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E4TW12

- E4TW12_MARTH

UniProt

E4TW12 - E4TW12_MARTH

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Protein

Alanine racemase

Gene

Ftrac_3256

Organism
Marivirga tractuosa (strain ATCC 23168 / DSM 4126 / NBRC 15989 / NCIMB 1408 / VKM B-1430 / H-43) (Microscilla tractuosa) (Flexibacter tractuosus)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei139 – 1391SubstrateUniRule annotation
Active sitei287 – 2871Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei335 – 3351Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciMTRA643867:GI2X-3299-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Ftrac_3256Imported
OrganismiMarivirga tractuosa (strain ATCC 23168 / DSM 4126 / NBRC 15989 / NCIMB 1408 / VKM B-1430 / H-43) (Microscilla tractuosa) (Flexibacter tractuosus)Imported
Taxonomic identifieri643867 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesFlammeovirgaceaeMarivirga
ProteomesiUP000008720: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE4TW12.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000166881.
KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4TW12-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNQSIFSTST ITLSKSAVRQ NVRFVRKRLA ENVLLSAVLK GNAYGHGIKG
60 70 80 90 100
MVPLFESANV KHLSVFSTHE AEQVCQVKKK TTEVMIMGWM EDEETEWAIE
110 120 130 140 150
NEVEFYVFEM GRLKAALHYA KTLNKIAKIH VEVETGMNRT GFEEEHLEEL
160 170 180 190 200
MQMMKENHEY ISFVGLCTHY AGAESITNYL RVVDQIKKYK KIYDLFVEND
210 220 230 240 250
LVPKRRHTAC SAAAMSYPET QMDMVRIGIL LYGFWPSQET FIAYQRSNGH
260 270 280 290 300
GQDGLDRKVR HPLKRVISWR SKIMSVKEVP VGEFIGYGTS YQATKKMKIA
310 320 330 340 350
TVPVGYAYGF ARSLSNQGRV IVNGKRVAVI STVNMNLMII NVTECKNVGK
360 370 380 390
GDEVIMIGSN GKVNVTVASF GELSNQLNYE LLSRLPMDIP RRVVI
Length:395
Mass (Da):44,758
Last modified:February 8, 2011 - v1
Checksum:i647D0232B79687CE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002349 Genomic DNA. Translation: ADR23230.1.
RefSeqiWP_013455372.1. NC_014759.1.
YP_004055338.1. NC_014759.1.

Genome annotation databases

EnsemblBacteriaiADR23230; ADR23230; Ftrac_3256.
GeneIDi10013414.
KEGGimtt:Ftrac_3256.
PATRICi45219957. VBIMarTra126157_3365.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002349 Genomic DNA. Translation: ADR23230.1 .
RefSeqi WP_013455372.1. NC_014759.1.
YP_004055338.1. NC_014759.1.

3D structure databases

ProteinModelPortali E4TW12.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADR23230 ; ADR23230 ; Ftrac_3256 .
GeneIDi 10013414.
KEGGi mtt:Ftrac_3256.
PATRICi 45219957. VBIMarTra126157_3365.

Phylogenomic databases

HOGENOMi HOG000166881.
KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci MTRA643867:GI2X-3299-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23168 / DSM 4126 / NBRC 15989 / NCIMB 1408 / VKM B-1430 / H-43Imported.

Entry informationi

Entry nameiE4TW12_MARTH
AccessioniPrimary (citable) accession number: E4TW12
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: October 29, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3