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Protein

UDP-N-acetylmuramoylalanine--D-glutamate ligase

Gene

murD

Organism
Calditerrivibrio nitroreducens (strain DSM 19672 / NBRC 101217 / Yu37-1)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).UniRule annotationSAAS annotation

Catalytic activityi

ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate.UniRule annotationSAAS annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi90 – 967ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tetrahydrofolylpolyglutamate synthase activity Source: InterPro
  3. UDP-N-acetylmuramoylalanine-D-glutamate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. cell wall organization Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  5. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciCNIT768670:GHD1-1766-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligaseUniRule annotation (EC:6.3.2.9UniRule annotation)
Alternative name(s):
D-glutamic acid-adding enzymeUniRule annotation
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseUniRule annotation
Gene namesi
Name:murDUniRule annotation
Ordered Locus Names:Calni_1727Imported
OrganismiCalditerrivibrio nitroreducens (strain DSM 19672 / NBRC 101217 / Yu37-1)Imported
Taxonomic identifieri768670 [NCBI]
Taxonomic lineageiBacteriaDeferribacteresDeferribacteralesDeferribacteraceae
ProteomesiUP000007039: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the MurCDEF family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000049428.
KOiK01925.
OMAiHNSENIA.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_00639. MurD.
InterProiIPR018109. Folylpolyglutamate_synth_CS.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view]
PfamiPF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsiTIGR01087. murD. 1 hit.
PROSITEiPS01011. FOLYLPOLYGLU_SYNT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4TFX7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKAAILGYGK SGQTAKRLLE IKGTETIEIY DDKMDGFKGI KDFNYEEFDT
60 70 80 90 100
VVVSPGIDLT NIDLPTERIT SELELAFEFI KDKKIIGITG TNGKSTVTFL
110 120 130 140 150
TAQLLKNIGI NAEFCGNIGV TVGDTYLLKN PDVYVVEVSS FQLDLLKRFR
160 170 180 190 200
FDTSTITNIT PDHLDRYKTM DRYITSKSRM VEFTEGVSFL EKGGWNEIFK
210 220 230 240 250
KYENIKYVDG ELKSYPLLNG NLLEFEDFYV DVNRYNLFGF HNIVNLSFAL
260 270 280 290 300
LLTNQIVRLK GDVTGLVENL TPLEHRCELV TEINGVKYIN DSKGTNVDST
310 320 330 340 350
LTALKSSSYP TTLILGGKDK NGDFSVLSDE INKKAKLVIC CGAAGEKIYN
360 370 380 390 400
SLKDIIDVKI VRVELLKDAI SLAYRETKEG TVLFSPACAS FDEFNNFEER
410
GRFFKNYVNN LKVRGC
Length:416
Mass (Da):46,826
Last modified:February 8, 2011 - v1
Checksum:i1DA6835077503310
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002347 Genomic DNA. Translation: ADR19633.1.
RefSeqiYP_004051796.1. NC_014758.1.

Genome annotation databases

EnsemblBacteriaiADR19633; ADR19633; Calni_1727.
GeneIDi10009764.
KEGGicni:Calni_1727.
PATRICi45191256. VBICalNit163602_1817.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002347 Genomic DNA. Translation: ADR19633.1.
RefSeqiYP_004051796.1. NC_014758.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADR19633; ADR19633; Calni_1727.
GeneIDi10009764.
KEGGicni:Calni_1727.
PATRICi45191256. VBICalNit163602_1817.

Phylogenomic databases

HOGENOMiHOG000049428.
KOiK01925.
OMAiHNSENIA.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciCNIT768670:GHD1-1766-MONOMER.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_00639. MurD.
InterProiIPR018109. Folylpolyglutamate_synth_CS.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view]
PfamiPF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsiTIGR01087. murD. 1 hit.
PROSITEiPS01011. FOLYLPOLYGLU_SYNT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 19672.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 19672 / NBRC 101217 / Yu37-1Imported.

Entry informationi

Entry nameiE4TFX7_CALNY
AccessioniPrimary (citable) accession number: E4TFX7
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: February 4, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.