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E4TFX7

- E4TFX7_CALNY

UniProt

E4TFX7 - E4TFX7_CALNY

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Protein
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Gene
murD, Calni_1727
Organism
Calditerrivibrio nitroreducens (strain DSM 19672 / NBRC 101217 / Yu37-1)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate.UniRule annotationSAAS annotations

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi90 – 967ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. UDP-N-acetylmuramoylalanine-D-glutamate ligase activity Source: UniProtKB-HAMAP
  3. tetrahydrofolylpolyglutamate synthase activity Source: InterPro

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  4. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotationSAAS annotations, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotations, Peptidoglycan synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciCNIT768670:GHD1-1766-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligaseUniRule annotation (EC:6.3.2.9UniRule annotation)
Alternative name(s):
D-glutamic acid-adding enzyme
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Gene namesi
Name:murDUniRule annotation
Ordered Locus Names:Calni_1727Imported
OrganismiCalditerrivibrio nitroreducens (strain DSM 19672 / NBRC 101217 / Yu37-1)Imported
Taxonomic identifieri768670 [NCBI]
Taxonomic lineageiBacteriaDeferribacteresDeferribacteralesDeferribacteraceae
ProteomesiUP000007039: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Belongs to the MurCDEF family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000049428.
KOiK01925.
OMAiPEYWAVE.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_00639. MurD.
InterProiIPR018109. Folylpolyglutamate_synth_CS.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view]
PfamiPF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsiTIGR01087. murD. 1 hit.
PROSITEiPS01011. FOLYLPOLYGLU_SYNT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4TFX7-1 [UniParc]FASTAAdd to Basket

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MKAAILGYGK SGQTAKRLLE IKGTETIEIY DDKMDGFKGI KDFNYEEFDT    50
VVVSPGIDLT NIDLPTERIT SELELAFEFI KDKKIIGITG TNGKSTVTFL 100
TAQLLKNIGI NAEFCGNIGV TVGDTYLLKN PDVYVVEVSS FQLDLLKRFR 150
FDTSTITNIT PDHLDRYKTM DRYITSKSRM VEFTEGVSFL EKGGWNEIFK 200
KYENIKYVDG ELKSYPLLNG NLLEFEDFYV DVNRYNLFGF HNIVNLSFAL 250
LLTNQIVRLK GDVTGLVENL TPLEHRCELV TEINGVKYIN DSKGTNVDST 300
LTALKSSSYP TTLILGGKDK NGDFSVLSDE INKKAKLVIC CGAAGEKIYN 350
SLKDIIDVKI VRVELLKDAI SLAYRETKEG TVLFSPACAS FDEFNNFEER 400
GRFFKNYVNN LKVRGC 416
Length:416
Mass (Da):46,826
Last modified:February 8, 2011 - v1
Checksum:i1DA6835077503310
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002347 Genomic DNA. Translation: ADR19633.1.
RefSeqiYP_004051796.1. NC_014758.1.

Genome annotation databases

EnsemblBacteriaiADR19633; ADR19633; Calni_1727.
GeneIDi10009764.
KEGGicni:Calni_1727.
PATRICi45191256. VBICalNit163602_1817.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002347 Genomic DNA. Translation: ADR19633.1 .
RefSeqi YP_004051796.1. NC_014758.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADR19633 ; ADR19633 ; Calni_1727 .
GeneIDi 10009764.
KEGGi cni:Calni_1727.
PATRICi 45191256. VBICalNit163602_1817.

Phylogenomic databases

HOGENOMi HOG000049428.
KOi K01925.
OMAi PEYWAVE.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci CNIT768670:GHD1-1766-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.10. 1 hit.
3.90.190.20. 1 hit.
HAMAPi MF_00639. MurD.
InterProi IPR018109. Folylpolyglutamate_synth_CS.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view ]
Pfami PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view ]
SUPFAMi SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsi TIGR01087. murD. 1 hit.
PROSITEi PS01011. FOLYLPOLYGLU_SYNT_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 19672.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 19672 / NBRC 101217 / Yu37-1.

Entry informationi

Entry nameiE4TFX7_CALNY
AccessioniPrimary (citable) accession number: E4TFX7
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: June 11, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3