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E4TFX7

- E4TFX7_CALNY

UniProt

E4TFX7 - E4TFX7_CALNY

Protein

UDP-N-acetylmuramoylalanine--D-glutamate ligase

Gene

murD

Organism
Calditerrivibrio nitroreducens (strain DSM 19672 / NBRC 101217 / Yu37-1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).UniRule annotationSAAS annotation

    Catalytic activityi

    ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate.UniRule annotationSAAS annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi90 – 967ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tetrahydrofolylpolyglutamate synthase activity Source: InterPro
    3. UDP-N-acetylmuramoylalanine-D-glutamate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    4. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotationSAAS annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCNIT768670:GHD1-1766-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-N-acetylmuramoylalanine--D-glutamate ligaseUniRule annotation (EC:6.3.2.9UniRule annotation)
    Alternative name(s):
    D-glutamic acid-adding enzymeUniRule annotation
    UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseUniRule annotation
    Gene namesi
    Name:murDUniRule annotation
    Ordered Locus Names:Calni_1727Imported
    OrganismiCalditerrivibrio nitroreducens (strain DSM 19672 / NBRC 101217 / Yu37-1)Imported
    Taxonomic identifieri768670 [NCBI]
    Taxonomic lineageiBacteriaDeferribacteresDeferribacteralesDeferribacteraceae
    ProteomesiUP000007039: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MurCDEF family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000049428.
    KOiK01925.
    OMAiPEYWAVE.

    Family and domain databases

    Gene3Di3.40.1190.10. 1 hit.
    3.90.190.20. 1 hit.
    HAMAPiMF_00639. MurD.
    InterProiIPR018109. Folylpolyglutamate_synth_CS.
    IPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR005762. UDP-N-AcMur-Glu_ligase.
    [Graphical view]
    PfamiPF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view]
    SUPFAMiSSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    TIGRFAMsiTIGR01087. murD. 1 hit.
    PROSITEiPS01011. FOLYLPOLYGLU_SYNT_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E4TFX7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKAAILGYGK SGQTAKRLLE IKGTETIEIY DDKMDGFKGI KDFNYEEFDT    50
    VVVSPGIDLT NIDLPTERIT SELELAFEFI KDKKIIGITG TNGKSTVTFL 100
    TAQLLKNIGI NAEFCGNIGV TVGDTYLLKN PDVYVVEVSS FQLDLLKRFR 150
    FDTSTITNIT PDHLDRYKTM DRYITSKSRM VEFTEGVSFL EKGGWNEIFK 200
    KYENIKYVDG ELKSYPLLNG NLLEFEDFYV DVNRYNLFGF HNIVNLSFAL 250
    LLTNQIVRLK GDVTGLVENL TPLEHRCELV TEINGVKYIN DSKGTNVDST 300
    LTALKSSSYP TTLILGGKDK NGDFSVLSDE INKKAKLVIC CGAAGEKIYN 350
    SLKDIIDVKI VRVELLKDAI SLAYRETKEG TVLFSPACAS FDEFNNFEER 400
    GRFFKNYVNN LKVRGC 416
    Length:416
    Mass (Da):46,826
    Last modified:February 8, 2011 - v1
    Checksum:i1DA6835077503310
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002347 Genomic DNA. Translation: ADR19633.1.
    RefSeqiYP_004051796.1. NC_014758.1.

    Genome annotation databases

    EnsemblBacteriaiADR19633; ADR19633; Calni_1727.
    GeneIDi10009764.
    KEGGicni:Calni_1727.
    PATRICi45191256. VBICalNit163602_1817.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002347 Genomic DNA. Translation: ADR19633.1 .
    RefSeqi YP_004051796.1. NC_014758.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADR19633 ; ADR19633 ; Calni_1727 .
    GeneIDi 10009764.
    KEGGi cni:Calni_1727.
    PATRICi 45191256. VBICalNit163602_1817.

    Phylogenomic databases

    HOGENOMi HOG000049428.
    KOi K01925.
    OMAi PEYWAVE.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci CNIT768670:GHD1-1766-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.10. 1 hit.
    3.90.190.20. 1 hit.
    HAMAPi MF_00639. MurD.
    InterProi IPR018109. Folylpolyglutamate_synth_CS.
    IPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR005762. UDP-N-AcMur-Glu_ligase.
    [Graphical view ]
    Pfami PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    TIGRFAMsi TIGR01087. murD. 1 hit.
    PROSITEi PS01011. FOLYLPOLYGLU_SYNT_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 19672.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 19672 / NBRC 101217 / Yu37-1Imported.

    Entry informationi

    Entry nameiE4TFX7_CALNY
    AccessioniPrimary (citable) accession number: E4TFX7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 8, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3