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E4TX47

- E4TX47_SULKY

UniProt

E4TX47 - E4TX47_SULKY

Protein

Pantothenate synthetase

Gene

panC

Organism
Sulfuricurvum kujiense (strain ATCC BAA-921 / DSM 16994 / JCM 11577 / YK-1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei34 – 341Proton donorUniRule annotation
    Binding sitei58 – 581Beta-alanineUniRule annotation
    Binding sitei58 – 581PantoateUniRule annotation
    Binding sitei150 – 1501PantoateUniRule annotation
    Binding sitei173 – 1731ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi27 – 348ATPUniRule annotation
    Nucleotide bindingi144 – 1474ATPUniRule annotation
    Nucleotide bindingi181 – 1844ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Pantothenate biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSKUJ709032:GHTQ-2299-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PSUniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligaseUniRule annotation
    Pantoate-activating enzymeUniRule annotation
    Gene namesi
    Name:panCUniRule annotation
    Ordered Locus Names:Sulku_2253Imported
    OrganismiSulfuricurvum kujiense (strain ATCC BAA-921 / DSM 16994 / JCM 11577 / YK-1)Imported
    Taxonomic identifieri709032 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeSulfuricurvum
    ProteomesiUP000008721: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pantothenate synthetase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000175517.
    KOiK01918.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    InterProiIPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
    PfamiPF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E4TX47-1 [UniParc]FASTAAdd to Basket

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    MIIARSAQEL KDALETKTGS VGFVPTMGAL HIGHRTLIDA ARKGNDTVVV    50
    SIFVNPTQFL PGEDLSKYPR REEADFKICS LSGIDILFYP DVNAMYGDDE 100
    VRITAPDVRG FILEGASRPG HFDGVLTVVM KLFNIVRPTR AYFGKKDAQQ 150
    LAMIIQMVNN FFMDVEIVPM ETVRESDGLA LSSRNVYLSP SERQEALKLS 200
    AALKSATKMV MQGNLSSSDI KTNMESILSP LDVEYVAIVN RAFESIEKVV 250
    LGNTIILVAA RVGTTRLIDN VWM 273
    Length:273
    Mass (Da):30,121
    Last modified:February 8, 2011 - v1
    Checksum:i9A3C55BB0CDCC725
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002355 Genomic DNA. Translation: ADR34913.1.
    RefSeqiYP_004061113.1. NC_014762.1.

    Genome annotation databases

    EnsemblBacteriaiADR34913; ADR34913; Sulku_2253.
    GeneIDi10019436.
    KEGGisku:Sulku_2253.
    PATRICi45373303. VBISulKuj150841_2491.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002355 Genomic DNA. Translation: ADR34913.1 .
    RefSeqi YP_004061113.1. NC_014762.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADR34913 ; ADR34913 ; Sulku_2253 .
    GeneIDi 10019436.
    KEGGi sku:Sulku_2253.
    PATRICi 45373303. VBISulKuj150841_2491.

    Phylogenomic databases

    HOGENOMi HOG000175517.
    KOi K01918.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci SKUJ709032:GHTQ-2299-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    InterProi IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
    Pfami PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-921 / DSM 16994 / JCM 11577 / YK-1Imported.

    Entry informationi

    Entry nameiE4TX47_SULKY
    AccessioniPrimary (citable) accession number: E4TX47
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 8, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3