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E4TG52

- E4TG52_CALNY

UniProt

E4TG52 - E4TG52_CALNY

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Protein

LexA repressor

Gene

lexA

Organism
Calditerrivibrio nitroreducens (strain DSM 19672 / NBRC 101217 / Yu37-1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.UniRule annotationSAAS annotation

Catalytic activityi

Hydrolysis of Ala-|-Gly bond in repressor LexA.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei82 – 832Cleavage; by autolysisUniRule annotation
Active sitei117 – 1171For autocatalytic cleavage activityUniRule annotation
Active sitei154 – 1541For autocatalytic cleavage activityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi27 – 4721H-T-H motifUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. serine-type endopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA repair Source: UniProtKB-HAMAP
  2. DNA replication Source: UniProtKB-HAMAP
  3. negative regulation of transcription, DNA-templated Source: UniProtKB-HAMAP
  4. SOS response Source: UniProtKB-HAMAP
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation, RepressorUniRule annotationSAAS annotation

Keywords - Biological processi

DNA damage, DNA repair, DNA replicationUniRule annotationSAAS annotation, SOS responseUniRule annotationSAAS annotation, Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCNIT768670:GHD1-704-MONOMER.

Protein family/group databases

MEROPSiS24.001.

Names & Taxonomyi

Protein namesi
Recommended name:
LexA repressorUniRule annotation (EC:3.4.21.88UniRule annotation)
Gene namesi
Name:lexAUniRule annotation
Ordered Locus Names:Calni_0691Imported
OrganismiCalditerrivibrio nitroreducens (strain DSM 19672 / NBRC 101217 / Yu37-1)Imported
Taxonomic identifieri768670 [NCBI]
Taxonomic lineageiBacteriaDeferribacteresDeferribacteralesDeferribacteraceae
ProteomesiUP000007039: Chromosome

PTM / Processingi

Keywords - PTMi

Autocatalytic cleavageUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S24 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000232167.
KOiK01356.
OMAiWLEPANS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.10.109.10. 1 hit.
HAMAPiMF_00015. LexA.
InterProiIPR006200. LexA.
IPR006199. LexA_DNA-bd_dom.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR006197. Peptidase_S24_LexA.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01726. LexA_DNA_bind. 1 hit.
PF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00726. LEXASERPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR00498. lexA. 1 hit.

Sequencei

Sequence statusi: Complete.

E4TG52-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLTDRQKEC INFISRFIKD YGYPPTIQEI CNNLGIRSKN AGFKLLNALE
60 70 80 90 100
SKGFIRRNRS ISRGIELLKI NNGIPILGRI TAGIPIDAEE NIEGYIPLED
110 120 130 140 150
ILGDISGYFG LRVIGDSMVE KGILDGDIAI IKKQPDILNN QVGAFMINGE
160 170 180 190 200
FTLKTFKMMD DGRIYLKPEN NKYKPIYITE NDTFEVVGLL KMVVRLFGED

YEARKY
Length:206
Mass (Da):23,394
Last modified:February 8, 2011 - v1
Checksum:iA54DD314E769234C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002347 Genomic DNA. Translation: ADR18602.1.
RefSeqiWP_013450815.1. NC_014758.1.
YP_004050765.1. NC_014758.1.

Genome annotation databases

EnsemblBacteriaiADR18602; ADR18602; Calni_0691.
GeneIDi10008702.
KEGGicni:Calni_0691.
PATRICi45189099. VBICalNit163602_0764.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002347 Genomic DNA. Translation: ADR18602.1 .
RefSeqi WP_013450815.1. NC_014758.1.
YP_004050765.1. NC_014758.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S24.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADR18602 ; ADR18602 ; Calni_0691 .
GeneIDi 10008702.
KEGGi cni:Calni_0691.
PATRICi 45189099. VBICalNit163602_0764.

Phylogenomic databases

HOGENOMi HOG000232167.
KOi K01356.
OMAi WLEPANS.

Enzyme and pathway databases

BioCyci CNIT768670:GHD1-704-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.10.109.10. 1 hit.
HAMAPi MF_00015. LexA.
InterProi IPR006200. LexA.
IPR006199. LexA_DNA-bd_dom.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR006197. Peptidase_S24_LexA.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF01726. LexA_DNA_bind. 1 hit.
PF00717. Peptidase_S24. 1 hit.
[Graphical view ]
PRINTSi PR00726. LEXASERPTASE.
SUPFAMi SSF51306. SSF51306. 1 hit.
TIGRFAMsi TIGR00498. lexA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 19672.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 19672 / NBRC 101217 / Yu37-1Imported.

Entry informationi

Entry nameiE4TG52_CALNY
AccessioniPrimary (citable) accession number: E4TG52
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: October 29, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3