILR 150
    TVTGRLRLGV GDATVLEALA LAFLGDRAKK PLLERAYNLT SDLAYVARLA 200
    LEGEEALRQV KLEVGKPVRM MLAERLPGPE QIMEKLGPHF AEHKYDGERV 250
    QVHFDGERFW VYSRRLENIT HQYPDLLEAL REVQHGPFIL EAEAVVTDPV 300
    TGEMRPFQNV LNRKVKHLTP ELLEKYPIKG FVFELLYADG EVLIERPYSE 350
    RRERLERWFR PHERLELSTK RFVETTEELV QFFDASIEAG CEGLVCKKPD 400
    GDYEAGKRGF KWVKYKRGIA GKLSDTLDLV IVGAWLGRGR RAGTYGSLLA 450
    AAYNPDEDRF ETLTKVGSGF SDEDLNEVLP RRLDPYRRGE RHPRVWSLLE 500
    PDVWFEPVQV IEVEAQEITL SPNHTCAFGA VQEGRGLALR FPRFVRYRDD 550
    KSPEEATTTK EVVEMYKNQW A 571
    Length:571
    Mass (Da):64,634
    Last modified:February 8, 2011 - v1
    Checksum:iD64EF7D3C7741DED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002361 Genomic DNA. Translation: ADR36372.1.
    RefSeqiWP_013457542.1. NC_014761.1.
    YP_004057545.1. NC_014761.1.

    Genome annotation databases

    EnsemblBacteriaiADR36372; ADR36372; Ocepr_0915.
    GeneIDi10015765.
    KEGGiopr:Ocepr_0915.
    PATRICi45305173. VBIOcePro145519_1040.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002361 Genomic DNA. Translation: ADR36372.1 .
    RefSeqi WP_013457542.1. NC_014761.1.
    YP_004057545.1. NC_014761.1.

    3D structure databases

    ProteinModelPortali E4U4G9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADR36372 ; ADR36372 ; Ocepr_0915 .
    GeneIDi 10015765.
    KEGGi opr:Ocepr_0915.
    PATRICi 45305173. VBIOcePro145519_1040.

    Phylogenomic databases

    HOGENOMi HOG000036008.
    KOi K10747.

    Enzyme and pathway databases

    BioCyci OPRO670487:GH5I-931-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 14977 / NBRC 100410 / VKM B-2274 / 506Imported.

    Entry informationi

    Entry nameiE4U4G9_OCEP5
    AccessioniPrimary (citable) accession number: E4U4G9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 8, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3