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E4TX47 (E4TX47_SULKY) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pantothenate synthetase HAMAP-Rule MF_00158

Short name=PS HAMAP-Rule MF_00158
EC=6.3.2.1 HAMAP-Rule MF_00158
Alternative name(s):
Pantoate--beta-alanine ligase HAMAP-Rule MF_00158
Pantoate-activating enzyme HAMAP-Rule MF_00158
Gene names
Name:panC HAMAP-Rule MF_00158
Ordered Locus Names:Sulku_2253 EMBL ADR34913.1
OrganismSulfuricurvum kujiense (strain ATCC BAA-921 / DSM 16994 / JCM 11577 / YK-1) [Complete proteome] [HAMAP] EMBL ADR34913.1
Taxonomic identifier709032 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeSulfuricurvum

Protein attributes

Sequence length273 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity. HAMAP-Rule MF_00158

Catalytic activity

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP-Rule MF_00158 SAAS SAAS003721

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP-Rule MF_00158

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00158

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00158.

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity. HAMAP-Rule MF_00158

Sequence similarities

Belongs to the pantothenate synthetase family. HAMAP-Rule MF_00158

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding27 – 348ATP By similarity HAMAP-Rule MF_00158
Nucleotide binding144 – 1474ATP By similarity HAMAP-Rule MF_00158
Nucleotide binding181 – 1844ATP By similarity HAMAP-Rule MF_00158

Sites

Active site341Proton donor By similarity HAMAP-Rule MF_00158
Binding site581Beta-alanine By similarity HAMAP-Rule MF_00158
Binding site581Pantoate By similarity HAMAP-Rule MF_00158
Binding site1501Pantoate By similarity HAMAP-Rule MF_00158
Binding site1731ATP; via amide nitrogen and carbonyl oxygen By similarity HAMAP-Rule MF_00158

Sequences

Sequence LengthMass (Da)Tools
E4TX47 [UniParc].

Last modified February 8, 2011. Version 1.
Checksum: 9A3C55BB0CDCC725

FASTA27330,121
        10         20         30         40         50         60 
MIIARSAQEL KDALETKTGS VGFVPTMGAL HIGHRTLIDA ARKGNDTVVV SIFVNPTQFL 

        70         80         90        100        110        120 
PGEDLSKYPR REEADFKICS LSGIDILFYP DVNAMYGDDE VRITAPDVRG FILEGASRPG 

       130        140        150        160        170        180 
HFDGVLTVVM KLFNIVRPTR AYFGKKDAQQ LAMIIQMVNN FFMDVEIVPM ETVRESDGLA 

       190        200        210        220        230        240 
LSSRNVYLSP SERQEALKLS AALKSATKMV MQGNLSSSDI KTNMESILSP LDVEYVAIVN 

       250        260        270 
RAFESIEKVV LGNTIILVAA RVGTTRLIDN VWM 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002355 Genomic DNA. Translation: ADR34913.1.
RefSeqYP_004061113.1. NC_014762.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADR34913; ADR34913; Sulku_2253.
GeneID10019436.
KEGGsku:Sulku_2253.
PATRIC45373303. VBISulKuj150841_2491.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000175517.
KOK01918.

Enzyme and pathway databases

BioCycSKUJ709032:GHTQ-2299-MONOMER.
UniPathwayUPA00028; UER00005.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00158. PanC.
InterProIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00018. panC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameE4TX47_SULKY
AccessionPrimary (citable) accession number: E4TX47
Entry history
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: June 11, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)