Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

E4U4G9 (E4U4G9_OCEP5) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Probable DNA ligase HAMAP-Rule MF_00407

EC=6.5.1.1 HAMAP-Rule MF_00407
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] HAMAP-Rule MF_00407
Gene names
Name:lig HAMAP-Rule MF_00407
Ordered Locus Names:Ocepr_0915 EMBL ADR36372.1
OrganismOceanithermus profundus (strain DSM 14977 / NBRC 100410 / VKM B-2274 / 506) [Complete proteome] [HAMAP] EMBL ADR36372.1
Taxonomic identifier670487 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeOceanithermus

Protein attributes

Sequence length571 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. RuleBase RU004196 HAMAP-Rule MF_00407

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2441N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2421ATP By similarity HAMAP-Rule MF_00407
Binding site2491ATP By similarity HAMAP-Rule MF_00407
Binding site2641ATP By similarity HAMAP-Rule MF_00407
Binding site2931ATP By similarity HAMAP-Rule MF_00407
Binding site3331ATP By similarity HAMAP-Rule MF_00407
Binding site4081ATP By similarity HAMAP-Rule MF_00407
Binding site4141ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
E4U4G9 [UniParc].

Last modified February 8, 2011. Version 1.
Checksum: D64EF7D3C7741DED

FASTA57164,634
        10         20         30         40         50         60 
MTFQRFVATL LEVERASSRI AMVKMLAEAF RELPPEEVPL AVLLLQGRVA PEFEGLEFGV 

        70         80         90        100        110        120 
AEKEAAKALA LALGRDEAET VQAVKEKGDI GAYALEVLPR RAGGLSLRHV YGELRAIAED 

       130        140        150        160        170        180 
AGPGSQARKR ERLSRLVAEA SPEEAAVILR TVTGRLRLGV GDATVLEALA LAFLGDRAKK 

       190        200        210        220        230        240 
PLLERAYNLT SDLAYVARLA LEGEEALRQV KLEVGKPVRM MLAERLPGPE QIMEKLGPHF 

       250        260        270        280        290        300 
AEHKYDGERV QVHFDGERFW VYSRRLENIT HQYPDLLEAL REVQHGPFIL EAEAVVTDPV 

       310        320        330        340        350        360 
TGEMRPFQNV LNRKVKHLTP ELLEKYPIKG FVFELLYADG EVLIERPYSE RRERLERWFR 

       370        380        390        400        410        420 
PHERLELSTK RFVETTEELV QFFDASIEAG CEGLVCKKPD GDYEAGKRGF KWVKYKRGIA 

       430        440        450        460        470        480 
GKLSDTLDLV IVGAWLGRGR RAGTYGSLLA AAYNPDEDRF ETLTKVGSGF SDEDLNEVLP 

       490        500        510        520        530        540 
RRLDPYRRGE RHPRVWSLLE PDVWFEPVQV IEVEAQEITL SPNHTCAFGA VQEGRGLALR 

       550        560        570 
FPRFVRYRDD KSPEEATTTK EVVEMYKNQW A 

« Hide

References

[1]"The complete sequence of chromosome of Oceanithermus profundus DSM 14977."
US DOE Joint Genome Institute (JGI-PGF)
Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Zhang X., Brettin T., Detter J.C., Tapia R., Han C., Land M., Hauser L., Markowitz V. expand/collapse author list , Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Tindall B., Faehnrich R., Brambilla E., Klenk H.-P., Eisen J.A.
Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 14977 / NBRC 100410 / VKM B-2274 / 506.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002361 Genomic DNA. Translation: ADR36372.1.
RefSeqYP_004057545.1. NC_014761.1.

3D structure databases

ProteinModelPortalE4U4G9.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADR36372; ADR36372; Ocepr_0915.
GeneID10015765.
KEGGopr:Ocepr_0915.
PATRIC45305173. VBIOcePro145519_1040.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000036008.
KOK10747.

Enzyme and pathway databases

BioCycOPRO670487:GH5I-931-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE4U4G9_OCEP5
AccessionPrimary (citable) accession number: E4U4G9
Entry history
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: June 11, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)