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Protein

Alanine racemase

Gene

RA0C_1428

Organism
Riemerella anatipestifer (strain ATCC 11845 / DSM 15868 / JCM 9532 / NCTC 11014)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (RA0C_1428)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei483Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei582SubstrateUniRule annotation1
Active sitei709Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei758Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciRANA693978:GHF6-1323-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
ORF Names:RA0C_1428Imported
OrganismiRiemerella anatipestifer (strain ATCC 11845 / DSM 15868 / JCM 9532 / NCTC 11014)Imported
Taxonomic identifieri693978 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeRiemerella
Proteomesi
  • UP000010093 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei483N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliE4TAG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini688 – 812Ala_racemase_CInterPro annotationAdd BLAST125

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000274965.
KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
3.40.1190.10. 1 hit.
3.40.1390.10. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR036565. Mur-like_cat_sf.
IPR036615. Mur_ligase_C_dom_sf.
IPR013221. Mur_ligase_cen.
IPR035911. MurE/MurF_N.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

E4TAG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYTARQIAE ITGAKLIGAG DKIIKHFAFD SRIIYSPKNT GFVAIKTKKN
60 70 80 90 100
NGEKYIASAV EKGIELIVSE HKTLDNEHLS WLIVDDTVKF LQKLAHLHLK
110 120 130 140 150
SHNIQTIGIT GSNGKTIVKE WLYQCLSEDI RCVKSPKSFN SQIGLPLSLL
160 170 180 190 200
NIKPEHKVGI FEVGISEPNE MTTLETIFSP KIGVLTHIGS AHISNFKSEK
210 220 230 240 250
HLVDEKISLF KDSESIIFNG DNILVSNKIN TLYSSKNLIS YGFNKDNNIH
260 270 280 290 300
ISSNWKDRQQ PITVQCFDKS FSFPAQQRDE ATLSNVLAII AVMHLLEFST
310 320 330 340 350
EKMIEKINNL KAVEMRLESV NGIKNNLIIN DSFNLDLDSL KIAFEFIKSY
360 370 380 390 400
QKPKKSLIIT DFTEKSDADN LYQEVASLIN EQNFNKVFLI GEEISQYQHL
410 420 430 440 450
LNTESFSFNT TNDLFSNQEF KDLENELILL KGARKFEIEQ VKTYLELQKH
460 470 480 490 500
DTVLEVNLNN LLHNINVHKS LLKPETKIMA MVKAYSYGLG GYEIAEFLQH
510 520 530 540 550
HHIDYLGVAV ADEGVELRKN GITVPIVVMN PEQHSYNTII EYNLEPNIYS
560 570 580 590 600
FRVLELFHKQ LKQNGYEGRY PIHIKLETGM HRLGFKEDEI DQLKDYLNQM
610 620 630 640 650
SVKVESIFSH LSSSDIPQEK DYTLAQCQKF DKLSQNIIKD LNYKPLRHIL
660 670 680 690 700
NSAGITNYTY YQMDMVRIGI GMMGISASPE IQPLLNPVVA FKSVISQISE
710 720 730 740 750
IQPNDSVSYG RRYKASKSTR IATIPVGYAD GVPRLLSNGV GYVGIKNTLC
760 770 780 790 800
PIVGSVCMDM MMVDISDLPT KEGDEVTIFH EKPSLEDFAM YSQTIPYEVL
810
TSISRRVKRV YIKD
Length:814
Mass (Da):92,484
Last modified:February 8, 2011 - v1
Checksum:i9FD4B39EDB4B2E6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003388 Genomic DNA. Translation: AFD56323.1.
RefSeqiWP_004920603.1. NC_017045.1.

Genome annotation databases

EnsemblBacteriaiAFD56323; AFD56323; RA0C_1428.
GeneIDi29730430.
KEGGirai:RA0C_1428.
ran:Riean_1160.
PATRICifig|693978.17.peg.1415.

Similar proteinsi

Entry informationi

Entry nameiE4TAG0_RIEAD
AccessioniPrimary (citable) accession number: E4TAG0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: October 25, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported