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E4TFX3 (E4TFX3_CALNY) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Calni_1723 EMBL ADR19629.1
OrganismCalditerrivibrio nitroreducens (strain DSM 19672 / NBRC 101217 / Yu37-1) [Complete proteome] [HAMAP] EMBL ADR19629.1
Taxonomic identifier768670 [NCBI]
Taxonomic lineageBacteriaDeferribacteresDeferribacteralesDeferribacteraceae

Protein attributes

Sequence length298 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain103 – 291189ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding129 – 17850ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2461Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2581Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2581Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2601Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
E4TFX3 [UniParc].

Last modified February 8, 2011. Version 1.
Checksum: 96A35AD932B14A8A

FASTA29833,622
        10         20         30         40         50         60 
MHSDKIAVLY GGLSSERDVS IKTGNGIYNA LLRKGFKNSF LLDVDWSLPE KLIKHKPDFC 

        70         80         90        100        110        120 
YIALHGRYGE DGTVQGLLEY MRIPYNGPGV TASAISFDKV ITKKILKSVN IPTADYFEYK 

       130        140        150        160        170        180 
NEQSSPFYPC VVKPAREGST IGVTIVYEDK EFIPAIEDAK KYDNKIIVER FIKGKELTIS 

       190        200        210        220        230        240 
IIDDLVLPII WIKPKKGFYD YTSKYTKGMT EYLFETGLNA KEEEMVKKVA KDAYEVVGCE 

       250        260        270        280        290 
GASRVDIIYD GDIPNVLEIN TLPGMTETSL LPNAAAKYGI AYDELVEMLY FKGKNRYE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002347 Genomic DNA. Translation: ADR19629.1.
RefSeqYP_004051792.1. NC_014758.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADR19629; ADR19629; Calni_1723.
GeneID10009760.
KEGGcni:Calni_1723.
PATRIC45191248. VBICalNit163602_1813.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011592.
KOK01921.
OMARSAYGIY.

Enzyme and pathway databases

BioCycCNIT768670:GHD1-1762-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE4TFX3_CALNY
AccessionPrimary (citable) accession number: E4TFX3
Entry history
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: June 11, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)