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E4TG52

- E4TG52_CALNY

UniProt

E4TG52 - E4TG52_CALNY

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Protein
LexA repressor
Gene
lexA, Calni_0691
Organism
Calditerrivibrio nitroreducens (strain DSM 19672 / NBRC 101217 / Yu37-1)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair By similarity.UniRule annotationSAAS annotations

Catalytic activityi

Hydrolysis of Ala-|-Gly bond in repressor LexA.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei82 – 832Cleavage; by autolysis By similarityUniRule annotation
Active sitei117 – 1171For autocatalytic cleavage activity By similarityUniRule annotation
Active sitei154 – 1541For autocatalytic cleavage activity By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi27 – 4721H-T-H motif By similarityUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. serine-type endopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. DNA repair Source: UniProtKB-HAMAP
  2. DNA replication Source: UniProtKB-HAMAP
  3. SOS response Source: UniProtKB-HAMAP
  4. negative regulation of transcription, DNA-templated Source: UniProtKB-HAMAP
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotations, RepressorUniRule annotationSAAS annotations

Keywords - Biological processi

DNA damage, DNA repair, DNA replicationUniRule annotationSAAS annotations, SOS responseUniRule annotationSAAS annotations, Transcription, Transcription regulationUniRule annotationSAAS annotations

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciCNIT768670:GHD1-704-MONOMER.

Protein family/group databases

MEROPSiS24.001.

Names & Taxonomyi

Protein namesi
Recommended name:
LexA repressorUniRule annotation (EC:3.4.21.88UniRule annotation)
Gene namesi
Name:lexAUniRule annotation
Ordered Locus Names:Calni_0691Imported
OrganismiCalditerrivibrio nitroreducens (strain DSM 19672 / NBRC 101217 / Yu37-1)Imported
Taxonomic identifieri768670 [NCBI]
Taxonomic lineageiBacteriaDeferribacteresDeferribacteralesDeferribacteraceae
ProteomesiUP000007039: Chromosome

PTM / Processingi

Keywords - PTMi

Autocatalytic cleavageUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000232167.
KOiK01356.
OMAiWLEPANS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.10.109.10. 1 hit.
HAMAPiMF_00015. LexA.
InterProiIPR006200. LexA.
IPR006199. LexA_DNA-bd_dom.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR006197. Peptidase_S24_LexA.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01726. LexA_DNA_bind. 1 hit.
PF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00726. LEXASERPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR00498. lexA. 1 hit.

Sequencei

Sequence statusi: Complete.

E4TG52-1 [UniParc]FASTAAdd to Basket

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MDLTDRQKEC INFISRFIKD YGYPPTIQEI CNNLGIRSKN AGFKLLNALE    50
SKGFIRRNRS ISRGIELLKI NNGIPILGRI TAGIPIDAEE NIEGYIPLED 100
ILGDISGYFG LRVIGDSMVE KGILDGDIAI IKKQPDILNN QVGAFMINGE 150
FTLKTFKMMD DGRIYLKPEN NKYKPIYITE NDTFEVVGLL KMVVRLFGED 200
YEARKY 206
Length:206
Mass (Da):23,394
Last modified:February 8, 2011 - v1
Checksum:iA54DD314E769234C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002347 Genomic DNA. Translation: ADR18602.1.
RefSeqiWP_013450815.1. NC_014758.1.
YP_004050765.1. NC_014758.1.

Genome annotation databases

EnsemblBacteriaiADR18602; ADR18602; Calni_0691.
GeneIDi10008702.
KEGGicni:Calni_0691.
PATRICi45189099. VBICalNit163602_0764.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002347 Genomic DNA. Translation: ADR18602.1 .
RefSeqi WP_013450815.1. NC_014758.1.
YP_004050765.1. NC_014758.1.

3D structure databases

ModBasei Search...

Protein family/group databases

MEROPSi S24.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADR18602 ; ADR18602 ; Calni_0691 .
GeneIDi 10008702.
KEGGi cni:Calni_0691.
PATRICi 45189099. VBICalNit163602_0764.

Phylogenomic databases

HOGENOMi HOG000232167.
KOi K01356.
OMAi WLEPANS.

Enzyme and pathway databases

BioCyci CNIT768670:GHD1-704-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.10.109.10. 1 hit.
HAMAPi MF_00015. LexA.
InterProi IPR006200. LexA.
IPR006199. LexA_DNA-bd_dom.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR006197. Peptidase_S24_LexA.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF01726. LexA_DNA_bind. 1 hit.
PF00717. Peptidase_S24. 1 hit.
[Graphical view ]
PRINTSi PR00726. LEXASERPTASE.
SUPFAMi SSF51306. SSF51306. 1 hit.
TIGRFAMsi TIGR00498. lexA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 19672.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 19672 / NBRC 101217 / Yu37-1.

Entry informationi

Entry nameiE4TG52_CALNY
AccessioniPrimary (citable) accession number: E4TG52
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 3, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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