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E4TG52

- E4TG52_CALNY

UniProt

E4TG52 - E4TG52_CALNY

Protein

LexA repressor

Gene

lexA

Organism
Calditerrivibrio nitroreducens (strain DSM 19672 / NBRC 101217 / Yu37-1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.UniRule annotationSAAS annotation

    Catalytic activityi

    Hydrolysis of Ala-|-Gly bond in repressor LexA.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei82 – 832Cleavage; by autolysisUniRule annotation
    Active sitei117 – 1171For autocatalytic cleavage activityUniRule annotation
    Active sitei154 – 1541For autocatalytic cleavage activityUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi27 – 4721H-T-H motifUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-HAMAP
    2. serine-type endopeptidase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA repair Source: UniProtKB-HAMAP
    2. DNA replication Source: UniProtKB-HAMAP
    3. negative regulation of transcription, DNA-templated Source: UniProtKB-HAMAP
    4. SOS response Source: UniProtKB-HAMAP
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    HydrolaseUniRule annotationSAAS annotation, RepressorUniRule annotationSAAS annotation

    Keywords - Biological processi

    DNA damage, DNA repair, DNA replicationUniRule annotationSAAS annotation, SOS responseUniRule annotationSAAS annotation, Transcription, Transcription regulationUniRule annotationSAAS annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciCNIT768670:GHD1-704-MONOMER.

    Protein family/group databases

    MEROPSiS24.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LexA repressorUniRule annotation (EC:3.4.21.88UniRule annotation)
    Gene namesi
    Name:lexAUniRule annotation
    Ordered Locus Names:Calni_0691Imported
    OrganismiCalditerrivibrio nitroreducens (strain DSM 19672 / NBRC 101217 / Yu37-1)Imported
    Taxonomic identifieri768670 [NCBI]
    Taxonomic lineageiBacteriaDeferribacteresDeferribacteralesDeferribacteraceae
    ProteomesiUP000007039: Chromosome

    PTM / Processingi

    Keywords - PTMi

    Autocatalytic cleavageUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S24 family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000232167.
    KOiK01356.
    OMAiWLEPANS.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.10.109.10. 1 hit.
    HAMAPiMF_00015. LexA.
    InterProiIPR006200. LexA.
    IPR006199. LexA_DNA-bd_dom.
    IPR028360. Peptidase_S24/S26_b-rbn.
    IPR006197. Peptidase_S24_LexA.
    IPR019759. Peptidase_S24_S26.
    IPR015927. Peptidase_S24_S26A/B/C.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF01726. LexA_DNA_bind. 1 hit.
    PF00717. Peptidase_S24. 1 hit.
    [Graphical view]
    PRINTSiPR00726. LEXASERPTASE.
    SUPFAMiSSF51306. SSF51306. 1 hit.
    TIGRFAMsiTIGR00498. lexA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E4TG52-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLTDRQKEC INFISRFIKD YGYPPTIQEI CNNLGIRSKN AGFKLLNALE    50
    SKGFIRRNRS ISRGIELLKI NNGIPILGRI TAGIPIDAEE NIEGYIPLED 100
    ILGDISGYFG LRVIGDSMVE KGILDGDIAI IKKQPDILNN QVGAFMINGE 150
    FTLKTFKMMD DGRIYLKPEN NKYKPIYITE NDTFEVVGLL KMVVRLFGED 200
    YEARKY 206
    Length:206
    Mass (Da):23,394
    Last modified:February 8, 2011 - v1
    Checksum:iA54DD314E769234C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002347 Genomic DNA. Translation: ADR18602.1.
    RefSeqiWP_013450815.1. NC_014758.1.
    YP_004050765.1. NC_014758.1.

    Genome annotation databases

    EnsemblBacteriaiADR18602; ADR18602; Calni_0691.
    GeneIDi10008702.
    KEGGicni:Calni_0691.
    PATRICi45189099. VBICalNit163602_0764.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002347 Genomic DNA. Translation: ADR18602.1 .
    RefSeqi WP_013450815.1. NC_014758.1.
    YP_004050765.1. NC_014758.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S24.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADR18602 ; ADR18602 ; Calni_0691 .
    GeneIDi 10008702.
    KEGGi cni:Calni_0691.
    PATRICi 45189099. VBICalNit163602_0764.

    Phylogenomic databases

    HOGENOMi HOG000232167.
    KOi K01356.
    OMAi WLEPANS.

    Enzyme and pathway databases

    BioCyci CNIT768670:GHD1-704-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.10.109.10. 1 hit.
    HAMAPi MF_00015. LexA.
    InterProi IPR006200. LexA.
    IPR006199. LexA_DNA-bd_dom.
    IPR028360. Peptidase_S24/S26_b-rbn.
    IPR006197. Peptidase_S24_LexA.
    IPR019759. Peptidase_S24_S26.
    IPR015927. Peptidase_S24_S26A/B/C.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF01726. LexA_DNA_bind. 1 hit.
    PF00717. Peptidase_S24. 1 hit.
    [Graphical view ]
    PRINTSi PR00726. LEXASERPTASE.
    SUPFAMi SSF51306. SSF51306. 1 hit.
    TIGRFAMsi TIGR00498. lexA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 19672.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 19672 / NBRC 101217 / Yu37-1Imported.

    Entry informationi

    Entry nameiE4TG52_CALNY
    AccessioniPrimary (citable) accession number: E4TG52
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 8, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3