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E4TX47

- E4TX47_SULKY

UniProt

E4TX47 - E4TX47_SULKY

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Protein
Pantothenate synthetase
Gene
panC, Sulku_2253
Organism
Sulfuricurvum kujiense (strain ATCC BAA-921 / DSM 16994 / JCM 11577 / YK-1)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei34 – 341Proton donor By similarityUniRule annotation
Binding sitei58 – 581Beta-alanine By similarityUniRule annotation
Binding sitei58 – 581Pantoate By similarityUniRule annotation
Binding sitei150 – 1501Pantoate By similarityUniRule annotation
Binding sitei173 – 1731ATP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi27 – 348ATP By similarityUniRule annotation
Nucleotide bindingi144 – 1474ATP By similarityUniRule annotation
Nucleotide bindingi181 – 1844ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Pantothenate biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciSKUJ709032:GHTQ-2299-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:Sulku_2253Imported
OrganismiSulfuricurvum kujiense (strain ATCC BAA-921 / DSM 16994 / JCM 11577 / YK-1)Imported
Taxonomic identifieri709032 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeSulfuricurvum
ProteomesiUP000008721: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000175517.
KOiK01918.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

E4TX47-1 [UniParc]FASTAAdd to Basket

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MIIARSAQEL KDALETKTGS VGFVPTMGAL HIGHRTLIDA ARKGNDTVVV    50
SIFVNPTQFL PGEDLSKYPR REEADFKICS LSGIDILFYP DVNAMYGDDE 100
VRITAPDVRG FILEGASRPG HFDGVLTVVM KLFNIVRPTR AYFGKKDAQQ 150
LAMIIQMVNN FFMDVEIVPM ETVRESDGLA LSSRNVYLSP SERQEALKLS 200
AALKSATKMV MQGNLSSSDI KTNMESILSP LDVEYVAIVN RAFESIEKVV 250
LGNTIILVAA RVGTTRLIDN VWM 273
Length:273
Mass (Da):30,121
Last modified:February 8, 2011 - v1
Checksum:i9A3C55BB0CDCC725
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002355 Genomic DNA. Translation: ADR34913.1.
RefSeqiYP_004061113.1. NC_014762.1.

Genome annotation databases

EnsemblBacteriaiADR34913; ADR34913; Sulku_2253.
GeneIDi10019436.
KEGGisku:Sulku_2253.
PATRICi45373303. VBISulKuj150841_2491.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002355 Genomic DNA. Translation: ADR34913.1 .
RefSeqi YP_004061113.1. NC_014762.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADR34913 ; ADR34913 ; Sulku_2253 .
GeneIDi 10019436.
KEGGi sku:Sulku_2253.
PATRICi 45373303. VBISulKuj150841_2491.

Phylogenomic databases

HOGENOMi HOG000175517.
KOi K01918.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci SKUJ709032:GHTQ-2299-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-921 / DSM 16994 / JCM 11577 / YK-1.

Entry informationi

Entry nameiE4TX47_SULKY
AccessioniPrimary (citable) accession number: E4TX47
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: June 11, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi