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E4TD77

- E4TD77_RIEAD

UniProt

E4TD77 - E4TD77_RIEAD

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Protein
D-alanine--D-alanine ligase
Gene
ddl, Riean_1579, RA0C_1871
Organism
Riemerella anatipestifer (strain ATCC 11845 / DSM 15868 / JCM 9532 / NCTC 11014)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotations

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi277 – 2771Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi289 – 2891Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi289 – 2891Magnesium or manganese 2 By similarityUniRule annotation
Metal bindingi291 – 2911Magnesium or manganese 2 By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi151 – 20656ATP By similarityUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  2. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotations, Peptidoglycan synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, ManganeseUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciRANA693978:GHF6-1627-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:Riean_1579Imported
ORF Names:RA0C_1871Imported
OrganismiRiemerella anatipestifer (strain ATCC 11845 / DSM 15868 / JCM 9532 / NCTC 11014)Imported
Taxonomic identifieri693978 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeRiemerella
ProteomesiUP000010093: Chromosome, UP000008719: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini123 – 322200ATP-grasp By similarityUniRule annotation
Add
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotations

Phylogenomic databases

HOGENOMiHOG000011592.
KOiK01921.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4TD77-1 [UniParc]FASTAAdd to Basket

« Hide

MSKKNIAVVM GGYSDEYKVS LKSGQLIYDS LDRDLYNVYK VVVLKEGWFY    50
LDENEAKLPI QKGDFSVNLP SGEVLRFDVC FNTIHGTPGE NGVLQAYWDA 100
IGQKYTGCDF YQSALTFNKK DTLAVLAKYG IPSAKSFYIK KGEAYDKDKI 150
INELKLPLFV KPNQSGSSLG ISKVKEVSEF EAALEKAFLE DDEVLVESFL 200
DGMEVSVGVL DYKGETIVLG ITEIIPETEF FDYEAKYQGA SQEITPARLD 250
EATRLRVEEV AKRAYNSLGM KGFSRSEYII MNGVPYMLEM NTNPGFSPAS 300
ILPQQARIYG ISIKDLCGNE VEKALAK 327
Length:327
Mass (Da):36,504
Last modified:February 8, 2011 - v1
Checksum:iCC0D89F980A0ACE6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002346 Genomic DNA. Translation: ADQ82736.1.
CP003388 Genomic DNA. Translation: AFD56746.1.
RefSeqiWP_013447134.1. NC_017045.1.
YP_004046242.1. NC_014738.1.
YP_005395289.1. NC_017045.1.

Genome annotation databases

EnsemblBacteriaiADQ82736; ADQ82736; Riean_1579.
AFD56746; AFD56746; RA0C_1871.
GeneIDi10002357.
11997644.
KEGGirai:RA0C_1871.
ran:Riean_1579.
PATRICi45353953. VBIRieAna155424_1607.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002346 Genomic DNA. Translation: ADQ82736.1 .
CP003388 Genomic DNA. Translation: AFD56746.1 .
RefSeqi WP_013447134.1. NC_017045.1.
YP_004046242.1. NC_014738.1.
YP_005395289.1. NC_017045.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADQ82736 ; ADQ82736 ; Riean_1579 .
AFD56746 ; AFD56746 ; RA0C_1871 .
GeneIDi 10002357.
11997644.
KEGGi rai:RA0C_1871.
ran:Riean_1579.
PATRICi 45353953. VBIRieAna155424_1607.

Phylogenomic databases

HOGENOMi HOG000011592.
KOi K01921.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci RANA693978:GHF6-1627-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 11845 / DSM 15868 / JCM 9532 / NCTC 11014 and DSM 15868Imported.
  2. "Complete Genome Sequence of Riemerella anatipestifer Reference Strain."
    Wang X., Zhu D., Wang M., Cheng A., Jia R., Zhou Y., Chen Z., Luo Q., Liu F., Wang Y., Chen X.Y.
    J. Bacteriol. 194:3270-3271(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 11845Imported.
  3. "Riemerella anatipestifer ATCC 11845 Complete Genome."
    Cheng A.-C., Wang M.-S., Zhu D.-K., Wang X.-J.
    Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC 11845Imported.

Entry informationi

Entry nameiE4TD77_RIEAD
AccessioniPrimary (citable) accession number: E4TD77
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 3, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi