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Protein

D-alanine--D-alanine ligase

Gene

Ftrac_0935

Organism
Marivirga tractuosa (strain ATCC 23168 / DSM 4126 / NBRC 15989 / NCIMB 1408 / VKM B-1430 / H-43) (Microscilla tractuosa) (Flexibacter tractuosus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Mg2+SAAS annotation, Mn2+SAAS annotationNote: Binds 2 magnesium or manganese ions per subunit.SAAS annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotationImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTRA643867:GI2X-951-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseSAAS annotation (EC:6.3.2.4SAAS annotation)
Gene namesi
Ordered Locus Names:Ftrac_0935Imported
OrganismiMarivirga tractuosa (strain ATCC 23168 / DSM 4126 / NBRC 15989 / NCIMB 1408 / VKM B-1430 / H-43) (Microscilla tractuosa) (Flexibacter tractuosus)Imported
Taxonomic identifieri643867 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesFlammeovirgaceaeMarivirga
ProteomesiUP000008720: Chromosome

Subcellular locationi

Cytoplasm SAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Family & Domainsi

Sequence similaritiesi

Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000121145.
KOiK01921.
OMAiARLCCPK.

Family and domain databases

Gene3Di3.30.1490.20. 2 hits.
3.30.470.20. 2 hits.
3.40.50.20. 2 hits.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 3 hits.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 2 hits.
PROSITEiPS50975. ATP_GRASP. 2 hits.
PS00843. DALA_DALA_LIGASE_1. 2 hits.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4TTM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIGIFFGGQ SREREISFAG GRTVYDNLNK SIFDAVPIFI DSKGHFVLLD
60 70 80 90 100
WQYIYKGTIR DFYPPVNFLP KSDLPVQIYA ESLKNLSDED WDKLIAEVGQ
110 120 130 140 150
KINPSDFKKH IDFAFLALHG PYGEDGNIQG ILEWNGIPFS GAGILPSAIG
160 170 180 190 200
ISKIAQRQFL QQAGFEGPKS RILNQNDWNH QPHENIYQNL KKELGLPLVI
210 220 230 240 250
KAPHQGSSIG VSILNEDDPN KFEKLVQKSF FELEITEDEW NGYSQEEKIG
260 270 280 290 300
FIAKLVDIRE GIGLPVIAEE GMLYTPDELL EFLNNTFTAK KQSIKLKAID
310 320 330 340 350
SENSLLIESF IEGKEFSCIV IQDENERPIA LPPTEIRKGK DVFDYRSKYL
360 370 380 390 400
PGISRKITPI DAPQDIIEKI RSQCAALFKA LQIDVYARID GFITKEGKVF
410 420 430 440 450
LNDPNTTSGM LPSSFFFHQA AEIGLNPSQF LSYIIRTSLQ ARLKTGKHHF
460 470 480 490 500
ELQKMIKQLD AALEGLKKEA QKKINVGVIM GGFSTERHIS VESGRNIYEK
510 520 530 540 550
LSSSEKYLPI PIFLSGNEDQ HELYVLPINI MLKDNADDIK DKIQNYEVHP
560 570 580 590 600
IISQIKFESS EITEKYVGIE NIVLKKISYH DLPDIIDVTF IALHGRPGED
610 620 630 640 650
GAVQAELEKL NIPYNGSDVE SSKITINKYD TNEILKNAGI SVADHRLVFE
660 670 680 690 700
NKWQSNKEAE IAAIEEQLSY PLIAKPADDG CSSAVKKIKN KAELEAFAGM
710 720 730 740 750
MFRPQAEFIE DLANILKLKK NEEFPQKNFF LLEELIEKKD AKYFLEITGG
760 770 780 790 800
LLTHFKEDGS IEYEIFEPSE ALAGGEVLSL EEKFLAGEGQ NITPARYTPQ
810 820 830 840 850
AENYKVVAEQ VKATLKKTAE VLNITGYARI DAFVRVYEDL SVETIIIEVN
860 870 880 890
SLPGMTPATC IFHQTAINGY KPYDFIDKIL AFGTEKMKKQ TITK
Length:894
Mass (Da):100,870
Last modified:February 8, 2011 - v1
Checksum:i4A199DC548908161
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002349 Genomic DNA. Translation: ADR20937.1.
RefSeqiWP_013453088.1. NC_014759.1.
YP_004053045.1. NC_014759.1.

Genome annotation databases

EnsemblBacteriaiADR20937; ADR20937; Ftrac_0935.
GeneIDi10011067.
KEGGimtt:Ftrac_0935.
PATRICi45215113. VBIMarTra126157_0974.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002349 Genomic DNA. Translation: ADR20937.1.
RefSeqiWP_013453088.1. NC_014759.1.
YP_004053045.1. NC_014759.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADR20937; ADR20937; Ftrac_0935.
GeneIDi10011067.
KEGGimtt:Ftrac_0935.
PATRICi45215113. VBIMarTra126157_0974.

Phylogenomic databases

HOGENOMiHOG000121145.
KOiK01921.
OMAiARLCCPK.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciMTRA643867:GI2X-951-MONOMER.

Family and domain databases

Gene3Di3.30.1490.20. 2 hits.
3.30.470.20. 2 hits.
3.40.50.20. 2 hits.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 3 hits.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 2 hits.
PROSITEiPS50975. ATP_GRASP. 2 hits.
PS00843. DALA_DALA_LIGASE_1. 2 hits.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23168 / DSM 4126 / NBRC 15989 / NCIMB 1408 / VKM B-1430 / H-43Imported.

Entry informationi

Entry nameiE4TTM0_MARTH
AccessioniPrimary (citable) accession number: E4TTM0
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: March 4, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.